{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T05:35:34Z","timestamp":1790832934624,"version":"4.1.0"},"reference-count":81,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2021,11,26]],"date-time":"2021-11-26T00:00:00Z","timestamp":1637884800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["FIS-PI19\/00166"],"award-info":[{"award-number":["FIS-PI19\/00166"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006541","name":"Comunidad de Madrid","doi-asserted-by":"publisher","award":["B-2017\/BMD-3751 and S2017\/BMD3684 MOIR-2"],"award-info":[{"award-number":["B-2017\/BMD-3751 and S2017\/BMD3684 MOIR-2"]}],"id":[{"id":"10.13039\/501100006541","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003329","name":"Ministry of Economy, Industry and Competitiveness","doi-asserted-by":"publisher","award":["RTI2018-095166-B-I00"],"award-info":[{"award-number":["RTI2018-095166-B-I00"]}],"id":[{"id":"10.13039\/501100003329","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Anorexia nervosa (AN) is a mental disorder characterized by an intense fear of weight gain that affects mainly young women. It courses with a negative body image leading to altered eating behaviors that have devastating physical, metabolic, and psychological consequences for the patients. Although its origin is postulated to be multifactorial, the etiology of AN remains unknown, and this increases the likelihood of chronification and relapsing. Thus, expanding the available knowledge on the pathophysiology of AN is of enormous interest. Metabolomics is proposed as a powerful tool for the elucidation of disease mechanisms and to provide new insights into the diagnosis, treatment, and prognosis of AN. A review of the literature related to studies of AN patients by employing metabolomic strategies to characterize the main alterations associated with the metabolic phenotype of AN during the last 10 years is described. The most common metabolic alterations are derived from chronic starvation, including amino acid, lipid, and carbohydrate disturbances. Nonetheless, recent findings have shifted the attention to gut-microbiota metabolites as possible factors contributing to AN development, progression, and maintenance. We have identified the areas of ongoing research in AN and propose further perspectives to improve our knowledge and understanding of this disease.<\/jats:p>","DOI":"10.3390\/nu13124249","type":"journal-article","created":{"date-parts":[[2021,11,30]],"date-time":"2021-11-30T23:22:56Z","timestamp":1638314576000},"page":"4249","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Unveiling Metabolic Phenotype Alterations in Anorexia Nervosa through Metabolomics"],"prefix":"10.3390","volume":"13","author":[{"given":"Laura","family":"Mayo-Mart\u00ednez","sequence":"first","affiliation":[{"name":"Centre for Metabolomics and Bioanalysis (CEMBIO), Faculty of Pharmacy, Universidad San Pablo-CEU, Montepr\u00edncipe Campus, 28660 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6457-6234","authenticated-orcid":false,"given":"Francisco J.","family":"Rup\u00e9rez","sequence":"additional","affiliation":[{"name":"Centre for Metabolomics and Bioanalysis (CEMBIO), Faculty of Pharmacy, Universidad San Pablo-CEU, Montepr\u00edncipe Campus, 28660 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5524-2646","authenticated-orcid":false,"given":"Gabriel \u00c1.","family":"Martos-Moreno","sequence":"additional","affiliation":[{"name":"Departments of Pediatrics & Pediatric Endocrinology, Hospital Infantil Universitario Ni\u00f1o Jes\u00fas, 28009 Madrid, Spain"},{"name":"La Princesa Research Institute, 28006 Madrid, Spain"},{"name":"Department of Pediatrics, Universidad Aut\u00f3noma de Madrid, 28006 Madrid, Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Fisiopatolog\u00eda de la Obesidad y Nutrici\u03ccn (CIBEROBN), Instituto de Salud Carlos III, 28029 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Montserrat","family":"Graell","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Hospital Infantil Universitario Ni\u00f1o Jes\u00fas, 28009 Madrid, Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red Salud Mental (CIBERSAM), Instituto de Salud Carlos III, 28029 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4722-491X","authenticated-orcid":false,"given":"Coral","family":"Barbas","sequence":"additional","affiliation":[{"name":"Centre for Metabolomics and Bioanalysis (CEMBIO), Faculty of Pharmacy, Universidad San Pablo-CEU, Montepr\u00edncipe Campus, 28660 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5826-0276","authenticated-orcid":false,"given":"Jes\u00fas","family":"Argente","sequence":"additional","affiliation":[{"name":"Departments of Pediatrics & Pediatric Endocrinology, Hospital Infantil Universitario Ni\u00f1o Jes\u00fas, 28009 Madrid, Spain"},{"name":"La Princesa Research Institute, 28006 Madrid, Spain"},{"name":"Department of Pediatrics, Universidad Aut\u00f3noma de Madrid, 28006 Madrid, Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Fisiopatolog\u00eda de la Obesidad y Nutrici\u03ccn (CIBEROBN), Instituto de Salud Carlos III, 28029 Madrid, Spain"},{"name":"IMDEA Food Institute, CEI UAM & CSIC, 28049 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonia","family":"Garc\u00eda","sequence":"additional","affiliation":[{"name":"Centre for Metabolomics and Bioanalysis (CEMBIO), Faculty of Pharmacy, Universidad San Pablo-CEU, Montepr\u00edncipe Campus, 28660 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,11,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1021\/acs.analchem.9b04553","article-title":"Recent Developments along the Analytical Process for Metabolomics Workflows","volume":"92","author":"Dudzik","year":"2020","journal-title":"Anal. 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