{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T05:56:03Z","timestamp":1790142963133,"version":"4.0.1"},"reference-count":75,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2021,11,26]],"date-time":"2021-11-26T00:00:00Z","timestamp":1637884800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["HMRC APP1141699"],"award-info":[{"award-number":["HMRC APP1141699"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Preeclampsia is a pregnancy disorder characterized by hypertension. Epidemiological studies have associated preeclampsia with an increased risk of neurodevelopmental disorders in offspring, such as autism and schizophrenia. Preeclampsia has also been linked with maternal vitamin D deficiency, another candidate risk factor also associated with autism. Our laboratory has established a gestational vitamin-D-deficient rat model that shows consistent and robust behavioural phenotypes associated with autism- and schizophrenia-related animal models. Therefore, we explored here whether this model also produces preeclampsia as a possible mediator of behavioural phenotypes in offspring. We showed that gestational vitamin D deficiency was not associated with maternal blood pressure or proteinuria during late gestation. Maternal and placental angiogenic and vasculogenic factors were also not affected by a vitamin-D-deficient diet. We further showed that exposure to low vitamin D levels did not expose the placenta to oxidative stress. Overall, gestational vitamin D deficiency in our rat model was not associated with preeclampsia-related features, suggesting that well-described behavioural phenotypes in offspring born to vitamin-D-deficient rat dams are unlikely to be mediated via a preeclampsia-related mechanism.<\/jats:p>","DOI":"10.3390\/nu13124254","type":"journal-article","created":{"date-parts":[[2021,11,30]],"date-time":"2021-11-30T23:22:56Z","timestamp":1638314576000},"page":"4254","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Developmental Vitamin D Deficiency in Pregnant Rats Does Not Induce Preeclampsia"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3607-1620","authenticated-orcid":false,"given":"Asad","family":"Ali","sequence":"first","affiliation":[{"name":"Neurobiology, Queensland Brain Institute, University of Queensland, St. Lucia, QLD 4072, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suzanne","family":"Alexander","sequence":"additional","affiliation":[{"name":"Neurobiology, Queensland Brain Institute, University of Queensland, St. Lucia, QLD 4072, Australia"},{"name":"Neurobiology, Queensland Centre for Mental Health Research, Wacol, QLD 4076, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pauline","family":"Ko","sequence":"additional","affiliation":[{"name":"Neurobiology, Queensland Brain Institute, University of Queensland, St. Lucia, QLD 4072, Australia"},{"name":"Neurobiology, Queensland Centre for Mental Health Research, Wacol, QLD 4076, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2675-8149","authenticated-orcid":false,"given":"James S. M.","family":"Cuffe","sequence":"additional","affiliation":[{"name":"Placental Endocrinology, School of Biomedical Sciences, University of Queensland, St. Lucia, QLD 4072, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew J. O.","family":"Whitehouse","sequence":"additional","affiliation":[{"name":"Autism Research Team, Telethon Kids Institute, The University of Western Australia, Crawley, WA 6009, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4792-6068","authenticated-orcid":false,"given":"John J.","family":"McGrath","sequence":"additional","affiliation":[{"name":"Neurobiology, Queensland Brain Institute, University of Queensland, St. Lucia, QLD 4072, Australia"},{"name":"Neurobiology, Queensland Centre for Mental Health Research, Wacol, QLD 4076, Australia"},{"name":"NCRR\u2014National Centre for Register-Based Research, Department of Economics and Business Economics, Aarhus University, 8000 Aarhus, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darryl","family":"Eyles","sequence":"additional","affiliation":[{"name":"Neurobiology, Queensland Brain Institute, University of Queensland, St. Lucia, QLD 4072, Australia"},{"name":"Neurobiology, Queensland Centre for Mental Health Research, Wacol, QLD 4076, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,11,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.tins.2020.02.003","article-title":"Neurodevelopmental Outcomes of Prenatal Preeclampsia Exposure","volume":"43","author":"Gumusoglu","year":"2020","journal-title":"Trends Neurosci."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1192\/bjp.2017.27","article-title":"Pre-eclampsia and the risk of autism-spectrum disorder in offspring: Meta-analysis","volume":"212","author":"Dachew","year":"2018","journal-title":"Br. 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