{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T11:08:47Z","timestamp":1791284927627,"version":"4.1.0"},"reference-count":169,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2021,12,8]],"date-time":"2021-12-08T00:00:00Z","timestamp":1638921600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Background: Cancer and its therapy is commonly associated with a variety of side effects that impact eating behaviors that reduce nutritional intake. This review will outline potential causes of chemotherapy and radiation damage as well as approaches for the amelioration of the side effects of cancer during therapy. Methods: Information for clinicians, patients, and their caregivers about toxicity mitigation including nausea reduction, damage to epithelial structures such as skin and mucosa, organ toxicity, and education is reviewed. Results: How to anticipate, reduce, and prevent some toxicities encountered during chemotherapy and radiation is detailed with the goal to improve eating behaviors. Strategies for health care professionals, caregivers, and patients to consider include (a) the reduction in nausea and vomiting, (b) decreasing damage to the mucosa, (c) avoiding a catabolic state and muscle wasting (sarcopenia), and (d) developing therapeutic alliances with patients, caregivers, and oncologists. Conclusions: Although the reduction of side effects involves anticipatory guidance and proactive team effort (e.g., forward observation, electronic interactions, patient reported outcomes), toxicity reduction can be satisfying for not only the patient, but everyone involved in cancer care.<\/jats:p>","DOI":"10.3390\/nu13124397","type":"journal-article","created":{"date-parts":[[2021,12,8]],"date-time":"2021-12-08T23:30:00Z","timestamp":1639006200000},"page":"4397","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Strategies to Mitigate Chemotherapy and Radiation Toxicities That Affect Eating"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0011-0969","authenticated-orcid":false,"given":"Peter M.","family":"Anderson","sequence":"first","affiliation":[{"name":"Pediatric Hematology\/Oncology and Bone Marrow Transplant, Cleveland Clinic Children\u2019s, Cleveland, OH 44195, USA"},{"name":"Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH 44195, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefanie M.","family":"Thomas","sequence":"additional","affiliation":[{"name":"Pediatric Hematology\/Oncology and Bone Marrow Transplant, Cleveland Clinic Children\u2019s, Cleveland, OH 44195, USA"},{"name":"Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH 44195, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shauna","family":"Sartoski","sequence":"additional","affiliation":[{"name":"Pediatric Hematology\/Oncology and Bone Marrow Transplant, Cleveland Clinic Children\u2019s, Cleveland, OH 44195, USA"},{"name":"Department of Nursing, Cleveland Clinic, Cleveland, OH 44195, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob G.","family":"Scott","sequence":"additional","affiliation":[{"name":"Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH 44195, USA"},{"name":"Department of Radiation Oncology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaitlin","family":"Sobilo","sequence":"additional","affiliation":[{"name":"Pediatric Hematology\/Oncology and Bone Marrow Transplant, Cleveland Clinic Children\u2019s, Cleveland, OH 44195, USA"},{"name":"Department of Nursing, Cleveland Clinic, Cleveland, OH 44195, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Bewley","sequence":"additional","affiliation":[{"name":"Pediatric Hematology\/Oncology and Bone Marrow Transplant, Cleveland Clinic Children\u2019s, Cleveland, OH 44195, USA"},{"name":"Peds Nutritional Services, Cleveland Clinic, Cleveland, OH 44195, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura K.","family":"Salvador","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, MD Anderson Cancer Center, Houston, TX 77030, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maritza","family":"Salazar-Abshire","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, MD Anderson Cancer Center, Houston, TX 77030, USA"},{"name":"Department of Nursing Education, MD Anderson Cancer Center, Houston, TX 77030, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,12,8]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1648","DOI":"10.1093\/jnci\/djab131","article-title":"Annual report to the nation on the status of cancer, Part 1: National cancer statistics","volume":"113","author":"Islami","year":"2021","journal-title":"J. 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