{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T10:10:17Z","timestamp":1783937417929,"version":"3.55.0"},"reference-count":31,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2021,12,10]],"date-time":"2021-12-10T00:00:00Z","timestamp":1639094400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P30DK072482"],"award-info":[{"award-number":["P30DK072482"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P30DK089507"],"award-info":[{"award-number":["P30DK089507"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01DK095738"],"award-info":[{"award-number":["R01DK095738"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Poor linear growth is common in children with cystic fibrosis (CF) and predicts pulmonary status and mortality. Growth impairment develops in infancy, prior to pulmonary decline and despite aggressive nutritional measures. We hypothesized that growth restriction during early childhood in CF is associated with reduced adult height. We used the Cystic Fibrosis Foundation (CFF) patient registry to identify CF adults between 2011 and 2015 (ages 18\u201319 y, n = 3655) and had height for age (HFA) records between ages 2 and 4 y. We found that only 26% CF adults were \u2265median HFA and 25% were &lt;10th percentile. Between 2 and 4 years, those with height &lt; 10th percentile had increased odds of being &lt;10th percentile in adulthood compared to children \u2265 10th percentile (OR = 7.7). Of HFA measured between the 10th and 25th percentiles at ages 2\u20134, 58% were &lt;25th percentile as adults. Only 13% between the 10th and 25th percentile HFA at age 2\u20134 years were &gt;50th percentile as adults. Maximum height between ages 2 and 4 highly correlated with adult height. These results demonstrate that low early childhood CF height correlates with height in adulthood. Since linear growth correlates with lung growth, identifying both risk factors and interventions for growth failure (nutritional support, confounders of clinical care, and potential endocrine involvement) could lead to improved overall health.<\/jats:p>","DOI":"10.3390\/nu13124414","type":"journal-article","created":{"date-parts":[[2021,12,10]],"date-time":"2021-12-10T02:07:18Z","timestamp":1639102038000},"page":"4414","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Most Short Children with Cystic Fibrosis Do Not Catch Up by Adulthood"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8499-4369","authenticated-orcid":false,"given":"Margaret P.","family":"Marks","sequence":"first","affiliation":[{"name":"Department of Pediatrics, University of Alabama, Birmingham, AL 35233, USA"},{"name":"Cystic Fibrosis Research Center, University of Alabama, Birmingham, AL 35233, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonya L.","family":"Heltshe","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Washington, Seattle, WA 98105, USA"},{"name":"CFF TDNCC, Seattle Children\u2019s Research Institute, Seattle, WA 98121, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2616-4911","authenticated-orcid":false,"given":"Arthur","family":"Baines","sequence":"additional","affiliation":[{"name":"CFF TDNCC, Seattle Children\u2019s Research Institute, Seattle, WA 98121, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bonnie W.","family":"Ramsey","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Washington, Seattle, WA 98105, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucas R.","family":"Hoffman","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Washington, Seattle, WA 98105, USA"},{"name":"Department of Microbiology, University of Washington, Seattle, WA 98105, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael S.","family":"Stalvey","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Alabama, Birmingham, AL 35233, USA"},{"name":"Cystic Fibrosis Research Center, University of Alabama, Birmingham, AL 35233, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,12,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1126\/science.2772657","article-title":"Identification of the cystic fibrosis gene: Chromosome walking and jumping","volume":"245","author":"Rommens","year":"1989","journal-title":"Science"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.jcf.2015.09.008","article-title":"Cystic fibrosis in young children: A review of disease manifestation, progression, and response to early treatment","volume":"15","author":"VanDevanter","year":"2016","journal-title":"J. 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