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Osteoporosis is a common disease mainly resulting from an imbalance of bone formation and bone resorption. Pharmaceutically active compounds that both activate osteogenesis, while repressing osteoclastogenesis hold the potential of being therapeutic medications for osteoporosis treatment. In the present study, sesamin, a bioactive ingredient derived from the seed of Sesamum Indicum, was screened out from a bioactive compound library and shown to exhibit dual-regulating functions on these two processes. Sesamin was demonstrated to promote osteogenesis by upregulating Wnt\/\u03b2-catenin, while repressing osteoclastogenesis via downregulating NF-\u03baB signaling . Furthermore, DANCR was found to be the key regulator in sesamin-mediated bone formation and resorption . In an ovariectomy (OVX)-induced osteoporotic mouse model, sesamin could rescue OVX-induced bone loss and impairment. The increased serum level of DANCR caused by OVX was also downregulated upon sesamin treatment. In conclusion, our results demonstrate that sesamin plays a dual-functional role in both osteogenesis activation and osteoclastogenesis de-activation in a DANCR-dependent manner, suggesting that it may be a possible medication candidate for osteoporotic patients with elevated DNACR expression levels.<\/jats:p>","DOI":"10.3390\/nu13124455","type":"journal-article","created":{"date-parts":[[2021,12,14]],"date-time":"2021-12-14T01:22:05Z","timestamp":1639444925000},"page":"4455","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["DANCR Mediates the Rescuing Effects of Sesamin on Postmenopausal Osteoporosis Treatment via Orchestrating Osteogenesis and Osteoclastogenesis"],"prefix":"10.3390","volume":"13","author":[{"given":"Zhengmeng","family":"Yang","sequence":"first","affiliation":[{"name":"Stem Cells and Regenerative Medicine Laboratory, Department of Orthopaedics & Traumatology Li Ka Shing Institute of Health Sciences, The Chinese University of Hospital, Hong Kong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Feng","sequence":"additional","affiliation":[{"name":"Centre for Regenerative Medicine and Health, Hong Kong Institute of Science & Innovation, Chinese Academy of Sciences, Hong Kong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haixing","family":"Wang","sequence":"additional","affiliation":[{"name":"Stem Cells and Regenerative Medicine Laboratory, Department of Orthopaedics & Traumatology Li Ka Shing Institute of Health Sciences, The Chinese University of Hospital, Hong Kong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yucong","family":"Li","sequence":"additional","affiliation":[{"name":"Stem Cells and Regenerative Medicine Laboratory, Department of Orthopaedics & Traumatology Li Ka Shing Institute of Health Sciences, The Chinese University of Hospital, Hong Kong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica Hiu Tung","family":"Lo","sequence":"additional","affiliation":[{"name":"Stem Cells and Regenerative Medicine Laboratory, Department of Orthopaedics & Traumatology Li Ka Shing Institute of Health Sciences, The Chinese University of Hospital, Hong Kong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoting","family":"Zhang","sequence":"additional","affiliation":[{"name":"Stem Cells and Regenerative Medicine Laboratory, Department of Orthopaedics & Traumatology Li Ka Shing Institute of Health Sciences, The Chinese University of Hospital, Hong Kong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuan","family":"Lu","sequence":"additional","affiliation":[{"name":"Stem Cells and Regenerative Medicine Laboratory, Department of Orthopaedics & Traumatology Li Ka Shing Institute of Health Sciences, The Chinese University of Hospital, Hong Kong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaofeng","family":"Wang","sequence":"additional","affiliation":[{"name":"Centre for Regenerative Medicine and Health, Hong Kong Institute of Science & Innovation, Chinese Academy of Sciences, Hong Kong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sien","family":"Lin","sequence":"additional","affiliation":[{"name":"Stem Cells and Regenerative Medicine Laboratory, Department of Orthopaedics & Traumatology Li Ka Shing Institute of Health Sciences, The Chinese University of Hospital, Hong Kong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Micky D.","family":"Tortorella","sequence":"additional","affiliation":[{"name":"Centre for Regenerative Medicine and Health, Hong Kong Institute of Science & Innovation, Chinese Academy of Sciences, Hong Kong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gang","family":"Li","sequence":"additional","affiliation":[{"name":"Stem Cells and Regenerative Medicine Laboratory, Department of Orthopaedics & Traumatology Li Ka Shing Institute of Health Sciences, The Chinese University of Hospital, Hong Kong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,12,13]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.jot.2019.08.004","article-title":"The efficacy and safety of denosumab in postmenopausal women with osteoporosis previously treated with bisphosphonates: A review","volume":"22","author":"Zhu","year":"2020","journal-title":"J. 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