{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,30]],"date-time":"2025-12-30T17:55:15Z","timestamp":1767117315304,"version":"build-2065373602"},"reference-count":56,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2021,12,14]],"date-time":"2021-12-14T00:00:00Z","timestamp":1639440000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI20\/01758"],"award-info":[{"award-number":["PI20\/01758"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"name":"and Sociedad de Endocrinolog\u00eda, Nutrici\u00f3n y Diabetes de la Comunidad de Madrid (SENDIMAD)","award":["IPI\/2018\/NR5"],"award-info":[{"award-number":["IPI\/2018\/NR5"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>A pre-gestational thyroid reserve of iodine is crucial to guarantee the increased demand for thyroid hormone production of early pregnancy. An iodine intake \u2265150 \u00b5g\/day is currently recommended. The objective of this study was to assess average pre-gestational food-based iodine consumption in pregnant women at their first prenatal visit (&lt;12 gestational weeks), and its association with adverse materno-fetal events (history of miscarriages, early fetal losses, Gestational Diabetes, prematurity, caesarean sections, and new-borns large\/small for gestational age). Between 2015\u20132017, 2523 normoglycemic women out of 3026 eligible had data in the modified Diabetes Nutrition and Complication Trial (DNCT) questionnaire permitting assessment of pre-gestational food-based iodine consumption, and were included in this study. Daily food-based iodine intake was 123 \u00b1 48 \u00b5g, with 1922 (76.1%) not reaching 150 \u00b5g\/day. Attaining this amount was associated with consuming 8 weekly servings of vegetables (3.84; 3.16\u20134.65), 1 of shellfish (8.72; 6.96\u201310.93) and\/or 2 daily dairy products (6.43; 5.27\u20137.86). Women who reached a pre-gestational intake \u2265150 \u00b5g had lower rates of hypothyroxinemia (104 (17.3%)\/384 (21.4%); p = 0.026), a lower miscarriage rate, and a decrease in the composite of materno-fetal adverse events (0.81; 0.67\u20130.98). Reaching the recommended iodine pre-pregnancy intake with foods could benefit the progression of pregnancy.<\/jats:p>","DOI":"10.3390\/nu13124458","type":"journal-article","created":{"date-parts":[[2021,12,14]],"date-time":"2021-12-14T22:06:10Z","timestamp":1639519570000},"page":"4458","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["The Consumption of Food-Based Iodine in the Immediate Pre-Pregnancy Period in Madrid Is Insufficient. San Carlos and Pregnancy Cohort Study"],"prefix":"10.3390","volume":"13","author":[{"given":"Ver\u00f3nica","family":"Melero","sequence":"first","affiliation":[{"name":"Endocrinology and Nutrition Department, Hospital Cl\u00ednico Universitario San Carlos and Instituto de Investigaci\u00f3n Sanitaria del Hospital Cl\u00ednico San Carlos (IdISSC), 28040 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabelle","family":"Runkle","sequence":"additional","affiliation":[{"name":"Endocrinology and Nutrition Department, Hospital Cl\u00ednico Universitario San Carlos and Instituto de Investigaci\u00f3n Sanitaria del Hospital Cl\u00ednico San Carlos (IdISSC), 28040 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3546-9231","authenticated-orcid":false,"given":"Nuria","family":"Garcia de la Torre","sequence":"additional","affiliation":[{"name":"Endocrinology and Nutrition Department, Hospital Cl\u00ednico 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