{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T11:27:22Z","timestamp":1793014042151,"version":"4.5.0"},"reference-count":65,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2021,12,15]],"date-time":"2021-12-15T00:00:00Z","timestamp":1639526400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003329","name":"Ministry of Economy, Industry and Competitiveness","doi-asserted-by":"publisher","award":["PSI2016-77234-R"],"award-info":[{"award-number":["PSI2016-77234-R"]}],"id":[{"id":"10.13039\/501100003329","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003329","name":"Ministry of Economy, Industry and Competitiveness","doi-asserted-by":"publisher","award":["PID2020-119391GB-I00"],"award-info":[{"award-number":["PID2020-119391GB-I00"]}],"id":[{"id":"10.13039\/501100003329","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004837","name":"Ministerio de Ciencia e Innovaci\u00f3n","doi-asserted-by":"publisher","award":["BES-2017-081939"],"award-info":[{"award-number":["BES-2017-081939"]}],"id":[{"id":"10.13039\/501100004837","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011104","name":"Universitat Aut\u00f2noma de Barcelona","doi-asserted-by":"publisher","award":["PIF-UAB2018"],"award-info":[{"award-number":["PIF-UAB2018"]}],"id":[{"id":"10.13039\/501100011104","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Diet-induced obesity models are widely used to investigate dietary interventions for treating obesity. This study was aimed to test whether a dietary intervention based on a calorie-restricted cafeteria diet (CAF-R) and a polyphenolic compound (Oleuropein, OLE) supplementation modified sucrose intake, preference, and taste reactivity in cafeteria diet (CAF)-induced obese rats. CAF diet consists of high-energy, highly palatable human foods. Male rats fed standard chow (STD) or CAF diet were compared with obese rats fed CAF-R diet, alone or supplemented with an olive tree leaves extract (25 mg\/kg*day) containing a 20.1% of OLE (CAF-RO). Biometric, food consumption, and serum parameters were measured. CAF diet increased body weight, food and energy consumption and obesity-associated metabolic parameters. CAF-R and CAF-RO diets significantly attenuated body weight gain and BMI, diminished food and energy intake and improved biochemical parameters such as triacylglycerides and insulin resistance which did not differ between CAF-RO and STD groups. The three cafeteria groups diminished sucrose intake and preference compared to STD group. CAF-RO also diminished the hedonic responses for the high sucrose concentrations compared with the other groups. These results indicate that CAF-R diet may be an efficient strategy to restore obesity-associated alterations, whilst OLE supplementation seems to have an additional beneficial effect on sweet taste function.<\/jats:p>","DOI":"10.3390\/nu13124474","type":"journal-article","created":{"date-parts":[[2021,12,15]],"date-time":"2021-12-15T21:47:36Z","timestamp":1639604856000},"page":"4474","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Behavioral and Metabolic Effects of a Calorie-Restricted Cafeteria Diet and Oleuropein Supplementation in Obese Male Rats"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6981-7383","authenticated-orcid":false,"given":"Alex","family":"Subias-Gusils","sequence":"first","affiliation":[{"name":"Institut de Neuroci\u00e8ncies, Universitat Aut\u00f2noma de Barcelona, 08193 Bellaterra, Spain"},{"name":"Departament de Psiquiatria i Medicina Legal, Facultat de Medicina, Universitat Aut\u00f2noma de Barcelona, 08193 Bellaterra, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam","family":"\u00c1lvarez-Monell","sequence":"additional","affiliation":[{"name":"Institut de Neuroci\u00e8ncies, Universitat Aut\u00f2noma de Barcelona, 08193 Bellaterra, Spain"},{"name":"Department of Cell Biology, Physiology and Immunology, Faculty of Medicine, Universitat Aut\u00f2noma de Barcelona, 08913 Bellaterra, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7173-5512","authenticated-orcid":false,"given":"Noem\u00ed","family":"Boqu\u00e9","sequence":"additional","affiliation":[{"name":"Eurecat, Centre Tecnol\u00f2gic de Catalunya, Technological Unit of Nutrition and Health, 43204 Reus, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6144-0294","authenticated-orcid":false,"given":"Antoni","family":"Caimari","sequence":"additional","affiliation":[{"name":"Eurecat, Centre Tecnol\u00f2gic de Catalunya, Technological Unit of Nutrition and Health, 43204 Reus, Spain"},{"name":"Eurecat, Centre Tecnol\u00f2gic de Catalunya, Biotechnology Area and Technological Unit of Nutrition and Health, 43204 Reus, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josep M.","family":"Del Bas","sequence":"additional","affiliation":[{"name":"Eurecat, Centre Tecnol\u00f2gic de Catalunya, Technological Unit of Nutrition and Health, 43204 Reus, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0924-4920","authenticated-orcid":false,"given":"Roger","family":"Marin\u00e9-Casad\u00f3","sequence":"additional","affiliation":[{"name":"Eurecat, Centre Tecnol\u00f2gic de Catalunya, Technological Unit of Nutrition and Health, 43204 Reus, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Montserrat","family":"Solanas","sequence":"additional","affiliation":[{"name":"Institut de Neuroci\u00e8ncies, Universitat Aut\u00f2noma de Barcelona, 08193 Bellaterra, Spain"},{"name":"Department of Cell Biology, Physiology and Immunology, Faculty of Medicine, Universitat Aut\u00f2noma de Barcelona, 08913 Bellaterra, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosa M.","family":"Escorihuela","sequence":"additional","affiliation":[{"name":"Institut de Neuroci\u00e8ncies, Universitat Aut\u00f2noma de Barcelona, 08193 Bellaterra, Spain"},{"name":"Departament de Psiquiatria i Medicina Legal, Facultat de Medicina, Universitat Aut\u00f2noma de Barcelona, 08193 Bellaterra, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,12,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1159\/000480525","article-title":"Obesity and type 2 diabetes: Two diseases with a need for combined treatment strategies\u2014EASO can lead the way","volume":"10","author":"Leitner","year":"2017","journal-title":"Obes. Facts"},{"key":"ref_2","unstructured":"World Health Organization (2021, October 25). Obesity and Overweight. Key Facts. Available online: www.who.int\/news-room\/fact-sheets\/detail\/obesity-and-overweight."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1098\/rstb.2006.1853","article-title":"Psychophysics of sweet and fat perception in obesity: Problems, solutions and new perspectives","volume":"361","author":"Bartoshuk","year":"2006","journal-title":"Philos. Trans. R. Soc. B Biol. Sci."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Melis, M., Pintus, S., Mastinu, M., Fantola, G., Moroni, R., Pepino, M.Y., and Tomassini Barbarossa, I. (2021). Changes of Taste, Smell and Eating Behavior in Patients Undergoing Bariatric Surgery: Associations with PROP Phenotypes and Polymorphisms in the Odorant-Binding Protein OBPIIa and CD36 Receptor Genes. Nutrients, 13.","DOI":"10.3390\/nu13010250"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"3755","DOI":"10.1111\/1541-4337.12643","article-title":"Effect of physiological factors, pathologies, and acquired habits on the sweet taste threshold: A systematic review and meta-analysis","volume":"19","author":"Moreno","year":"2020","journal-title":"Compr. Rev. Food Sci. Food Saf."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"3469","DOI":"10.1007\/s00018-020-03458-2","article-title":"The neuroscience of sugars in taste, gut-reward, feeding circuits, and obesity","volume":"77","author":"Gutierrez","year":"2020","journal-title":"Cell. Mol. Life Sci."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.tem.2020.11.011","article-title":"Confection Confusion: Interplay Between Diet, Taste, and Nutrition","volume":"32","author":"May","year":"2021","journal-title":"Trends Endocrinol. Metab."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1254\/jphs.09R07FM","article-title":"New Frontiers in Gut Nutrient Sensor Research: Nutrient Sensors in the Gastrointestinal Tract: Modulation of Sweet Taste Sensitivity by Leptin","volume":"112","author":"Horio","year":"2010","journal-title":"J. Pharmacol. Sci."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/j.semcdb.2012.08.004","article-title":"Modulation of sweet responses of taste receptor cells","volume":"24","author":"Yoshida","year":"2013","journal-title":"Semin. Cell Dev. Biol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1038\/sj.ijo.0803351","article-title":"Body fat loss achieved by stimulation of thermogenesis by a combination of bioactive food ingredients: A placebo-controlled, double-blind 8-week intervention in obese subjects","volume":"31","author":"Belza","year":"2007","journal-title":"Int. J. Obes."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"84","DOI":"10.3389\/fnut.2020.00084","article-title":"The Effects of Polyphenol Supplementation in Addition to Calorie Restricted Diets and\/or Physical Activity on Body Composition Parameters: A Systematic Review of Randomized Trials","volume":"7","author":"Llaha","year":"2020","journal-title":"Front. Nutr."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Konstantinidi, M., and Koutelidakis, A.E. (2019). Functional Foods and Bioactive Compounds: A Review of Its Possible Role on Weight Management and Obesity\u2019s Metabolic Consequences. Medicines, 6.","DOI":"10.3390\/medicines6030094"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"3112","DOI":"10.1002\/ptr.6511","article-title":"Oleuropein: A natural antioxidant molecule in the treatment of metabolic syndrome","volume":"33","author":"Ahamad","year":"2019","journal-title":"Phyther. Res."},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Castej\u00f3n, M.L., Montoya, T., Alarc\u00f3n-de-la-Lastra, C., and S\u00e1nchez-Hidalgo, M. (2020). Potential Protective Role Exerted by Secoiridoids from Olea europaea L. in Cancer, Cardiovascular, Neurodegenerative, Aging-Related, and Immunoinflammatory Diseases. Antioxidants, 9.","DOI":"10.3390\/antiox9020149"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1038\/nrendo.2017.161","article-title":"Animal models of obesity and diabetes mellitus","volume":"14","author":"Kleinert","year":"2018","journal-title":"Nat. Rev. Endocrinol."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Lalanza, J.F., Caimari, A., del Bas, J.M., Torregrosa, D., Cigarroa, I., Pall\u00e0s, M., Capdevila, L., Arola, L., and Escorihuela, R.M. (2014). Effects of a post-weaning cafeteria diet in young rats: Metabolic syndrome, reduced activity and low anxiety-like behaviour. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0085049"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.neubiorev.2020.11.003","article-title":"The cafeteria diet: A standardized protocol and its effects on behavior","volume":"122","author":"Lalanza","year":"2021","journal-title":"Neurosci. Biobehav. Rev."},{"key":"ref_18","first-page":"e60262","article-title":"Palatable Western-style Cafeteria Diet as a Reliable Method for Modeling Diet-induced Obesity in Rodents","volume":"153","author":"Leigh","year":"2019","journal-title":"J. Vis. Exp."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1038\/oby.2011.18","article-title":"Cafeteria Diet Is a Robust Model of Human Metabolic Syndrome with Liver and Adipose Inflammation: Comparison to High-Fat Diet","volume":"19","author":"Sampey","year":"2011","journal-title":"Obesity"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.jff.2017.09.029","article-title":"Heat-killed Bifidobacterium animalis subsp. Lactis CECT 8145 increases lean mass and ameliorates metabolic syndrome in cafeteria-fed obese rats","volume":"38","author":"Caimari","year":"2017","journal-title":"J. Funct. Foods"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"103504","DOI":"10.1016\/j.jff.2019.103504","article-title":"Supplementation with biscuits enriched with hesperidin and naringenin is associated with an improvement of the Metabolic Syndrome induced by a cafeteria diet in rats","volume":"61","author":"Arola","year":"2019","journal-title":"J. Funct. Foods"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"431453","DOI":"10.1155\/2015\/431453","article-title":"Oral Administration of Oleuropein and Its Semisynthetic Peracetylated Derivative Prevents Hepatic Steatosis, Hyperinsulinemia, and Weight Gain in Mice Fed with High Fat Cafeteria Diet","volume":"2015","author":"Lepore","year":"2015","journal-title":"Int. J. Endocrinol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"2166","DOI":"10.1002\/mnfr.201400159","article-title":"Oleuropein attenuates visceral adiposity in high-fat diet-induced obese mice through the modulation of WNT10b- and galanin-mediated signalings","volume":"58","author":"Kuem","year":"2014","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"946","DOI":"10.3945\/jn.109.117812","article-title":"Olive leaf extract attenuates cardiac, hepatic, and metabolic changes in high carbohydrate-, high fat-fed rats","volume":"140","author":"Poudyal","year":"2010","journal-title":"J. Nutr."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1186\/1475-2891-9-46","article-title":"Effects of olive oil and its minor phenolic constituents on obesity-induced cardiac metabolic changes","volume":"9","author":"Ebaid","year":"2010","journal-title":"Nutr. J."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.nutres.2019.05.003","article-title":"Olive leaf tea is beneficial for lipid metabolism in adults with prediabetes: An exploratory randomized controlled trial","volume":"67","author":"Araki","year":"2019","journal-title":"Nutr. Res."},{"key":"ref_27","first-page":"767","article-title":"A restricted cafeteria diet ameliorates biometric and metabolic profile in a rat diet-induced obesity model","volume":"71","author":"Caimari","year":"2021","journal-title":"Int. J. Food Sci. Nutr."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1007\/BF00280883","article-title":"Homeostasis model assessment: Insulin resistance and \u03b2-cell function from fasting plasma glucose and insulin concentrations in man","volume":"28","author":"Matthews","year":"1985","journal-title":"Diabetologia"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1093\/chemse\/bjr048","article-title":"Rats display a robust bimodal preference profile for sucralose","volume":"36","author":"Loney","year":"2011","journal-title":"Chem. Senses"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/S0149-7634(99)00072-X","article-title":"Measuring hedonic impact in animals and infants: Microstructure of affective taste reactivity patterns","volume":"24","author":"Berridge","year":"2000","journal-title":"Neurosci. Biobehav. Rev."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"R1267","DOI":"10.1152\/ajpregu.00314.2011","article-title":"\u201cLiking\u201d and \u201cwanting\u201d of sweet and oily food stimuli as affected by high-fat diet-induced obesity, weight loss, leptin, and genetic predisposition","volume":"301","author":"Shin","year":"2011","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"104487","DOI":"10.1016\/j.phrs.2019.104487","article-title":"The metabolic and vascular protective effects of olive (Olea europaea L.) leaf extract in diet-induced obesity in mice are related to the amelioration of gut microbiota dysbiosis and to its immunomodulatory properties","volume":"150","author":"Vezza","year":"2019","journal-title":"Pharmacol. Res."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1016\/j.jff.2015.02.040","article-title":"Nutraceutical oleuropein supplementation prevents high fat diet-induced adiposity in mice","volume":"14","author":"Swarts","year":"2015","journal-title":"J. Funct. Foods"},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Duca, F.A., Swartz, T.D., and Covasa, M. (2014). Effect of Diet on Preference and Intake of Sucrose in Obese Prone and Resistant Rats. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0111232"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.physbeh.2015.10.001","article-title":"Behavioral characterization of a model of differential susceptibility to obesity induced by standard and personalized cafeteria diet feeding","volume":"152","author":"Gac","year":"2015","journal-title":"Physiol. Behav."},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Bernard, A., Ancel, D., Neyrinck, A.M., Dastugue, A., Bindels, L.B., Delzenne, N.M., and Besnard, P. (2019). A preventive prebiotic supplementation improves the sweet taste perception in diet-induced obese mice. Nutrients, 11.","DOI":"10.3390\/nu11030549"},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Maliphol, A.B., Garth, D.J., and Medler, K.F. (2013). Diet-induced obesity reduces the responsiveness of the peripheral taste receptor cells. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0079403"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.brainres.2010.02.026","article-title":"Nutritional status alters saccharin intake and sweet receptor mRNA expression in rat taste buds","volume":"1325","author":"Chen","year":"2010","journal-title":"Brain Res."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1007\/s00213-008-1102-2","article-title":"Relevance of animal models to human eating disorders and obesity","volume":"199","author":"Casper","year":"2008","journal-title":"Psychopharmacology"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1002\/eat.20481","article-title":"The clinical significance of loss of control over eating in overweight adolescents","volume":"41","author":"Goldschmidt","year":"2008","journal-title":"Int. J. Eat. Disord."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1093\/chemse\/bjv007","article-title":"Obese individuals have higher preference and sensitivity to odor of chocolate","volume":"40","author":"Stafford","year":"2015","journal-title":"Chem. Senses"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"579-e460","DOI":"10.1111\/nmo.12125","article-title":"Differences in brain responses between lean and obese women to a sweetened drink","volume":"25","author":"Connolly","year":"2013","journal-title":"Neurogastroenterol. Motil."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/S0006-8993(01)02451-9","article-title":"Accumbens dopamine mechanisms in sucrose intake","volume":"904","author":"Hajnal","year":"2001","journal-title":"Brain Res."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.physbeh.2018.12.016","article-title":"Prolonged ad libitum access to low-concentration sucrose changes the neurochemistry of the nucleus accumbens in male Sprague-Dawley rats","volume":"201","author":"Hakim","year":"2019","journal-title":"Physiol. Behav."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/0091-3057(91)90541-9","article-title":"Sweetness-dependent facilitation of sucrose drinking by raclopride is unrelated to calorie content","volume":"40","author":"Muscat","year":"1991","journal-title":"Pharmacol. Biochem. Behav."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1016\/j.neuron.2008.01.032","article-title":"Food Reward in the Absence of Taste Receptor Signaling","volume":"57","author":"Sotnikova","year":"2008","journal-title":"Neuron"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1126\/science.173.4002.1103","article-title":"Physiological Role of Pleasure","volume":"173","author":"Cabanac","year":"1971","journal-title":"Science"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1086\/410981","article-title":"Sensory Pleasure","volume":"54","author":"Cabanac","year":"1979","journal-title":"Q. Rev. Biol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1006\/appe.1993.1043","article-title":"Pleasantness of a Sweet Taste during Hunger and Satiety: Effects of Gender and \u201cSweet Tooth\u201d","volume":"21","author":"Laeng","year":"1993","journal-title":"Appetite"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/0195-6663(91)90036-R","article-title":"Modulation of taste affect by hunger, caloric satiety, and sensory-specific satiety in the rat","volume":"16","author":"Berridge","year":"1991","journal-title":"Appetite"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"R677","DOI":"10.1152\/ajpregu.1996.271.3.R677","article-title":"A new taste reactivity analysis of the integration of taste and physiological state information","volume":"271","author":"Grill","year":"1996","journal-title":"Am. J. Physiol. Integr. Comp. Physiol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1038\/nn.2519","article-title":"Dopamine D2 receptors in addiction-like reward dysfunction and compulsive eating in obese rats","volume":"13","author":"Johnson","year":"2010","journal-title":"Nat. Neurosci."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1038\/npp.2011.4","article-title":"Chronic high-fat diet drives postnatal epigenetic regulation of-opioid receptor in the brain","volume":"36","author":"Vucetic","year":"2011","journal-title":"Neuropsychopharmacology"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1111\/j.1467-789X.2012.01031.x","article-title":"Obesity and addiction: Neurobiological overlaps","volume":"14","author":"Volkow","year":"2013","journal-title":"Obes. Rev."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"104739","DOI":"10.1016\/j.appet.2020.104739","article-title":"Chronic high-fat diet affects food-motivated behavior and hedonic systems in the nucleus accumbens of male rats","volume":"153","author":"Arcego","year":"2020","journal-title":"Appetite"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"1874","DOI":"10.1038\/npp.2015.357","article-title":"High-Fat Diet Induced Anxiety and Anhedonia: Impact on Brain Homeostasis and Inflammation","volume":"41","author":"Dutheil","year":"2016","journal-title":"Neuropsychopharmacology"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"919","DOI":"10.3389\/fpsyg.2014.00919","article-title":"Dopamine and glucose, obesity, and reward deficiency syndrome","volume":"5","author":"Blum","year":"2014","journal-title":"Front. Psychol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1016\/j.ultsonch.2011.12.006","article-title":"Direct enrichment of olive oil in oleuropein by ultrasound-assisted maceration at laboratory and pilot plant scale","volume":"19","author":"Achat","year":"2012","journal-title":"Ultrason. Sonochem."},{"key":"ref_59","doi-asserted-by":"crossref","unstructured":"Hirai, M., Kobori, R., Doge, R., Tsuji, I., and Saito, A. (2021). Efficient Concentration of Functional Polyphenols Using Their Interaction with Gelatin. Foods, 10.","DOI":"10.3390\/foods10040698"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"5759","DOI":"10.1039\/C8FO01874J","article-title":"Peracetylation as a strategy to improve oleuropein stability and its affinity to fatty foods","volume":"9","author":"Bonacci","year":"2018","journal-title":"Food Funct."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1007\/s12576-016-0446-3","article-title":"Oleuropein attenuates cognitive dysfunction and oxidative stress induced by some anesthetic drugs in the hippocampal area of rats","volume":"67","author":"Alirezaei","year":"2017","journal-title":"J. Physiol. Sci."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"2737","DOI":"10.1111\/1750-3841.15388","article-title":"A comparative study of the antioxidant profiles of olive fruit and leaf extracts against five reactive oxygen species as measured with a multiple free-radical scavenging method","volume":"85","author":"Sueishi","year":"2020","journal-title":"J. Food Sci."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1111\/jnc.15268","article-title":"Phosphatidylinositol-3 kinase mediates the sweet suppressive effect of leptin in mouse taste cells","volume":"158","author":"Yoshida","year":"2021","journal-title":"J. Neurochem."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"11044","DOI":"10.1073\/pnas.190066697","article-title":"Leptin as a modulator of sweet taste sensitivities in mice","volume":"97","author":"Kawai","year":"2000","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1210\/en.2003-0602","article-title":"Leptin Modulates Behavioral Responses to Sweet Substances by Influencing Peripheral Taste Structures","volume":"145","author":"Shigemura","year":"2004","journal-title":"Endocrinology"}],"container-title":["Nutrients"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6643\/13\/12\/4474\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T07:48:23Z","timestamp":1760168903000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6643\/13\/12\/4474"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12,15]]},"references-count":65,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2021,12]]}},"alternative-id":["nu13124474"],"URL":"https:\/\/doi.org\/10.3390\/nu13124474","relation":{},"ISSN":["2072-6643"],"issn-type":[{"value":"2072-6643","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,12,15]]}}}