{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:59:37Z","timestamp":1787029177982,"version":"build-2736575974"},"reference-count":30,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2021,12,15]],"date-time":"2021-12-15T00:00:00Z","timestamp":1639526400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Research &amp; Development Division, Mitsui Sugar Co., Ltd","award":["No grant number as this is a joint research project."],"award-info":[{"award-number":["No grant number as this is a joint research project."]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Increased arterial stiffness during acute hyperglycemia is a risk factor for cardiovascular disease, but the type of carbohydrate that inhibits it is unknown. The purpose of this study was to determine the efficacy of low-glycemic-index isomaltulose on arterial stiffness during hyperglycemia in middle-aged and older adults. Ten healthy middle-aged and older adult subjects orally ingested a solution containing 25 g of isomaltulose (ISI trial) and sucrose (SSI trial) in a crossover study. In the SSI trial, the brachial\u2013ankle (ba) pulse wave velocity (PWV) increased 30, 60, and 90 min after ingestion compared with that before ingestion (p &lt; 0.01); however, in the ISI trial, the baPWV did not change after ingestion compared with that before ingestion. Blood glucose levels 30 min after intake were lower in the ISI trial than in the SSI trial (p &lt; 0.01). The baPWV and systolic blood pressure were positively correlated 90 min after isomaltulose and sucrose ingestion (r = 0.640, p &lt; 0.05). These results indicate that isomaltulose intake inhibits an acute increase in arterial stiffness. The results of the present study may have significant clinical implications on the implementation of dietary programs for middle-aged and elderly patients.<\/jats:p>","DOI":"10.3390\/nu13124493","type":"journal-article","created":{"date-parts":[[2021,12,15]],"date-time":"2021-12-15T21:47:36Z","timestamp":1639604856000},"page":"4493","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Effects of Different Types of Carbohydrates on Arterial Stiffness: A Comparison of Isomaltulose and Sucrose"],"prefix":"10.3390","volume":"13","author":[{"given":"Ryota","family":"Kobayashi","sequence":"first","affiliation":[{"name":"Center for Fundamental Education, Teikyo University of Science, Tokyo 120-0045, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miki","family":"Sakazaki","sequence":"additional","affiliation":[{"name":"Research & Development Division, Mitsui Sugar Co., Ltd., Tokyo 103-8423, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukie","family":"Nagai","sequence":"additional","affiliation":[{"name":"Research & Development Division, Mitsui Sugar Co., Ltd., Tokyo 103-8423, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenji","family":"Asaki","sequence":"additional","affiliation":[{"name":"Department of Tokyo Judo Therapy, Teikyo University of Science, Tokyo 120-0045, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeo","family":"Hashiguchi","sequence":"additional","affiliation":[{"name":"Department of School Education, Teikyo University of Science, Tokyo 120-0045, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9661-2770","authenticated-orcid":false,"given":"Hideyuki","family":"Negoro","sequence":"additional","affiliation":[{"name":"Harvard PKD Center for Polycystic Kidney Disease Research, Boston, MA 02115, USA"},{"name":"Faculty of Medicine, Nara Medical University, Nara 634-8521, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,12,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"920","DOI":"10.2337\/diacare.22.6.920","article-title":"Impaired Glucose Tolerance Is a Risk Factor for Cardiovascular Disease, but Not Impaired Fasting Glucose. The Funagata Diabetes Study","volume":"22","author":"Tominaga","year":"1999","journal-title":"Diabetes Care"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"DECODE Study Group, the European Diabetes Epidemiology Group (2001). Glucose Tolerance and Cardiovascular Mortality: Comparison of Fasting and 2-Hour Diagnostic Criteria. Arch. Intern. Med., 161, 397\u2013405.","DOI":"10.1001\/archinte.161.3.397"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"364","DOI":"10.3945\/an.115.010397","article-title":"Postprandial Metabolism of Macronutrients and Cardiometabolic Risk: Recent Developments, Emerging Concepts, and Future Directions","volume":"7","author":"Parks","year":"2016","journal-title":"Adv. Nutr."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1134","DOI":"10.1210\/jc.2015-3635","article-title":"Influence of Postprandial Hyperglycemic Conditions on Arterial Stiffness in Patients With Type 2 Diabetes","volume":"101","author":"Gordin","year":"2016","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"446","DOI":"10.5603\/CJ.a2019.0108","article-title":"Acute Effects of Difference in Glucose Intake on Arterial Stiffness in Healthy Subjects","volume":"28","author":"Kobayashi","year":"2021","journal-title":"Cardiol. J."},{"key":"ref_6","first-page":"709","article-title":"Effects of Age on Plasma Glucose Levels in Non-Diabetic Hong Kong Chinese","volume":"47","author":"Ko","year":"2006","journal-title":"Croat. Med. J."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1961","DOI":"10.2169\/internalmedicine.54.3596","article-title":"Association between the Postprandial Glucose Levels and Arterial Stiffness Measured According to the Cardio-Ankle Vascular Index in Non-Diabetic Subjects","volume":"54","author":"Tsuboi","year":"2015","journal-title":"Intern. Med."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1111\/ggi.12450","article-title":"Japan as the Front-Runner of Super-Aged Societies: Perspectives from Medicine and Medical Care in Japan","volume":"15","author":"Arai","year":"2015","journal-title":"Geriatr. Gerontol. Int."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1152\/japplphysiol.00030.2021","article-title":"Arterial Stiffness Responses to Prolonged Sitting Combined with a High-Glycemic-Index Meal: A Double-Blind, Randomized Crossover Trial","volume":"131","author":"Kelsch","year":"2021","journal-title":"J. Appl. Physiol. (1985)"},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Gaesser, G.A., Rodriguez, J., Patrie, J.T., Whisner, C.M., and Angadi, S.S. (2019). Effects of Glycemic Index and Cereal Fiber on Postprandial Endothelial Function, Glycemia, and Insulinemia in Healthy Adults. Nutrients, 11.","DOI":"10.3390\/nu11102387"},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Sanchez-Aguadero, N., Patino-Alonso, M.C., Mora-Simon, S., Gomez-Marcos, M.A., Alonso-Dominguez, R., Sanchez-Salgado, B., Recio-Rodriguez, J.I., and Garcia-Ortiz, L. (2017). Postprandial Effects of Breakfast Glycemic Index on Vascular Function among Young Healthy Adults: A Crossover Clinical Trial. Nutrients, 9.","DOI":"10.3390\/nu9070712"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1080\/00218839.1988.11100810","article-title":"Carbohydrate Analysis of Western Canadian Honeys and Their Nectar Sources to Determine the Origin of Honey Oligosaccharides","volume":"27","author":"Low","year":"1988","journal-title":"J. Apic. Res."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1055\/s-2007-1009230","article-title":"Usefulness of Palatinose as a Caloric Sweetener for Diabetic Patients","volume":"21","author":"Kawai","year":"1989","journal-title":"Horm. Metab. Res."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1507\/endocrj1954.32.933","article-title":"Changes in Blood Glucose and Insulin after an Oral Palatinose Administration in Normal Subjects","volume":"32","author":"Kawai","year":"1985","journal-title":"Endocrinol. Jpn"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"146","DOI":"10.3164\/jcbn.19-32","article-title":"Arterial Stiffness during Hyperglycemia in Older Adults with High Physical Activity vs Low Physical Activity","volume":"65","author":"Kobayashi","year":"2019","journal-title":"J. Clin. Biochem. Nutr."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"238","DOI":"10.3164\/jcbn.19-69","article-title":"Effects of a Short-Term Increase in Physical Activity on Arterial Stiffness during Hyperglycemia","volume":"66","author":"Kobayashi","year":"2020","journal-title":"J. Clin. Biochem. Nutr."},{"key":"ref_17","unstructured":"(2015). Guideline: Sugars Intake for Adults and Children, World Health Organization. WHO Guidelines Approved by the Guidelines Review Committee."},{"key":"ref_18","unstructured":"Bonora, E. (2002). Postprandial Peaks as a Risk Factor for Cardiovascular Disease: Epidemiological Perspectives. Int. J. Clin. Pract. Suppl., 5\u201311."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1093\/ajcn\/48.4.1041","article-title":"Second-Meal Effect: Low-Glycemic-Index Foods Eaten at Dinner Improve Subsequent Breakfast Glycemic Response","volume":"48","author":"Wolever","year":"1988","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"189","DOI":"10.2169\/internalmedicine.53.0690","article-title":"Insulin Resistance Correlates with the Arterial Stiffness before Glucose Intolerance","volume":"53","author":"Fang","year":"2014","journal-title":"Intern. Med."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"253","DOI":"10.5551\/jat.10.253","article-title":"Pulse Wave Velocity in Lower-Limb Arteries among Diabetic Patients with Peripheral Arterial Disease","volume":"10","author":"Yokoyama","year":"2003","journal-title":"J. Atheroscler. Thromb."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1139\/apnm-2015-0131","article-title":"Arterial Stiffness after Glucose Ingestion in Exercise-Trained versus Untrained Men","volume":"40","author":"Kobayashi","year":"2015","journal-title":"Appl. Physiol. Nutr. Metab."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"H188","DOI":"10.1152\/ajpheart.00384.2017","article-title":"High-Intensity Interval Exercise Attenuates but Does Not Eliminate Endothelial Dysfunction after a Fast Food Meal","volume":"314","author":"Tucker","year":"2018","journal-title":"Am. J. Physiol. Heart. Circ. Physiol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1159\/000430771","article-title":"Brachial-Ankle Pulse Wave Velocity: Myths, Misconceptions, and Realities","volume":"3","author":"Sugawara","year":"2015","journal-title":"Pulse"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1093\/ajh\/hpy166","article-title":"Heart-to-Brachium Pulse Wave Velocity as a Measure of Proximal Aortic Stiffness: MRI and Longitudinal Studies","volume":"32","author":"Sugawara","year":"2019","journal-title":"Am. J. Hypertens"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1291\/hypres.29.309","article-title":"Correlation between Brachial-Ankle Pulse Wave Velocity and Arterial Compliance and Cardiovascular Risk Factors in Elderly Patients with Arteriosclerosis","volume":"29","author":"Li","year":"2006","journal-title":"Hypertens Res."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1291\/hypres.27.925","article-title":"Relationship between Brachial-Ankle Pulse Wave Velocity and Heart Rate Variability in Young Japanese Men","volume":"27","author":"Nakao","year":"2004","journal-title":"Hypertens Res."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1023\/A:1026698800742","article-title":"Postprandial Changes of Sympathovagal Balance Measured by Heart Rate Variability","volume":"44","author":"Lu","year":"1999","journal-title":"Dig. Dis. Sci."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1253\/circj.71.202","article-title":"Close Relationship between Sympathetic Activation and Coronary Microvascular Dysfunction during Acute Hyperglycemia in Subjects with Atherosclerotic Risk Factors","volume":"71","author":"Takei","year":"2007","journal-title":"Circ. J."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1961","DOI":"10.3945\/jn.111.144592","article-title":"Postprandial Hyperglycemia Impairs Vascular Endothelial Function in Healthy Men by Inducing Lipid Peroxidation and Increasing Asymmetric Dimethylarginine:Arginine","volume":"141","author":"Mah","year":"2011","journal-title":"J. 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