{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T09:58:09Z","timestamp":1790330289909,"version":"4.1.0"},"reference-count":56,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2021,12,19]],"date-time":"2021-12-19T00:00:00Z","timestamp":1639872000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Most studies confirm the beneficial effects of enteral nutrition on the quality of life, but some studies indicate an inverse association and its detrimental impacts. However, there are insufficient data on the effects of enteral nutrition on the quality of life of cancer patients. This systematic review aimed to describe the influence of applied enteral nutrition on the quality of life of cancer patients, based on the results of randomized controlled trials. It was registered in the PROSPERO database (CRD42021261226) and conducted based on the PRISMA guidelines. The searching procedure was conducted using the PubMed and Web of Science databases, as well as Cochrane Library, and it included studies published until June 2021. It was conducted to select randomized controlled trials assessing the influence of enteral nutrition (compared with the other model of nutrition) on the quality of life of cancer patients. A general number of 761 records were screened and a final number of 16 studies were included in the systematic review. The studies were included and assessed by two independent researchers, while the risk of bias was analyzed using the Newcastle\u2013Ottawa Scale (NOS). Studies compared patients treated with and without enteral nutrition, patients treated with various methods of enteral nutrition or with enteral diets of various content, as well as patients treated with enteral and parenteral nutrition. Within the included studies, the majority were conducted in patients with cancers located in various parts of the body, or diverse areas within the gastrointestinal system, while some studies were conducted in specific populations of patients with a defined cancer location\u2014esophagus, stomach, or ovary. The duration of applied enteral nutrition within the included studies was diversified\u2014from two weeks or less to half a year or even more. The vast majority of studies used well-known and validated tools to assess the quality of life, either developed for a specific group of head\/neck, esophagus\/stomach, and ovary cancer patients or developed for more general patient populations. Most studies concerning patients treated with and without enteral nutrition supported applying enteral nutrition, which was concluded in seven studies out of ten (including four studies with a low risk of bias). The other important observations to be emphasized\u2014formulated based on the studies with a low risk of bias\u2014presented the role of oral supportive nutrition guided by a dietitian, as well as the beneficial role of enteral and parenteral nutrition, combined. In spite of a relatively low number of randomized controlled trials assessing the influence of enteral nutrition on the quality of life of cancer patients, which should be considered as a limitation, the results were promising. Most studies supported the positive influence of enteral nutrition on the quality of life, either assessed based on the psychological measures of the quality of life or by considering the other potential determinants (e.g., malnutrition, complications, etc.). Taking this into account, enteral nutrition should be applied whenever possible, both to prevent and treat malnutrition in cancer patients. However, considering the limited number of studies conducted so far, further research conducted in homogenic populations of patients is necessary.<\/jats:p>","DOI":"10.3390\/nu13124551","type":"journal-article","created":{"date-parts":[[2021,12,20]],"date-time":"2021-12-20T02:50:18Z","timestamp":1639968618000},"page":"4551","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Quality of Life of Cancer Patients Receiving Enteral Nutrition: A Systematic Review of Randomized Controlled Trials"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5434-9927","authenticated-orcid":false,"given":"Elwira","family":"Gliwska","sequence":"first","affiliation":[{"name":"Department of Food Market and Consumer Research, Institute of Human Nutrition Sciences, Warsaw University of Life Sciences (WULS-SGGW), 159C Nowoursynowska Street, 02-776 Warsaw, Poland"},{"name":"Cancer Epidemiology and Primary Prevention Department, The Maria Sklodowska-Curie National Research Institute of Oncology, 15B Wawelska Street, 02-034 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0784-3604","authenticated-orcid":false,"given":"Dominika","family":"Guzek","sequence":"additional","affiliation":[{"name":"Department of Food Market and Consumer Research, Institute of Human Nutrition Sciences, Warsaw University of Life Sciences (WULS-SGGW), 159C Nowoursynowska Street, 02-776 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2555-9831","authenticated-orcid":false,"given":"Zuzanna","family":"Przekop","sequence":"additional","affiliation":[{"name":"Department of Clinical Dietetics, Faculty of Health Sciences, Medical University of Warsaw, 27 Cio\u0142ka Street, 01-445 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0587-823X","authenticated-orcid":false,"given":"Jacek","family":"Sobocki","sequence":"additional","affiliation":[{"name":"Department of General Surgery and Clinical Nutrition, Centre of Postgraduate Medical Education in Warsaw, 231 Czerniakowska Street, 00-416 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8588-7357","authenticated-orcid":false,"given":"Dominika","family":"G\u0142\u0105bska","sequence":"additional","affiliation":[{"name":"Department of Dietetics, Institute of Human Nutrition Sciences, Warsaw University of Life Sciences (WULS-SGGW), 159C Nowoursynowska Street, 02-776 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,12,19]]},"reference":[{"key":"ref_1","unstructured":"World Health Organizations (WHO) (2021, November 05). Cause-Specific Mortality, 2000\u20132019. Available online: https:\/\/www.who.int\/data\/gho\/data\/themes\/mortality-and-global-health-estimates\/ghe-leading-causes-of-death."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"209","DOI":"10.3322\/caac.21660","article-title":"Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"1","author":"Sung","year":"2021","journal-title":"CA Cancer J. Clin."},{"key":"ref_3","unstructured":"World Health Organizations (WHO) (2021, November 05). Cancer. Available online: https:\/\/www.who.int\/health-topics\/cancer#tab=tab_1."},{"key":"ref_4","unstructured":"National Institute of Health (NIH), and National Cancer Institute (NIC) (2021, November 05). Types of Cancer Treatment, Available online: https:\/\/www.cancer.gov\/about-cancer\/treatment\/types."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1002\/pon.5054","article-title":"Quality of life versus length of life considerations in cancer patients: A systematic literature review","volume":"28","author":"Shrestha","year":"2019","journal-title":"Psychooncology"},{"key":"ref_6","first-page":"217","article-title":"Quality of life of cancer patients","volume":"12","author":"Jitender","year":"2018","journal-title":"J. Exp. Ther. Oncol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"445","DOI":"10.4103\/IJPC.IJPC_82_17","article-title":"Quality of Life among Cancer Patients","volume":"23","author":"Nayak","year":"2017","journal-title":"Indian J. Palliat. Care"},{"key":"ref_8","first-page":"109","article-title":"Quality of life in cancer patients and its related factors","volume":"1","author":"Abdollahzadeh","year":"2012","journal-title":"J. Caring. Sci."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.3332\/ecancer.2020.1007","article-title":"Health-related quality of life before and during chemotherapy in patients with early-stage breast cancer","volume":"14","author":"Binotto","year":"2020","journal-title":"Ecancermedicalscience"},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Lewandowska, A., Rudzki, G., Lewandowski, T., Pr\u00f3chnicki, M., Rudzki, S., Laskowska, B., and Brudniak, J. (2020). Quality of Life of Cancer Patients Treated with Chemotherapy. Int. J. Environ. Res. Public Health, 17.","DOI":"10.3390\/ijerph17196938"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"682999","DOI":"10.3389\/fonc.2021.682999","article-title":"Awareness of Cancer-Related Malnutrition and Its Management: Analysis of the Results From a Survey Conducted Among Medical Oncologists","volume":"11","author":"Muscaritoli","year":"2021","journal-title":"Front. Oncol."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Bossi, P., Delrio, P., Mascheroni, A., and Zanetti, M. (2021). The Spectrum of Malnutrition\/Cachexia\/Sarcopenia in Oncology According to Different Cancer Types and Settings: A Narrative Review. Nutrients, 13.","DOI":"10.3390\/nu13061980"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1038\/s41430-018-0245-4","article-title":"Cancer-associated malnutrition","volume":"72","author":"Baracos","year":"2018","journal-title":"Eur. J. Clin. Nutr."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"455","DOI":"10.5217\/ir.2019.00076","article-title":"Nutritional issues in patients with cancer","volume":"17","author":"Kim","year":"2019","journal-title":"Intest. Res."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.2147\/CMAR.S287551","article-title":"Relationship Between Nutritional Status and Quality of Life in Patients with Lung Cancer","volume":"13","author":"Mazur","year":"2021","journal-title":"Cancer Manag. Res."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1186\/s12955-021-01735-7","article-title":"A poorer nutritional status impacts quality of life in a sample population of elderly cancer patients","volume":"19","author":"Rios","year":"2021","journal-title":"Health Qual. Life Outcomes"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1007\/s12032-021-01460-7","article-title":"Quality of life, symptoms and dietary habits in oncology outpatients with malnutrition: A cross-sectional study","volume":"38","author":"Dubois","year":"2021","journal-title":"Med. Oncol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1016\/j.clnu.2017.06.017","article-title":"ESPEN expert group recommendations for action against cancer-related malnutrition","volume":"36","author":"Arends","year":"2017","journal-title":"Clin. Nutr."},{"key":"ref_19","first-page":"42","article-title":"Enteral versus parenteral nutrition in cancer patients: Evidences and controversies","volume":"5","author":"Cotogni","year":"2016","journal-title":"Ann. Palliat. Med."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.clnu.2019.04.022","article-title":"ESPEN guideline on home enteral nutrition","volume":"39","author":"Bischoff","year":"2020","journal-title":"Clin. Nutr."},{"key":"ref_21","first-page":"30","article-title":"Enteral and parenteral nutrition in cancer patients: A systematic review and meta-analysis","volume":"5","author":"Chow","year":"2016","journal-title":"Ann. Palliat. Med."},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Ojo, O., Keaveney, E., Wang, X.-H., and Feng, P. (2019). The Effect of Enteral Tube Feeding on Patients\u2019 Health-Related Quality of Life: A Systematic Review. Nutrients, 11.","DOI":"10.3390\/nu11051046"},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Moher, D., Liberati, A., Tetzlaff, J., Altman, D.G., and PRISMA Group (2009). Preferred reporting items for systematic reviews and meta-analyses: The PRISMA statement. PLoS Med., 6.","DOI":"10.1371\/journal.pmed.1000097"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1007\/s00270-021-02806-4","article-title":"Randomized Controlled Trial of Percutaneous Radiologic Gastrostomy Performed With and Without Gastropexy: Technical Success, Patient-Reported Outcomes and Safety","volume":"44","author":"Patel","year":"2021","journal-title":"Cardiovasc. Intervent. Radiol."},{"key":"ref_25","unstructured":"Assessing Risk of Bias in Non-Randomized Studies (2021, November 16). Chapter 13.5.2.3. Available online: http:\/\/handbook-5-1.cochrane.org\/."},{"key":"ref_26","unstructured":"Wells, G.A., Shea, B., O\u2019Connell, D., Peterson, J., Welch, V., Losos, M., and Tugwell, P. (2021, November 16). The Newcastle-Ottawa Scale (NOS) for Assessing the Quality of Nonrandomised Studies in Meta-Analyses. Available online: http:\/\/www.ohri.ca\/programs\/clinical_epidemiology\/oxford.asp."},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"You, S., Kong, T.H., and Han, W. (2020). The Effects of short-term and long-term hearing changes on music exposure: A systematic review and meta-analysis. Int. J. Environ. Res. Public Health, 17.","DOI":"10.3390\/ijerph17062091"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1054\/clnu.2000.0148","article-title":"Perioperative enteral nutrition and quality of life of severely malnourished head and neck cancer patients: A randomized clinical trial","volume":"19","author":"Langendoen","year":"2000","journal-title":"Clin. Nutr."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1016\/S1542-3565(05)00151-5","article-title":"Supportive nutrition on recovery of metabolism, nutritional state, health-related quality of life, and exercise capacity after major surgery: A randomized study","volume":"3","author":"Hyltander","year":"2005","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1111\/j.1440-1673.2008.02003.x","article-title":"Randomized study of percutaneous endoscopic gastrostomy versus nasogastric tubes for enteral feeding in head and neck cancer patients treated with (chemo)radiation","volume":"52","author":"Corry","year":"2008","journal-title":"J. Med. Imaging. Radiat. Oncol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"226","DOI":"10.3109\/15360288.2012.702199","article-title":"Nasogastric and percutaneous endoscopic gastrostomy tube use in advanced head and neck cancer patients: A comparative study","volume":"26","author":"Sadasivan","year":"2012","journal-title":"J. Pain Palliat. Care Pharmacother."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/hed.21700","article-title":"Impact of prophylactic percutaneous endoscopic gastrostomy on malnutrition and quality of life in patients with head and neck cancer: A randomized study","volume":"34","author":"Silander","year":"2012","journal-title":"Head Neck"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1038\/ejcn.2012.172","article-title":"Energy intake and sources of nutritional support in patients with head and neck cancer\u2014A randomised longitudinal study","volume":"67","author":"Silander","year":"2013","journal-title":"Eur. J. Clin. Nutr."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1002\/hed.24707","article-title":"Effect of prophylactic percutaneous endoscopic gastrostomy tube on swallowing in advanced head and neck cancer: A randomized controlled study","volume":"39","author":"Axelsson","year":"2017","journal-title":"Head Neck"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1186\/s13063-015-1053-y","article-title":"A randomised controlled trial of six weeks of home enteral nutrition versus standard care after oesophagectomy or total gastrectomy for cancer: Report on a pilot and feasibility study","volume":"21","author":"Bowrey","year":"2015","journal-title":"Trials"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1016\/j.ygyno.2015.03.048","article-title":"Quality of life after early enteral feeding versus standard care for proven or suspected advanced epithelial ovarian cancer: Results from a randomised trial","volume":"137","author":"Baker","year":"2015","journal-title":"Gynecol. Oncol."},{"key":"ref_37","first-page":"1345","article-title":"The effect of low-nitrogen and low-calorie parenteral nutrition combined with enteral nutrition on inflammatory cytokines and immune functions in patients with gastric cancer: A double blind placebo trial","volume":"19","author":"Li","year":"2015","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.ejca.2016.05.032","article-title":"Impact of home enteral nutrition in malnourished patients with upper gastrointestinal cancer: A multicentre randomised clinical trial","volume":"64","author":"Gavazzi","year":"2016","journal-title":"Eur. J. Cancer"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1516","DOI":"10.1016\/j.clnu.2016.10.022","article-title":"A randomised trial of post-discharge enteral feeding following surgical resection of an upper gastrointestinal malignancy","volume":"36","author":"Froghi","year":"2017","journal-title":"Clin. Nutr."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.1177\/0148607116651509","article-title":"Effect of Early Full-Calorie Nutrition Support Following Esophagectomy: A Randomized Controlled Trial","volume":"41","author":"Wu","year":"2017","journal-title":"JPEN J. Parenter. Enteral. Nutr."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1038\/bjc.2017.138","article-title":"Randomised controlled trial of early prophylactic feeding vs standard care in patients with head and neck cancer","volume":"117","author":"Brown","year":"2017","journal-title":"Br. J. Cancer"},{"key":"ref_42","first-page":"9684","article-title":"Effects of 4 weeks of Lactobacillus plantarum 299v supplementation on nutritional status, enteral nutrition tolerance, and quality of life in cancer patients receiving home enteral nutrition\u2014A double-blind, randomized, and placebo-controlled trial","volume":"24","author":"Folwarski","year":"2020","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"ref_43","first-page":"doz030","article-title":"Safety, feasibility, and effect of an enhanced nutritional support pathway including extended preoperative and home enteral nutrition in patients undergoing enhanced recovery after esophagectomy: A pilot randomized clinical trial","volume":"33","author":"Liu","year":"2020","journal-title":"Dis. Esophagus"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"3279","DOI":"10.3390\/cancers3033279","article-title":"Assessment of the evolution of cancer treatment therapies","volume":"3","author":"Arruebo","year":"2011","journal-title":"Cancers"},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Meyer, A.C., Drefahl, S., Ahlbom, A., Lambe, M., and Modig, K. (2020). Trends in life expectancy: Did the gap between the healthy and the ill widen or close?. BMC Med., 18.","DOI":"10.1186\/s12916-020-01514-z"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1007\/s11136-020-02633-z","article-title":"Quality of life of cancer patients at palliative care units in developing countries: Systematic review of the published literature","volume":"30","author":"Gayatri","year":"2021","journal-title":"Qual. Life Res."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1186\/1475-2891-11-27","article-title":"Role of nutritional status in predicting quality of life outcomes in cancer\u2014A systematic review of the epidemiological literature","volume":"11","author":"Lis","year":"2012","journal-title":"Nutr. J."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"2898","DOI":"10.1016\/j.clnu.2021.02.005","article-title":"ESPEN practical guideline: Clinical Nutrition in cancer","volume":"40","author":"Muscaritoli","year":"2021","journal-title":"Clin. Nutr."},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Wanden-Berghe, C., Patino-Alonso, M.C., Galindo-Villard\u00f3n, P., and Sanz-Valero, J. (2019). Complications Associated with Enteral Nutrition: CAFANE Study. Nutrients, 11.","DOI":"10.3390\/nu11092041"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.nano.2013.07.005","article-title":"Meta-analysis of inter-patient pharmacokinetic variability of liposomal and non-liposomal anticancer agents","volume":"10","author":"Schell","year":"2014","journal-title":"Nanomedicine"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1053\/ejso.1999.0734","article-title":"Quality of life in patients with early and advanced carcinoma of the breast","volume":"26","author":"Pandey","year":"2000","journal-title":"Eur. J. Surg. Oncol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1023\/A:1008937724943","article-title":"A follow-up study of the quality of life in cancer patients with different prognoses","volume":"9","author":"Ringdal","year":"2000","journal-title":"Qual. Life Res."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1186\/s12955-017-0660-6","article-title":"Nutritional status and quality of life of cancer patients needing exclusive chemotherapy: A longitudinal study","volume":"15","author":"Salas","year":"2017","journal-title":"Health Qual. Life Outcomes"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1006\/gyno.2001.6199","article-title":"Quality of life in ovarian cancer patients receiving chemotherapy","volume":"81","author":"Lakusta","year":"2001","journal-title":"Gynecol. Oncol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"e23973","DOI":"10.1097\/MD.0000000000023973","article-title":"The effectiveness of enteral nutrition for patients with primary liver cancer: A randomized controlled study protocol","volume":"100","author":"Wang","year":"2021","journal-title":"Medicine"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"3343","DOI":"10.1002\/cncr.28197","article-title":"A disease-specific enteral nutrition formula improves nutritional status and functional performance in patients with head and neck and esophageal cancer undergoing chemoradiotherapy: Results of a randomized, controlled, multicenter trial","volume":"119","author":"Fietkau","year":"2013","journal-title":"Cancer"}],"container-title":["Nutrients"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6643\/13\/12\/4551\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T07:51:49Z","timestamp":1760169109000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6643\/13\/12\/4551"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12,19]]},"references-count":56,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2021,12]]}},"alternative-id":["nu13124551"],"URL":"https:\/\/doi.org\/10.3390\/nu13124551","relation":{},"ISSN":["2072-6643"],"issn-type":[{"value":"2072-6643","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,12,19]]}}}