{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T02:08:22Z","timestamp":1776132502334,"version":"3.50.1"},"reference-count":68,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2022,1,2]],"date-time":"2022-01-02T00:00:00Z","timestamp":1641081600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Small and large birth weights (BWs) for gestational age (GA) represent extremes, but the correlation between extreme BW and metabolic syndrome (MetS) has not been fully elucidated. In this study, we examined this correlation in obese children based on changes in their metabolic profile from childhood to adolescence. A retrospective observational study was performed on 535 obese patients aged 0\u201318 years in the Clinical and Emergency Hospital for Children \u201cLouis Turcanu\u201d in Timisoara, Romania, based on clinical and biological data from January 2015 to December 2019. We emphasized the links between extreme BW and obesity, extreme BW and cardiometabolic risk, obesity and cardiometabolic risk, and extreme BW, obesity and MetS. Children born large for gestational age (LGA) predominated over those born small for gestational age (SGA). Our findings showed that BW has an independent effect on triglycerides and insulin resistance, whereas obesity had a direct influence on hypertension, impaired glucose metabolism and hypertriglyceridemia. The influences of BW and obesity on the development of MetS and its components are difficult to separate; therefore, large prospective studies in normal-weight patients are needed.<\/jats:p>","DOI":"10.3390\/nu14010204","type":"journal-article","created":{"date-parts":[[2022,1,9]],"date-time":"2022-01-09T20:21:56Z","timestamp":1641759716000},"page":"204","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Extreme Birth Weight and Metabolic Syndrome in Children"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1599-5579","authenticated-orcid":false,"given":"Teofana Otilia","family":"Bizerea-Moga","sequence":"first","affiliation":[{"name":"Department XI of Pediatrics\u20141st Pediatric Discipline, Center for Research on Growth and Developmental Disorders in Children, \u2018Victor Babe\u0219\u2019 University of Medicine and Pharmacy Timi\u0219oara, Eftimie Murgu Sq no. 2, 300041 Timi\u0219oara, Romania"},{"name":"1st Pediatric Clinic, \u2018Louis \u021aurcanu\u2019 Children\u2019s Clinical and Emergency Hospital, Iosif Nemoianu 2, 300011 Timi\u0219oara, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5991-6203","authenticated-orcid":false,"given":"Laura","family":"Pitulice","sequence":"additional","affiliation":[{"name":"Department of Biology-Chemistry, West University of Timi\u015foara, Pestallozi 16, 300115 Timi\u015foara, Romania"},{"name":"Laboratory of Advanced Researches in Environmental Protection, Oituz 4, 300086 Timi\u015foara, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina Loredana","family":"Pantea","sequence":"additional","affiliation":[{"name":"1st Pediatric Clinic, \u2018Louis \u021aurcanu\u2019 Children\u2019s Clinical and Emergency Hospital, Iosif Nemoianu 2, 300011 Timi\u0219oara, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Orsolya","family":"Olah","sequence":"additional","affiliation":[{"name":"1st Pediatric Clinic, \u2018Louis \u021aurcanu\u2019 Children\u2019s Clinical and Emergency Hospital, Iosif Nemoianu 2, 300011 Timi\u0219oara, Romania"},{"name":"Department VIII of Neuroscience\u2014Psychology Discipline, \u2018Victor Babe\u0219\u2019 University of Medicine and Pharmacy Timi\u0219oara, Eftimie Murgu Sq no. 2, 300041 Timi\u0219oara, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Otilia","family":"Marginean","sequence":"additional","affiliation":[{"name":"Department XI of Pediatrics\u20141st Pediatric Discipline, Center for Research on Growth and Developmental Disorders in Children, \u2018Victor Babe\u0219\u2019 University of Medicine and Pharmacy Timi\u0219oara, Eftimie Murgu Sq no. 2, 300041 Timi\u0219oara, Romania"},{"name":"1st Pediatric Clinic, \u2018Louis \u021aurcanu\u2019 Children\u2019s Clinical and Emergency Hospital, Iosif Nemoianu 2, 300011 Timi\u0219oara, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tudor Voicu","family":"Moga","sequence":"additional","affiliation":[{"name":"Department VII of Internal Medicine\u2014Gastroenterology Discipline, Advanced Regional Research Center in Gastroenterology and Hepatology, \u2018Victor Babe\u0219\u2019 University of Medicine and Pharmacy Timi\u0219oara, Eftimie Murgu Sq no. 2, 300041 Timi\u0219oara, Romania"},{"name":"Gastroenterology and Hepatology Clinic, \u2018Pius Br\u00eenzeu\u2019 County Emergency Clinical Hospital, Liviu Rebreanu 156, 300723 Timi\u0219oara, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,1,2]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1001\/archpedi.152.12.1225","article-title":"Growth of Infants and Young Children Born Small or Large for Gestational Age: Findings from the Third National Health and Nutrition Examination Survey","volume":"152","author":"Hediger","year":"1998","journal-title":"Arch. 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