{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T18:01:50Z","timestamp":1773252110953,"version":"3.50.1"},"reference-count":42,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2022,1,4]],"date-time":"2022-01-04T00:00:00Z","timestamp":1641254400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>The current fast-moving, hectic lifestyle has increased the number of individuals worldwide with difficulties in managing stress, which in turn is also affecting their sleep quality. Therefore, the objective of the current study was to assess a natural plant-based dietary supplement comprised of lemon verbena (Lippia citriodora) extract, purified in phenylpropanoids, in alleviating stress and improving quality of sleep. A double-blind, placebo-controlled study was conducted for 8 weeks, followed by a 4-week washout period. Both validated questionnaires and functional tests were performed during the study, whereas questionnaires were used after the washout. As a result, the group taking the lemon verbena extract significantly reduced their perception of stress after 8 weeks, which was corroborated by a significant decrease in cortisol levels. After the washout period, the subjects reported to present even lower stress levels, due to the lasting effect of the ingredient. As for sleep quality, the subjects taking the supplement reported feeling better rested, with a stronger effect observed in women. Sleep tracking using a wearable device revealed that the supplement users improved their times in the deeper stages of sleep, specifically their percentage of time in deep sleep and REM. In conclusion, lemon verbena extract purified in phenylpropanoids is revealed as a natural solution to help individuals to improve their stress and sleep quality.<\/jats:p>","DOI":"10.3390\/nu14010218","type":"journal-article","created":{"date-parts":[[2022,1,9]],"date-time":"2022-01-09T20:21:56Z","timestamp":1641759716000},"page":"218","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Anxiolytic Effect and Improved Sleep Quality in Individuals Taking Lippia citriodora Extract"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7499-1471","authenticated-orcid":false,"given":"Alejandro","family":"Mart\u00ednez-Rodr\u00edguez","sequence":"first","affiliation":[{"name":"Department of Analytical Chemistry, Nutrition and Food Science, University of Alicante, 03690 Alicante, Spain"},{"name":"Alicante Institute of Health and Biomedical Research (ISABIAL), 03010 Alicante, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3146-5778","authenticated-orcid":false,"given":"Mar\u00eda","family":"Mart\u00ednez-Olcina","sequence":"additional","affiliation":[{"name":"Department of Analytical Chemistry, Nutrition and Food Science, University of Alicante, 03690 Alicante, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan","family":"Mora","sequence":"additional","affiliation":[{"name":"Department of Analytical Chemistry, Nutrition and Food Science, University of Alicante, 03690 Alicante, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pau","family":"Navarro","sequence":"additional","affiliation":[{"name":"Monteloeder, S.L., Miguel Servet 16, Nave 17, 03203 Elche, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3464-0594","authenticated-orcid":false,"given":"Nuria","family":"Caturla","sequence":"additional","affiliation":[{"name":"Monteloeder, S.L., Miguel Servet 16, Nave 17, 03203 Elche, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan","family":"Jones","sequence":"additional","affiliation":[{"name":"Monteloeder, S.L., Miguel Servet 16, Nave 17, 03203 Elche, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,1,4]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1176\/appi.ajp.157.5.669","article-title":"Quality of life in individuals with anxiety disorders","volume":"157","author":"Mendlowicz","year":"2000","journal-title":"Am. 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