{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T00:31:42Z","timestamp":1788395502316,"version":"build-2803163510"},"reference-count":73,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2022,1,9]],"date-time":"2022-01-09T00:00:00Z","timestamp":1641686400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Bauhinia scandens L. (Family: Fabaceae) is commonly used to treat cholera, diarrhea, asthma, and diabetes disorder in integrative medicine. This study aimed to screen the presence of phytochemicals (preliminary and UPLC-QTOF\u2013M.S. analysis) and to examine the pharmacological activities of Bauhinia scandens L. stems (MEBS) stem extracts. Besides, in silico study was also implemented to elucidate the binding affinity and drug capability of the selected phytochemicals. In vivo anti diarrheal activity was investigated in mice models. In vitro, antibacterial and antifungal properties of MEBS against several pathogenic strains were evaluated using the disc diffusion method. In addition, in silico study has been employed using Discovery studio 2020, UCFS Chimera, PyRx autodock vina, and online tools. In the anti-diarrheal investigation, MEBS showed a significant dose-dependent inhibition rate in all three methods. The antibacterial and antifungal screening showed a remarkable zone of inhibition, of the diameter 14\u201326 mm and 12\u201328 mm, by MEBS. The present study revealed that MEBS has remarkable anti-diarrheal potential and is highly effective in wide-spectrum bacterial and fungal strains. Moreover, the in silico study validated the results of biological screenings. To conclude, MEBS is presumed to be a good source in treating diarrhea, bacterial and fungal infections.<\/jats:p>","DOI":"10.3390\/nu14020265","type":"journal-article","created":{"date-parts":[[2022,1,9]],"date-time":"2022-01-09T23:06:15Z","timestamp":1641769575000},"page":"265","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Chemical, Pharmacological and Computerized Molecular Analysis of Stem\u2019s Extracts of Bauhinia scandens L. Provide Insights into the Management of Diarrheal and Microbial Infections"],"prefix":"10.3390","volume":"14","author":[{"given":"Md Minarul","family":"Islam","sequence":"first","affiliation":[{"name":"Department of Biomedical Sciences and Institute for Medical Science, Jeonbuk National University Medical School, Jeonju 54907, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rashedul","family":"Alam","sequence":"additional","affiliation":[{"name":"Department of Medical Science, Jeonbuk National University Medical School, Jeonju 54907, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1185-7654","authenticated-orcid":false,"given":"Hea-Jong","family":"Chung","sequence":"additional","affiliation":[{"name":"Gwanju Center, Korea Basic Science Institute, Gwanju 61715, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7567-4796","authenticated-orcid":false,"given":"Nazim Uddin","family":"Emon","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Faculty of Science and Engineering, International Islamic University Chittagong, Chattogram 4318, Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad","family":"Fazlul Kabir","sequence":"additional","affiliation":[{"name":"Department of Biology, Georgia State University, Atlanta, GA 30303, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sajib","family":"Rudra","sequence":"additional","affiliation":[{"name":"Department of Botany, Faculty of Biological Sciences, University of Chittagong, Chattogram 4331, Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1831-2278","authenticated-orcid":false,"given":"Safaet","family":"Alam","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, State University of Bangladesh, 77 Satmasjid Road, Dhanmondi, Dhaka 1205, Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahsan","family":"Ullah","sequence":"additional","affiliation":[{"name":"Department of Medical Science, Jeonbuk National University Medical School, Jeonju 54907, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8254-6581","authenticated-orcid":false,"given":"Seong-Tshool","family":"Hong","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences and Institute for Medical Science, Jeonbuk National University Medical School, Jeonju 54907, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed","family":"Aktar Sayeed","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Faculty of Science and Engineering, International Islamic University Chittagong, Chattogram 4318, Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,1,9]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.jep.2015.03.066","article-title":"Anti-diarrheal effect of Alpinia oxyphylla Miq. 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