{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T16:52:25Z","timestamp":1787503945108,"version":"build-2736575974"},"reference-count":53,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2022,1,12]],"date-time":"2022-01-12T00:00:00Z","timestamp":1641945600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Assuta Medical Center","award":["No grant number. Internal grant"],"award-info":[{"award-number":["No grant number. Internal grant"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>One anastomosis gastric bypass (OAGB) is an emerging bariatric procedure, yet data on its effect on the gastrointestinal tract are lacking. This study sought to evaluate the incidence of small-intestinal bacterial overgrowth (SIBO) following OAGB; explore its effect on nutritional, gastrointestinal, and weight outcomes; and assess post-OABG occurrence of pancreatic exocrine insufficiency (PEI) and altered gut microbiota composition. A prospective pilot cohort study of patients who underwent primary-OAGB surgery is here reported. The pre-surgical and 6-months-post-surgery measurements included anthropometrics, glucose breath-tests, biochemical tests, gastrointestinal symptoms, quality-of-life, dietary intake, and fecal sample collection. Thirty-two patients (50% females, 44.5 \u00b1 12.3 years) participated in this study, and 29 attended the 6-month follow-up visit. The mean excess weight loss at 6 months post-OAGB was 67.8 \u00b1 21.2%. The glucose breath-test was negative in all pre-surgery and positive in 37.0% at 6 months (p = 0.004). Positive glucose breath-test was associated with lower reported dietary intake and folate levels and higher vitamin A deficiency rates (p \u2264 0.036). Fecal elastase-1 test (FE1) was negative for all pre-surgery and positive in 26.1% at 6 months (p = 0.500). Both alpha and beta diversity decreased at 6 months post-surgery compared to pre-surgery (p \u2264 0.026). Relatively high incidences of SIBO and PEI were observed at 6 months post-OAGB, which may explain some gastrointestinal symptoms and nutritional deficiencies.<\/jats:p>","DOI":"10.3390\/nu14020304","type":"journal-article","created":{"date-parts":[[2022,1,12]],"date-time":"2022-01-12T09:10:36Z","timestamp":1641978636000},"page":"304","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["The Effects of One Anastomosis Gastric Bypass Surgery on the Gastrointestinal Tract"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0361-9015","authenticated-orcid":false,"given":"Osnat","family":"Kaniel","sequence":"first","affiliation":[{"name":"Department of Health Policy and Management, Guilford Glazer Faculty of Business and Management, Ben-Gurion University of the Negev, Beer-Sheva 84105, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1225-7551","authenticated-orcid":false,"given":"Shiri","family":"Sherf-Dagan","sequence":"additional","affiliation":[{"name":"Department of Nutritional Sciences, School of Health Sciences, Ariel University, Ariel 40700, Israel"},{"name":"Department of Nutrition, Assuta Medical Center, Tel Aviv 69710, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amir","family":"Szold","sequence":"additional","affiliation":[{"name":"Assia Medical Group, Assuta Medical Center, Tel Aviv 69710, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Langer","sequence":"additional","affiliation":[{"name":"Assia Medical Group, Assuta Medical Center, Tel Aviv 69710, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1695-6544","authenticated-orcid":false,"given":"Boris","family":"Khalfin","sequence":"additional","affiliation":[{"name":"Department of Health Policy and Management, School of Public Health, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva 84105, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yafit","family":"Kessler","sequence":"additional","affiliation":[{"name":"Department of Nutritional Sciences, School of Health Sciences, Ariel University, Ariel 40700, Israel"},{"name":"Assia Medical Group, Assuta Medical Center, Tel Aviv 69710, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asnat","family":"Raziel","sequence":"additional","affiliation":[{"name":"Assia Medical Group, Assuta Medical Center, Tel Aviv 69710, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6658-8981","authenticated-orcid":false,"given":"Nasser","family":"Sakran","sequence":"additional","affiliation":[{"name":"Assia Medical Group, Assuta Medical Center, Tel Aviv 69710, Israel"},{"name":"Department of Surgery, Holy Family Hospital, Nazareth 16234, Israel"},{"name":"The Azrieli Faculty of Medicine Safed, Bar-Ilan University, Ramat Gan 52900, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1289-6919","authenticated-orcid":false,"given":"Yair","family":"Motro","sequence":"additional","affiliation":[{"name":"Department of Health Policy and Management, School of Public Health, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva 84105, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0570-8150","authenticated-orcid":false,"given":"David","family":"Goitein","sequence":"additional","affiliation":[{"name":"Assia Medical Group, Assuta Medical Center, Tel Aviv 69710, Israel"},{"name":"Department of Surgery C, Sheba Medical Center, Ramat Gan 52621, Israel"},{"name":"Sackler Faculty of Medicine, Tel-Aviv University, Tel Aviv 69978, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob","family":"Moran-Gilad","sequence":"additional","affiliation":[{"name":"Department of Health Policy and Management, School of Public Health, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva 84105, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,1,12]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"3783","DOI":"10.1007\/s11695-018-3450-2","article-title":"IFSO Worldwide Survey 2016: Primary, Endoluminal, and Revisional Procedures","volume":"28","author":"Angrisani","year":"2018","journal-title":"Obes. 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