{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T21:16:36Z","timestamp":1788815796031,"version":"build-2803163510"},"reference-count":90,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2022,1,17]],"date-time":"2022-01-17T00:00:00Z","timestamp":1642377600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004410","name":"Scientific and Technological Research Council of Turkey","doi-asserted-by":"publisher","award":["216S272"],"award-info":[{"award-number":["216S272"]}],"id":[{"id":"10.13039\/501100004410","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Previous studies have pointed out a link between vitamin D status and metabolic traits, however, consistent evidence has not been provided yet. This cross-sectional study has used a nutrigenetic approach to investigate the interaction between metabolic-genetic risk score (GRS) and dietary intake on serum 25-hydroxyvitamin D [25(OH)D] concentrations in 396 unrelated Turkish adults, aged 24\u201350 years. Serum 25(OH)D concentration was significantly lower in those with a metabolic-GRS \u2265 1 risk allele than those with a metabolic-GRS &lt; 1 risk allele (p = 0.020). A significant interaction between metabolic-GRS and dietary fat intake (energy%) on serum 25(OH)D levels was identified (Pinteraction = 0.040). Participants carrying a metabolic-GRS \u2265 1 risk allele and consuming a high fat diet (\u226538% of energy = 122.3 \u00b1 52.51 g\/day) had significantly lower serum 25(OH)D concentration (p = 0.006) in comparison to those consuming a low-fat diet (&lt;38% of energy = 82.5 \u00b1 37.36 g\/d). In conclusion, our study suggests a novel interaction between metabolic-GRS and dietary fat intake on serum 25(OH)D level, which emphasises that following the current dietary fat intake recommendation (&lt;35% total fat) could be important in reducing the prevalence of vitamin D deficiency in this Turkish population. Nevertheless, further larger studies are needed to verify this interaction, before implementing personalized dietary recommendations for the maintenance of optimal vitamin D status.<\/jats:p>","DOI":"10.3390\/nu14020382","type":"journal-article","created":{"date-parts":[[2022,1,17]],"date-time":"2022-01-17T20:46:03Z","timestamp":1642452363000},"page":"382","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Interaction between Dietary Fat Intake and Metabolic Genetic Risk Score on 25-Hydroxyvitamin D Concentrations in a Turkish Adult Population"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3088-8675","authenticated-orcid":false,"given":"Kubra","family":"Isgin-Atici","sequence":"first","affiliation":[{"name":"Department of Nutrition and Dietetics, Faculty of Health Sciences, Hacettepe University, Ankara 06230, Turkey"},{"name":"Department of Nutrition and Dietetics, Faculty of Health Sciences, Amasya University, Amasya 05000, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Buthaina E.","family":"Alathari","sequence":"additional","affiliation":[{"name":"Hugh Sinclair Unit of Human Nutrition, Department of Food and Nutritional Sciences, University of Reading, Reading RG6 6DZ, UK"},{"name":"Department of Food Science and Nutrition, Faculty of Health Sciences, The Public Authority for Applied Education and Training, AlFaiha 72853, Kuwait"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5497-0887","authenticated-orcid":false,"given":"Busra","family":"Turan-Demirci","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Dietetics, Faculty of Health Sciences, Hacettepe University, Ankara 06230, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suleyman Nahit","family":"Sendur","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, School of Medicine, Hacettepe University, Ankara 06230, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1466-5746","authenticated-orcid":false,"given":"Incilay","family":"Lay","sequence":"additional","affiliation":[{"name":"Department of Medical Biochemistry, Faculty of Medicine, Hacettepe University, Ankara 06230, Turkey"},{"name":"Clinical Pathology Laboratory, Hacettepe University Hospitals, Ankara 06230, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6825-9770","authenticated-orcid":false,"given":"Basma","family":"Ellahi","sequence":"additional","affiliation":[{"name":"Faculty of Health and Social Care, University of Chester, Chester CH1 4DS, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehmet","family":"Alikasifoglu","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics, School of Medicine, Hacettepe University, Ankara 06230, Turkey"},{"name":"Genetics Diagnostic Centre, DAMAGEN, Ankara 06230, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1377-9394","authenticated-orcid":false,"given":"Tomris","family":"Erbas","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, School of Medicine, Hacettepe University, Ankara 06230, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zehra","family":"Buyuktuncer","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Dietetics, Faculty of Health Sciences, Hacettepe University, Ankara 06230, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8485-8930","authenticated-orcid":false,"given":"Karani Santhanakrishnan","family":"Vimaleswaran","sequence":"additional","affiliation":[{"name":"Hugh Sinclair Unit of Human Nutrition, Department of Food and Nutritional Sciences, University of Reading, Reading RG6 6DZ, UK"},{"name":"Institute for Food, Nutrition, and Health, University of Reading, Reading RG6 6AH, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,1,17]]},"reference":[{"key":"ref_1","unstructured":"Sizar, O., Khare, S., Goyal, A., Bansal, P., and Givler, A. 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