{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T18:33:29Z","timestamp":1788287609317,"version":"build-2803163510"},"reference-count":31,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2022,1,17]],"date-time":"2022-01-17T00:00:00Z","timestamp":1642377600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP18K07848"],"award-info":[{"award-number":["JP18K07848"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Kawano Masanori Memorial Public Interest Incorporated Foundation for Promotion of Pediatrics","award":["27-13"],"award-info":[{"award-number":["27-13"]}]},{"name":"Morinaga Foundation for Health &amp; Nutrition","award":["None"],"award-info":[{"award-number":["None"]}]},{"name":"Grant-in-Aid for Translational Research of Yamaguchi University Hospital 2018","award":["None"],"award-info":[{"award-number":["None"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Food protein-induced enterocolitis syndrome (FPIES) is a non-immunoglobin E-mediated food hypersensitivity disorder. However, little is known about the clinical features of FPIES in patients with Down syndrome (DS). Medical records of children with DS diagnosed at our hospital between 2000 and 2019 were retrospectively reviewed. Among the 43 children with DS, five (11.6%) were diagnosed with FPIES; all cases were severe. In the FPIES group, the median age at onset and tolerance was 84 days and 37.5 months, respectively. Causative foods were cow\u2019s milk formula and wheat. The surgical history of colostomy was significantly higher in the FPIES group than in the non-FPIES group. A colostomy was performed in two children in the FPIES group, both of whom had the most severe symptoms of FPIES, including severe dehydration and metabolic acidosis. The surgical history of colostomy and postoperative nutrition of formula milk feeding may have led to the onset of FPIES. Therefore, an amino acid-based formula should be considered for children who undergo gastrointestinal surgeries, especially colostomy in neonates or early infants. When an acute gastrointestinal disease is suspected in children with DS, FPIES should be considered. This may prevent unnecessary tests and invasive treatments.<\/jats:p>","DOI":"10.3390\/nu14020388","type":"journal-article","created":{"date-parts":[[2022,1,17]],"date-time":"2022-01-17T20:46:03Z","timestamp":1642452363000},"page":"388","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Food Protein-Induced Enterocolitis Syndrome in Children with Down Syndrome: A Pilot Case-Control Study"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9870-8036","authenticated-orcid":false,"given":"Fumiko","family":"Okazaki","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Yamaguchi University Graduate School of Medicine, 1-1-1 Minamikogushi, Ube, Yamaguchi 755-8505, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1534-2583","authenticated-orcid":false,"given":"Hiroyuki","family":"Wakiguchi","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Yamaguchi University Graduate School of Medicine, 1-1-1 Minamikogushi, Ube, Yamaguchi 755-8505, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuno","family":"Korenaga","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Yamaguchi University Graduate School of Medicine, 1-1-1 Minamikogushi, Ube, Yamaguchi 755-8505, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7804-1131","authenticated-orcid":false,"given":"Kazumasa","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Yamaguchi University Graduate School of Medicine, 1-1-1 Minamikogushi, Ube, Yamaguchi 755-8505, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroki","family":"Yasudo","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Yamaguchi University Graduate School of Medicine, 1-1-1 Minamikogushi, Ube, Yamaguchi 755-8505, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ken","family":"Fukuda","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Yamaguchi University Graduate School of Medicine, 1-1-1 Minamikogushi, Ube, Yamaguchi 755-8505, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mototsugu","family":"Shimokawa","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, Yamaguchi University Graduate School of Medicine, 1-1-1 Minamikogushi, Ube, Yamaguchi 755-8505, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shunji","family":"Hasegawa","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Yamaguchi University Graduate School of Medicine, 1-1-1 Minamikogushi, Ube, Yamaguchi 755-8505, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,1,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1016\/j.jaci.2015.03.025","article-title":"Non-IgE-mediated gastrointestinal food allergy","volume":"135","author":"Katz","year":"2015","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_2","first-page":"28","article-title":"Food protein-induced enterocolitis of infancy: Differential diagnosis and management","volume":"12","author":"Powell","year":"1986","journal-title":"Compr. Ther."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.jaip.2013.04.004","article-title":"Food protein-induced enterocolitis syndrome (FPIES): Current management strategies and review of the literature","volume":"1","year":"2013","journal-title":"J. Allergy Clin. Immunol. Pract."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1016\/j.jaci.2016.02.047","article-title":"Humoral and cellular responses to casein in patients with food protein-induced enterocolitis to cow\u2019s milk","volume":"139","author":"Caubet","year":"2017","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1016\/j.jaci.2010.12.1105","article-title":"The prevalence and natural course of food protein-induced enterocolitis syndrome to cow\u2019s milk: A large-scale, prospective population-based study","volume":"127","author":"Katz","year":"2011","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1016\/j.jaci.2018.08.045","article-title":"Food protein-induced enterocolitis syndrome: Increased prevalence of this great unknown-results of the PREVALE study","volume":"143","author":"Alonso","year":"2019","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1016\/j.jaci.2019.06.032","article-title":"Food protein-induced enterocolitis syndrome in the US population-based study","volume":"144","author":"Warren","year":"2019","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1586\/eci.11.13","article-title":"Current understanding of the immune mechanisms of food protein-induced enterocolitis syndrome","volume":"7","author":"Caubet","year":"2011","journal-title":"Expert Rev. Clin. Immunol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1111\/pai.12288","article-title":"The role of casein-specific IgA and TGF-\u03b2 in children with food protein-induced enterocolitis syndrome to milk","volume":"25","author":"Konstantinou","year":"2014","journal-title":"Pediatr. Allergy Immunol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1002\/(SICI)1096-8628(19990604)84:4<340::AID-AJMG6>3.0.CO;2-N","article-title":"Recent trends in the prevalence of Down syndrome in Japan, 1980\u20131997","volume":"84","author":"Hoshi","year":"1999","journal-title":"Am. J. Med. Genet."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1565","DOI":"10.1542\/peds.2009-0745","article-title":"Prevalence of Down syndrome among children and adolescents in 10 regions of the United States","volume":"124","author":"Shin","year":"2009","journal-title":"Pediatrics"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1038\/ejhg.2012.94","article-title":"Twenty-year trends in the prevalence of Down syndrome and other trisomies in Europe: Impact of maternal age and prenatal screening","volume":"21","author":"Loane","year":"2013","journal-title":"Eur. J. Hum. Genet."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1542\/peds.2011-1605","article-title":"Health supervision for children with Down syndrome","volume":"128","author":"Bull","year":"2011","journal-title":"Pediatrics"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1111\/pai.12796","article-title":"Lower percentage of allergic sensitization in children with Down syndrome","volume":"28","author":"Eijsvoogel","year":"2017","journal-title":"Pediatr. Allergy Immunol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1111\/pai.12351","article-title":"Long-lasting non-IgE-mediated gastrointestinal cow\u2019s milk allergy in infants with Down syndrome","volume":"26","author":"Wakiguchi","year":"2015","journal-title":"Pediatr. Allergy Immunol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1016\/j.jaci.2016.12.966","article-title":"International consensus guidelines for the diagnosis and management of food protein-induced enterocolitis syndrome: Executive summary-Workgroup Report of the Adverse Reactions to Foods Committee, American Academy of Allergy, Asthma & Immunology","volume":"139","author":"Chehade","year":"2017","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1007\/s00383-018-4325-2","article-title":"Neonates undergoing gastrointestinal surgery have a higher incidence of non-IgE-mediated gastrointestinal food allergies","volume":"34","author":"Korai","year":"2018","journal-title":"Pediatr. Surg. Int."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"152","DOI":"10.3389\/fimmu.2013.00152","article-title":"Generation and function of induced regulatory T cells","volume":"4","author":"Schmitt","year":"2013","journal-title":"Front. Immunol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1542\/peds.63.1.80","article-title":"Thymic deficiency in Down\u2019s syndrome","volume":"63","author":"Levin","year":"1979","journal-title":"Pediatrics"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1679","DOI":"10.1084\/jem.20032121","article-title":"Allergen-responsive CD4+CD25+ regulatory T cells in children who have outgrown cow\u2019s milk allergy","volume":"199","author":"Karlsson","year":"2004","journal-title":"J. Exp. Med."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1111\/j.1365-2249.2012.04610.x","article-title":"Down syndrome, autoimmunity and T regulatory cells","volume":"169","author":"Pellegrini","year":"2012","journal-title":"Clin. Exp. Immunol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/j.coph.2009.04.008","article-title":"Anti-inflammatory and pro-inflammatory roles of TGF-beta, IL-10, and IL-22 in immunity and autoimmunity","volume":"9","author":"Sanjabi","year":"2009","journal-title":"Curr. Opin. Pharmacol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1146\/annurev.immunol.24.021605.090737","article-title":"Transforming growth factor-beta regulation of immune responses","volume":"24","author":"Li","year":"2006","journal-title":"Ann. Rev. Immunol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"679381","DOI":"10.1155\/2009\/679381","article-title":"Cytokine expression in CD3+ cells in an infant with food protein-induced enterocolitis syndrome (FPIES): Case report","volume":"2009","author":"Mori","year":"2009","journal-title":"Clin. Dev. Immunol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1038\/ni.2020","article-title":"The transcription factor E4BP4 regulates the production of IL-10 and IL-13 in CD4+ T cells","volume":"12","author":"Motomura","year":"2011","journal-title":"Nat. Immunol"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1016\/j.jaci.2012.06.017","article-title":"Food protein-induced enterocolitis syndrome can occur in adults","volume":"130","author":"Fernandes","year":"2012","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1016\/j.jaip.2015.09.020","article-title":"Shrimp allergy: Gastrointestinal symptoms commonly occur in the absence of IgE sensitization","volume":"4","author":"Gleich","year":"2016","journal-title":"J. Allergy Clin. Immunol. Pract."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1016\/j.anai.2018.08.003","article-title":"FPIES in adults","volume":"121","author":"Du","year":"2018","journal-title":"Ann. Allergy Asthma Immunol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/j.jaip.2014.02.002","article-title":"Non-IgE-mediated gastrointestinal food hypersensitivity syndrome in adults","volume":"2","author":"Tan","year":"2014","journal-title":"J. Allergy Clin. Immunol. Pract."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1016\/j.jaip.2018.07.028","article-title":"Food protein-induced enterocolitis-like syndrome in a population of adolescents and adults caused by seafood","volume":"7","author":"Moreno","year":"2019","journal-title":"J. Allergy Clin. Immunol. Pract."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1111\/cea.13415","article-title":"Food protein-induced enterocolitis syndrome","volume":"49","author":"Caubet","year":"2019","journal-title":"Clin. Exp. Allergy"}],"container-title":["Nutrients"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6643\/14\/2\/388\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T22:02:35Z","timestamp":1760133755000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6643\/14\/2\/388"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1,17]]},"references-count":31,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2022,1]]}},"alternative-id":["nu14020388"],"URL":"https:\/\/doi.org\/10.3390\/nu14020388","relation":{},"ISSN":["2072-6643"],"issn-type":[{"value":"2072-6643","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,1,17]]}}}