{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T23:03:05Z","timestamp":1793746985505,"version":"4.6.1"},"reference-count":73,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2022,1,17]],"date-time":"2022-01-17T00:00:00Z","timestamp":1642377600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>The disruption of redox homeostasis and neuroinflammation are key mechanisms in the pathogenesis of brain hypoxia\u2013ischemia (HI); medicinal plants have been studied as a therapeutic strategy, generally associated with the prevention of oxidative stress and inflammatory response. This study evaluates the neuroprotective role of the Plinia trunciflora fruit extract (PTE) in neonatal rats submitted to experimental HI. The HI insult provoked a marked increase in the lipoperoxidation levels and glutathione peroxidase (GPx) activity, accompanied by a decrease in the brain concentration of glutathione (GSH). Interestingly, PTE was able to prevent most of the HI-induced pro-oxidant effects. It was also observed that HI increased the levels of interleukin-1\u03b2 in the hippocampus, and that PTE-treatment prevented this effect. Furthermore, PTE was able to prevent neuronal loss and astrocyte reactivity induced by HI, as demonstrated by NeuN and GFAP staining, respectively. PTE also attenuated the anxiety-like behavior and prevented the spatial memory impairment caused by HI. Finally, PTE prevented neural tissue loss in the brain hemisphere, the hippocampus, cerebral cortex, and the striatum ipsilateral to the HI. Taken together our results provide good evidence that the PTE extract has the potential to be investigated as an adjunctive therapy in the treatment of brain insult caused by neonatal hypoxia\u2013ischemia.<\/jats:p>","DOI":"10.3390\/nu14020395","type":"journal-article","created":{"date-parts":[[2022,1,17]],"date-time":"2022-01-17T20:46:03Z","timestamp":1642452363000},"page":"395","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Plinia trunciflora Extract Administration Prevents HI-Induced Oxidative Stress, Inflammatory Response, Behavioral Impairments, and Tissue Damage in Rats"],"prefix":"10.3390","volume":"14","author":[{"given":"Andrey Vinicios S.","family":"Carvalho","sequence":"first","affiliation":[{"name":"Post-Graduation Program of Neuroscience, Instituto de Ci\u00eancias B\u00e1sicas da Sa\u00fade, Universidade Federal do Rio Grande do Sul, Porto Alegre 90046-900, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael T.","family":"Ribeiro","sequence":"additional","affiliation":[{"name":"Post-Graduation Program of Biochemistry, Instituto de Ci\u00eancias B\u00e1sicas da Sa\u00fade, Universidade Federal do Rio Grande do Sul, Porto Alegre 90460-060, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luz Elena","family":"Dur\u00e1n-Carabali","sequence":"additional","affiliation":[{"name":"Post-Graduation Program of Physiology, Instituto de Ci\u00eancias B\u00e1sicas da Sa\u00fade, Universidade Federal do Rio Grande do Sul, Porto Alegre 90050-170, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Paula R.","family":"Martini","sequence":"additional","affiliation":[{"name":"Post-Graduation Program of Neuroscience, Instituto de Ci\u00eancias B\u00e1sicas da Sa\u00fade, Universidade Federal do Rio Grande do Sul, Porto Alegre 90046-900, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduarda","family":"Hoeper","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Instituto de Ci\u00eancias B\u00e1sicas da Sa\u00fade, Universidade Federal do Rio Grande do Sul, Porto Alegre 90460-060, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo F.","family":"Sanches","sequence":"additional","affiliation":[{"name":"Post-Graduation Program of Biochemistry, Instituto de Ci\u00eancias B\u00e1sicas da Sa\u00fade, Universidade Federal do Rio Grande do Sul, Porto Alegre 90460-060, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo Luis","family":"Konrath","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, Faculdade de Farm\u00e1cia, Universidade Federal do Rio Grande do Sul, Porto Alegre 90610-000, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carla","family":"Dalmaz","sequence":"additional","affiliation":[{"name":"Post-Graduation Program of Neuroscience, Instituto de Ci\u00eancias B\u00e1sicas da Sa\u00fade, Universidade Federal do Rio Grande do Sul, Porto Alegre 90046-900, Brazil"},{"name":"Post-Graduation Program of Biochemistry, Instituto de Ci\u00eancias B\u00e1sicas da Sa\u00fade, Universidade Federal do Rio Grande do Sul, Porto Alegre 90460-060, Brazil"},{"name":"Department of Biochemistry, Instituto de Ci\u00eancias B\u00e1sicas da Sa\u00fade, Universidade Federal do Rio Grande do Sul, Porto Alegre 90460-060, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moacir","family":"Wajner","sequence":"additional","affiliation":[{"name":"Post-Graduation Program of Biochemistry, Instituto de Ci\u00eancias B\u00e1sicas da Sa\u00fade, Universidade Federal do Rio Grande do Sul, Porto Alegre 90460-060, Brazil"},{"name":"Department of Biochemistry, Instituto de Ci\u00eancias B\u00e1sicas da Sa\u00fade, Universidade Federal do Rio Grande do Sul, Porto Alegre 90460-060, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos Alexandre","family":"Netto","sequence":"additional","affiliation":[{"name":"Post-Graduation Program of Neuroscience, Instituto de Ci\u00eancias B\u00e1sicas da Sa\u00fade, Universidade Federal do Rio Grande do Sul, Porto Alegre 90046-900, Brazil"},{"name":"Post-Graduation Program of Biochemistry, Instituto de Ci\u00eancias B\u00e1sicas da Sa\u00fade, Universidade Federal do Rio Grande do Sul, Porto Alegre 90460-060, Brazil"},{"name":"Post-Graduation Program of Physiology, Instituto de Ci\u00eancias B\u00e1sicas da Sa\u00fade, Universidade Federal do Rio Grande do Sul, Porto Alegre 90050-170, Brazil"},{"name":"Department of Biochemistry, Instituto de Ci\u00eancias B\u00e1sicas da Sa\u00fade, Universidade Federal do Rio Grande do Sul, Porto Alegre 90460-060, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,1,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/S1474-4422(08)70294-1","article-title":"Brain injury in premature infants: A complex amalgam of destructive and developmental disturbances","volume":"8","author":"Volpe","year":"2009","journal-title":"Lancet Neurol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1159\/000046143","article-title":"Oxidant mechanisms in neonatal hypoxia-ischemia","volume":"23","author":"Ferriero","year":"2001","journal-title":"Dev. 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