{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T01:01:10Z","timestamp":1790470870154,"version":"4.1.0"},"reference-count":64,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2022,1,24]],"date-time":"2022-01-24T00:00:00Z","timestamp":1642982400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"France Embassy in Cameroon","award":["2005"],"award-info":[{"award-number":["2005"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>It remains unclear whether sickle cell trait (SCT) should be considered a risk factor during intense physical activity. By triggering the polymerization-sickling-vaso-occlusion cascade, lactate accumulation-associated acidosis in response to high-intensity exercise is believed to be one of the causes of complications. However, our understanding of lactate metabolism in response to high-intensity exercise in SCT carriers is incomplete. Thirty male SCT carriers (n = 15) and healthy subjects (n = 15) with and without \u03b1-thalassemia performed a 2-min high-intensity exercise. Blood and muscle lactate concentrations were measured at exercise completion. Time courses of blood lactate and glucose concentrations were followed during the subsequent recovery. Additional biochemical analyses were performed on biopsies of the vastus lateralis muscle. SCT was associated with lower blood and muscle lactate concentrations in response to the short high-intensity exercise. Compared to controls, the muscle content among SCT carriers of lactate transporter MCT4 and \u03b22-adrenergic receptor were higher and lower, respectively. During recovery, the lactate removal ability was higher in SCT carriers. In the present study, no effect of \u03b1-thalassemia was observed. The lower blood and muscle lactate accumulations in SCT carriers may, to some extent, act as protective mechanisms: (i) against exercise-related acidosis and subsequent sickling, that may explain the relatively rare complications observed in exercising SCT carriers; and (ii) against the deleterious effects of intracellular lactate and associated acidosis on muscle function, that might explain the elevated presence of SCT carriers among the best sprinters.<\/jats:p>","DOI":"10.3390\/nu14030501","type":"journal-article","created":{"date-parts":[[2022,1,25]],"date-time":"2022-01-25T21:07:11Z","timestamp":1643144831000},"page":"501","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Lower Muscle and Blood Lactate Accumulation in Sickle Cell Trait Carriers in Response to Short High-Intensity Exercise"],"prefix":"10.3390","volume":"14","author":[{"given":"Laurent A.","family":"Messonnier","sequence":"first","affiliation":[{"name":"Universit\u00e9 Savoie Mont Blanc, Laboratoire Interuniversitaire de Biologie de la Motricit\u00e9, EA 7424, F-73000 Chamb\u00e9ry, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel","family":"Oyono-Engu\u00e9ll\u00e9","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Yaound\u00e9 1, Laboratoire de Physiologie, Facult\u00e9 de M\u00e9decine et des Sciences Biom\u00e9dicales, Yaound\u00e9, Cameroon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucile","family":"Vincent","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Savoie Mont Blanc, Laboratoire Interuniversitaire de Biologie de la Motricit\u00e9, EA 7424, F-73000 Chamb\u00e9ry, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1268-6110","authenticated-orcid":false,"given":"Herv\u00e9","family":"Dubouchaud","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Grenoble Alpes, Inserm, LBFA, F-38000 Grenoble, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8197-1903","authenticated-orcid":false,"given":"Benjamin","family":"Chatel","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Savoie Mont Blanc, Laboratoire Interuniversitaire de Biologie de la Motricit\u00e9, EA 7424, F-73000 Chamb\u00e9ry, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Herv\u00e9","family":"Sanchez","sequence":"additional","affiliation":[{"name":"Institut de Recherche Biom\u00e9dicale des Arm\u00e9es, Unit\u00e9 Physiologie de l\u2019Exercice et des Activit\u00e9s en Conditions Extr\u00eames, F-91223 Br\u00e9tigny-sur-Orge, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Malgoyre","sequence":"additional","affiliation":[{"name":"Institut de Recherche Biom\u00e9dicale des Arm\u00e9es, Unit\u00e9 Physiologie de l\u2019Exercice et des Activit\u00e9s en Conditions Extr\u00eames, F-91223 Br\u00e9tigny-sur-Orge, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cyril","family":"Martin","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Lyon, Universit\u00e9 Claude Bernard Lyon 1, Laboratoire Interuniversitaire de Biologie de la Motricit\u00e9, EA 7424, F-69100 Villeurbanne, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fr\u00e9d\u00e9ric","family":"Galact\u00e9ros","sequence":"additional","affiliation":[{"name":"Sickle Cell Referral Center, Department of Internal Medicine, Henri-Mondor University Hospital-UPEC, AP-HP, F-94000 Cr\u00e9teil, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7007-1344","authenticated-orcid":false,"given":"Pablo","family":"Bartolucci","sequence":"additional","affiliation":[{"name":"Sickle Cell Referral Center, Department of Internal Medicine, Henri-Mondor University Hospital-UPEC, AP-HP, F-94000 Cr\u00e9teil, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrice","family":"Thiriet","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Lyon, Universit\u00e9 Claude Bernard Lyon 1, Laboratoire Interuniversitaire de Biologie de la Motricit\u00e9, EA 7424, F-69100 Villeurbanne, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8163-5539","authenticated-orcid":false,"given":"L\u00e9onard","family":"F\u00e9asson","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Lyon, Universit\u00e9 Jean Monnet Saint-Etienne, Laboratoire Interuniversitaire de Biologie de la Motricit\u00e9, EA 7424, F-42000 Saint-Etienne, France"},{"name":"Referent Center of Neuromuscular Diseases Euro-NmD, Myology Unit, Department of Clinical and Exercise Physiology, University Hospital of Saint-Etienne, F-42055 Saint-Etienne, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,1,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1001\/jama.1970.03180050063015","article-title":"Prevalence and awareness of sickle cell hemoglobin in a military population. 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