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Nevertheless, despite its prevalence, the management of the CIPN is considered particularly challenging, with this condition often being perceived as very difficult or even impossible to prevent with currently available agents. Therefore, it is imperative to find better options for patients diagnosed with this condition. While the search for the new agents must continue, another opportunity should be taken into consideration\u2014repurposing of the already known medications. As proposed, acetyl-L-carnitine, vitamins (group B and E), extracts of medical plants, including goshajinkigan, curcumin and others, unsaturated fatty acids, as well as the diet composed of so-called \u201csirtuin-activating foods\u201d, could change the typical way of treatment of CIPN, improve the quality of life of patients and maintain the continuity of chemotherapy. This review summarizes currently available data regarding mentioned above agents and evaluates the rationale behind future research focused on their efficacy in CIPN.<\/jats:p>","DOI":"10.3390\/nu14030625","type":"journal-article","created":{"date-parts":[[2022,1,31]],"date-time":"2022-01-31T08:20:29Z","timestamp":1643617229000},"page":"625","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Dietary Supplements in Chemotherapy-Induced Peripheral Neuropathy: A New Hope?"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8033-3574","authenticated-orcid":false,"given":"Katarzyna","family":"Szklener","sequence":"first","affiliation":[{"name":"Department of Clinical Oncology and Chemotherapy, Medical University of Lublin, 8 Jaczewski Street, 20-090 Lublin, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sebastian","family":"Szklener","sequence":"additional","affiliation":[{"name":"Department of Neurology, Medical University of Lublin, 8 Jaczewski Street, 20-090 Lublin, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9598-373X","authenticated-orcid":false,"given":"Adam","family":"Michalski","sequence":"additional","affiliation":[{"name":"Student Scientific Association, Department of Clinical Oncology and Chemotherapy, Medical University of Lublin, 8 Jaczewski Street, 20-090 Lublin, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Klaudia","family":"\u017bak","sequence":"additional","affiliation":[{"name":"Student Scientific Association, Department of Clinical Oncology and Chemotherapy, Medical University of Lublin, 8 Jaczewski Street, 20-090 Lublin, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weronika","family":"Kury\u0142o","sequence":"additional","affiliation":[{"name":"Student Scientific Association, Department of Clinical Oncology and Chemotherapy, Medical University of Lublin, 8 Jaczewski Street, 20-090 Lublin, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7019-6681","authenticated-orcid":false,"given":"Konrad","family":"Rejdak","sequence":"additional","affiliation":[{"name":"Department of Neurology, Medical University of Lublin, 8 Jaczewski Street, 20-090 Lublin, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S\u0142awomir","family":"Ma\u0144dziuk","sequence":"additional","affiliation":[{"name":"Department of Clinical Oncology and Chemotherapy, Medical University of Lublin, 8 Jaczewski Street, 20-090 Lublin, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,1,31]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1016\/S0140-6736(20)30925-9","article-title":"Global Burden of 369 Diseases and Injuries in 204 Countries and Territories, 1990\u20132019: A Systematic Analysis for the Global Burden of Disease Study 2019","volume":"396","author":"Vos","year":"2020","journal-title":"Lancet"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Peters, E., Mendoza Schulz, L., and Reuss-Borst, M. (2016). Quality of Life after Cancer\u2014How the Extent of Impairment Is Influenced by Patient Characteristics. BMC Cancer, 16.","DOI":"10.1186\/s12885-016-2822-z"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"2","DOI":"10.5455\/2319-2003.ijbcp000812","article-title":"Toxicities of Anticancer Drugs and Its Management","volume":"1","author":"Remesh","year":"2012","journal-title":"Int. J. Basic Clin. Pharmacol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1007\/S12094-010-0474-z","article-title":"Chemotherapy-Induced Peripheral Neuropathy: Clinical Features, Diagnosis, Prevention and Treatment Strategies","volume":"12","author":"Sereno","year":"2010","journal-title":"Clin. Transl. Oncol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1097\/j.pain.0000000000001540","article-title":"Chemotherapy-Induced Peripheral Neuropathy: Where Are We Now?","volume":"160","author":"Colvin","year":"2019","journal-title":"Pain"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"156","DOI":"10.3389\/fphar.2013.00156","article-title":"Pathobiology of Cancer Chemotherapy-Induced Peripheral Neuropathy (CIPN)","volume":"4","author":"Han","year":"2013","journal-title":"Front. Pharmacol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"4","DOI":"10.4097\/kjae.2014.67.1.4","article-title":"Chemotherapy Induced Peripheral Neuropathic Pain","volume":"67","author":"Park","year":"2014","journal-title":"Korean J. Anesthesiol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"9587","DOI":"10.1200\/jco.2009.27.15_suppl.9587","article-title":"Relationship of Sensory Symptoms and Motor Function in Patients with Chemotherapy-Induced Peripheral Neuropathy (CIPN) Utilizing the EORTC QLQ CIPN20: NCCTG Study N06CA","volume":"27","author":"Wolf","year":"2009","journal-title":"J. Clin. Oncol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"2059","DOI":"10.1007\/s00520-013-1766-y","article-title":"Falls and Functional Impairments in Cancer Survivors with Chemotherapy-Induced Peripheral Neuropathy (CIPN): A University of Rochester CCOP Study","volume":"21","author":"Gewandter","year":"2013","journal-title":"Support. Care Cancer"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"2461","DOI":"10.1016\/j.pain.2014.09.020","article-title":"Incidence, Prevalence, and Predictors of Chemotherapy-Induced Peripheral Neuropathy: A Systematic Review and Meta-Analysis","volume":"155","author":"Seretny","year":"2014","journal-title":"Pain"},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Zaj\u0105czkowska, R., Kocot-K\u0119pska, M., Leppert, W., Wrzosek, A., Mika, J., and Wordliczek, J. (2019). Mechanisms of Chemotherapy-Induced Peripheral Neuropathy. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20061451"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"e00558","DOI":"10.1002\/brb3.558","article-title":"Chemotherapy-Induced Neuropathies-a Growing Problem for Patients and Health Care Providers","volume":"7","author":"Banach","year":"2017","journal-title":"Brain Behav."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1007\/s10549-016-3939-0","article-title":"Long-Term Chemotherapy-Induced Peripheral Neuropathy among Breast Cancer Survivors: Prevalence, Risk Factors, and Fall Risk","volume":"159","author":"Bao","year":"2016","journal-title":"Breast Cancer Res. Treat."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"e01312","DOI":"10.1002\/brb3.1312","article-title":"Risk Factors for Chemotherapy-induced Peripheral Neuropathy in Patients Receiving Taxane- and Platinum-based Chemotherapy","volume":"9","author":"Molassiotis","year":"2019","journal-title":"Brain Behav."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"86","DOI":"10.3389\/fphar.2017.00086","article-title":"Long-Term Effects, Pathophysiological Mechanisms, and Risk Factors of Chemotherapy-Induced Peripheral Neuropathies: A Comprehensive Literature Review","volume":"8","author":"Kerckhove","year":"2017","journal-title":"Front. Pharmacol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1007\/s11916-014-0459-7","article-title":"Cancer Treatment-Related Neuropathic Pain Syndromes\u2014Epidemiology and Treatment: An Update","volume":"18","author":"Smith","year":"2014","journal-title":"Curr. Pain Headache Rep."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.pain.2007.06.001","article-title":"Chemotherapy-Evoked Neuropathic Pain: Abnormal Spontaneous Discharge in A-Fiber and C-Fiber Primary Afferent Neurons and Its Suppression by Acetyl-l-Carnitine","volume":"135","author":"Xiao","year":"2008","journal-title":"Pain"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.redox.2014.01.006","article-title":"Oxidative Stress and Nerve Damage: Role in Chemotherapy Induced Peripheral Neuropathy","volume":"2","author":"Areti","year":"2014","journal-title":"Redox Biol."},{"key":"ref_19","first-page":"178","article-title":"Chemotherapy-Induced Peripheral Neuropathy: Mechanisms and Therapeutic Avenues","volume":"165","author":"Bae","year":"2021","journal-title":"Neurotherapeutics"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1007\/s43440-020-00109-y","article-title":"Chemotherapy-Induced Peripheral Neuropathy: Part 1\u2014Current State of Knowledge and Perspectives for Pharmacotherapy","volume":"72","year":"2020","journal-title":"Pharmacol. Rep."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.brainresbull.2021.07.026","article-title":"Chemotherapy-Induced Peripheral Neuropathy Is Promoted by Enhanced Spinal Insulin-like Growth Factor-1 Levels via Astrocyte-Dependent Mechanisms","volume":"175","author":"Le","year":"2021","journal-title":"Brain Res. Bull."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.expneurol.2014.06.016","article-title":"Glial Role in Oxaliplatin-Induced Neuropathic Pain","volume":"261","author":"Pacini","year":"2014","journal-title":"Exp. Neurol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.jpain.2012.11.002","article-title":"Spinal Astrocyte Gap Junctions Contribute to Oxaliplatin-Induced Mechanical Hypersensitivity","volume":"14","author":"Yoon","year":"2013","journal-title":"J. Pain"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1585","DOI":"10.1016\/j.jpain.2013.08.002","article-title":"Morphologic Features and Glial Activation in Rat Oxaliplatin-Dependent Neuropathic Pain","volume":"14","author":"Pacini","year":"2013","journal-title":"J. Pain"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1016\/j.neuroscience.2014.05.051","article-title":"Astrocytes, but Not Microglia, Are Activated in Oxaliplatin and Bortezomib-Induced Peripheral Neuropathy in the Rat","volume":"274","author":"Robinson","year":"2014","journal-title":"Neuroscience"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.critrevonc.2011.04.012","article-title":"Chemotherapy-Induced Peripheral Neurotoxicity (CIPN): An Update","volume":"82","author":"Argyriou","year":"2012","journal-title":"Crit. Rev. Oncol. Hematol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1507","DOI":"10.1016\/j.ejca.2008.04.018","article-title":"Chemotherapy-Induced Peripheral Neuropathy: Prevention and Treatment Strategies","volume":"44","author":"Wolf","year":"2008","journal-title":"Eur. J. Cancer"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1002\/ana.24951","article-title":"Chemotherapy-Induced Peripheral Neuropathy: A Current Review","volume":"81","author":"Staff","year":"2017","journal-title":"Ann. Neurol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.neulet.2005.12.013","article-title":"Acetyl-l-Carnitine Prevents and Reduces Paclitaxel-Induced Painful Peripheral Neuropathy","volume":"397","author":"Flatters","year":"2006","journal-title":"Neurosci. Lett."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"39","DOI":"10.2165\/00023210-200721001-00006","article-title":"Acetyl-L-Carnitine for the Treatment of Chemotherapy-Induced Peripheral Neuropathy","volume":"21","year":"2007","journal-title":"CNS Drugs"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1900","DOI":"10.1172\/JCI118621","article-title":"Primary Preventive and Secondary Interventionary Effects of Acetyl-L-Carnitine on Diabetic Neuropathy in the Bio-Breeding Worcester Rat","volume":"97","author":"Sima","year":"1996","journal-title":"J. Clin. Investig."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1016\/0026-0495(95)90128-0","article-title":"Acetyl-l-Carnitine Corrects the Altered Peripheral Nerve Function of Experimental Diabetes","volume":"44","author":"Lowitt","year":"1995","journal-title":"Metabolism"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.2147\/JPR.S190231","article-title":"Acetyl-L-Carnitine in Painful Peripheral Neuropathy: A Systematic Review","volume":"12","author":"Galosi","year":"2019","journal-title":"J. Pain Res."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1080\/01616412.1989.11739863","article-title":"Effects of L-Carnitine, L-Acetylcarnitine and Gangliosides on the Regeneration of the Transected Sciatic Nerve in Rats","volume":"11","author":"Fernandez","year":"1989","journal-title":"Neurol. Res."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.eurger.2017.01.002","article-title":"Effect of Acetyl-l-Carnitine in the Treatment of Diabetic Peripheral Neuropathy: A Systematic Review and Meta-Analysis","volume":"8","author":"Veronese","year":"2017","journal-title":"Eur. Geriatr. Med."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"223","DOI":"10.2165\/00126839-200203040-00001","article-title":"Acetyl-L-Carnitine (Levacecarnine) in the Treatment of Diabetic Neuropathy","volume":"3","author":"Minardi","year":"2002","journal-title":"Drugs R D"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"2627","DOI":"10.1200\/JCO.2012.44.8738","article-title":"Randomized Double-Blind Placebo-Controlled Trial of Acetyl-L-Carnitine for the Prevention of Taxane-Induced Neuropathy in Women Undergoing Adjuvant Breast Cancer Therapy","volume":"31","author":"Hershman","year":"2013","journal-title":"J. Clin. Oncol."},{"key":"ref_38","first-page":"5756","article-title":"Paclitaxel and Cisplatin-Induced Neurotoxicity: A Protective Role of Acetyl-L-Carnitine","volume":"9","author":"Pisano","year":"2003","journal-title":"Clin. Cancer Res. Off. J. Am. Assoc. Cancer Res."},{"key":"ref_39","first-page":"2681","article-title":"Acetyl-L-Carnitine Prevents and Reverts Experimental Chronic Neurotoxicity Induced by Oxaliplatin, without Altering Its Antitumor Properties","volume":"25","author":"Ghirardi","year":"2005","journal-title":"Anticancer Res."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1746","DOI":"10.1016\/j.ejca.2005.04.028","article-title":"Symptomatic and Neurophysiological Responses of Paclitaxel- or Cisplatin-Induced Neuropathy to Oral Acetyl-l-Carnitine","volume":"41","author":"Bianchi","year":"2005","journal-title":"Eur. J. Cancer"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1007\/s00520-016-3404-y","article-title":"A Randomised, Placebo-Controlled Trial Assessing the Efficacy of an Oral B Group Vitamin in Preventing the Development of Chemotherapy-Induced Peripheral Neuropathy (CIPN)","volume":"25","author":"Schloss","year":"2017","journal-title":"Support. Care Cancer"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1720","DOI":"10.1056\/NEJM198806303182604","article-title":"Neuropsychiatric Disorders Caused by Cobalamin Deficiency in the Absence of Anemia or Macrocytosis","volume":"318","author":"Lindenbaum","year":"1988","journal-title":"N. Engl. J. Med."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1097\/00005792-199107000-00001","article-title":"Neurologic Aspects of Cobalamin Deficiency","volume":"70","author":"Healton","year":"1991","journal-title":"Medicine"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.mayocpiqo.2019.03.002","article-title":"The Many Faces of Cobalamin (Vitamin B12) Deficiency","volume":"3","author":"Wolffenbuttel","year":"2019","journal-title":"Mayo Clin. Proc. Innov. Qual. Outcomes"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"3489","DOI":"10.1007\/s00520-016-3175-5","article-title":"Functional Vitamin B12 Deficiency in Advanced Malignancy: Implications for the Management of Neuropathy and Neuropathic Pain","volume":"24","author":"Solomon","year":"2016","journal-title":"Support. Care Cancer"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1007\/s11912-017-0636-z","article-title":"B Vitamin Complex and Chemotherapy-Induced Peripheral Neuropathy","volume":"19","author":"Schloss","year":"2017","journal-title":"Curr. Oncol. Rep."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"145","DOI":"10.7861\/clinmedicine.15-2-145","article-title":"Vitamin B12 Deficiency\u2014A 21st Century Perspective","volume":"15","author":"Shipton","year":"2015","journal-title":"Clin. Med."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"1843","DOI":"10.1007\/s00520-015-2725-6","article-title":"Chemotherapy-Induced Peripheral Neuropathy (CIPN) and Vitamin B12 Deficiency","volume":"23","author":"Schloss","year":"2015","journal-title":"Support. Care Cancer"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1002\/ajh.2830420212","article-title":"New Assay for the Rapid Determination of Plasma Holotranscobalamin II Levels: Preliminary Evaluation in Cancer Patients","volume":"42","author":"Vu","year":"1993","journal-title":"Am. J. Hematol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"6351","DOI":"10.7314\/APJCP.2013.14.11.6351","article-title":"The Kampo Medicine Goshajinkigan Prevents Neuropathy in Breast Cancer Patients Treated with Docetaxel","volume":"14","author":"Abe","year":"2013","journal-title":"Asian Pac. J. Cancer Prev."},{"key":"ref_51","first-page":"275","article-title":"Folic Acid and Vitamin B12 Supplementation and the Risk of Cancer: Long-Term Follow-up of the B Vitamins for the Prevention of Osteoporotic Fractures (B-PROOF) Trial","volume":"28","author":"Araghi","year":"2019","journal-title":"Cancer Epidemiol. Biomark. Prev. A Publ. Am. Assoc. Cancer Res. Cosponsored Am. Soc. Prev. Oncol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.1016\/j.fct.2010.04.007","article-title":"New Advances in Molecular Mechanisms and the Prevention of Adriamycin Toxicity by Antioxidant Nutrients","volume":"48","author":"Quiles","year":"2010","journal-title":"Food Chem. Toxicol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"1915","DOI":"10.2337\/diacare.21.11.1915","article-title":"Reversal of Defective Nerve Conduction with Vitamin E Supplementation in Type 2 Diabetes: A Preliminary Study","volume":"21","author":"Bayraktar","year":"1998","journal-title":"Diabetes Care"},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"Ng, Y.T., Phang, S.C.W., Tan, G.C.J., Ng, E.Y., Botross Henien, N.P., Palanisamy, U.D.M., Ahmad, B., and Abdul Kadir, K. (2020). The Effects of Tocotrienol-Rich Vitamin E (Tocovid) on Diabetic Neuropathy: A Phase II Randomized Controlled Trial. Nutrients, 12.","DOI":"10.3390\/nu12051522"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1097\/00005537-200403000-00028","article-title":"Vitamin E Reduces Cisplatin Ototoxicity","volume":"114","author":"Kalkanis","year":"2004","journal-title":"Laryngoscope"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"13","DOI":"10.36330\/kmj.v17i1.1945","article-title":"Docetaxel Chemotherapy Induced Peripheral Neuropathy in Breast Cancer Patients and Its Amelioration by Vitamin E","volume":"17","author":"Kamoona","year":"2017","journal-title":"Kufa Med. J."},{"key":"ref_57","doi-asserted-by":"crossref","unstructured":"Shamsaei, G., Ahmadzadeh, A., and Mehraban, N. (Jundishapur J. Nat. Pharm. Prod., 2017). The Vitamin E Preventive Effect on Taxol-Induced Neuropathy among Patients with Breast Cancer: A Randomized Clinical Trial, Jundishapur J. Nat. Pharm. Prod., in press.","DOI":"10.5812\/jjnpp.65027"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1002\/iub.1993","article-title":"Vitamin E: Mechanism of Transport and Regulation in the CNS","volume":"71","author":"Lee","year":"2019","journal-title":"IUBMB Life"},{"key":"ref_59","first-page":"277","article-title":"A Pilot Study on the Relation between Cisplatin Neuropathy and Vitamin E","volume":"20","author":"Bove","year":"2001","journal-title":"J. Exp. Clin. Cancer Res. CR"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1093\/ajcn\/79.6.1029","article-title":"Low Antioxidant Vitamin Intakes Are Associated with Increases in Adverse Effects of Chemotherapy in Children with Acute Lymphoblastic Leukemia","volume":"79","author":"Kennedy","year":"2004","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_61","first-page":"235","article-title":"Vitamin E\u2014Its Status and Role in Leukemia and Lymphoma","volume":"40","author":"Dasgupta","year":"1993","journal-title":"Neoplasma"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1016\/j.clinbiochem.2008.01.027","article-title":"Measurement of Oxidative Stress and Antioxidant Status in Acute Lymphoblastic Leukemia Patients","volume":"41","author":"Battisti","year":"2008","journal-title":"Clin. Biochem."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1023\/A:1008407014084","article-title":"Cisplatin Combination Chemotherapy Induces a Fall in Plasma Antioxidants of Cancer Patients","volume":"9","author":"Weijl","year":"1998","journal-title":"Ann. Oncol."},{"key":"ref_64","doi-asserted-by":"crossref","unstructured":"Kava, M., Walsh, P., SrinivasJois, R., Cole, C., Lewis, B., and Nagarajan, L. (2017). Clinical and Electrophysiological Characteristics of Vincristine Induced Peripheral Neuropathy in Children. J. Int. Child Neurol. Assoc., 1.","DOI":"10.17724\/jicna.2017.75"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"3","DOI":"10.2174\/187152007779314044","article-title":"Biochemical Mechanisms of Cisplatin Cytotoxicity","volume":"7","author":"Cepeda","year":"2007","journal-title":"Anti-Cancer Agents Med. Chem."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1080\/15569527.2018.1482494","article-title":"The Effects of Rutin on Cisplatin Induced Oxidative Retinal and Optic Nerve Injury: An Experimental Study","volume":"37","author":"Karakurt","year":"2018","journal-title":"Cutan. Ocul. Toxicol."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"4306","DOI":"10.1038\/s41598-018-22640-y","article-title":"Cisplatin Generates Oxidative Stress Which Is Accompanied by Rapid Shifts in Central Carbon Metabolism","volume":"8","author":"Yu","year":"2018","journal-title":"Sci. Rep."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1200\/JCO.2003.05.139","article-title":"Neuroprotective Effect of Vitamin E Supplementation in Patients Treated with Cisplatin Chemotherapy","volume":"21","author":"Pace","year":"2003","journal-title":"J. Clin. Oncol."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1212\/01.WNL.0000148609.35718.7D","article-title":"Vitamin E for Prophylaxis against Chemotherapy-Induced Neuropathy: A Randomized Controlled Trial","volume":"64","author":"Argyriou","year":"2005","journal-title":"Neurology"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"1134","DOI":"10.1007\/s00520-006-0072-3","article-title":"A Randomized Controlled Trial Evaluating the Efficacy and Safety of Vitamin E Supplementation for Protection against Cisplatin-Induced Peripheral Neuropathy: Final Results","volume":"14","author":"Argyriou","year":"2006","journal-title":"Support. Care Cancer"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.jpainsymman.2006.03.013","article-title":"Preventing Paclitaxel-Induced Peripheral Neuropathy: A Phase II Trial of Vitamin E Supplementation","volume":"32","author":"Argyriou","year":"2006","journal-title":"J. Pain Symptom Manag."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1212\/WNL.0b013e3181d5279e","article-title":"Vitamin E Neuroprotection for Cisplatin Neuropathy: A Randomized, Placebo-Controlled Trial","volume":"74","author":"Pace","year":"2010","journal-title":"Neurology"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1016\/j.jpain.2021.03.142","article-title":"Antioxidants Improve Oxaliplatin-Induced Peripheral Neuropathy in Tumor-Bearing Mice Model: Role of Spinal Cord Oxidative Stress and Inflammation","volume":"22","author":"Agnes","year":"2021","journal-title":"J. Pain"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1590\/S1516-31802013000100006","article-title":"Vitamin E for Prevention of Oxaliplatin-Induced Peripheral Neuropathy: A Pilot Randomized Clinical Trial","volume":"131","author":"Afonseca","year":"2013","journal-title":"Sao Paulo Med. J."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"104","DOI":"10.4103\/2008-7802.169021","article-title":"Effect of Vitamin E on Oxaliplatin-Induced Peripheral Neuropathy Prevention: A Randomized Controlled Trial","volume":"6","author":"Salehi","year":"2015","journal-title":"Int. J. Prev. Med."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"1769","DOI":"10.1007\/s00520-010-1018-3","article-title":"The Use of Vitamin E for the Prevention of Chemotherapy-Induced Peripheral Neuropathy: Results of a Randomized Phase III Clinical Trial","volume":"19","author":"Kottschade","year":"2011","journal-title":"Support. Care Cancer"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1159\/000515620","article-title":"Protective Effects of Vitamin E on Chemotherapy-Induced Peripheral Neuropathy: A Meta-Analysis of Randomized Controlled Trials","volume":"77","author":"Miao","year":"2021","journal-title":"Ann. Nutr. Metab."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1007\/s00280-021-04347-6","article-title":"The Use of Vitamin E in Preventing Taxane-Induced Peripheral Neuropathy","volume":"88","author":"Heiba","year":"2021","journal-title":"Cancer Chemother. Pharmacol."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.1001\/jama.2011.1437","article-title":"Vitamin E and the Risk of Prostate Cancer","volume":"306","author":"Klein","year":"2011","journal-title":"JAMA"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1142\/S0192415X20500019","article-title":"Effects of Herbal Medicines on Pain Management","volume":"48","author":"Luo","year":"2020","journal-title":"Am. J. Chin. Med."},{"key":"ref_81","doi-asserted-by":"crossref","unstructured":"Makkar, R., Behl, T., Bungau, S., Zengin, G., Mehta, V., Kumar, A., Uddin, M.S., Ashraf, G.M., Abdel-Daim, M.M., and Arora, S. (2020). Nutraceuticals in Neurological Disorders. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21124424"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"1701","DOI":"10.1142\/S0192415X18500866","article-title":"Oriental Herbal Medicine for Neurological Disorders in Children: An Overview of Systematic Reviews","volume":"46","author":"Lee","year":"2018","journal-title":"Am. J. Chin. Med."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1007\/s40199-019-00255-6","article-title":"Medicinal Plants and Their Isolated Phytochemicals for the Management of Chemotherapy-Induced Neuropathy: Therapeutic Targets and Clinical Perspective","volume":"27","author":"Oveissi","year":"2019","journal-title":"DARU J. Pharm. Sci."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1007\/s11418-019-01327-2","article-title":"Search of Anti-Allodynic Compounds from Plantaginis Semen, a Crude Drug Ingredient of Kampo Formula \u201cGoshajinkigan\u201d","volume":"73","author":"Toume","year":"2019","journal-title":"J. Nat. Med."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/S2095-4964(17)60313-3","article-title":"Potential Application of the Kampo Medicine Goshajinkigan for Prevention of Chemotherapy-Induced Peripheral Neuropathy","volume":"15","author":"Cascella","year":"2017","journal-title":"J. Integr. Med."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"60","DOI":"10.3892\/etm.2011.375","article-title":"Objective Evaluation of the Alleviating Effects of Goshajinkigan on Peripheral Neuropathy Induced by Paclitaxel\/Carboplatin Therapy: A Multicenter Collaborative Study","volume":"3","author":"Kaku","year":"2012","journal-title":"Exp. Ther. Med."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1007\/s00280-013-2306-7","article-title":"Goshajinkigan Oxaliplatin Neurotoxicity Evaluation (GONE): A Phase 2, Multicenter, Randomized, Double-Blind, Placebo-Controlled Trial of Goshajinkigan to Prevent Oxaliplatin-Induced Neuropathy","volume":"72","author":"Kono","year":"2013","journal-title":"Cancer Chemother. Pharmacol."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"128726","DOI":"10.1155\/2014\/128726","article-title":"Long-Term Effects of Goshajinkigan in Prevention of Diabetic Complications: A Randomized Open-Labeled Clinical Trial","volume":"2014","author":"Watanabe","year":"2014","journal-title":"Evid. Based Complement. Altern. Med."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/0168-8227(94)90149-X","article-title":"The Effects of Goshajinkigan, a Herbal Medicine, on Subjective Symptoms and Vibratory Threshold in Patients with Diabetic Neuropathy","volume":"26","author":"Tawata","year":"1994","journal-title":"Diabetes Res. Clin. Pract."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/0022-510X(95)00141-N","article-title":"Gosha-Jinki-Gan (Herbal Medicine) in Streptozocin-Induced Diabetic Neuropathy","volume":"132","author":"Nishizawa","year":"1995","journal-title":"J. Neurol. Sci."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1254\/jphs.13244FP","article-title":"Goshajinkigan, a Traditional Japanese Medicine, Prevents Oxaliplatin-Induced Acute Peripheral Neuropathy by Suppressing Functional Alteration of TRP Channels in Rat","volume":"125","author":"Mizuno","year":"2014","journal-title":"J. Pharmacol. Sci."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.neuron.2005.03.011","article-title":"Pain TRPs","volume":"46","author":"Wang","year":"2005","journal-title":"Neuron"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1038\/nature719","article-title":"Identification of a Cold Receptor Reveals a General Role for TRP Channels in Thermosensation","volume":"416","author":"McKemy","year":"2002","journal-title":"Nature"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/j.neuron.2007.04.017","article-title":"Attenuated Cold Sensitivity in TRPM8 Null Mice","volume":"54","author":"Colburn","year":"2007","journal-title":"Neuron"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1016\/S0092-8674(03)00158-2","article-title":"ANKTM1, a TRP-like Channel Expressed in Nociceptive Neurons, Is Activated by Cold Temperatures","volume":"112","author":"Story","year":"2003","journal-title":"Cell"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1016\/S0896-6273(04)00150-3","article-title":"Noxious Cold Ion Channel TRPA1 Is Activated by Pungent Compounds and Bradykinin","volume":"41","author":"Bandell","year":"2004","journal-title":"Neuron"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.1016\/j.ejca.2011.08.009","article-title":"Goshajinkigan Reduces Oxaliplatin-Induced Peripheral Neuropathy without Affecting Anti-Tumour Efficacy in Rodents","volume":"48","author":"Ushio","year":"2012","journal-title":"Eur. J. Cancer"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1007\/s10147-010-0183-1","article-title":"The Kampo Medicine, Goshajinkigan, Prevents Neuropathy in Patients Treated by FOLFOX Regimen","volume":"16","author":"Nishioka","year":"2011","journal-title":"Int. J. Clin. Oncol."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"418481","DOI":"10.1093\/ecam\/nep200","article-title":"Efficacy of Goshajinkigan for Peripheral Neurotoxicity of Oxaliplatin in Patients with Advanced or Recurrent Colorectal Cancer","volume":"2011","author":"Kono","year":"2011","journal-title":"Evid. Based Complement. Altern. Med."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1007\/s10147-015-0784-9","article-title":"Preventive Effect of Goshajinkigan on Peripheral Neurotoxicity of FOLFOX Therapy (GENIUS Trial): A Placebo-Controlled, Double-Blind, Randomized Phase III Study","volume":"20","author":"Oki","year":"2015","journal-title":"Int. J. Clin. Oncol."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"ix80","DOI":"10.1093\/annonc\/mdt460.68","article-title":"Reduction of Paclitaxel-Related Peripheral Sensory Neuropathy by Gosha-Jinki-Gan or Carbon Dioxide Feet and Hand Bathing","volume":"24","author":"Kawabata","year":"2013","journal-title":"Ann. Oncol."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"1328","DOI":"10.1021\/js9702168","article-title":"Influence of Race or Ethnicity on Pharmacokinetics of Drugs","volume":"86","author":"Ja","year":"1997","journal-title":"J. Pharm. Sci."},{"key":"ref_103","first-page":"1","article-title":"Racial and Ethnic Differences in Response to Medicines: Towards Individualized Pharmaceutical Treatment","volume":"94","author":"Burroughs","year":"2002","journal-title":"J. Natl. Med. Assoc."},{"key":"ref_104","first-page":"1051","article-title":"Goshajinkigan for Prevention of Chemotherapy-Induced Peripheral Neuropathy: A Systematic Review and Meta-Analysis","volume":"26","author":"Kuriyama","year":"2017","journal-title":"Support. Care Cancer Off. J. Multinatl. Assoc. Support. Care Cancer"},{"key":"ref_105","unstructured":"(2021, November 14). Eastern Clinical Oncology Group (ECOG) Common Toxicity Criteria. Available online: http:\/\/www.ecog.org\/general\/ctc.pdf."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1182\/hem.V11.3.2728","article-title":"Assessment and Management of Patients with Chemotherapy-Induced Peripheral Neuropathy","volume":"11","author":"Abrahm","year":"2014","journal-title":"Hematologist"},{"key":"ref_107","unstructured":"(2022, January 20). National Cancer Institute Common Terminology Criteria for Adverse Events (CTCAE) Version 4.0, Available online: https:\/\/ctep.cancer.gov\/protocoldevelopment\/electronic_applications\/ctc.htm."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1007\/s10147-011-0298-z","article-title":"Discrepancy between the NCI-CTCAE and DEB-NTC Scales in the Evaluation of Oxaliplatin-Related Neurotoxicity in Patients with Metastatic Colorectal Cancer","volume":"17","author":"Inoue","year":"2011","journal-title":"Int. J. Clin. Oncol."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"1660","DOI":"10.1212\/WNL.53.8.1660","article-title":"Total Neuropathy Score","volume":"53","author":"Cornblath","year":"1999","journal-title":"Neurology"},{"key":"ref_110","first-page":"283","article-title":"Physico-Chemical Characterization of Bitter Apple (Citrullus Colosynthis) Seed Oil and Seed Residue","volume":"6","author":"Riaz","year":"2015","journal-title":"Int. J. Biosci."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.jep.2014.06.011","article-title":"Citrullus Colocynthis (L.) Schrad (Bitter Apple Fruit): A Review of Its Phytochemistry, Pharmacology, Traditional Uses and Nutritional Potential","volume":"155","author":"Hussain","year":"2014","journal-title":"J. Ethnopharmacol."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1089\/acm.2011.0297","article-title":"A Review on Citrullus Colocynthis Schrad: From Traditional Iranian Medicine to Modern Phytotherapy","volume":"18","author":"Rahimi","year":"2012","journal-title":"J. Altern. Complement. Med."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"2685","DOI":"10.1002\/ptr.6442","article-title":"Efficacy of Topical Citrullus Colocynthis (Bitter Apple) Extract Oil in Chemotherapy-induced Peripheral Neuropathy: A Pilot Double-blind Randomized Placebo-controlled Clinical Trial","volume":"33","author":"Rostami","year":"2019","journal-title":"Phytother. Res."},{"key":"ref_114","first-page":"895","article-title":"Chamomile: A Herbal Medicine of the Past with a Bright Future (Review)","volume":"3","author":"Srivastava","year":"2010","journal-title":"Mol. Med. Rep."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1007\/s12565-019-00486-2","article-title":"The Natural Plant Flavonoid Apigenin Is a Strong Antioxidant That Effectively Delays Peripheral Neurodegenerative Processes","volume":"94","author":"Kim","year":"2019","journal-title":"Anat. Sci. Int."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/j.phrs.2017.10.008","article-title":"Apigenin as Neuroprotective Agent: Of Mice and Men","volume":"128","author":"Nabavi","year":"2018","journal-title":"Pharmacol. Res."},{"key":"ref_117","first-page":"469","article-title":"Nitric Oxide and Superoxide in Inflammation and Immune Regulation","volume":"54","author":"Guzik","year":"2003","journal-title":"J. Physiol. Pharmacol. Off. J. Pol. Physiol. Soc."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1016\/S1359-6101(03)00059-5","article-title":"Cytokine-Mediated Inflammation in Acute Lung Injury","volume":"14","author":"Goodman","year":"2003","journal-title":"Cytokine Growth Factor Rev."},{"key":"ref_119","first-page":"126","article-title":"Effect of Matricaria Chamomilla Hydroalcoholic Extract on Cisplatin-Induced Neuropathy in Mice","volume":"9","author":"Abad","year":"2011","journal-title":"Chin. J. Nat. Med."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1089\/jmf.2017.0035","article-title":"The Anti-Inflammatory and Antioxidant Effects of Salvia Officinalis on Lipopolysaccharide-Induced Inflammation in Rats","volume":"20","author":"Kolac","year":"2017","journal-title":"J. Med. Food"},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1007\/s40268-016-0157-5","article-title":"Salvia (Sage): A Review of Its Potential Cognitive-Enhancing and Protective Effects","volume":"17","author":"Lopresti","year":"2017","journal-title":"Drugs R D"},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1046\/j.1365-2710.2003.00463.x","article-title":"Salvia Officinalis Extract in the Treatment of Patients with Mild to Moderate Alzheimer\u2019s Disease: A Double Blind, Randomized and Placebo-Controlled Trial","volume":"28","author":"Akhondzadeh","year":"2003","journal-title":"J. Clin. Pharm. Ther."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1111\/cns.12270","article-title":"Systematic Review of Clinical Trials Assessing Pharmacological Properties of Salvia Species on Memory, Cognitive Impairment and Alzheimer\u2019s Disease","volume":"20","author":"Miroddi","year":"2014","journal-title":"CNS Neurosci. Ther."},{"key":"ref_124","first-page":"354","article-title":"Effect of Salvia Officinalis Hydroalcoholic Extract on Vincristine-Induced Neuropathy in Mice","volume":"9","author":"Abad","year":"2011","journal-title":"Chin. J. Nat. Med."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1007\/s12017-016-8395-9","article-title":"Trans-Cinnamaldehyde, An Essential Oil in Cinnamon Powder, Ameliorates Cerebral Ischemia-Induced Brain Injury via Inhibition of Neuroinflammation Through Attenuation of INOS, COX-2 Expression and NF\u03ba-B Signaling Pathway","volume":"18","author":"Chen","year":"2016","journal-title":"NeuroMol. Med."},{"key":"ref_126","doi-asserted-by":"crossref","unstructured":"Kim, C., Lee, J.H., Kim, W., Li, D., Kim, Y., Lee, K., and Kim, S.K. (2016). The Suppressive Effects of Cinnamomi Cortex and Its Phytocompound Coumarin on Oxaliplatin-Induced Neuropathic Cold Allodynia in Rats. Molecules, 21.","DOI":"10.3390\/molecules21091253"},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"107343","DOI":"10.1016\/j.biotechadv.2019.01.010","article-title":"Curcumin, the Golden Spice in Treating Cardiovascular Diseases","volume":"38","author":"Li","year":"2020","journal-title":"Biotechnol. Adv."},{"key":"ref_128","doi-asserted-by":"crossref","unstructured":"Pivari, F., Mingione, A., Brasacchio, C., and Soldati, L. (2019). Curcumin and Type 2 Diabetes Mellitus: Prevention and Treatment. Nutrients, 11.","DOI":"10.3390\/nu11081837"},{"key":"ref_129","doi-asserted-by":"crossref","unstructured":"Giordano, A., and Tommonaro, G. (2019). Curcumin and Cancer. Nutrients, 11.","DOI":"10.3390\/nu11102376"},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1002\/biof.1533","article-title":"Benefits of Curcumin in Brain Disorders","volume":"45","author":"Bhat","year":"2019","journal-title":"BioFactors"},{"key":"ref_131","doi-asserted-by":"crossref","unstructured":"di Meo, F., Margarucci, S., Galderisi, U., Crispi, S., and Peluso, G. (2019). Curcumin, Gut Microbiota, and Neuroprotection. Nutrients, 11.","DOI":"10.3390\/nu11102426"},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.phymed.2018.06.022","article-title":"Intranasal Curcumin Regulates Chronic Asthma in Mice by Modulating NF-\u0138B Activation and MAPK Signaling","volume":"51","author":"Chauhan","year":"2018","journal-title":"Phytomedicine"},{"key":"ref_133","doi-asserted-by":"crossref","unstructured":"Menon, V.P., and Sudheer, A.R. (2007). Antioxidant and Anti-Inflammatory Properties of Curcumin. The Molecular Targets and Therapeutic Uses of Curcumin in Health and Disease, Springer.","DOI":"10.1007\/978-0-387-46401-5_3"},{"key":"ref_134","doi-asserted-by":"crossref","unstructured":"Cole, G.M., Teter, B., and Frautschy, S.A. (2007). Neuroprotective Effects of Curcumin. The Molecular Targets and Therapeutic Uses of Curcumin in Health and Disease, Springer.","DOI":"10.1007\/978-0-387-46401-5_8"},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"838","DOI":"10.3109\/13880209.2014.943247","article-title":"Effect of Curcumin in Mice Model of Vincristine-Induced Neuropathy","volume":"53","author":"Babu","year":"2015","journal-title":"Pharm. Biol."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"139","DOI":"10.5607\/en.2015.24.2.139","article-title":"Curcumin Ameliorates Functional and Structural Abnormalities in Cisplatin-Induced Neuropathy","volume":"24","author":"Agthong","year":"2015","journal-title":"Exp. Neurobiol."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"8370","DOI":"10.1523\/JNEUROSCI.21-21-08370.2001","article-title":"The Curry Spice Curcumin Reduces Oxidative Damage and Amyloid Pathology in an Alzheimer Transgenic Mouse","volume":"21","author":"Lim","year":"2001","journal-title":"J. Neurosci."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1016\/S0891-5849(00)00294-X","article-title":"Curcumin, an Antioxidant and Anti-Inflammatory Agent, Induces Heme Oxygenase-1 and Protects Endothelial Cells against Oxidative Stress","volume":"28","author":"Motterlini","year":"2000","journal-title":"Free Radic. Biol. Med."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1089\/107555303321223035","article-title":"Safety and Anti-Inflammatory Activity of Curcumin: A Component of Tumeric (Curcuma Longa)","volume":"9","year":"2003","journal-title":"J. Altern. Complement. Med."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.plefa.2017.08.001","article-title":"Docosahexaenoic Acid (DHA), a Fundamental Fatty Acid for the Brain: New Dietary Sources","volume":"124","author":"Valenzuela","year":"2017","journal-title":"Prostaglandins Leukot. Essent. Fat. Acids"},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1159\/000448262","article-title":"Docosahexaenoic Acid","volume":"69","author":"Calder","year":"2016","journal-title":"Ann. Nutr. Metab."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.ijdevneu.2019.10.004","article-title":"Docosahexaenoic Acid, 22:6n-3: Its Roles in the Structure and Function of the Brain","volume":"79","author":"Mallick","year":"2019","journal-title":"Int. J. Dev. Neurosci."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/0891-5849(95)00017-R","article-title":"Alpha-Lipoic Acid as a Biological Antioxidant","volume":"19","author":"Packer","year":"1995","journal-title":"Free Radic. Biol. Med."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.neulet.2018.02.012","article-title":"The Protective Effect of Alpha-Lipoic Acid against Brain Ischemia and Reperfusion Injury via MTOR Signaling Pathway in Rats","volume":"671","author":"Gao","year":"2018","journal-title":"Neurosci. Lett."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"2843121","DOI":"10.1155\/2019\/2843121","article-title":"Role of Combined Lipoic Acid and Vitamin D3 on Astrocytes as a Way to Prevent Brain Ageing by Induced Oxidative Stress and Iron Accumulation","volume":"2019","author":"Molinari","year":"2019","journal-title":"Oxidative Med. Cell. Longev."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"153473541988858","DOI":"10.1177\/1534735419888584","article-title":"The Effect of Docosahexaenoic Acid and \u03b1-Lipoic Acid as Prevention of Bortezomib-Related Neurotoxicity in Patients with Multiple Myeloma","volume":"18","author":"Maschio","year":"2019","journal-title":"Integr. Cancer Ther."},{"key":"ref_147","first-page":"4739","article-title":"Natural Products\u2014Alpha-Lipoic Acid and Acetyl-L-Carnitine\u2014In the Treatment of Chemotherapy-Induced Peripheral Neuropathy","volume":"22","author":"Dinicola","year":"2018","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1007\/s12032-017-0907-4","article-title":"Use of an Alpha Lipoic, Methylsulfonylmethane and Bromelain Dietary Supplement (Opera\u00ae) for Chemotherapy-Induced Peripheral Neuropathy Management, a Prospective Study","volume":"34","author":"Desideri","year":"2017","journal-title":"Med. Oncol."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"2578","DOI":"10.2337\/diabetes.52.10.2578","article-title":"Neuroprotective Effect of Docosahexaenoic Acid-Enriched Phospholipids in Experimental Diabetic Neuropathy","volume":"52","author":"Coste","year":"2003","journal-title":"Diabetes"},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.expneurol.2015.06.022","article-title":"Docosahexaenoic Acid Inhibits Mechanical Allodynia and Thermal Hyperalgesia in Diabetic Rats by Decreasing the Excitability of DRG Neurons","volume":"271","author":"Heng","year":"2015","journal-title":"Exp. Neurol."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1007\/s00520-013-2075-1","article-title":"Oral Alpha-Lipoic Acid to Prevent Chemotherapy-Induced Peripheral Neuropathy: A Randomized, Double-Blind, Placebo-Controlled Trial","volume":"22","author":"Guo","year":"2014","journal-title":"Support. Care Cancer"},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"100961","DOI":"10.1016\/j.arr.2019.100961","article-title":"SIRT2: Controversy and Multiple Roles in Disease and Physiology","volume":"55","author":"Wang","year":"2019","journal-title":"Ageing Res. Rev."},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"3986","DOI":"10.1093\/hmg\/ddr326","article-title":"The Sirtuin 2 Microtubule Deacetylase Is an Abundant Neuronal Protein That Accumulates in the Aging CNS","volume":"20","author":"Maxwell","year":"2011","journal-title":"Hum. Mol. Genet."},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"222","DOI":"10.2174\/138945012799201711","article-title":"NAD+ Metabolism and NAD+-Dependent Enzymes: Promising Therapeutic Targets for Neurological Diseases","volume":"13","author":"Ma","year":"2012","journal-title":"Curr. Drug Targets"},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"778","DOI":"10.3389\/fnins.2018.00778","article-title":"Sirtuins in Neuroendocrine Regulation and Neurological Diseases","volume":"12","author":"Fujita","year":"2018","journal-title":"Front. Neurosci."},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"172847","DOI":"10.1016\/j.ejphar.2019.172847","article-title":"Review of the Anti-Inflammatory Effect of SIRT1 and SIRT2 Modulators on Neurodegenerative Diseases","volume":"867","author":"Zhang","year":"2020","journal-title":"Eur. J. Pharmacol."},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"372","DOI":"10.3389\/fnagi.2019.00372","article-title":"Emerging Role of Sirtuin 2 in Parkinson\u2019s Disease","volume":"11","author":"Liu","year":"2020","journal-title":"Front. Aging Neurosci."},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"3737","DOI":"10.1093\/brain\/awz324","article-title":"Overexpression of Sirtuin 1 Protein in Neurons Prevents and Reverses Experimental Diabetic Neuropathy","volume":"142","author":"Chandrasekaran","year":"2019","journal-title":"Brain"},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.jnutbio.2017.05.001","article-title":"Isoliquiritigenin Reduces Oxidative Damage and Alleviates Mitochondrial Impairment by SIRT1 Activation in Experimental Diabetic Neuropathy","volume":"47","author":"Yerra","year":"2017","journal-title":"J. Nutr. Biochem."},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.expneurol.2018.08.001","article-title":"High Glucose Concentration Suppresses a SIRT2 Regulated Pathway That Enhances Neurite Outgrowth in Cultured Adult Sensory Neurons","volume":"309","author":"Schartner","year":"2018","journal-title":"Exp. Neurol."},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"2953","DOI":"10.1172\/JCI123159","article-title":"SIRT2 Protects Peripheral Neurons from Cisplatin-Induced Injury by Enhancing Nucleotide Excision Repair","volume":"130","author":"Zhang","year":"2020","journal-title":"J. Clin. Investig."},{"key":"ref_162","doi-asserted-by":"crossref","unstructured":"Zhao, X., Du, W., Zhang, M., Atiq, Z.O., and Xia, F. (2020). Sirt2-Associated Transcriptome Modifications in Cisplatin-Induced Neuronal Injury. BMC Genom., 21.","DOI":"10.1186\/s12864-020-6584-2"},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"707421","DOI":"10.1155\/2013\/707421","article-title":"Nutrition and Healthy Ageing: Calorie Restriction or Polyphenol-Rich \u201cMediterrAsian\u201d Diet?","volume":"2013","author":"Pallauf","year":"2013","journal-title":"Oxidative Med. Cell. Longev."},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/S1470-2045(10)70218-7","article-title":"Definition and Classification of Cancer Cachexia: An International Consensus","volume":"12","author":"Fearon","year":"2011","journal-title":"Lancet Oncol."},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"173735","DOI":"10.1016\/j.ejphar.2020.173735","article-title":"Atractylenolides, Essential Components of Atractylodes-Based Traditional Herbal Medicines: Antioxidant, Anti-Inflammatory and Anticancer Properties","volume":"891","author":"Bailly","year":"2021","journal-title":"Eur. J. Pharmacol."},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"2607872","DOI":"10.1155\/2019\/2607872","article-title":"Safety and Effectiveness of Mist Antiaris, a Herbal Preparation for Treatment of Peripheral Neuropathy","volume":"2019","author":"Antwi","year":"2019","journal-title":"BioMed Res. 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