{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T11:43:30Z","timestamp":1791287010663,"version":"4.1.0"},"reference-count":134,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2022,2,10]],"date-time":"2022-02-10T00:00:00Z","timestamp":1644451200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>For normal maintenance of blood pressure and blood volume a well-balanced renin-angiotensin-aldosterone system (RAS) is necessary. For this purpose, renin is secreted as the situation demands by the juxtaglomerular cells (also called as granular cells) that are in the walls of the afferent arterioles. Juxtaglomerular cells can sense minute changes in the blood pressure and blood volume and accordingly synthesize, store, and secrete appropriate amounts of renin. Thus, when the blood pressure and blood volume are decreased JGA cells synthesize and secrete higher amounts of renin and when the blood pressure and blood volume is increased the synthesis and secretion of renin is decreased such that homeostasis is restored. To decipher this important function, JGA cells (renin cells) need to sense and transmit the extracellular physical forces to their chromatin to control renin gene expression for appropriate renin synthesis. The changes in perfusion pressure are sensed by Integrin \u03b21 that is transmitted to the renin cell\u2019s nucleus via lamin A\/C that produces changes in the architecture of the chromatin. This results in an alteration (either increase or decrease) in renin gene expression. Cell membrane is situated in an unique location since all stimuli need to be transmitted to the cell nucleus and messages from the DNA to the cell external environment can be conveyed only through it. This implies that cell membrane structure and integrity is essential for all cellular functions. Cell membrane is composed to proteins and lipids. The lipid components of the cell membrane regulate its (cell membrane) fluidity and the way the messages are transmitted between the cell and its environment. Of all the lipids present in the membrane, arachidonic acid (AA) forms an important constituent. In response to pressure and other stimuli, cellular and nuclear shape changes occur that render nucleus to act as an elastic mechanotransducer that produces not only changes in cell shape but also in its dynamic behavior. Cell shape changes in response to external pressure(s) result(s) in the activation of cPLA2 (cytosolic phospholipase 2)-AA pathway that stretches to recruit myosin II which produces actin-myosin cytoskeleton contractility. Released AA can undergo peroxidation and peroxidized AA binds to DNA to regulate the expression of several genes. Alterations in the perfusion pressure in the afferent arterioles produces parallel changes in the renin cell membrane leading to changes in renin release. AA and its metabolic products regulate not only the release of renin but also changes in the vanilloid type 1 (TRPV1) expression in renal sensory nerves. Thus, AA and its metabolites function as intermediate\/mediator molecules in transducing changes in perfusion and mechanical pressures that involves nuclear mechanotransduction mechanism. This mechanotransducer function of AA has relevance to the synthesis and release of insulin, neurotransmitters, and other soluble mediators release by specialized and non-specialized cells. Thus, AA plays a critical role in diseases such as diabetes mellitus, hypertension, atherosclerosis, coronary heart disease, sepsis, lupus, rheumatoid arthritis, and cancer.<\/jats:p>","DOI":"10.3390\/nu14040749","type":"journal-article","created":{"date-parts":[[2022,2,11]],"date-time":"2022-02-11T02:35:51Z","timestamp":1644546951000},"page":"749","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Arachidonic Acid as Mechanotransducer of Renin Cell Baroreceptor"],"prefix":"10.3390","volume":"14","author":[{"given":"Undurti N.","family":"Das","sequence":"first","affiliation":[{"name":"UND Life Sciences, 2221 NW 5th St., Battle Ground, WA 98604, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,2,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1161\/CIRCRESAHA.120.318711","article-title":"Renin Cell Baroreceptor, a Nuclear Mechanotransducer Central for Homeostasis","volume":"129","author":"Watanabe","year":"2021","journal-title":"Circ. Res."},{"key":"ref_2","first-page":"S234","article-title":"Reflexes that Control Cardiovascular Function","volume":"277","author":"Heesch","year":"1999","journal-title":"Am. J. Physiol. Content"},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Das, U. (2021). \u201cCell Membrane Theory of Senescence\u201d and the Role of Bioactive Lipids in Aging, and Aging Associated Diseases and their Therapeutic Implications. Biomolecules, 11.","DOI":"10.3390\/biom11020241"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"eaba2894","DOI":"10.1126\/science.aba2894","article-title":"The Nucleus Acts as a Ruler Tailoring Cell Responses to Spatial Constraints","volume":"370","author":"Lomakin","year":"2020","journal-title":"Science"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"eaba2644","DOI":"10.1126\/science.aba2644","article-title":"The Nucleus Measures Shape Changes for Cellular Proprioception to Control Dynamic Cell Behavior","volume":"370","author":"Venturini","year":"2020","journal-title":"Science"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"3811","DOI":"10.1210\/en.2011-0141","article-title":"Inhibition of Renin Release by Arachidonic Acid Metabolites, 12(s)-HPETE and 12-HETE: Role of TRPV1 Channels","volume":"152","author":"Xie","year":"2011","journal-title":"Endocrinology"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"F235","DOI":"10.1152\/ajprenal.00454.2004","article-title":"Prostacyclin Signaling in the Kidney: Implications for Health and Disease","volume":"289","author":"Nasrallah","year":"2005","journal-title":"Am. J. Physiol. Physiol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1161\/01.HYP.10.1.61","article-title":"The Inhibitory Role of 12- and 15-Lipoxygenase Products on Renin Release","volume":"10","author":"Antonipillai","year":"1987","journal-title":"Hypertension"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1016\/0090-6980(81)90062-9","article-title":"Effect of Precursors of the 1, 2, and 3 Series Prostaglandins on Renin Release and Renal Blood Flow in the Dog","volume":"22","author":"Gerkens","year":"1981","journal-title":"Prostaglandins"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1159\/000401657","article-title":"Renal Prostaglandins in the Control of Renin1","volume":"12","author":"Weber","year":"1978","journal-title":"Contr. Nephrol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"F1035","DOI":"10.1152\/ajprenal.00054.2011","article-title":"A Major Role for the EP4 Receptor in Regulation of Renin","volume":"301","author":"Facemire","year":"2011","journal-title":"Am. J. Physiol. Renal Physiol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"F1782","DOI":"10.1152\/ajprenal.00513.2006","article-title":"COX-2 Activity Determines the Level of Renin Expression but Is Dispensable for Acute Upregulation of Renin Expression in Rat Kidneys","volume":"292","author":"Matzdorf","year":"2007","journal-title":"Am. J. Physiol. Renal Physiol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"F427","DOI":"10.1152\/ajprenal.00072.2004","article-title":"Stimulation of Renin Release by Prostaglandin E2 Is Mediated by EP2 and EP4 Receptors in Mouse Kidneys","volume":"287","author":"Schweda","year":"2004","journal-title":"Am. J. Physiol. Renal Physiol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"F12","DOI":"10.1152\/ajprenal.2000.279.1.F12","article-title":"Prostaglandin E Receptors and the Kidney","volume":"279","author":"Breyer","year":"2000","journal-title":"Am. J. Physiol. Renal Physiol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"38308","DOI":"10.1038\/srep38308","article-title":"Human Mesenchymal Stem Cells Program Macrophage Plasticity by Altering their Metabolic Status via a PGE2-Dependent Mechanism","volume":"6","author":"Vasandan","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1506","DOI":"10.5966\/sctm.2015-0243","article-title":"Human Mesenchymal Stem Cells Impact Th17 and Th1 Responses Through a Prostaglandin E2 and Myeloid-Dependent Mechanism","volume":"5","author":"Rozenberg","year":"2016","journal-title":"Stem Cells Transl. Med."},{"key":"ref_17","first-page":"42","article-title":"Bone Marrow Stromal Cells Attenuate Sepsis via Prostaglandin E2\u2013Dependent Reprogramming of Host Macrophages to Increase their Interleukin-10 Production","volume":"15","author":"Leelahavanichkul","year":"2008","journal-title":"Nat. Med."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"2283","DOI":"10.1002\/stem.1191","article-title":"Human Mesenchymal Stem\/Stromal Cells Cultured as Spheroids are Self-activated to Produce Prostaglandin E2 that Directs Stimulated Macrophages into an Anti-inflammatory Phenotype","volume":"30","author":"Bartosh","year":"2012","journal-title":"Stem Cells"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/j.molimm.2012.12.010","article-title":"PGE2 Differentially Regulates Monocyte-Derived Dendritic Cell Cytokine Responses Depending on Receptor Usage (EP2\/EP4)","volume":"54","author":"Poloso","year":"2013","journal-title":"Mol. Immunol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.molimm.2012.08.014","article-title":"Prostaglandin E2 inhibits IL-23 and IL-12 Production by Human Monocytes through Down-Regulation of their Common p40 Subunit","volume":"53","author":"Kalim","year":"2013","journal-title":"Mol. Immunol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"eaar8320","DOI":"10.1126\/sciadv.aar8320","article-title":"PGE 2 Production at Sites of Tissue Injury Promotes an Anti-Inflammatory Neutrophil Phenotype and Determines the Outcome of Inflammation Resolution in Vivo","volume":"4","author":"Loynes","year":"2018","journal-title":"Sci. Adv."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"6418","DOI":"10.4049\/jimmunol.0903816","article-title":"Resolution of Inflammation in Murine Autoimmune Arthritis Is Disrupted by Cyclooxygenase-2 Inhibition and Restored by Prostaglandin E2-Mediated Lipoxin A4 Production","volume":"184","author":"Chan","year":"2010","journal-title":"J. Immunol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1016\/j.bbrc.2018.03.096","article-title":"Adipose-Derived Stem Cells Ameliorate Colitis by Suppression of Inflammasome Formation and Regulation of M1-Macrophage Population through Prostaglandin E2","volume":"498","author":"Park","year":"2018","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"An, J.-H., Song, W.-J., Li, Q., Kim, S.-M., Yang, J.-I., Ryu, M.-O., Nam, A.R., Bhang, D.H., Jung, Y.-C., and Youn, H.-Y. (2018). Prostaglandin E2 Secreted from Feline Adipose Tissue-Derived Mesenchymal Stem Cells Alleviate DSS-Induced Colitis by Increasing Regulatory T Cells in Mice. BMC Veter.-Res., 14.","DOI":"10.1186\/s12917-018-1684-9"},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Terraza-Aguirre, C., Campos-Mora, M., Elizondo-Vega, R., Contreras-L\u00f3pez, R., Luz-Crawford, P., Jorgensen, C., and Djouad, F. (2020). Mechanisms behind the Immunoregulatory Dialogue between Mesenchymal Stem Cells and Th17 Cells. Cells, 9.","DOI":"10.3390\/cells9071660"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1909","DOI":"10.1002\/stem.2369","article-title":"Mesenchymal Stromal Cells Induce Peculiar Alternatively Activated Macrophages Capable of Dampening Both Innate and Adaptive Immune Responses","volume":"34","author":"Chiossone","year":"2016","journal-title":"Stem Cells"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.4049\/jimmunol.1102996","article-title":"Mesenchymal Stem\/Stromal Cells Induce the Generation of Novel IL-10\u2013Dependent Regulatory Dendritic Cells by SOCS3 Activation","volume":"189","author":"Liu","year":"2012","journal-title":"J. Immunol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1006\/bbrc.2000.3779","article-title":"Prostaglandin E(2) Receptors, EP2 and EP4, Differentially Modulate TNF-Alpha and IL-6 Production Induced by Lipopolysaccharide in Mouse Peritoneal Neutrophils","volume":"278","author":"Yamane","year":"2000","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1007\/978-3-030-42667-5_3","article-title":"Bioactive Lipids in Age-Related Disorders","volume":"1260","author":"Das","year":"2020","journal-title":"Rev. New Drug Targets Age-Related Disord."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1054\/plef.1999.0085","article-title":"Essential Fatty Acids, Lipid Peroxidation and Apoptosis","volume":"61","author":"Das","year":"1999","journal-title":"Prostaglandins Leukot Essen Fat. Acids"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1038\/9550","article-title":"Inducible Cyclooxygenase May Have Anti-Inflammatory Properties","volume":"5","author":"Gilroy","year":"1999","journal-title":"Nat. Med."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.nut.2016.10.004","article-title":"Arachidonic Acid and LipoxinA4 Attenuate Streptozotocin-Induced Cytotoxicity to RIN5 F Cells in Vitro and Type 1 and Type 2 Diabetes Mellitus in Vivo","volume":"35","author":"Gundala","year":"2017","journal-title":"Nutrition"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1458","DOI":"10.1074\/jbc.M308697200","article-title":"Tumor Necrosis Factor-Alpha Activates NFkappaB to Inhibit Renin Transcription by Targeting cAMP-Responsive Element","volume":"279","author":"Todorov","year":"2004","journal-title":"J. Biol. Chem."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"24356","DOI":"10.1074\/jbc.M502968200","article-title":"Role of CREB1 and NF {\u03ba}B-p65 in the Down-Regulation of Renin Gene Expression by Tumor Necrosis Factor {\u03b1}","volume":"280","author":"Todorov","year":"2005","journal-title":"J. Biol. Chem."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1161\/01.RES.0000017622.25365.71","article-title":"Control of Renin Secretion from Rat Juxtaglomerular Cells by cAMP-Specific Phosphodiesterases","volume":"90","author":"Friis","year":"2002","journal-title":"Circ Res."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1146\/annurev-physiol-012110-142238","article-title":"Renin Release: Sites, Mechanisms, and Control","volume":"73","author":"Kurtz","year":"2011","journal-title":"Annu. Rev Physiol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"F1","DOI":"10.1152\/ajprenal.00143.2009","article-title":"The Role of Calcium in the Regulation of Renin Secretion","volume":"298","author":"Beierwaltes","year":"2010","journal-title":"Am. J. Physiol. Physiol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"3423","DOI":"10.1073\/pnas.86.9.3423","article-title":"Angiotensin II Induces Oscillations of Intracellular Calcium and Blocks Anomalous Inward Rectifying Potassium Current in Mouse Renal Juxtaglomerular Cells","volume":"86","author":"Kurtz","year":"1989","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_39","first-page":"F39","article-title":"Effects of Endothelins on Renin Secretion from Isolated Mouse Renal Juxtaglomerular Cells","volume":"268","author":"Ritthaler","year":"1995","journal-title":"Am. J. Physiol. Content"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1038\/hr.2011.65","article-title":"Pressure Induces Intracellular Calcium Changes in Juxtaglomerular Cells in Perfused Afferent Arterioles","volume":"34","author":"Lai","year":"2011","journal-title":"Hypertens. Res."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"4769","DOI":"10.1073\/pnas.83.13.4769","article-title":"Atrial Natriuretic Peptide Inhibits Renin Release from Juxtaglomerular Cells by a cGMP-Mediated Process","volume":"83","author":"Kurtz","year":"1986","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1161\/01.RES.32.2.290","article-title":"Adrenergic Stimulation of Renin Secretion in the Isolated Perfused Rat Kidney","volume":"32","author":"Vandongen","year":"1973","journal-title":"Circ. Res."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/0014-2999(75)90150-8","article-title":"Effect of Dopamine on Renin Secretion in the Anesthetized Dog","volume":"33","author":"Imbs","year":"1975","journal-title":"Eur. J. Pharmacol."},{"key":"ref_44","first-page":"F267","article-title":"Conditions for Enhancement of Renin Release by Isoproterenol, Dopamine, and Glucagon","volume":"242","author":"Holdaas","year":"1982","journal-title":"Am. J. Physiol. Content"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1172\/JCI113629","article-title":"Calcitonin Gene-Related Peptide Is a Stimulator of Renin Secretion","volume":"82","author":"Kurtz","year":"1988","journal-title":"J. Clin. Investig."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1111\/j.1749-6632.1988.tb27000.x","article-title":"Vasoactive Intestinal Peptide and Renin Secretion","volume":"527","author":"Porter","year":"1988","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.1681\/ASN.2006060633","article-title":"Pituitary Adenylate Cyclase\u2013Activating Polypeptide Stimulates Renin Secretion via Activation of PAC1 Receptors","volume":"18","author":"Hautmann","year":"2007","journal-title":"J. Am. Soc. Nephrol."},{"key":"ref_48","first-page":"F543","article-title":"Neuropeptide Y Inhibits Renin Release by a Pertussis Toxin-Sensitive Mechanism","volume":"252","author":"Hackenthal","year":"1987","journal-title":"Am. J. Physiol. Content"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1007\/s004240050538","article-title":"Renal effects of neuropeptide Y","volume":"435","author":"Bischoff","year":"1998","journal-title":"Pfl\u00fcgers Archiv"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1046\/j.1523-1755.2001.059002515.x","article-title":"Immunofluorescent Imaging of Beta 1- and Beta 2-Adrenergic Receptors in Rat Kidney","volume":"59","author":"Boivin","year":"2001","journal-title":"Kidney Int."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"e141","DOI":"10.1093\/cvr\/cvab274","article-title":"Radiance-Htn Trio: How the Saga of Renal Denervation Revisits Hypertensiontherapy","volume":"117","author":"Konstantinos","year":"2021","journal-title":"Cardiovasc. Res."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1152\/physrev.00011.2009","article-title":"Physiology of Kidney Renin","volume":"90","author":"Castrop","year":"2010","journal-title":"Physiol. Rev."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"F659","DOI":"10.1152\/ajprenal.1996.271.3.F659","article-title":"Prostaglandins Stimulate Renin Secretion and Renin mRNA in Mouse Renal Juxtaglomerular Cells","volume":"271","author":"Jensen","year":"1996","journal-title":"Am. J. Physiol. Physiol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"4743","DOI":"10.1073\/pnas.95.8.4743","article-title":"Stimulation of Renin Secretion by Nitric Oxide Is Mediated by Phosphodiesterase 3","volume":"95","author":"Kurtz","year":"1998","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"28608","DOI":"10.1074\/jbc.M111.225839","article-title":"Vesicle-Associated Membrane Protein-2 (VAMP2) Mediates cAMP-Stimulated Renin Release in Mouse Juxtaglomerular Cells","volume":"286","author":"Mendez","year":"2011","journal-title":"J. Biol. Chem."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"F498","DOI":"10.1152\/ajprenal.00556.2012","article-title":"Role of the SNARE Protein SNAP23 on cAMP-Stimulated Renin Release in Mouse Juxtaglomerular Cells","volume":"304","author":"Mendez","year":"2013","journal-title":"Am. J. Physiol. Ren. Physiol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1073\/pnas.94.3.769","article-title":"SNAREs and Regulated Vesicle Exocytosis","volume":"94","author":"Goda","year":"1997","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1038\/ajh.2011.246","article-title":"Control of Renin Synthesis and Secretion","volume":"25","author":"Kurtz","year":"2012","journal-title":"Am. J. Hypertens."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"R484","DOI":"10.1152\/ajpregu.00175.2014","article-title":"Renin Release: Role of SNAREs","volume":"307","author":"Mendez","year":"2014","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"1543","DOI":"10.1111\/j.1471-4159.2006.04286.x","article-title":"Arachidonic Acid Potentiates Exocytosis and Allows Neuronal SNARE Complex to Interact with Munc18a","volume":"100","author":"Latham","year":"2006","journal-title":"J. Neurochem."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1038\/35052017","article-title":"SNARE-Mediated Membrane Fusion","volume":"2","author":"Chen","year":"2001","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"2202","DOI":"10.1093\/emboj\/20.9.2202","article-title":"SNAREs are Concentrated in Cholesterol-Dependent Clusters that Define Docking and Fusion Sites for Exocytosis","volume":"20","author":"Lang","year":"2001","journal-title":"EMBO J."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"4750","DOI":"10.1073\/pnas.76.10.4750","article-title":"Theory of Protein-Lipid and Protein-Protein Interactions in Bilayer Membranes","volume":"76","author":"Owicki","year":"1979","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1016\/S0092-8674(00)81404-X","article-title":"SNAREpins: Minimal Machinery for Membrane Fusion","volume":"92","author":"Weber","year":"1998","journal-title":"Cell"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1080\/09687860600776734","article-title":"SNARES in Neurons\u2013Beyond Synaptic Vesicle Exocytosis","volume":"23","author":"Wang","year":"2006","journal-title":"Mol Membr Biol."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1038\/362318a0","article-title":"SNAP Receptors Implicated in Vesicle Targeting and Fusion","volume":"362","author":"Whiteheart","year":"1993","journal-title":"Nature"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1038\/387199a0","article-title":"Homotypic Vacuolar Fusion Mediated by t- and v-SNAREs","volume":"387","author":"Nichols","year":"1997","journal-title":"Nature"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1038\/nrm2002","article-title":"SNARES\u2013Engines for Membrane Fusion","volume":"7","author":"Jahn","year":"2006","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/gb-2001-2-11-reviews3012","article-title":"The Syntaxins","volume":"2","author":"Teng","year":"2001","journal-title":"Genome Biol."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1038\/sj.embor.7400935","article-title":"Mechanism of Arachidonic Acid Action on Syntaxin\u2013Munc18","volume":"8","author":"Connell","year":"2007","journal-title":"EMBO Rep."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1038\/nature04598","article-title":"Omega-3 and Omega-6 Fatty Acids Stimulate Cell Membrane Expansion by Acting on Syntaxin 3","volume":"440","author":"Darios","year":"2006","journal-title":"Nature"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1113\/jphysiol.2007.136812","article-title":"Phospholipases and Fatty Acid Signalling in Exocytosis","volume":"585","author":"Darios","year":"2007","journal-title":"J. Physiol."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"39675","DOI":"10.1074\/jbc.M212594200","article-title":"Fusion of Lamellar Body with Plasma Membrane Is Driven by the Dual Action of Annexin II Tetramer and Arachidonic Acid","volume":"278","author":"Chattopadhyay","year":"2003","journal-title":"J. Biol. Chem."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1038\/embor.2010.66","article-title":"Alpha-Synuclein Sequesters Arachidonic Acid to Modulate SNARE-Mediated Exocytosis","volume":"11","author":"Darios","year":"2010","journal-title":"EMBO Rep."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/j.chembiol.2005.03.004","article-title":"Arachidonic Acid Allows SNARE Complex Formation in the Presence of Munc18","volume":"12","author":"Rickman","year":"2005","journal-title":"Chem. Biol."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.2337\/diabetes.51.2007.S3","article-title":"Molecular Determinants of Regulated Exocytosis","volume":"51","author":"Gerber","year":"2002","journal-title":"Diabetes"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1038\/nrn898","article-title":"Snares and munc18 in Synaptic Vesicle Fusion","volume":"3","author":"Rizo","year":"2002","journal-title":"Nat. Rev. Neurosci."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1034\/j.1600-065X.2002.18913.x","article-title":"The Secretory Synapse: The Secrets of a Serial Killer","volume":"189","author":"Bossi","year":"2002","journal-title":"Immunol. Rev."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1038\/35073095","article-title":"Cell Control by Membrane\u2013Cytoskeleton Adhesion","volume":"2","author":"Sheetz","year":"2001","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1016\/S0092-8674(02)00668-2","article-title":"Fusion and Fission: Membrane Trafficking in Animal Cytokinesis","volume":"108","author":"Finger","year":"2002","journal-title":"Cell"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1034\/j.1600-0854.2002.30904.x","article-title":"Membrane Trafficking during Plant Cytokinesis","volume":"3","author":"Bednarek","year":"2002","journal-title":"Traffic"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1016\/S0955-0674(03)00074-7","article-title":"Spatial Control of Exocytosis","volume":"15","author":"Spiliotis","year":"2003","journal-title":"Curr. Opin. Cell Biol."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/S0092-8674(00)81278-7","article-title":"Origins of Cell Polarity","volume":"84","author":"Drubin","year":"1996","journal-title":"Cell"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"E73","DOI":"10.1152\/ajpendo.00086.2003","article-title":"cPLA2alpha-Evoked Formation of Arachidonic Acid and Lysophospholipids Is Required for Exocytosis in Mouse Pancreatic Beta-Cells","volume":"285","author":"Juhl","year":"2003","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1677\/joe.0.1370007","article-title":"Arachidonic Acid as a Second Messenger in Glucose-Induced Insulin Secretion from Pancreatic Beta-Cells","volume":"137","author":"Jones","year":"1993","journal-title":"J. Endocrinol."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"197","DOI":"10.2337\/db06-0490","article-title":"The Role of Arachidonic Acid and Its Metabolites in Insulin Secretion from Human Islets of Langerhans","volume":"56","author":"Persaud","year":"2007","journal-title":"Diabetes"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1038\/oby.2000.59","article-title":"Augmented Insulinotropic Action of Arachidonic Acid through the Lipoxygenase Pathway in the Obese Zucker Rat","volume":"8","author":"Magrum","year":"2000","journal-title":"Obes. Res."},{"key":"ref_88","doi-asserted-by":"crossref","unstructured":"Jayaraja, S., Dakhama, A., Yun, B., Ghosh, M., Lee, H., Redente, E.F., Uhlson, C.L., Murphy, R.C., and Leslie, C.C. (2016). Cytosolic Phospholipase A2 Contributes to Innate Immune Defense against Candida Albicans Lung Infection. BMC Immunol., 17.","DOI":"10.1186\/s12865-016-0165-9"},{"key":"ref_89","doi-asserted-by":"crossref","unstructured":"Suram, S., Silveira, L.J., Mahaffey, S., Brown, G.D., Bonventre, J.V., Williams, D.L., Gow, N.A.R., Bratton, D.L., Murphy, R.C., and Leslie, C.C. (2013). Cytosolic Phospholipase A2\u03b1 and Eicosanoids Regulate Expression of Genes in Macrophages Involved in Host Defense and Inflammation. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0069002"},{"key":"ref_90","first-page":"120","article-title":"Complement-Mediated Arachidonate Metabolism","volume":"20","author":"Clancy","year":"1985","journal-title":"Prog. Biochem. Pharmacol."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"801","DOI":"10.4049\/jimmunol.2000186","article-title":"Human NK Cell Cytoskeletal Dynamics and Cytotoxicity Are Regulated by LIM Kinase","volume":"205","author":"Duvall","year":"2020","journal-title":"J. Immunol."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"101180","DOI":"10.1016\/j.jbc.2021.101180","article-title":"Activation of the Cytosolic Calcium Independent Phospholipase A2 \u03b2 Isoform Contributes to TRPC6 Externalization via Release of Arachidonic Acid","volume":"297","author":"Putta","year":"2021","journal-title":"J. Biol. Chem."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"e00095-21","DOI":"10.1128\/IAI.00095-21","article-title":"Roles of Eicosanoids in Regulating Inflammation and Neutrophil Migration as an Innate Host Response to Bacterial Infections","volume":"89","author":"Sheppe","year":"2021","journal-title":"Infect. Immun."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.intimp.2016.07.026","article-title":"Lipoxin A4 Protects against Lipopolysaccharide-Induced Sepsis by Promoting Innate Response Activator B Cells Generation","volume":"39","author":"Cheng","year":"2016","journal-title":"Int. Immunopharmacol."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12944-015-0165-4","article-title":"Inflammatory bowel disease as a disorder of an imbalance between pro- and anti-inflammatory molecules and deficiency of resolution bioactive lipids","volume":"15","author":"Das","year":"2016","journal-title":"Lipids Health Dis."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1016\/j.bbrc.2015.07.076","article-title":"LXA4 Actions Direct Fibroblast Function and Wound Closure","volume":"464","author":"Herrera","year":"2015","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"5035","DOI":"10.4049\/jimmunol.181.7.5035","article-title":"Annexin A1 Regulates Intestinal Mucosal Injury, Inflammation, and Repair","volume":"181","author":"Babbin","year":"2008","journal-title":"J. Immunol."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"109473","DOI":"10.1016\/j.mehy.2019.109473","article-title":"Bioactive Lipids as Modulators of Immune Check Point Inhibitors","volume":"135","author":"Das","year":"2020","journal-title":"Med. Hypotheses"},{"key":"ref_99","first-page":"906","article-title":"Essential Fatty Acids in Health and Disease","volume":"47","author":"Das","year":"1999","journal-title":"J. Assoc. Physicians India"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.ejphar.2015.08.049","article-title":"COX-2, Aspirin and Metabolism of Arachidonic, Eicosapentaenoic and Docosahexaenoic Acids and their Physiological and Clinical Significance","volume":"785","author":"Poorani","year":"2016","journal-title":"Eur. J. Pharmacol."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1507\/endocrine1927.59.2_148","article-title":"The Role of Prostacyclin (PGI2) in the Regulation of Blood Pressure and Aldosterone Response to Angiotensin II","volume":"59","author":"Morise","year":"1983","journal-title":"Folia Endocrinol. Jpn."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/0161-4630(78)90123-4","article-title":"Antihypertensive Effect of Prostacyclin (PGI2) in Experimental Hypertension and its Influence on Plasma Renin Activity in Rats","volume":"1","year":"1978","journal-title":"Prostaglandins Med."},{"key":"ref_103","first-page":"S73","article-title":"Prostacyclin in Hypertension","volume":"8","year":"1990","journal-title":"Int. Soc. Hypertens."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1186\/1476-511X-7-37","article-title":"Essential Fatty Acids and their Metabolites Could Function as Endogenous HMG-CoA Reductase and ACE Enzyme Inhibitors, Anti-Arrhythmic, Anti-Hypertensive, Anti-Atherosclerotic, Anti-Inflammatory, Cytoprotective, and Cardioprotective Molecules","volume":"7","author":"Das","year":"2008","journal-title":"Lipids Health Dis."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1007\/s13105-016-0509-1","article-title":"Omega-3 Fatty Acids Control Productions of Superoxide and Nitrogen Oxide and Insulin Content in INS-1E Cells","volume":"72","author":"Graciano","year":"2016","journal-title":"J. Physiol. Biochem."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"1939","DOI":"10.1113\/EP089517","article-title":"Nitric Oxide Synthesis Stimulated by Arachidonic Acid Accumulation via PPAR\u03b1 in Acetylcholine-Stimulated Gastric Mucous Cells","volume":"106","author":"Tanaka","year":"2021","journal-title":"Exp. Physiol."},{"key":"ref_107","doi-asserted-by":"crossref","unstructured":"Berra-Romani, R., Faris, P., Negri, S., Botta, L., Genova, T., and Moccia, F. (2019). Arachidonic Acid Evokes an Increase in Intracellular Ca2+ Concentration and Nitric Oxide Production in Endothelial Cells from Human Brain Microcirculation. Cells, 8.","DOI":"10.3390\/cells8070689"},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1016\/j.bbamem.2013.07.018","article-title":"Interaction of Membrane\/Lipid Rafts with the Cytoskeleton: Impact on Signaling and Function","volume":"1838","author":"Head","year":"2013","journal-title":"Biochim. Biophys. Acta Biomembr."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"26391","DOI":"10.1074\/jbc.M602577200","article-title":"Microtubules and Actin Microfilaments Regulate Lipid Raft\/Caveolae Localization of Adenylyl Cyclase Signaling Components","volume":"281","author":"Head","year":"2006","journal-title":"J. Biol. Chem."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1111\/jipb.12342","article-title":"The Connection of Cytoskeletal Network with Plasma Membrane and the Cell Wall","volume":"57","author":"Liu","year":"2015","journal-title":"J. Integr. Plant Biol."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1126\/science.1439807","article-title":"Cytoskeleton--Plasma Membrane Interactions","volume":"258","author":"Luna","year":"1992","journal-title":"Science"},{"key":"ref_112","doi-asserted-by":"crossref","unstructured":"Di Giaimo, R., Penna, E., Pizzella, A., Cirillo, R., Perrone-Capano, C., and Crispino, M. (2020). Cross Talk at the Cytoskeleton-Plasma Membrane Interface: Impact on Neuronal Morphology and Functions. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21239133"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1152\/physrev.00036.2009","article-title":"Regulation of the Actin Cytoskeleton-Plasma Membrane Interplay by Phosphoinositides","volume":"90","author":"Saarikangas","year":"2010","journal-title":"Physiol. Rev."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/S0092-8674(00)81560-3","article-title":"Phosphatidylinositol 4,5-Bisphosphate Functions as a Second Messenger that Regulates Cytoskeleton-Plasma Membrane Adhesion","volume":"100","author":"Raucher","year":"2000","journal-title":"Cell"},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"125","DOI":"10.3389\/fendo.2013.00125","article-title":"Lipids in Regulated Exocytosis: What are They Doing?","volume":"4","author":"Ammar","year":"2013","journal-title":"Front. Endocrinol."},{"key":"ref_116","first-page":"117","article-title":"Free Radicals, Lipid Peroxidation and Essential Fatty Acids in Patients with Pneumonia, Septicemia and Collagen Vascular Diseases","volume":"3","author":"Das","year":"1992","journal-title":"J. Nutr. Med."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/0952-3278(95)90066-7","article-title":"Essential Fatty Acid Metabolism in Patients with Essential Hypertension, Diabetes Mellitus and Coronary Heart Disease","volume":"52","author":"Das","year":"1995","journal-title":"Prostaglandins Leukot. Essent. Fat. Acids"},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"1528","DOI":"10.1038\/s41430-021-00925-2","article-title":"Bioactive Lipids and Vascular Disease","volume":"75","author":"Das","year":"2021","journal-title":"Eur. J. Clin. Nutr."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"75","DOI":"10.2174\/157340109788185599","article-title":"Cross Talk Among Leukocytes, Platelets, and Endothelial Cells and its Relevance to Atherosclerosis and Coronary Heart Disease","volume":"5","author":"Das","year":"2009","journal-title":"Curr. Nutr. Food Sci."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/0163-7827(81)90069-2","article-title":"Atherosclerosis: An Intracellular Deficiency in Essential Fatty Acids","volume":"20","author":"Cornwell","year":"1981","journal-title":"Prog. Lipid Res."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"467","DOI":"10.2174\/138920106779116856","article-title":"Essential Fatty Acids -A Review","volume":"7","author":"Das","year":"2006","journal-title":"Curr. Pharm. Biotechnol."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"463","DOI":"10.2217\/clp.11.34","article-title":"Essential fatty Acids Enhance Free Radical Generation and Lipid Peroxidation to Induce Apoptosis of Tumor Cells","volume":"6","author":"Das","year":"2011","journal-title":"Clin. Lipidol."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1186\/1476-511X-13-30","article-title":"Dietary Supplementation of Arachidonic Acid Increases Arachidonic Acid and Lipoxin A4 Contents in Colon, but Does not Affect Severity or Prostaglandin E2 Content in Murine Colitis Model","volume":"13","author":"Tateishi","year":"2014","journal-title":"Lipids Health Dis."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/1476-511X-14-3","article-title":"Dietary Supplementation with Arachidonic Acid Increases Arachidonic Acid Content in Paw, but Does not Affect Arthritis Severity or Prostaglandin E2 Content in Rat Adjuvant-Induced Arthritis Model","volume":"14","author":"Tateishi","year":"2015","journal-title":"Lipids Health Dis."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1186\/1476-511X-10-241","article-title":"Supplementation of Arachidonic Acid-Enriched Oil Increases Arachidonic Acid Contents in Plasma Phospholipids, but Does not Increase their Metabolites and Clinical Parameters in Japanese Healthy Elderly Individuals: A Randomized Controlled Study","volume":"10","author":"Kakutani","year":"2011","journal-title":"Lipids Health Dis."},{"key":"ref_126","doi-asserted-by":"crossref","unstructured":"Bathina, S., and Das, U. (2021). Resolvin D1 Decreases Severity of Streptozotocin-Induced Type 1 Diabetes Mellitus by Enhancing BDNF Levels, Reducing Oxidative Stress, and Suppressing Inflammation. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22041516"},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1038\/ni.1627","article-title":"Resolvin E1 Regulates Interleukin 23, Interferon-Gamma and Lipoxin A4 to Promote the Resolution of Allergic Airway Inflammation","volume":"9","author":"Haworth","year":"2008","journal-title":"Nat. Immunol."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1016\/j.arcmed.2020.05.002","article-title":"Resolvin D1 Ameliorates Nicotinamide-Streptozotocin-Induced Type 2 Diabetes Mellitus by its Anti-inflammatory Action and Modulating PI3K\/Akt\/mTOR Pathway in the Brain","volume":"51","author":"Bathina","year":"2020","journal-title":"Arch. Med. Res."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1186\/s12944-019-1164-7","article-title":"PUFAs, BDNF and Lipoxin A4 Inhibit Chemical-Induced Cytotoxicity of RIN5F Cells in Vitro and Streptozotocin-Induced Type 2 Diabetes Mellitus in Vivo","volume":"18","author":"Bathina","year":"2019","journal-title":"Lipids Health Dis."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1002\/biof.1336","article-title":"Arachidonic Acid and Lipoxin A4 Attenuate Alloxan-Induced Cytotoxicity to RIN5F Cells in Vitro and Type 1 Diabetes Mellitus in Vivo","volume":"43","author":"Gundala","year":"2017","journal-title":"Biofactors"},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1161\/CIRCULATIONAHA.108.191627","article-title":"Omega-6 Fatty Acids and Risk for Cardiovascular Disease: A Science Advisory from the American Heart Association Nutrition SubCommittee of the Council on Nutrition, Physical Activity, and Metabolism; Council on Cardiovascular Nursing; and Council on Epidemiology and Prevention","volume":"119","author":"Harris","year":"2009","journal-title":"Circulation"},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1007\/s11745-997-0055-7","article-title":"The Effect of Dietary Arachidonic Acid on Platelet Function, Platelet Fatty Acid Composition, and Blood Coagulation in Humans","volume":"32","author":"Nelson","year":"1997","journal-title":"Lipids"},{"key":"ref_133","unstructured":"Wilborn, C.M., Roberts, C., Kerksick, M.I., Taylor, L., Campbell, B., and Kreider, R. (2006, January 9\u201311). Changes in Whole Blood and Clinical Safety Markers over 50 Days of Concomitant Arachidonic Acid Supplementation and Resistance Training. Proceedings of the International Society of Sports Nutrition Archived, Clearwater Beach, FL, USA."},{"key":"ref_134","doi-asserted-by":"crossref","unstructured":"De Souza, E.O., Lowery, R.P., Wilson, J.M., Sharp, M.H., Mobley, C.B., Fox, C.D., Lopez, H.L., Shields, K.A., Rauch, J.T., and Healy, J.C. (2016). Effects of Arachidonic Acid Supplementation on Acute Anabolic Signaling and Chronic Functional Performance and Body Composition Adaptations. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0155153"}],"container-title":["Nutrients"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6643\/14\/4\/749\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T22:18:01Z","timestamp":1760134681000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6643\/14\/4\/749"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2,10]]},"references-count":134,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2022,2]]}},"alternative-id":["nu14040749"],"URL":"https:\/\/doi.org\/10.3390\/nu14040749","relation":{},"ISSN":["2072-6643"],"issn-type":[{"value":"2072-6643","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,2,10]]}}}