{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T23:45:38Z","timestamp":1789170338355,"version":"build-2803163510"},"reference-count":19,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2022,2,17]],"date-time":"2022-02-17T00:00:00Z","timestamp":1645056000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Grant-in Aid for Scientific Research from the Ministry of Education, Science, Sports, and Culture of Japan","award":["JP19K1865709"],"award-info":[{"award-number":["JP19K1865709"]}]},{"name":"Japan Science and Technology Agency - Hokkaido University Center of Innovation","award":["JPMJCE1301"],"award-info":[{"award-number":["JPMJCE1301"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>It is undetermined which blood variables related to iron storage during the first trimester of pregnancy could efficiently predict anemia occurring during the third trimester. Red blood cell count (RBC), hemoglobin concentration, hematocrit, ferritin, iron, and total iron binding capacity (TIBC) were assessed longitudinally during the first, second, and third trimesters of 231 healthy Japanese women. None of the patients had anemia in the first trimester and none used iron supplementation before the second trimester blood test. Anemia was defined as hemoglobin (Hb) &lt; 11 g\/dL for the first trimester and Hb &lt; 10.0 g\/dL for the third trimester. Forty-seven (20%) women developed anemia in the third trimester. The first trimester RBC, Hb, hematocrit, and ferritin levels were significantly lower in women with third-trimester anemia than those without anemia. The first trimester hemoglobin level exhibited a greater area under the curve of the receiver operating characteristic curve for prediction of the third trimester anemia than other blood variables; the optimal cut-off (12.6 g\/dL) of hemoglobin yielded a sensitivity of 83% (39\/47). First trimester hemoglobin levels were significantly better predictors of anemia during the third trimester than the indices of iron storage, including serum iron, ferritin, and TIBC levels.<\/jats:p>","DOI":"10.3390\/nu14040839","type":"journal-article","created":{"date-parts":[[2022,2,17]],"date-time":"2022-02-17T20:25:45Z","timestamp":1645129545000},"page":"839","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Hemoglobin Concentration during Early Pregnancy as an Accurate Predictor of Anemia during Late Pregnancy"],"prefix":"10.3390","volume":"14","author":[{"given":"Kiwamu","family":"Noshiro","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Hokkaido University Graduate School of Medicine, Sapporo 060-8638, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9236-9945","authenticated-orcid":false,"given":"Takeshi","family":"Umazume","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Hokkaido University Graduate School of Medicine, Sapporo 060-8638, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rifumi","family":"Hattori","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Obihiro-Kosei General Hospital, Obihiro 080-0024, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soromon","family":"Kataoka","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Hakodate Central General Hospital, Hakodate 040-8585, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Yamada","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Japan Community Health Care Organization Hokkaido Hospital, Sapporo 062-8618, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hidemichi","family":"Watari","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Hokkaido University Graduate School of Medicine, Sapporo 060-8638, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,2,17]]},"reference":[{"key":"ref_1","unstructured":"World Health Organization (2021, December 26). Iron Deficiency Anaemia: Assessment, Prevention and Control: A Guide for Programme Managers. Available online: https:\/\/www.who.int\/nutrition\/publications\/en\/ida_assessment_prevention_control.pdf?ua=1."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"2123","DOI":"10.1016\/S0140-6736(10)62304-5","article-title":"Anaemia in Low-Income and Middle-Income Countries","volume":"378","author":"Balarajan","year":"2011","journal-title":"Lancet"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"e000026","DOI":"10.1136\/bmjgh-2015-000026","article-title":"Association between Maternal Anaemia and Pregnancy Outcomes: A Cohort Study in Assam, India","volume":"1","author":"Nair","year":"2016","journal-title":"BMJ Glob. Health"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1177\/003693306300800402","article-title":"Maternal Anaemia as a Factor in Prematurity and Perinatal Mortality","volume":"8","author":"Macgregor","year":"1963","journal-title":"Scott. Med. J."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/0002-9378(91)90626-3","article-title":"Anemia and Spontaneous Preterm Birth","volume":"164","author":"Klebanoff","year":"1991","journal-title":"Am. J. Obstet. Gynecol."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Owiredu, W.K.B.A., Osakunor, D.N.M., Turpin, C.A., and Owusu-Afriyie, O. (2016). Laboratory Prediction of Primary Postpartum Haemorrhage: A Comparative Cohort Study. BMC Pregnancy Childbirth, 16.","DOI":"10.1186\/s12884-016-0805-3"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1111\/j.1447-0756.2008.00980.x","article-title":"Iron Deficiency Anemia, Cigarette Smoking and Risk of Abruptio Placentae","volume":"35","author":"Arnold","year":"2009","journal-title":"J. Obstet. Gynaecol. Res."},{"key":"ref_8","first-page":"Art. No.: CD003094","article-title":"Treatments for Iron-Deficiency Anaemia in Pregnancy","volume":"10","author":"Reveiz","year":"2011","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1016\/j.jpeds.2011.12.011","article-title":"Iron Deficiency in Infancy Is Associated With Altered Neural Correlates of Recognition Memory at 10 Years","volume":"160","author":"Congdon","year":"2012","journal-title":"J. Pediatr."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1111\/tme.12408","article-title":"Serum Ferritin Thresholds for the Diagnosis of Iron Deficiency in Pregnancy: A Systematic Review","volume":"27","author":"Daru","year":"2017","journal-title":"Transfus. Med."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1111\/bjh.16221","article-title":"UK Guidelines on the Management of Iron Deficiency in Pregnancy","volume":"188","author":"Pavord","year":"2020","journal-title":"Br. J. Haematol."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"FIGO Working Group on Good Clinical Practice in Maternal-Fetal Medicine (2019). Good Clinical Practice Advice: Iron Deficiency Anemia In Pregnancy. Int. J. Gynaecol. Obstet., 144, 322\u2013324.","DOI":"10.1002\/ijgo.12740"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1002\/ajh.24201","article-title":"How We Diagnose and Treat Iron Deficiency Anemia","volume":"91","author":"Auerbach","year":"2016","journal-title":"Am. J. Hematol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1111\/j.1471-0528.2008.01709.x","article-title":"Reference Values for Clinical Chemistry Tests During Normal Pregnancy","volume":"115","author":"Larsson","year":"2008","journal-title":"BJOG"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1007\/s00277-008-0518-4","article-title":"Prepartum Anaemia: Prevention and Treatment","volume":"87","author":"Milman","year":"2008","journal-title":"Ann. Hematol."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Zhang, A.S., and Enns, C.A. (2009). Molecular Mechanisms of Normal Iron Homeostasis. Hematol. Am. Soc. Hematol. Educ. Program., 207\u2013214.","DOI":"10.1182\/asheducation-2009.1.207"},{"key":"ref_17","first-page":"232","article-title":"Association Between Anaemia During Pregnancy and Blood Loss at and After Delivery Among Women With Vaginal Births in Pemba Island, Zanzibar, Tanzania","volume":"26","author":"Kavle","year":"2008","journal-title":"J. Health Popul. Nutr."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1111\/j.1471-0528.1983.tb08891.x","article-title":"Iron Requirement in Normal Pregnancy as Assessed by Serum Ferritin, Serum Transferrin Saturation and Erythrocyte Protoporphyrin Determinations","volume":"90","author":"Romslo","year":"1983","journal-title":"Br. J. Obstet. Gynaecol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/S0925-5710(97)00031-5","article-title":"Serum Erythropoietin During Normal Pregnancy: Relationship to Hemoglobin and Iron Status Markers and Impact of Iron Supplementation in a Longitudinal, Placebo-Controlled Study on 118 Women","volume":"66","author":"Milman","year":"1997","journal-title":"Int. J. Hematol."}],"container-title":["Nutrients"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6643\/14\/4\/839\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T22:21:25Z","timestamp":1760134885000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6643\/14\/4\/839"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2,17]]},"references-count":19,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2022,2]]}},"alternative-id":["nu14040839"],"URL":"https:\/\/doi.org\/10.3390\/nu14040839","relation":{},"ISSN":["2072-6643"],"issn-type":[{"value":"2072-6643","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,2,17]]}}}