{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T21:22:59Z","timestamp":1790716979738,"version":"4.1.0"},"reference-count":249,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2022,2,18]],"date-time":"2022-02-18T00:00:00Z","timestamp":1645142400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["CM20\/00028"],"award-info":[{"award-number":["CM20\/00028"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI18\/00654"],"award-info":[{"award-number":["PI18\/00654"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Spanish Society of Medical Oncology","award":["2021 D. Jes\u00fas Angel S\u00e1nchez Castillo for Research Projects"],"award-info":[{"award-number":["2021 D. Jes\u00fas Angel S\u00e1nchez Castillo for Research Projects"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Prostate cancer (PCa) is the most commonly diagnosed malignant neoplasm in men in the Western world. Localized low-risk PCa has an excellent prognosis thanks to effective local treatments; however, despite the incorporation of new therapeutic strategies, metastatic PCa remains incurable mainly due to disease heterogeneity and the development of resistance to therapy. The mechanisms underlying PCa progression and therapy resistance are multiple and include metabolic reprogramming, especially in relation to lipid metabolism, as well as epigenetic remodelling, both of which enable cancer cells to adapt to dynamic changes in the tumour. Interestingly, metabolism and epigenetics are interconnected. Metabolism can regulate epigenetics through the direct influence of metabolites on epigenetic processes, while epigenetics can control metabolism by directly or indirectly regulating the expression of metabolic genes. Moreover, epidemiological studies suggest an association between a high-fat diet, which can alter the availability of metabolites, and PCa progression. Here, we review the alterations of lipid metabolism and epigenetics in PCa, before focusing on the mechanisms that connect them. We also discuss the influence of diet in this scenario. This information may help to identify prognostic and predictive biomarkers as well as targetable vulnerabilities.<\/jats:p>","DOI":"10.3390\/nu14040851","type":"journal-article","created":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T08:22:19Z","timestamp":1645431739000},"page":"851","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":53,"title":["Lipid Metabolism and Epigenetics Crosstalk in Prostate Cancer"],"prefix":"10.3390","volume":"14","author":[{"given":"Juan C.","family":"Pardo","sequence":"first","affiliation":[{"name":"Department of Medical Oncology, Catalan Institute of Oncology, University Hospital Germans Trias i Pujol, Ctra. Can Ruti-Cam\u00ed de les Escoles s\/n, 08916 Badalona, Spain"},{"name":"Catalan Institute of Oncology, Badalona Applied Research Group in Oncology (B\u00b7ARGO), Ctra. Can Ruti-Cam\u00ed de les Escoles s\/n, 08916 Badalona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4352-1784","authenticated-orcid":false,"given":"Vicen\u00e7","family":"Ruiz de Porras","sequence":"additional","affiliation":[{"name":"Catalan Institute of Oncology, Badalona Applied Research Group in Oncology (B\u00b7ARGO), Ctra. Can Ruti-Cam\u00ed de les Escoles s\/n, 08916 Badalona, Spain"},{"name":"Germans Trias i Pujol Research Institute (IGTP), Ctra. Can Ruti-Cam\u00ed de les Escoles s\/n, 08916 Badalona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1030-9119","authenticated-orcid":false,"given":"Joan","family":"Gil","sequence":"additional","affiliation":[{"name":"Germans Trias i Pujol Research Institute (IGTP), Ctra. Can Ruti-Cam\u00ed de les Escoles s\/n, 08916 Badalona, Spain"},{"name":"Department of Endocrinology and Medicine, CIBERER U747, ISCIII, Research Center for Pituitary Diseases, Hospital Sant Pau, IIB-SPau, Universitat Aut\u00f2noma de Barcelona, 08041 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albert","family":"Font","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Catalan Institute of Oncology, University Hospital Germans Trias i Pujol, Ctra. Can Ruti-Cam\u00ed de les Escoles s\/n, 08916 Badalona, Spain"},{"name":"Catalan Institute of Oncology, Badalona Applied Research Group in Oncology (B\u00b7ARGO), Ctra. Can Ruti-Cam\u00ed de les Escoles s\/n, 08916 Badalona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manel","family":"Puig-Domingo","sequence":"additional","affiliation":[{"name":"Germans Trias i Pujol Research Institute (IGTP), Ctra. Can Ruti-Cam\u00ed de les Escoles s\/n, 08916 Badalona, Spain"},{"name":"Department of Endocrinology and Nutrition, University Germans Trias i Pujol Hospital, Ctra. Can Ruti-Cam\u00ed de les Escoles s\/n, 08916 Badalona, Spain"},{"name":"Department of Medicine, Autonomous University of Barcelona (UAB), Ctra. Can Ruti-Cam\u00ed de les Escoles s\/n, 08916 Badalona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mireia","family":"Jord\u00e0","sequence":"additional","affiliation":[{"name":"Germans Trias i Pujol Research Institute (IGTP), Ctra. Can Ruti-Cam\u00ed de les Escoles s\/n, 08916 Badalona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,2,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"7","DOI":"10.3322\/caac.21654","article-title":"Cancer Statistics, 2021","volume":"71","author":"Siegel","year":"2021","journal-title":"CA Cancer J. 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