{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T15:38:19Z","timestamp":1787240299584,"version":"build-2736575974"},"reference-count":83,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2022,2,28]],"date-time":"2022-02-28T00:00:00Z","timestamp":1646006400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004242","name":"Princess Nourah bint Abdulrahman University","doi-asserted-by":"publisher","award":["PNURSP2022R74"],"award-info":[{"award-number":["PNURSP2022R74"]}],"id":[{"id":"10.13039\/501100004242","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>This study investigated the ameliorative potential of methanolic date flesh extract (MDFE) against cisplatin-induced hepatic injury. Twenty male rats (weighing 180\u2013200 g) were allocated into four groups: control; date flesh (DF) group (oral 600 mg\/kg MDFE for 21 days); Cis group (7.5 mg\/kg i.p. at day 16); and date flesh\/cisplatin (DF\/Cis) group (oral 600 mg\/kg MDFE for 21 days and 7.5 mg\/kg i.p. at day 16). Hepatic biochemical parameters in sera, and inflammatory and oxidant\/antioxidant hepatic biomarkers were estimated. Hepatic histological changes and the immunohistochemistry of cyclooxygenase-2 (COX-2), nuclear factor kappa B (NF-\u03baB), and alpha smooth muscle actin (\u03b1-SMA) were assessed. Pretreatment with MDFE decreased Cis-triggered liver biochemical parameters, oxidative stress, inflammatory biomarkers, and histological damage. Moreover, MDFE treatment reduced Cis-induced hepatic NF-\u03baB, COX-2, and \u03b1-SMA protein expression. MDFE exerted a hepatoprotective effect when used concomitantly with Cis. Its effect was mediated via its antioxidant and anti-inflammatory ingredients.<\/jats:p>","DOI":"10.3390\/nu14051025","type":"journal-article","created":{"date-parts":[[2022,2,28]],"date-time":"2022-02-28T20:11:14Z","timestamp":1646079074000},"page":"1025","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Methanolic Phoenix dactylifera L. Extract Ameliorates Cisplatin-Induced Hepatic Injury in Male Rats"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1967-6866","authenticated-orcid":false,"given":"Heba Nageh","family":"Gad El-Hak","sequence":"first","affiliation":[{"name":"Zoology Department, Faculty of Sciences, Suez Canal University, Ismailia 41522, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hany Salah","family":"Mahmoud","sequence":"additional","affiliation":[{"name":"Center of Scientific Foundation for Experimental Studies and Research, Ismailia 41511, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0973-2630","authenticated-orcid":false,"given":"Eman A.","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Faculty of Veterinary Medicine, Suez Canal University, Ismailia 41522, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heba M.","family":"Elnegris","sequence":"additional","affiliation":[{"name":"Department of Histology and Cell Biology, Faculty of Medicine, Zagazig University, Zagazig 44519, Egypt"},{"name":"Department of Histology and Cell Biology, Faculty of Medicine, Badr University in Cairo, Cairo 11829, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0516-2175","authenticated-orcid":false,"given":"Tahany Saleh","family":"Aldayel","sequence":"additional","affiliation":[{"name":"Department of Physical Sport Sciences, College of Education, Princess Nourah Bint Abdulrahman University, Riyadh 11671, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heba M. A.","family":"Abdelrazek","sequence":"additional","affiliation":[{"name":"Department of Physiology, Faculty of Veterinary Medicine, Suez Canal University, Ismailia 41522, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7414-8313","authenticated-orcid":false,"given":"Mohamed T. A.","family":"Soliman","sequence":"additional","affiliation":[{"name":"Department of Medical Laboratory Sciences, College of Applied Medical Sciences, University of Bisha, Bisha 67614, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Menna Allah I.","family":"El-Menyawy","sequence":"additional","affiliation":[{"name":"Department of Physiology, Faculty of Medicine, Suez Canal University, Ismailia 41522, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,2,28]]},"reference":[{"key":"ref_1","first-page":"466","article-title":"Histopathological effects of cisplatin, doxorubicin and 5-flurouracil (5-FU) on the liver of male albino rats","volume":"5","author":"Ismail","year":"2009","journal-title":"Int. J. Biol. 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