{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T02:54:15Z","timestamp":1760151255054,"version":"build-2065373602"},"reference-count":44,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2022,2,28]],"date-time":"2022-02-28T00:00:00Z","timestamp":1646006400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI17\/00169"],"award-info":[{"award-number":["PI17\/00169"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Increased dietary acid load has a negative impact on health, particularly when renal function is compromised. Fibroblast growth factor 23 (FGF23) is a bone-derived hormone that is elevated during renal failure. The relationship between metabolic acidosis and FGF23 remains unclear. To investigate the effect of dietary acid load on circulating levels of FGF23, rats with normal renal function and with a graded reduction in renal mass (1\/2 Nx and 5\/6 Nx) received oral NH4Cl for 1 month. Acid intake resulted in a consistent decrease of plasma FGF23 concentrations in all study groups when compared with their non-acidotic control: 239.3 \u00b1 13.5 vs. 295.0 \u00b1 15.8 pg\/mL (intact), 346.4 \u00b1 19.7 vs. 522.6 \u00b1 29.3 pg\/mL (1\/2 Nx) and 988.0 \u00b1 125.5 vs. 2549.4 \u00b1 469.7 pg\/mL (5\/6 Nx). Acidosis also decreased plasma PTH in all groups, 96.5 \u00b1 22.3 vs. 107.3 \u00b1 19.1 pg\/mL, 113.1 \u00b1 17.3 vs. 185.8 \u00b1 22.2 pg\/mL and 504.9 \u00b1 75.7 vs. 1255.4 \u00b1 181.1 pg\/mL. FGF23 showed a strong positive correlation with PTH (r = 0.877, p &lt; 0.0001) and further studies demonstrated that acidosis did not influence plasma FGF23 concentrations in parathyroidectomized rats, 190.0 \u00b1 31.6 vs. 215 \u00b1 25.6 pg\/mL. In conclusion, plasma concentrations of FGF23 are consistently decreased in rats with metabolic acidosis secondary to increased acid intake, both in animals with intact renal function and with decreased renal function. The in vivo effect of metabolic acidosis on FGF23 appears to be related to the simultaneous decrease in PTH.<\/jats:p>","DOI":"10.3390\/nu14051041","type":"journal-article","created":{"date-parts":[[2022,2,28]],"date-time":"2022-02-28T20:11:14Z","timestamp":1646079074000},"page":"1041","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Oral Acid Load Down-Regulates Fibroblast Growth Factor 23"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1009-6902","authenticated-orcid":false,"given":"Angela","family":"Vidal","sequence":"first","affiliation":[{"name":"Department of Animal Medicine and Surgery, University of Cordoba, Campus Universitario Rabanales, 14014 Cordoba, Spain"},{"name":"Maimonides Biomedical Research Institute of Cordoba (IMIBIC), Reina Sofia University Hospital, University of Cordoba, 14004 Cordoba, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3664-8699","authenticated-orcid":false,"given":"Carmen","family":"Pineda","sequence":"additional","affiliation":[{"name":"Department of Animal Medicine and Surgery, University of Cordoba, Campus Universitario Rabanales, 14014 Cordoba, Spain"},{"name":"Maimonides Biomedical Research Institute of Cordoba (IMIBIC), Reina Sofia University Hospital, University of Cordoba, 14004 Cordoba, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana I.","family":"Raya","sequence":"additional","affiliation":[{"name":"Department of Animal Medicine and Surgery, University of Cordoba, Campus Universitario Rabanales, 14014 Cordoba, Spain"},{"name":"Maimonides Biomedical Research Institute of Cordoba (IMIBIC), Reina Sofia University Hospital, University of Cordoba, 14004 Cordoba, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rafael","family":"Rios","sequence":"additional","affiliation":[{"name":"Department of Animal Medicine and Surgery, University of Cordoba, Campus Universitario Rabanales, 14014 Cordoba, Spain"},{"name":"Maimonides Biomedical Research Institute of Cordoba (IMIBIC), Reina Sofia University Hospital, University of Cordoba, 14004 Cordoba, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Azahara","family":"Espartero","sequence":"additional","affiliation":[{"name":"Department of Animal Medicine and Surgery, University of Cordoba, Campus Universitario Rabanales, 14014 Cordoba, Spain"},{"name":"Maimonides Biomedical Research Institute of Cordoba (IMIBIC), Reina Sofia University Hospital, University of Cordoba, 14004 Cordoba, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9341-0724","authenticated-orcid":false,"given":"Juan R.","family":"Mu\u00f1oz-Casta\u00f1eda","sequence":"additional","affiliation":[{"name":"Maimonides Biomedical Research Institute of Cordoba (IMIBIC), Reina Sofia University Hospital, University of Cordoba, 14004 Cordoba, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariano","family":"Rodriguez","sequence":"additional","affiliation":[{"name":"Maimonides Biomedical Research Institute of Cordoba (IMIBIC), Reina Sofia University Hospital, University of Cordoba, 14004 Cordoba, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Escolastico","family":"Aguilera-Tejero","sequence":"additional","affiliation":[{"name":"Department of Animal Medicine and Surgery, University of Cordoba, Campus Universitario Rabanales, 14014 Cordoba, Spain"},{"name":"Maimonides Biomedical Research Institute of Cordoba (IMIBIC), Reina Sofia University Hospital, University of Cordoba, 14004 Cordoba, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ignacio","family":"Lopez","sequence":"additional","affiliation":[{"name":"Department of Animal Medicine and Surgery, University of Cordoba, Campus Universitario Rabanales, 14014 Cordoba, Spain"},{"name":"Maimonides Biomedical Research Institute of Cordoba (IMIBIC), Reina Sofia University Hospital, University of Cordoba, 14004 Cordoba, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,2,28]]},"reference":[{"key":"ref_1","first-page":"343","article-title":"Dietary Acid Load: Mechanisms and evidence of its health repercussions","volume":"39","year":"2019","journal-title":"Nefrologia"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1053\/j.ajkd.2005.03.003","article-title":"Metabolic Acidosis of CKD: Diagnosis, Clinical Characteristics, and Treatment","volume":"45","author":"Kraut","year":"2005","journal-title":"Am. 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