{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T03:25:34Z","timestamp":1788924334483,"version":"build-2803163510"},"reference-count":65,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2022,2,28]],"date-time":"2022-02-28T00:00:00Z","timestamp":1646006400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Ministerio de Economi\u0301a, Industria y Competitividad, the Agencia Estatal de Investigaci\u00f3n (AEI), and the European Regional Development Fund (ERDF)","award":["Grant Nos. MEFOPC Project, AGL2012-40144-C03-02, and AppleCOR Project, AGL2016-76943-C2-2-R"],"award-info":[{"award-number":["Grant Nos. MEFOPC Project, AGL2012-40144-C03-02, and AppleCOR Project, AGL2016-76943-C2-2-R"]}]},{"name":"Sara Borrell post-doctoral grant","award":["CD14\/00275; Spain"],"award-info":[{"award-number":["CD14\/00275; Spain"]}]},{"name":"Torres quevedo post-doctorall grant","award":["PTQ-15-08068; Spain"],"award-info":[{"award-number":["PTQ-15-08068; Spain"]}]},{"name":"Pla estrat\u00e8gic de recerca i innovaci\u00f3 en salut (PERIS) post-doctoral grant","award":["SLT002\/16\/00239; Catalunya, Spain"],"award-info":[{"award-number":["SLT002\/16\/00239; Catalunya, Spain"]}]},{"name":"to Consejo Superior de Investigaciones Cient\u00edficas-CSIC","award":["Reference 201870I129"],"award-info":[{"award-number":["Reference 201870I129"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>The impact of a red-fleshed apple (RFA) rich in anthocyanins (ACNs), a white-fleshed apple (WFA) without ACNs, and an extract infusion from Aronia fruit (AI) equivalent in dose of cyanidin-3-O-galactoside (main ACN) as RFA was determined by the proteome profile of aorta and heart as key cardiovascular tissues. Hypercholesterolaemic Wistar rats were separated into six groups (n = 6\/group; three males and three females) and the proteomic profiles were analyzed using nanoliquid chromatography coupled to mass spectrometry. No adverse events were reported and all products were well tolerated. RFA downregulated C1QB and CFP in aorta and CRP in heart. WFA downregulated C1QB and CFP in aorta and C9 and C3 in aorta and heart, among other proteins. AI downregulated PRKACA, IQGAP1, and HSP90AB1 related to cellular signaling. Thus, both apples showed an anti-inflammatory effect through the complement system, while RFA reduced CRP. Regardless of the ACN content, an apple matrix effect was observed that involved different bioactive components, and inflammatory proteins were reduced.<\/jats:p>","DOI":"10.3390\/nu14051047","type":"journal-article","created":{"date-parts":[[2022,2,28]],"date-time":"2022-02-28T20:11:14Z","timestamp":1646079074000},"page":"1047","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Red-Fleshed Apples Rich in Anthocyanins and White-Fleshed Apples Modulate the Aorta and Heart Proteome in Hypercholesterolaemic Rats: The AppleCOR Study"],"prefix":"10.3390","volume":"14","author":[{"given":"\u00darsula","family":"Catal\u00e1n","sequence":"first","affiliation":[{"name":"Functional Nutrition, Oxidation, and CVD Research Group (NFOC-Salut), Medicine and Surgery Department, Faculty of Medicine and Health Sciences, Universitat Rovira i Virgili, 43201 Reus, Spain"},{"name":"Institut d\u2019Investigaci\u00f3 Sanit\u00e0ria Pere Virgili (IISPV), 43204 Reus, Spain"},{"name":"Unitat de Nutrici\u00f3 i Salut, Eurecat, Centre Tecnol\u00f2gic de Catalunya, 43204 Reus, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5327-932X","authenticated-orcid":false,"given":"Anna","family":"Pedret","sequence":"additional","affiliation":[{"name":"Functional Nutrition, Oxidation, and CVD Research Group (NFOC-Salut), Medicine and Surgery Department, Faculty of Medicine and Health Sciences, Universitat Rovira i Virgili, 43201 Reus, Spain"},{"name":"Unitat de Nutrici\u00f3 i Salut, Eurecat, Centre Tecnol\u00f2gic de Catalunya, 43204 Reus, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0775-2179","authenticated-orcid":false,"given":"Silvia","family":"Yuste","sequence":"additional","affiliation":[{"name":"Food Technology Department, Universitat de Lleida-AGROTECNIO Center, 25198 Lleida, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Rubi\u00f3","sequence":"additional","affiliation":[{"name":"Food Technology Department, Universitat de Lleida-AGROTECNIO Center, 25198 Lleida, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0626-1298","authenticated-orcid":false,"given":"Carme","family":"Pi\u00f1ol","sequence":"additional","affiliation":[{"name":"Department of Medicine, Universitat de Lleida, 25008 Lleida, Spain"},{"name":"Institut de Recerca Biom\u00e8dica de Lleida, Fundaci\u00f3 Dr. Pifarr\u00e9-IRBLleida, 25198 Lleida, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Berner Andr\u00e9e","family":"Sandoval-Ram\u00edrez","sequence":"additional","affiliation":[{"name":"Functional Nutrition, Oxidation, and CVD Research Group (NFOC-Salut), Medicine and Surgery Department, Faculty of Medicine and Health Sciences, Universitat Rovira i Virgili, 43201 Reus, 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Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0261-2396","authenticated-orcid":false,"given":"N\u00faria","family":"Canela","sequence":"additional","affiliation":[{"name":"Eurecat, Centre Tecnol\u00f2gic de Catalunya, Centre for Omic Sciences (COS), Joint Unit Universitat Rovira i Virgili-EURECAT, 43204 Reus, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8985-7737","authenticated-orcid":false,"given":"Maria-Jose","family":"Motilva","sequence":"additional","affiliation":[{"name":"Instituto de Ciencias de la Vid y del Vino (ICVV), Gobierno de La Rioja, CSIC, Universidad de La Rioja, 26007 Logro\u00f1o, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosa","family":"Sol\u00e0","sequence":"additional","affiliation":[{"name":"Functional Nutrition, Oxidation, and CVD Research Group (NFOC-Salut), Medicine and Surgery Department, Faculty of Medicine and Health 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