{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T01:44:48Z","timestamp":1792806288006,"version":"4.5.0"},"reference-count":50,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2022,3,5]],"date-time":"2022-03-05T00:00:00Z","timestamp":1646438400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Tai\u2019an Science and Technology Innovation Development Project","award":["2020NS191"],"award-info":[{"award-number":["2020NS191"]}]},{"name":"Young Taishan Scholars Program of Shandong Province of China","award":["tsqn20161046"],"award-info":[{"award-number":["tsqn20161046"]}]},{"name":"Academic Promotion Programme of Shandong First Medical University","award":["2019RC010"],"award-info":[{"award-number":["2019RC010"]}],"id":[{"id":"https:\/\/ror.org\/05jb9pq57","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Shandong Province Higher Educational Young and Innovation Technology Supporting Program","award":["2019KJL004"],"award-info":[{"award-number":["2019KJL004"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Previous observational studies have highlighted associations between adipokines and hyperuricemia, as well as gout, but the causality and direction of these associations are not clear. Therefore, we attempted to assess whether there are causal effects of specific adipokines (such as adiponectin (ADP) and soluble leptin receptors (sOB-R)) on uric acid (UA) or gout in a two-sample Mendelian randomization (MR) analysis, based on summary statistics from large genome-wide association studies. The inverse-variance weighted (IVW) method was performed as the primary analysis. Sensitivity analyses (including MR-Egger regression, weighted median, penalized weighted median, and MR pleiotropy residual sum and outlier methods) were also performed, to ensure reliable results. In the IVW models, no causal effect was found for sOB-R (odds ratios (OR), 1.002; 95% confidence intervals (CI), 0.999\u20131.004; p = 0.274) on UA, or ADP (OR, 1.198; 95% CI, 0.865\u20131.659; p = 0.277) or sOB-R (OR, 0.988; 95% CI, 0.940\u20131.037; p = 0.616) on gout. The results were confirmed in sensitivity analyses. There was no notable directional pleiotropy or heterogeneity. This study suggests that these specific adipokines may not play causal roles in UA or gout development.<\/jats:p>","DOI":"10.3390\/nu14051091","type":"journal-article","created":{"date-parts":[[2022,3,6]],"date-time":"2022-03-06T20:40:02Z","timestamp":1646599202000},"page":"1091","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Assessing the Causal Effects of Adipokines on Uric Acid and Gout: A Two-Sample Mendelian Randomization Study"],"prefix":"10.3390","volume":"14","author":[{"given":"Ruyi","family":"Cong","sequence":"first","affiliation":[{"name":"School of Public Health, Shandong First Medical University & Shandong Academy of Medical Sciences, Tai\u2019an 271000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Sanbo Brain Hospital, Capital Medical University, Beijing 100093, China"},{"name":"Beijing Key Laboratory of Clinical Epidemiology, School of Public Health, Capital Medical University, Beijing 100069, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zihong","family":"Song","sequence":"additional","affiliation":[{"name":"School of Public Health, Shandong First Medical University & Shandong Academy of Medical Sciences, Tai\u2019an 271000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shanshan","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Public Health, Shandong First Medical University & Shandong Academy of Medical Sciences, Tai\u2019an 271000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guanhua","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Public Health, Shandong First Medical University & Shandong Academy of Medical Sciences, Tai\u2019an 271000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yizhi","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Public Health, Shandong First Medical University & Shandong Academy of Medical Sciences, Tai\u2019an 271000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiuyu","family":"Pang","sequence":"additional","affiliation":[{"name":"School of Public Health, Shandong First Medical University & Shandong Academy of Medical Sciences, Tai\u2019an 271000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Dong","sequence":"additional","affiliation":[{"name":"School of Public Health, Shandong First Medical University & Shandong Academy of Medical Sciences, Tai\u2019an 271000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weijia","family":"Xing","sequence":"additional","affiliation":[{"name":"School of Public Health, Shandong First Medical University & Shandong Academy of Medical Sciences, Tai\u2019an 271000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6574-6706","authenticated-orcid":false,"given":"Youxin","family":"Wang","sequence":"additional","affiliation":[{"name":"Beijing Key Laboratory of Clinical Epidemiology, School of Public Health, Capital Medical University, Beijing 100069, China"},{"name":"School of Medical and Health Sciences, Edith Cowan University, Perth 6027, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xizhu","family":"Xu","sequence":"additional","affiliation":[{"name":"School of Public Health, Shandong First Medical University & Shandong Academy of Medical Sciences, Tai\u2019an 271000, China"},{"name":"The Second Affiliated Hospital of Shandong First Medical University, Tai\u2019an 271000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,3,5]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1038\/nrrheum.2012.143","article-title":"Uric acid as a danger signal in gout and its comorbidities","volume":"9","author":"Rock","year":"2013","journal-title":"Nat. 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