{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T01:25:01Z","timestamp":1790126701912,"version":"4.0.1"},"reference-count":43,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2022,3,5]],"date-time":"2022-03-05T00:00:00Z","timestamp":1646438400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003141","name":"Consejo Nacional de Ciencia y Tecnolog\u00eda","doi-asserted-by":"publisher","award":["261575"],"award-info":[{"award-number":["261575"]}],"id":[{"id":"10.13039\/501100003141","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Background: A diet containing non-caloric sweeteners (NCS) could reduce calorie intake; conversely, some animal studies suggest that NCS consumption may increase functional gastrointestinal disorder symptoms (FGDs). This study aimed to compare the effect of consuming a diet containing NCS (c-NCS) versus a non-caloric sweetener-free diet (NCS-f) on FGDs. Methods: We conducted a randomized, controlled, parallel-group study using two different diets for five weeks: the c-NCS diet contained 50\u2013100 mg\/day NCS, whereas the NCS-f diet had less than 10 mg\/day NCS. At the beginning of the study (PreTx) and at the end (PostTx), we assessed FGDs, dietary intake, and NCS consumption. Results: The percentage of participants with diarrhea (PreTx = 19% vs. PstTx = 56%; p = 0.02), post-prandial discomfort (PreTx = 9% vs. PstTx = 39%; p = 0.02), constipation (PreTx = 30% vs. PostTx = 56%; p &lt; 0.01), and burning (PreTx = 13% vs. PostTx = 33%; p &lt; 0.01) increased in the c-NCS diet group. Conversely, abdominal pain (PreTx = 15% vs. PostTx = 3%; p = 0.04), post-prandial discomfort (PreTx = 26% vs. PostTx = 6%; p = 0.02), burning (PreTx = 15% vs. PostTx = 0%; p = 0.02), early satiety (PreTx = 18% vs. PostTx = 3%; p &lt; 0.01), and epigastric pain (PreTx = 38% vs. PostTx = 3%; p &lt; 0.01) decreased in the NCS-f diet group. Conclusion: A c-NCS diet is associated with increased FGDs, including diarrhea, post-prandial discomfort, constipation, and burning or retrosternal pain. The NCS-f diet also decreased FGDs, as well as abdominal pain, post-prandial discomfort, burning or retrosternal pain, early satiety, and epigastric pain.<\/jats:p>","DOI":"10.3390\/nu14051095","type":"journal-article","created":{"date-parts":[[2022,3,6]],"date-time":"2022-03-06T20:40:02Z","timestamp":1646599202000},"page":"1095","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Is a Non-Caloric Sweetener-Free Diet Good to Treat Functional Gastrointestinal Disorder Symptoms? A Randomized Controlled Trial"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3621-7557","authenticated-orcid":false,"given":"Viridiana Montsserrat","family":"Mendoza-Mart\u00ednez","sequence":"first","affiliation":[{"name":"Proteomics and Metabolomics Laboratory, Research Division, General Hospital of Mexico \u201cDr. Eduardo Liceaga\u201d, Mexico City 06720, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00f3nica Roc\u00edo","family":"Zavala-Solares","sequence":"additional","affiliation":[{"name":"School of High Studies in Health, La Salle University, Mexico City 14010, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4881-6426","authenticated-orcid":false,"given":"Aranza Jhosadara","family":"Espinosa-Flores","sequence":"additional","affiliation":[{"name":"Proteomics and Metabolomics Laboratory, Research Division, General Hospital of Mexico \u201cDr. Eduardo Liceaga\u201d, Mexico City 06720, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen Lorena","family":"Le\u00f3n-Barrera","sequence":"additional","affiliation":[{"name":"Proteomics and Metabolomics Laboratory, Research Division, General Hospital of Mexico \u201cDr. Eduardo Liceaga\u201d, Mexico City 06720, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ra\u00fal","family":"Alc\u00e1ntara-Su\u00e1rez","sequence":"additional","affiliation":[{"name":"Laboratory of Immunometabolism, Research Division, General Hospital of Mexico \u201cDr. Eduardo Liceaga\u201d, Mexico City 06720, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Dami\u00e1n","family":"Carrillo-Ru\u00edz","sequence":"additional","affiliation":[{"name":"Neurology and Neurosurgery Unit, General Hospital of Mexico \u201cDr. Eduardo Liceaga\u201d, Mexico City 06720, Mexico"},{"name":"Faculty of Health Sciences, Mexico Anahuac University, Huixquilucan 52786, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9224-7400","authenticated-orcid":false,"given":"Galileo","family":"Escobedo","sequence":"additional","affiliation":[{"name":"Laboratory of Immunometabolism, Research Division, General Hospital of Mexico \u201cDr. Eduardo Liceaga\u201d, Mexico City 06720, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7116-5289","authenticated-orcid":false,"given":"Ernesto","family":"Roldan-Valadez","sequence":"additional","affiliation":[{"name":"Research Division, General Hospital of Mexico \u201cDr. Eduardo Liceaga\u201d, Mexico City 06720, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2975-8603","authenticated-orcid":false,"given":"Marcela","family":"Esquivel-Vel\u00e1zquez","sequence":"additional","affiliation":[{"name":"Proteomics and Metabolomics Laboratory, Research Division, General Hospital of Mexico \u201cDr. Eduardo Liceaga\u201d, Mexico City 06720, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2992-6395","authenticated-orcid":false,"given":"Guillermo","family":"Mel\u00e9ndez-Mier","sequence":"additional","affiliation":[{"name":"School of Public Health and Nutrition (FASPyN), Autonomous University of Nuevo Leon, Nuevo Leon 64460, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3961-0987","authenticated-orcid":false,"given":"Nallely","family":"Bueno-Hern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Proteomics and Metabolomics Laboratory, Research Division, General Hospital of Mexico \u201cDr. Eduardo Liceaga\u201d, Mexico City 06720, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,3,5]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1017\/S0029665117004049","article-title":"The role of low-calorie sweeteners in the prevention and management of overweight and obesity: Evidence v. conjecture","volume":"77","author":"Rogers","year":"2018","journal-title":"Proc. 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