{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T18:36:29Z","timestamp":1789497389850,"version":"build-2803163510"},"reference-count":60,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2022,3,8]],"date-time":"2022-03-08T00:00:00Z","timestamp":1646697600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Changsha Science and Technology Bureau Project","award":["kq1706109"],"award-info":[{"award-number":["kq1706109"]}]},{"name":"The Key R&amp;D Program of Hunan Province","award":["2020WK2017"],"award-info":[{"award-number":["2020WK2017"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Background: It is well known that obesity induced by high-fat diet (HFD) poses a serious threat to people\u2019s health. Fuzhuan brick tea, one of the most popular beverages, is reported to possess a significant effect on regulating lipid metabolism, attributed to its many bioactive ingredients. However, the efficacy and mechanism of compound Fuzhuan brick tea (CFBT) made from Fuzhuan brick tea and other six Chinese herbal medicines are still not well defined. Methods: Sixty mice were divided into six groups: normal control group (CK), high-fat model group (NK), positive control group with anti-hyperlipidemic drug (YK), CFBT at low-(FL), medium-(FM) and high-(FH) dosage. Intervening for 30 days, conventional indexes analysis combined with metabolomics were performed to evaluate the changes in biochemical indexes and liver metabolic profiles in mice submitted to HFD. Results: CFBT treatment was able to ameliorate obesity, serum biochemical parameters, antioxidant activity and hepatic steatosis. In addition, significant alterations in the liver tissue metabolic profiles were observed, with most of these associated with inflammation, glucose and lipid metabolism. Conclusions: This study provides evidence that consumption of CFBT is capable of preventing dyslipidemia, reducing weight gain, restoring liver injury, as well as improving metabolic disorders.<\/jats:p>","DOI":"10.3390\/nu14061128","type":"journal-article","created":{"date-parts":[[2022,3,9]],"date-time":"2022-03-09T01:53:54Z","timestamp":1646790834000},"page":"1128","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Metabolomics Analysis Reveals the Effects of Compound Fuzhuan Brick Tea (CFBT) on Regulating Dyslipidemia and Metabolic Disorders in Mice Induced by High-Fat Diet"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6593-8548","authenticated-orcid":false,"given":"Xiaolu","family":"Zhou","sequence":"first","affiliation":[{"name":"Key Laboratory of Tea Science of Ministry of Education, Hunan Agricultural University, Changsha 410128, China"},{"name":"College of Biological Science and Agriculture, Qiannan Normal University for Nationalities, Duyun 558000, China"},{"name":"School of Crop Production Technology, Institute of Agriculture Technology, Suranaree University of Technology, Nakhorn Ratchasima 30000, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Binggang","family":"Ge","sequence":"additional","affiliation":[{"name":"Key Laboratory of Tea Science of Ministry of Education, Hunan Agricultural University, Changsha 410128, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuwen","family":"Zhang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Tea Science of Ministry of Education, Hunan Agricultural University, Changsha 410128, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kunbo","family":"Wang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Tea Science of Ministry of Education, Hunan Agricultural University, Changsha 410128, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caibi","family":"Zhou","sequence":"additional","affiliation":[{"name":"College of Biological Science and Agriculture, Qiannan Normal University for Nationalities, Duyun 558000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donghe","family":"Fu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Tea Science of Ministry of Education, Hunan Agricultural University, Changsha 410128, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,3,8]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1016\/S0140-6736(14)60460-8","article-title":"Global, regional, and national prevalence of overweight and obesity in children and adults during 1980\u20132013: A systematic analysis for the Global Burden of Disease Study 2013","volume":"384","author":"Marie","year":"2014","journal-title":"Lancet"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1626","DOI":"10.1002\/oby.22869","article-title":"Obesity May Connect Insulin Resistance to Decreased Neuronal Viability in Human Diabetic Brain","volume":"28","author":"Lee","year":"2020","journal-title":"Obesity"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1056\/NEJMoa1614362","article-title":"Health Effects of Overweight and Obesity in 195 Countries over 25 Years","volume":"377","author":"Afshin","year":"2017","journal-title":"N. Engl. J. Med."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1016\/S0140-6736(11)60813-1","article-title":"The global obesity pandemic: Shaped by global drivers and local environments","volume":"378","author":"Swinburn","year":"2011","journal-title":"Lancet"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1111\/j.1753-4887.2011.00456.x","article-title":"Global nutrition transition and the pandemic of obesity in developing countries","volume":"70","author":"Popkin","year":"2012","journal-title":"Nutr. Rev."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1007\/s12325-019-0879-1","article-title":"Clinical Management of High and Very High Risk Patients with Hyperlipidaemia in Central and Eastern Europe: An Observational Study","volume":"36","author":"Ivo","year":"2019","journal-title":"Adv. Ther."},{"key":"ref_7","first-page":"29","article-title":"Influence of medicinal plant extracts on the functions and antioxidant protection of erythrocytes in rats with experimental diabetes mellitus","volume":"79","author":"Vengerovskii","year":"2016","journal-title":"Eksp. Klin. Farmakol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"113101","DOI":"10.1016\/j.jep.2020.113101","article-title":"A review on traditionally used South African medicinal plants, their secondary metabolites and their potential development into anticancer agents","volume":"261","author":"Danielle","year":"2020","journal-title":"J. Ethnopharmacol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"112225","DOI":"10.1016\/j.jep.2019.112225","article-title":"Improvement on metabolic syndrome in high fat diet-induced obese mice through modulation of gut microbiota by sangguayin decoction","volume":"246","author":"Zheng","year":"2020","journal-title":"J. Ethnopharmacol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"5318","DOI":"10.1021\/acs.jafc.8b05037","article-title":"Plant Resources, Chemical Constituents, and Bioactivities of Tea Plants from the Genus Camellia Section Thea","volume":"67","author":"Meng","year":"2019","journal-title":"J. Agric. Food Chem."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"5423","DOI":"10.1021\/acs.jafc.8b05140","article-title":"Impact of Six Typical Processing Methods on the Chemical Composition of Tea Leaves Using a Single Camellia sinensis Cultivar, Longjing 43","volume":"67","author":"Wang","year":"2019","journal-title":"J. Agric. Food Chem."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1002\/mnfr.201400470","article-title":"Green tea changes serum and liver metabolomic profiles in mice with high-fat diet-induced obesity","volume":"59","author":"Lee","year":"2015","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1021\/jf049375k","article-title":"Comparative studies on the hypolipidemic and growth suppressive effects of oolong, black, pu-erh, and green tea leaves in rats","volume":"53","author":"Kuo","year":"2005","journal-title":"J. Agric. Food Chem."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1159\/000214834","article-title":"Green Tea (\u2013)-Epigallocatechin-3-Gallate Reduces Body Weight with Regulation of Multiple Genes Expression in Adipose Tissue of Diet-Induced Obese Mice","volume":"54","author":"Lee","year":"2009","journal-title":"Ann. Nutr. Metab."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1078\/0944-7113-00078","article-title":"Recent findings of green tea extract AR25 (Exolise) and its activity for the treatment of obesity","volume":"9","author":"Chantre","year":"2002","journal-title":"Phytomedicine"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1079\/BJN20041061","article-title":"Effects of green tea on weight maintenance after body-weight loss","volume":"91","author":"Eva","year":"2004","journal-title":"Br. J. Nutr."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1038\/oby.2005.142","article-title":"Body weight loss and weight maintenance in relation to habitual caffeine intake and green tea supplementation","volume":"13","author":"Margriet","year":"2005","journal-title":"Obes. Res."},{"key":"ref_18","first-page":"33","article-title":"Tea decoctions prevent body weight gain in rats fed high-fat diet; black tea being more efficient than green tea","volume":"6","author":"Mohamed","year":"2016","journal-title":"J. Nutr. Int. Metab."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"103621","DOI":"10.1016\/j.jff.2019.103621","article-title":"Preventive consumption of green tea modifies the gut microbiota and provides persistent protection from high-fat diet-induced obesity","volume":"64","author":"Zhu","year":"2020","journal-title":"J. Funct. Foods"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1","DOI":"10.29219\/fnr.v64.1681","article-title":"Antiobesity and anti-inflammation effects of Hakka stir-fried tea of different storage years on high-fat diet-induced obese mice model via activating the AMPK\/ACC\/CPT1 pathway","volume":"64","author":"Li","year":"2020","journal-title":"Food Nutr. Res."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1142\/S0192415X18500325","article-title":"Epigallocatechin-3-Gallate-Rich Green Tea Extract Ameliorates Fatty Liver and Weight Gain in Mice Fed a High Fat Diet by Activating the Sirtuin 1 and AMP Activating Protein Kinase Pathway","volume":"46","author":"Bae","year":"2018","journal-title":"Am. J. Chin. Med."},{"key":"ref_22","first-page":"287","article-title":"Prevention of diet-induced obesity by dietary black tea polyphenols extract in vitro and in vivo","volume":"27","author":"Satoshi","year":"2010","journal-title":"Nutrition"},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Tong, T.T., Ren, N., Soomi, P., Wu, J.F., Guo, N., Kang, H., Kim, E., Wu, Y.Y., He, P.M., and Tu, Y.Y. (2018). Theaflavins Improve Insulin Sensitivity through Regulating Mitochondrial Biosynthesis in Palmitic Acid-Induced HepG2 Cells. Molecules, 23.","DOI":"10.20944\/preprints201811.0321.v1"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1007\/s10787-008-8022-y","article-title":"Tea polyphenols benefit vascular function","volume":"16","author":"Yung","year":"2008","journal-title":"Inflammopharmacology"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.fshw.2018.05.001","article-title":"The effects of the extract of oolong tea and its metabolites from Andraca theae in high fat diet induced obese Wistar rat","volume":"7","author":"Tung","year":"2018","journal-title":"Food Sci. Hum. Welln."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1002\/mnfr.200500138","article-title":"Mechanisms of hypolipidemic and anti-obesity effects of tea and tea polyphenols","volume":"50","author":"Lin","year":"2006","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1016\/j.nutres.2009.10.003","article-title":"Green tea, black tea, and epigallocatechin modify body composition, improve glucose tolerance, and differentially alter metabolic gene expression in rats fed a high-fat diet","volume":"29","author":"Chen","year":"2009","journal-title":"Nutr. Res."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/j.jnutbio.2011.01.001","article-title":"Green tea extract protects against nonalcoholic steatohepatitis in ob\/ob mice by decreasing oxidative and nitrative stress responses induced by proinflammatory enzymes","volume":"23","author":"Chung","year":"2012","journal-title":"J. Nutr. Biochem."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1547","DOI":"10.1016\/j.biopha.2018.11.007","article-title":"Mate tea reduces high fat diet-induced liver and metabolic disorders in mice","volume":"109","author":"Marina","year":"2019","journal-title":"Biomed. Pharmacother"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.toxlet.2020.01.018","article-title":"Metabolomics describes previously unknown toxicity mechanisms of isoniazid and rifampicin","volume":"322","author":"Monique","year":"2020","journal-title":"Toxicol. Lett."},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Htun, K.T., Pan, J., Pasanta, D., Tungjai, M., Udomtanakunchai, C., Chancharunee, S., Kaewjaeng, S., Kim, H.J., Kaewkhao, J., and Kothan, S. (2021). Identification of Metabolic Phenotypes in Young Adults with Obesity by 1H NMR Metabolomics of Blood Serum. Life, 11.","DOI":"10.3390\/life11060574"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1007\/978-1-4939-2377-9_17","article-title":"Metabonomics and systems biology","volume":"1277","author":"Preter","year":"2015","journal-title":"Methods Mol. Biol."},{"key":"ref_33","first-page":"109355","article-title":"Characterization of the key aroma compounds and microorganisms during the manufacturing process of Fu brick tea","volume":"127","author":"Li","year":"2020","journal-title":"Food Sci. Technol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"3598","DOI":"10.1002\/jsfa.10353","article-title":"Insight into effects of isolated Eurotium cristatum from Pingwu Fuzhuan brick tea on the fermentation process and quality characteristics of Fuzhuan brick tea","volume":"100","author":"Xiao","year":"2020","journal-title":"J. Sci. Food Agric."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"126043","DOI":"10.1016\/j.foodchem.2019.126043","article-title":"Microbial bioconversion of the chemical components in dark tea","volume":"312","author":"Zhu","year":"2020","journal-title":"Food Chem."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.foodchem.2014.12.045","article-title":"Investigation on biochemical compositional changes during the microbial fermentation process of Fu brick tea by LC\u2013MS based metabolomics","volume":"186","author":"Xu","year":"2015","journal-title":"Food Chem."},{"key":"ref_37","first-page":"210","article-title":"Formulation optimization and safety evaluation of the compound fuzhuan tea bag","volume":"36","author":"Zhou","year":"2020","journal-title":"Mod. Food Sci. Technol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"6971","DOI":"10.1039\/D0FO01282C","article-title":"Fubrick tea attenuates high-fat diet induced fat deposition and metabolic disorder by regulating gut microbiota and caffeine metabolism","volume":"11","author":"Jing","year":"2020","journal-title":"Food Funct."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"2783","DOI":"10.1021\/acs.jafc.8b00296","article-title":"Fuzhuan Brick Tea Polysaccharides Attenuate Metabolic Syndrome in High-Fat Diet Induced Mice in Association with Modulation in the Gut Microbiota","volume":"66","author":"Chen","year":"2018","journal-title":"J. Agric. Food Chem."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1007\/s13679-016-0233-8","article-title":"Global Changes in Food Supply and the Obesity Epidemic","volume":"5","author":"Zobel","year":"2016","journal-title":"Curr. Obes. Rep."},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Naqvi, S., Imani, S., Hosseinifard, H., Wen, Q.L., Shahzad, M.N., Ijaz, I., Deng, Y.C., Guo, M.a.n., and Xu, Y. (2019). Associations of serum low-density lipoprotein and systolic blood pressure levels with type 2 diabetic patients with and without peripheral neuropathy: Systemic review, meta-analysis and meta-regression analysis of observational studies. BMC Endocr. Disord., 19.","DOI":"10.1186\/s12902-019-0453-5"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1016\/j.jand.2019.09.012","article-title":"Dietary Patterns Associated with the Prevalence of Cardiovascular Disease Risk Factors in Kuwaiti Adults","volume":"120","author":"Ausman","year":"2020","journal-title":"J. Acad. Nutr. Diet."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1700485","DOI":"10.1002\/mnfr.201700485","article-title":"Kudingcha and Fuzhuan Brick Tea Prevent Obesity and Modulate Gut Microbiota in High-Fat Diet Fed Mice","volume":"62","author":"Chen","year":"2018","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"641","DOI":"10.5551\/jat.ED134","article-title":"Small-Dense Low-Density Lipoprotein Cholesterol: A Subclinical Marker for the Primary Prevention of Coronary Heart Disease","volume":"27","author":"Yoshihiro","year":"2020","journal-title":"J. Atheroscler. Thromb."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"e038121","DOI":"10.1136\/bmjopen-2020-038121","article-title":"Relationship between high-density lipoprotein cholesterol levels and endothelial function in women: A cross-sectional study","volume":"10","author":"Takaeko","year":"2020","journal-title":"BMJ Open"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.foodchem.2008.03.043","article-title":"Polyphenol contents of Pu-Erh teas and their abilities to inhibit cholesterol biosynthesis in Hep G2 cell line","volume":"111","author":"Lu","year":"2008","journal-title":"Food Chem."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"108324","DOI":"10.1016\/j.jnutbio.2019.108324","article-title":"Green tea polyphenols decrease weight gain, ameliorate alteration of gut microbiota, and mitigate intestinal inflammation in canines with high-fat-diet-induced obesity","volume":"78","author":"Li","year":"2020","journal-title":"J. Nutr. Biochem."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1002\/mnfr.201500654","article-title":"Fuzhuan tea consumption imparts hepatoprotective effects and alters intestinal microbiota in high saturated fat diet-fed rats","volume":"60","author":"Foster","year":"2016","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Zarzour, R.H.A., Ahmad, M., Asmawi, M.Z., Kaur, G., Saeed, M.A.A., Al-Mansoub, M.A., Saghir, S.A.M., Usman, N.S., Al-Dulaimi, D.W., and Yam, M.F. (2017). Phyllanthus Niruri Standardized Extract Alleviates the Progression of Non-Alcoholic Fatty Liver Disease and Decreases Atherosclerotic Risk in Sprague-Dawley Rats. Nutrients, 9.","DOI":"10.3390\/nu9070766"},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Panelli, M.F., Pierine, D.T., de Souza, S.L.B., Ferron, A.J.T., Garcia, J.L., Santos, K.C.D., and Corr\u00eaa, C.R. (2018). Bark of Passiflora edulis Treatment Stimulates Antioxidant Capacity, and Reduces Dyslipidemia and Body Fat in db\/db Mice. Antioxidants, 7.","DOI":"10.3390\/antiox7090120"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"653","DOI":"10.5740\/jaoacint.16-0403","article-title":"Antioxidant Evaluation and Composition Analysis of Extracts from Fuzhuan Brick Tea and Its Comparison with Two Instant Tea Products","volume":"100","author":"Zhang","year":"2017","journal-title":"J. AOAC Int."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1016\/j.talanta.2009.05.010","article-title":"Metabonomics study of atherosclerosis rats by ultra fast liquid chromatography coupled with ion trap-time of flight mass spectrometry","volume":"79","author":"Zhang","year":"2009","journal-title":"Talanta"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"10544","DOI":"10.1038\/s41598-017-11422-7","article-title":"UPLC-Q-TOF\/MS-based metabonomic studies on the intervention effects of aspirin eugenol ester in atherosclerosis hamsters","volume":"7","author":"Ma","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/j.cbi.2015.09.005","article-title":"Lipidomics: Novel insight into the biochemical mechanism of lipid metabolism and dysregulation-associated disease","volume":"240","author":"Zhao","year":"2015","journal-title":"Chem. Biol. Int."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.molmet.2018.01.005","article-title":"Reversal of metabolic disorders by pharmacological activation of bile acid receptors TGR5 and FXR","volume":"9","author":"Jadhav","year":"2018","journal-title":"Mol. Metab."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.livres.2017.03.002","article-title":"Bile acids as global regulators of hepatic nutrient metabolism","volume":"1","author":"Hylemon","year":"2017","journal-title":"Liver Res."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1002\/mnfr.201500795","article-title":"Dietary procyanidins selectively modulate intestinal farnesoid X receptor-regulated gene expression to alter enterohepatic bile acid recirculation: Elucidation of a novel mechanism to reduce triglyceridemia","volume":"60","author":"Rebecca","year":"2016","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"183412","DOI":"10.1016\/j.bbamem.2020.183412","article-title":"The mannose phosphotransferase system (Man-PTS)\u2014Mannose transporter and receptor for bacteriocins and bacteriophages","volume":"1862","author":"Jeckelmann","year":"2020","journal-title":"BBA Biomembr."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.bbrc.2018.01.062","article-title":"Eicosapentaenoic acid inhibits oxidation of high density lipoprotein particles in a manner distinct from docosahexaenoic acid","volume":"496","author":"Sherratt","year":"2018","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1002\/biot.200600012","article-title":"Essential fatty acids: Biochemistry, physiology and pathology","volume":"1","author":"Das","year":"2006","journal-title":"Biotechnol. J."}],"container-title":["Nutrients"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6643\/14\/6\/1128\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T22:33:39Z","timestamp":1760135619000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6643\/14\/6\/1128"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3,8]]},"references-count":60,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2022,3]]}},"alternative-id":["nu14061128"],"URL":"https:\/\/doi.org\/10.3390\/nu14061128","relation":{},"ISSN":["2072-6643"],"issn-type":[{"value":"2072-6643","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,3,8]]}}}