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This review discusses research progress on the effect of bacterial dysbiosis from a metabolic point of view, particularly on the biochemical mechanisms of butyrate, one of the main short chain fatty acids (SCFAs) with anti-inflammatory and anti-tumor properties in CRC. Increased daily intake of omega-3 polyunsaturated fatty acids (PUFAs) significantly increases the density of bacteria that are known to produce butyrate. Omega-3 PUFAs have been proposed as a treatment to prevent gut microbiota dysregulation and lower the risk or progression of CRC.<\/jats:p>","DOI":"10.3390\/nu14061152","type":"journal-article","created":{"date-parts":[[2022,3,10]],"date-time":"2022-03-10T02:10:35Z","timestamp":1646878235000},"page":"1152","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":44,"title":["Biochemical and Metabolical Pathways Associated with Microbiota-Derived Butyrate in Colorectal Cancer and Omega-3 Fatty Acids Implications: A Narrative Review"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3589-799X","authenticated-orcid":false,"given":"Adelina Silvana","family":"Gheorghe","sequence":"first","affiliation":[{"name":"Department of Oncology, \u201cCarol Davila\u201d University of Medicine and Pharmacy, 020021 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u0218erban Mircea","family":"Negru","sequence":"additional","affiliation":[{"name":"Department of Oncology, \u201cVictor Babe\u0219\u201d University of Medicine and Pharmacy, 300041 Timisoara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5927-7069","authenticated-orcid":false,"given":"M\u0103d\u0103lina","family":"Preda","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Parasitology and Virology, Faculty of Midwives and Nursing, \u201cCarol Davila\u201d University of Medicine and Pharmacy, 020021 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raluca Ioana","family":"Mih\u0103il\u0103","sequence":"additional","affiliation":[{"name":"Department of Oncology, \u201cCarol Davila\u201d University of Medicine and Pharmacy, 020021 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabela Anda","family":"Komporaly","sequence":"additional","affiliation":[{"name":"Department of Oncology, \u201cCarol Davila\u201d University of Medicine and Pharmacy, 020021 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena Adriana","family":"Dumitrescu","sequence":"additional","affiliation":[{"name":"Department of Oncology, \u201cCarol Davila\u201d University of Medicine and Pharmacy, 020021 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristian Virgil","family":"Lungulescu","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, University of Medicine and Pharmacy Craiova, 200349 Craiova, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lidia Anca","family":"Kajanto","sequence":"additional","affiliation":[{"name":"Department of Oncology, \u201cCarol Davila\u201d University of Medicine and Pharmacy, 020021 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bogdan","family":"Georgescu","sequence":"additional","affiliation":[{"name":"Department of Oncology, \u201cCarol Davila\u201d University of Medicine and Pharmacy, 020021 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emanuel Alin","family":"Radu","sequence":"additional","affiliation":[{"name":"Department of Oncology, \u201cCarol Davila\u201d University of Medicine and Pharmacy, 020021 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3930-2543","authenticated-orcid":false,"given":"Dana Lucia","family":"St\u0103nculeanu","sequence":"additional","affiliation":[{"name":"Department of Oncology, \u201cCarol Davila\u201d University of Medicine and Pharmacy, 020021 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,3,9]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1126\/science.1160809","article-title":"Understanding the Warburg effect: The metabolic requirements of cell proliferation","volume":"324","author":"Cantley","year":"2009","journal-title":"Science"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"209","DOI":"10.3322\/caac.21660","article-title":"Global Cancer Statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"71","author":"Sung","year":"2021","journal-title":"CA Cancer J. Clin."},{"key":"ref_3","first-page":"89","article-title":"Epidemiology of colorectal cancer: Incidence, mortality, survival, and risk factors","volume":"14","author":"Rawla","year":"2019","journal-title":"Prz. Gastroenterol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1136\/gutjnl-2015-310912","article-title":"Global patterns and trends in colorectal cancer incidence and mortality","volume":"66","author":"Arnold","year":"2017","journal-title":"Gut"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"16365","DOI":"10.3390\/ijms140816365","article-title":"Molecular pathways involved in colorectal cancer: Implications for disease behavior and prevention","volume":"14","author":"Colussi","year":"2013","journal-title":"Int. J. Mol. Sci."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1038\/nrgastro.2016.165","article-title":"Diet, microorganisms and their metabolites, and colon cancer","volume":"13","year":"2016","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1097\/PPO.0000000000000048","article-title":"Microbiome, inflammation and cancer","volume":"20","author":"Francescone","year":"2014","journal-title":"Cancer J."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.mam.2019.05.001","article-title":"Microbiome and colorectal cancer: Roles in carcinogenesis and clinical potential","volume":"69","author":"Saus","year":"2019","journal-title":"Mol. Asp. Med."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1624","DOI":"10.1136\/gutjnl-2019-318556","article-title":"International Cancer Microbiome Consortium consensus statement on the role of the human microbiome in carcinogenesis","volume":"68","author":"Scott","year":"2019","journal-title":"Gut"},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Tu, M., Wang, W., Zhang, G., and Hammock, B.D. (2020). \u03c9-3 Polyunsaturated fatty acids on colonic inflammation and colon cancer: Roles of lipid-metabolizing enzymes involved. Nutrients, 12.","DOI":"10.3390\/nu12113301"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1093\/ilar\/ilv007","article-title":"Pathogens, commensal symbionts, and pathobionts: Discovery and functional effects on the host","volume":"56","author":"Hornef","year":"2015","journal-title":"ILAR J."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1093\/femsre\/fuw046","article-title":"Exploring the human microbiome from multiple perspectives: Factors altering its composition and function","volume":"41","author":"Rojo","year":"2017","journal-title":"FEMS Microbiol. Rev."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"4162","DOI":"10.1172\/JCI78366","article-title":"The microbiome revolution","volume":"124","author":"Blaser","year":"2014","journal-title":"J. Clin. Investig."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"324","DOI":"10.15698\/mic2019.08.685","article-title":"The influence of the microbiota on immune development, chronic inflammation, and cancer in the context of aging","volume":"6","author":"Tibbs","year":"2019","journal-title":"Microb. Cell"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1038\/nrmicro.2017.58","article-title":"The resilience of the intestinal microbiota influences health and disease","volume":"15","author":"Sommer","year":"2017","journal-title":"Nat. Rev. Microbiol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.trsl.2016.07.012","article-title":"High-resolution characterization of the human microbiome","volume":"179","author":"Noecker","year":"2017","journal-title":"Transl. Res."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1038\/s41579-018-0041-0","article-title":"Culturing the human microbiota and culturomics","volume":"16","author":"Lagier","year":"2018","journal-title":"Nat. Rev. Microbiol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/s13062-019-0234-0","article-title":"Genome and pan-genome analysis to classify emerging bacteria","volume":"14","author":"Caputo","year":"2019","journal-title":"Biol. Direct"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/2049-2618-1-17","article-title":"Integrative analysis of the microbiome and metabolome of the human intestinal mucosal surface reveals exquisite inter-relationships","volume":"1","author":"Mchardy","year":"2013","journal-title":"Microbiome"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"2567","DOI":"10.1021\/acs.biochem.7b01277","article-title":"Deciphering Human Gut Microbiota\u2013Nutrient Interactions: A Role for Biochemistry","volume":"57","author":"Chittim","year":"2018","journal-title":"Biochemistry"},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Kov\u00e1cs, T., Mik\u00f3, E., Ujlaki, G., S\u00e1ri, Z., and Bai, P. (2020). The Microbiome as a Component of the Tumor Microenvironment. Tumor Microenvironment, Springer.","DOI":"10.1007\/978-3-030-35727-6_10"},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Weir, T.L., Manter, D.K., Sheflin, A.M., Barnett, B.A., Heuberger, A.L., and Ryan, E.P. (2013). Stool microbiome and metabolome differences between colorectal cancer patients and healthy adults. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0070803"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1007\/s11912-014-0406-0","article-title":"Cancer-promoting effects of microbial dysbiosis","volume":"16","author":"Sheflin","year":"2014","journal-title":"Curr. Oncol. Rep."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1007\/978-3-030-34025-4_5","article-title":"Gut Microbiota and Cancer of the Host: Colliding Interests","volume":"1219","author":"Baffy","year":"2020","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1177\/0260106019866963","article-title":"Design and baseline characteristics of the Biomarkers Of Risk In Colorectal Cancer (BORICC) Follow-Up study: A 12+ years follow-up","volume":"25","author":"Malcomson","year":"2019","journal-title":"Nutr. Health"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1519","DOI":"10.3748\/wjg.v17.i12.1519","article-title":"Potential beneficial effects of butyrate in intestinal and extraintestinal diseases","volume":"17","author":"Canani","year":"2011","journal-title":"World J. Gastroenterol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1017\/S0029665114001463","article-title":"Links between diet, gut microbiota composition and gut metabolism","volume":"74","author":"Flint","year":"2015","journal-title":"Proc. Nutr. Soc."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"3795","DOI":"10.21873\/anticanres.13528","article-title":"In vitro evaluation of apoptotic induction of butyric acid derivatives in colorectal carcinoma cells","volume":"39","author":"Pattayil","year":"2019","journal-title":"Anticancer Res."},{"key":"ref_29","first-page":"158900","article-title":"Effects of short chain fatty acids on metabolic and inflammatory processes in human health","volume":"1866","year":"2021","journal-title":"Biochim. Biophys. Acta (BBA) Mol. Cell Biol. Lipids"},{"key":"ref_30","first-page":"G601","article-title":"The role of butyrate in surgical and oncological outcomes in colorectal cancer","volume":"320","author":"Hajjar","year":"2021","journal-title":"Am. J. Physiol. Liver Physiol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1574-6968.2009.01514.x","article-title":"Diversity, metabolism and microbial ecology of butyrate-producing bacteria from the human large intestine","volume":"294","author":"Louis","year":"2009","journal-title":"FEMS Microbiol. Lett."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1242","DOI":"10.1016\/S1470-2045(12)70475-8","article-title":"Long-term effect of resistant starch on cancer risk in carriers of hereditary colorectal cancer: An analysis from the CAPP2 randomised controlled trial","volume":"13","author":"Mathers","year":"2012","journal-title":"Lancet Oncol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1158\/2159-8290.CD-14-0501","article-title":"A Gnotobiotic Mouse Model Demonstrates That Dietary Fiber Protects against Colorectal Tumorigenesis in a Microbiota- and Butyrate-Dependent Manner","volume":"4","author":"Donohoe","year":"2014","journal-title":"Cancer Discov."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1500902","DOI":"10.1002\/mnfr.201500902","article-title":"Interplay between diet, gut microbiota, epigenetic events, and colorectal cancer","volume":"61","author":"Bultman","year":"2017","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"e000145","DOI":"10.1136\/bmjgast-2017-000145","article-title":"Intestinal microbiota is altered in patients with colon cancer and modified by probiotic intervention","volume":"4","author":"Hibberd","year":"2017","journal-title":"BMJ Open Gastroenterol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1038\/ismej.2011.109","article-title":"Structural segregation of gut microbiota between colorectal cancer patients and healthy volunteers","volume":"6","author":"Wang","year":"2012","journal-title":"ISME J."},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Chen, W., Liu, F., Ling, Z., Tong, X., and Xiang, C. (2012). Human intestinal lumen and mucosa-associated microbiota in patients with colorectal cancer. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0039743"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1111\/j.1574-6968.2010.02197.x","article-title":"Quantification of butyryl CoA: Acetate CoA-transferase genes reveals different butyrate production capacity in individuals according to diet and age","volume":"316","author":"Hippe","year":"2011","journal-title":"FEMS Microbiol. Lett."},{"key":"ref_39","first-page":"89","article-title":"Regulation of colonic epithelial butyrate transport: Focus on colorectal cancer","volume":"1","author":"Martel","year":"2016","journal-title":"Porto Biomed. J."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1056\/NEJMra1402513","article-title":"The key role of epigenetics in human disease prevention and mitigation","volume":"378","author":"Feinberg","year":"2018","journal-title":"N. Engl. J. Med."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1002\/1521-1878(200009)22:9<836::AID-BIES9>3.0.CO;2-X","article-title":"Histone acetylation and an epigenetic code","volume":"22","author":"Turner","year":"2000","journal-title":"Bioessays"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1038\/268462a0","article-title":"n-Butyrate causes histone modification in HeLa and Friend erythroleukaemia cells","volume":"268","author":"Riggs","year":"1977","journal-title":"Nature"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1002\/med.21437","article-title":"The search for potent, small-molecule HDACIs in cancer treatment: A decade after vorinostat","volume":"37","author":"Zagni","year":"2017","journal-title":"Med. Res. Rev."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"5960","DOI":"10.1038\/onc.2015.46","article-title":"Histone deacetylase inhibitors prevent activation-induced cell death and promote anti-tumor immunity","volume":"34","author":"Cao","year":"2015","journal-title":"Oncogene"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"G696","DOI":"10.1152\/ajpgi.00575.2004","article-title":"The histone deacetylase inhibitor butyrate downregulates cyclin B1 gene expression via a p21\/WAF-1-dependent mechanism in human colon cancer cells","volume":"289","author":"Archer","year":"2005","journal-title":"Am. J. Physiol.\u2014Gastrointest. Liver Physiol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.immuni.2019.06.002","article-title":"Microbiota-derived short-chain fatty acids promote the memory potential of antigen-activated CD8+ T cells","volume":"51","author":"Bachem","year":"2019","journal-title":"Immunity"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1016\/j.cell.2014.04.051","article-title":"Gut microbial metabolism drives transformation of MSH2-deficient colon epithelial cells","volume":"158","author":"Belcheva","year":"2014","journal-title":"Cell"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"1726309","DOI":"10.1155\/2020\/1726309","article-title":"Molecular Aspects of Colorectal Adenomas: The Interplay among Microenvironment, Oxidative Stress, and Predisposition","volume":"2020","author":"Aceto","year":"2020","journal-title":"BioMed Res. Int."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1793","DOI":"10.1093\/ajcn\/87.6.1793","article-title":"Glycemic index, glycemic load, and cancer risk: A meta-analysis","volume":"87","author":"Gnagnarella","year":"2008","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"1702","DOI":"10.1093\/jnci\/djs399","article-title":"Dietary glycemic load and cancer recurrence and survival in patients with stage III colon cancer: Findings from CALGB 89803","volume":"104","author":"Meyerhardt","year":"2012","journal-title":"J. Natl. Cancer Inst."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"2640","DOI":"10.1073\/pnas.051629398","article-title":"Top-down morphogenesis of colorectal tumours","volume":"98","author":"Shih","year":"2001","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1207\/S15327914NC4501_10","article-title":"Butyrate restores motile function and actin cytoskeletal network integrity in APC mutated mouse colon epithelial cells","volume":"45","author":"Forest","year":"2003","journal-title":"Nutr. Cancer"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"1623","DOI":"10.1023\/A:1005529414765","article-title":"Short-chain fatty acids induce cytoskeletal and extracellular protein modifications associated with modulation of proliferation on primary culture of rat intestinal smooth muscle cells","volume":"45","author":"Blottiere","year":"2000","journal-title":"Dig. Dis. Sci."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"e202895","DOI":"10.1001\/jamanetworkopen.2020.2895","article-title":"Association of short-chain fatty acids in the gut microbiome with clinical response to treatment with nivolumab or pembrolizumab in patients with solid cancer tumors","volume":"3","author":"Nomura","year":"2020","journal-title":"JAMA Netw. Open"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1007\/s10555-018-9744-y","article-title":"Omega-3 polyunsaturated fatty acids as adjuvant therapy of colorectal cancer","volume":"37","author":"Volpato","year":"2018","journal-title":"Cancer Metastasis Rev."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"147","DOI":"10.7762\/cnr.2017.6.3.147","article-title":"Chemopreventive and Chemotherapeutic Effects of Fish Oil derived Omega-3 Polyunsaturated Fatty Acids on Colon Carcinogenesis","volume":"6","author":"Lee","year":"2017","journal-title":"Clin. Nutr. Res."},{"key":"ref_57","first-page":"2015","article-title":"Omega-3 polyunsaturated fatty acids: The way forward in times of mixed evidence","volume":"2","author":"Weylandt","year":"2015","journal-title":"BioMed Res. Int."},{"key":"ref_58","doi-asserted-by":"crossref","unstructured":"Druart, C., Neyrinck, A.M., Vlaeminck, B., Fievez, V., Cani, P.D., and Delzenne, N.M. (2014). Role of the lower and upper intestine in the production and absorption of gut microbiota-derived PUFA metabolites. PLoS ONE, 27.","DOI":"10.1371\/journal.pone.0087560"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"1974","DOI":"10.1136\/gutjnl-2017-314968","article-title":"A randomised trial of the effect of omega-3 polyunsaturated fatty acid supplements on the human intestinal microbiota","volume":"67","author":"Watson","year":"2018","journal-title":"Gut"},{"key":"ref_60","first-page":"2016","article-title":"Understanding the impact of omega-3 rich diet on the gut microbiota","volume":"14","author":"Noriega","year":"2016","journal-title":"Case Rep. Med."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1007\/s10620-020-06106-8","article-title":"Diet and Gut Microbes Act Coordinately to Enhance Programmed Cell Death and Reduce Colorectal Cancer Risk","volume":"65","author":"Chapkin","year":"2020","journal-title":"Dig. Dis. Sci."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1007\/s11745-004-1339-7","article-title":"Resolvins, docosatrienes, and neuroprotectins, novel omega-3-derived mediators, and their endogenous aspirin-triggered epimers","volume":"39","author":"Serhan","year":"2004","journal-title":"Lipids"},{"key":"ref_63","doi-asserted-by":"crossref","unstructured":"Zhang, C., Yu, H., Ni, X., Shen, S., and Das, U.N. (2015). Growth inhibitory effect of polyunsaturated fatty acids (PUFAs) on colon cancer cells via their growth inhibitory metabolites and fatty acid composition changes. 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