{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T18:26:15Z","timestamp":1791570375206,"version":"4.3.4"},"reference-count":39,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2022,3,12]],"date-time":"2022-03-12T00:00:00Z","timestamp":1647043200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>The quality of life (QOL) of patients with celiac disease (CD) can be altered by both symptoms of the disease and by the restrictions of the gluten-free diet (GFD). The objective was to determine the factors associated with better QOL in a large cohort of CD patients. A link to an online survey was sent to the members of the French Association of Gluten Intolerant People (AFDIAG). The French-Celiac Disease Questionnaire (F-CDQ), scoring from 0 to 100, was used to measure the QOL. Other data collected were sociodemographic characteristics, information on CD, purchasing and consumption habits of gluten-free products, and a self-assessment scale (ranging from 0 to 10) to determine the compliance with the GFD. Among the 907 CD patients who returned the questionnaire, 787 were analyzed (638 women (81%); median age: 49 years; 71% with self-assessed GFD compliance &gt; 8). Their median F-CDQ was 73 (range: 59\u201382). In multivariate analysis, the main factors associated with a better quality of life were the long duration of the GFD, good compliance with the GFD, and the number of follow-up visits. Compliance with and duration of the GFD are associated with a better quality of life in patients with CD. Taking this into consideration would offset its restrictive aspect and improve its adherence.<\/jats:p>","DOI":"10.3390\/nu14061210","type":"journal-article","created":{"date-parts":[[2022,3,13]],"date-time":"2022-03-13T21:44:17Z","timestamp":1647207857000},"page":"1210","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Compliance with Gluten Free Diet Is Associated with Better Quality of Life in Celiac Disease"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9493-5218","authenticated-orcid":false,"given":"Rapha\u00ebl","family":"Enaud","sequence":"first","affiliation":[{"name":"CHU de Bordeaux, H\u00f4pital des Enfants, Service d\u2019H\u00e9pato-Gastroent\u00e9rologie P\u00e9diatriques, 33000 Bordeaux, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Candice","family":"Tetard","sequence":"additional","affiliation":[{"name":"CHU de Bordeaux, H\u00f4pital des Enfants, Service d\u2019H\u00e9pato-Gastroent\u00e9rologie P\u00e9diatriques, 33000 Bordeaux, France"},{"name":"CHU de Bordeaux, Centre M\u00e9dico-chirurgical Magellan, H\u00f4pital Haut-L\u00e9v\u00eaque, Gastroenterology Department, Universit\u00e9 de Bordeaux, INSERM CIC 1401, 33000 Bordeaux, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rapha\u00ebl","family":"Dupuis","sequence":"additional","affiliation":[{"name":"CHU de Bordeaux, Centre M\u00e9dico-chirurgical Magellan, H\u00f4pital Haut-L\u00e9v\u00eaque, Gastroenterology Department, Universit\u00e9 de Bordeaux, INSERM CIC 1401, 33000 Bordeaux, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Laharie","sequence":"additional","affiliation":[{"name":"CHU de Bordeaux, Centre M\u00e9dico-chirurgical Magellan, H\u00f4pital Haut-L\u00e9v\u00eaque, Gastroenterology Department, Universit\u00e9 de Bordeaux, INSERM CIC 1401, 33000 Bordeaux, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5777-8492","authenticated-orcid":false,"given":"Thierry","family":"Lamireau","sequence":"additional","affiliation":[{"name":"CHU de Bordeaux, H\u00f4pital des Enfants, Service d\u2019H\u00e9pato-Gastroent\u00e9rologie P\u00e9diatriques, 33000 Bordeaux, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Zerbib","sequence":"additional","affiliation":[{"name":"CHU de Bordeaux, Centre M\u00e9dico-chirurgical Magellan, H\u00f4pital Haut-L\u00e9v\u00eaque, Gastroenterology Department, Universit\u00e9 de Bordeaux, INSERM CIC 1401, 33000 Bordeaux, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pauline","family":"Rivi\u00e8re","sequence":"additional","affiliation":[{"name":"CHU de Bordeaux, Centre M\u00e9dico-chirurgical Magellan, H\u00f4pital Haut-L\u00e9v\u00eaque, Gastroenterology Department, Universit\u00e9 de Bordeaux, INSERM CIC 1401, 33000 Bordeaux, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Shili-Mismoudi","sequence":"additional","affiliation":[{"name":"CHU de Bordeaux, Centre M\u00e9dico-chirurgical Magellan, H\u00f4pital Haut-L\u00e9v\u00eaque, Gastroenterology Department, Universit\u00e9 de Bordeaux, INSERM CIC 1401, 33000 Bordeaux, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0478-4258","authenticated-orcid":false,"given":"Florian","family":"Poullenot","sequence":"additional","affiliation":[{"name":"CHU de Bordeaux, Centre M\u00e9dico-chirurgical Magellan, H\u00f4pital Haut-L\u00e9v\u00eaque, Gastroenterology Department, Universit\u00e9 de Bordeaux, INSERM CIC 1401, 33000 Bordeaux, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,3,12]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1053\/j.gastro.2005.02.007","article-title":"National Institutes of Health Consensus Development Conference Statement on Celiac Disease, June 28\u201330, 2004","volume":"128","author":"James","year":"2005","journal-title":"Gastroenterology"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1053\/j.gastro.2020.06.098","article-title":"Epidemiology, Presentation, and Diagnosis of Celiac Disease","volume":"160","author":"Lebwohl","year":"2021","journal-title":"Gastroenterology"},{"key":"ref_3","first-page":"27","article-title":"Are patients with coeliac disease seeking alternative therapies to a gluten-free diet?","volume":"20","author":"Aziz","year":"2011","journal-title":"J. Gastrointest. Liver Dis."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.1038\/ajg.2014.29","article-title":"Patient perception of treatment burden is high in celiac disease compared with other common conditions","volume":"109","author":"Shah","year":"2014","journal-title":"Am. J. Gastroenterol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/0891-4222(94)00028-8","article-title":"Quality of life: Its definition and measurement","volume":"16","author":"Felce","year":"1995","journal-title":"Res. Dev. Disabil."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"2017","DOI":"10.1111\/j.1572-0241.1999.01272.x","article-title":"Health-related quality of life: A primer for gastroenterologists","volume":"94","author":"Eisen","year":"1999","journal-title":"Am. J. Gastroenterol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1177\/2050640619844125","article-title":"European Society for the Study of Coeliac Disease (ESsCD) guideline for coeliac disease and other gluten-related disorders","volume":"7","author":"Volta","year":"2019","journal-title":"United Eur. Gastroenterol. J."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1097\/01.meg.0000221855.19201.e8","article-title":"Health-related quality of life in adult coeliac disease in Germany: Results of a national survey","volume":"18","author":"Gold","year":"2006","journal-title":"Eur. J. Gastroenterol. Hepatol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1111\/j.1365-2036.2006.03227.x","article-title":"Predictors of reduced health-related quality of life in adults with coeliac disease","volume":"25","author":"Stallmach","year":"2007","journal-title":"Aliment. Pharmacol. Ther."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1038\/nrgastro.2009.37","article-title":"Celiac disease: Assessment of quality of life","volume":"6","author":"Mulder","year":"2009","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1586\/egh.10.81","article-title":"Celiac disease and health-related quality of life","volume":"5","author":"Kurppa","year":"2011","journal-title":"Expert Rev. Gastroenterol. Hepatol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1111\/j.1365-2788.2005.00742.x","article-title":"Cross-cultural study of person-centred quality of life domains and indicators: A replication","volume":"49","author":"Jenaro","year":"2005","journal-title":"J. Intellect. Disabil. Res."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Pouchot, J., Despujol, C., Malamut, G., Ecosse, E., Coste, J., and Cellier, C. (2014). Validation of a French Version of the Quality of Life \u201cCeliac Disease Questionnaire\u201d. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0096346"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1097\/01.mcg.0000225516.05666.4e","article-title":"Development and validation of the Celiac Disease Questionnaire (CDQ), a disease-specific health-related quality of life measure for adult patients with celiac disease","volume":"41","author":"Gold","year":"2007","journal-title":"J. Clin. Gastroenterol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1111\/j.2517-6161.1996.tb02080.x","article-title":"Regression Shrinkage and Selection via the Lasso","volume":"58","author":"Tibshirani","year":"1996","journal-title":"J. R. Stat. Soc. Ser. B (Methodol.)"},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Violato, M., and Gray, A. (2019). The impact of diagnosis on health-related quality of life in people with coeliac disease: A UK population-based longitudinal perspective. BMC Gastroenterol., 19.","DOI":"10.1186\/s12876-019-0980-6"},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Marsilio, I., Canova, C., D\u2019Odorico, A., Ghisa, M., Zingone, L., Lorenzon, G., Savarino, E.V., and Zingone, F. (2020). Quality-of-Life Evaluation in Coeliac Patients on a Gluten-Free Diet. Nutrients, 12.","DOI":"10.3390\/nu12102981"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"507","DOI":"10.14309\/ajg.0000000000000523","article-title":"Incidence of Celiac Disease Is Increasing Over Time: A Systematic Review and Meta-analysis","volume":"115","author":"King","year":"2020","journal-title":"Am. J. Gastroenterol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1038\/ajg.2011.21","article-title":"Screening for celiac disease in a North American population: Sequential serology and gastrointestinal symptoms","volume":"106","author":"Katz","year":"2011","journal-title":"Am. J. Gastroenterol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1016\/j.gie.2012.05.011","article-title":"Sex and racial disparities in duodenal biopsy to evaluate for celiac disease","volume":"76","author":"Lebwohl","year":"2012","journal-title":"Gastrointest. Endosc."},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Selleski, N., Zandonadi, R.P., Milde, L.B., Gandolfi, L., Pratesi, R., H\u00e4user, W., Uenishi, R.H., Nakano, E.Y., and Pratesi, C.B. (2020). Evaluation of Quality of Life of Adult Patients with Celiac Disease in Argentina: From Questionnaire Validation to Assessment. Int. J. Environ. Res. Public Health, 17.","DOI":"10.3390\/ijerph17197051"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1038\/s41598-020-58236-8","article-title":"Quality of life in people with ongoing symptoms of coeliac disease despite adherence to a strict gluten-free diet","volume":"10","author":"Harnett","year":"2020","journal-title":"Sci. Rep."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1016\/S2468-1253(20)30217-X","article-title":"Global prevalence of irritable bowel syndrome according to Rome III or IV criteria: A systematic review and meta-analysis","volume":"5","author":"Oka","year":"2020","journal-title":"Lancet Gastroenterol. Hepatol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1080\/09540261.2017.1314952","article-title":"Coeliac disease and psychiatric comorbidity: Epidemiology, pathophysiological mechanisms, quality-of-life, and gluten-free diet effects","volume":"29","author":"Cossu","year":"2017","journal-title":"Int. Rev. Psychiatry"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1097\/00042737-200312000-00006","article-title":"Affective disorders and quality of life in adult coeliac disease patients on a gluten-free diet","volume":"15","author":"Fera","year":"2003","journal-title":"Eur. J. Gastroenterol. Hepatol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1111\/j.1365-277X.2006.00659.x","article-title":"The impact of a gluten-free diet on adults with coeliac disease: Results of a national survey","volume":"19","author":"Zarkadas","year":"2006","journal-title":"J. Hum. Nutr. Diet"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1007\/s10620-006-9258-2","article-title":"The Canadian Celiac Health Survey","volume":"52","author":"Cranney","year":"2007","journal-title":"Dig. Dis. Sci."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.dld.2006.01.004","article-title":"Psychological well-being of adult coeliac patients treated for 10 years","volume":"38","author":"Roos","year":"2006","journal-title":"Dig. Liver Dis."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1159\/000265549","article-title":"Impact of gluten withdrawal on health-related quality of life in celiac subjects: An observational case-control study","volume":"82","author":"Tontini","year":"2010","journal-title":"Digestion"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/j.dld.2010.03.004","article-title":"Long-term deterioration of quality of life in adult patients with celiac disease is associated with treatment noncompliance","volume":"42","author":"Nachman","year":"2010","journal-title":"Dig. Liver Dis."},{"key":"ref_31","first-page":"447","article-title":"Impact of gluten-free diet on quality of life in celiac patients","volume":"79","author":"Borghini","year":"2016","journal-title":"Acta Gastroenterol. Belg."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1097\/MPG.0b013e31817fcb56","article-title":"Quality of life in adolescents with treated coeliac disease: Influence of compliance and age at diagnosis","volume":"47","author":"Wagner","year":"2008","journal-title":"J. Pediatr. Gastroenterol. Nutr."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1016\/S1590-8658(00)80354-0","article-title":"Prevalence of silent coeliac disease in atopics","volume":"32","author":"Zauli","year":"2000","journal-title":"Dig. Liver Dis."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1053\/j.gastro.2007.04.070","article-title":"Sera of patients with celiac disease and neurologic disorders evoke a mitochondrial-dependent apoptosis in vitro","volume":"133","author":"Cervio","year":"2007","journal-title":"Gastroenterology"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.dld.2005.11.013","article-title":"Anti-ganglioside antibodies in coeliac disease with neurological disorders","volume":"38","author":"Volta","year":"2006","journal-title":"Dig. Liver Dis."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1136\/pmj.78.921.393","article-title":"Neurological complications of coeliac disease","volume":"78","author":"Wills","year":"2002","journal-title":"Postgrad. Med. J."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"46","DOI":"10.3748\/wjg.14.46","article-title":"Factors that impact health-related quality of life in adults with celiac disease: A multicenter study","volume":"14","author":"Casellas","year":"2008","journal-title":"World J. Gastroenterol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1046\/j.1471-6712.2003.00228.x","article-title":"Perceptions of health-related quality of life of men and women living with coeliac disease","volume":"17","author":"Hallert","year":"2003","journal-title":"Scand J. Caring Sci."},{"key":"ref_39","first-page":"241","article-title":"Quality of life in Coeliac Disease is determined by perceived degree of difficulty adhering to a gluten-free diet, not the level of dietary adherence ultimately achieved","volume":"20","author":"Barratt","year":"2011","journal-title":"J. Gastrointest. Liver Dis."}],"container-title":["Nutrients"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6643\/14\/6\/1210\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T22:35:37Z","timestamp":1760135737000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6643\/14\/6\/1210"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3,12]]},"references-count":39,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2022,3]]}},"alternative-id":["nu14061210"],"URL":"https:\/\/doi.org\/10.3390\/nu14061210","relation":{},"ISSN":["2072-6643"],"issn-type":[{"value":"2072-6643","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,3,12]]}}}