{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T15:56:12Z","timestamp":1792252572264,"version":"4.4.0"},"reference-count":71,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2022,3,18]],"date-time":"2022-03-18T00:00:00Z","timestamp":1647561600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Classically, a secosteroid hormone, vitamin D, has been implicated in calcium and phosphate homeostasis and has been associated with the pathogenesis of rickets and osteomalacia in patients with severe nutritional vitamin D deficiency. The spectrum of known vitamin D-mediated effects has been expanded in recent years. However, the mechanisms of how exactly this hormone elicits its biological function are still not fully understood. The interaction of this metabolite with the vitamin D receptor (VDR) and, subsequently, with the vitamin D-responsive element in the region of specific target genes leading to the transcription of genes whose protein products are involved in the traditional function of calcitriol (known as genomic actions). Moreover, in addition to these transcription-dependent mechanisms, it has been recognized that the biologically active form of vitamin D3, as well as its immediate precursor metabolite, calcifediol, initiate rapid, non-genomic actions through the membrane receptors that are bound as described for other steroid hormones. So far, among the best candidates responsible for mediating rapid membrane response to vitamin D metabolites are membrane-associated VDR (VDRm) and protein disulfide isomerase family A member 3 (Pdia3). The purpose of this paper is to provide an overview of the rapid, non-genomic effects of calcifediol and calcitriol, whose elucidation could improve the understanding of the vitamin D3 endocrine system. This will contribute to a better recognition of the physiological acute functions of vitamin D3, and it could lead to the identification of novel therapeutic targets able to modulate these actions.<\/jats:p>","DOI":"10.3390\/nu14061291","type":"journal-article","created":{"date-parts":[[2022,3,20]],"date-time":"2022-03-20T21:34:27Z","timestamp":1647812067000},"page":"1291","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":43,"title":["Rapid Nontranscriptional Effects of Calcifediol and Calcitriol"],"prefix":"10.3390","volume":"14","author":[{"given":"Simone","family":"Donati","sequence":"first","affiliation":[{"name":"Department of Experimental and Clinical Biomedical Sciences, University of Florence, 50139 Florence, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8376-7404","authenticated-orcid":false,"given":"Gaia","family":"Palmini","sequence":"additional","affiliation":[{"name":"Department of Experimental and Clinical Biomedical Sciences, University of Florence, 50139 Florence, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cinzia","family":"Aurilia","sequence":"additional","affiliation":[{"name":"Department of Experimental and Clinical Biomedical Sciences, University of Florence, 50139 Florence, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene","family":"Falsetti","sequence":"additional","affiliation":[{"name":"Department of Experimental and Clinical Biomedical Sciences, University of Florence, 50139 Florence, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Miglietta","sequence":"additional","affiliation":[{"name":"Department of Experimental and Clinical Biomedical Sciences, University of Florence, 50139 Florence, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7461-330X","authenticated-orcid":false,"given":"Teresa","family":"Iantomasi","sequence":"additional","affiliation":[{"name":"Department of Experimental and Clinical Biomedical Sciences, University of Florence, 50139 Florence, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Luisa","family":"Brandi","sequence":"additional","affiliation":[{"name":"Fondazione Italiana Ricerca sulle Malattie dell\u2019Osso (F.I.R.M.O. 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Clin. Investig."},{"key":"ref_4","first-page":"63","article-title":"Metabolismo, fuentes end\u00f3genas y ex\u00f3genas de vitamina D","volume":"16","year":"2007","journal-title":"Rev. Esp. Enferm. Metab. Oseas"},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Chrousos, G.P., Loriaux, D.L., and Lipsett, M.B. (1986). The Metabolism and Functions of Vitamin D. Steroid Hormone Resistance: Mechanisms and Clinical Aspects, Springer. Advances in Experimental Medicine and Biology.","DOI":"10.1007\/978-1-4684-5101-6"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4172\/2324-9323.1000155","article-title":"Vitamin D: Genetics, Environment & Health","volume":"3","author":"Martin","year":"2014","journal-title":"J. Food Nutr. Disord."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1093\/ajcn\/79.3.362","article-title":"Vitamin D: Importance in the prevention of cancers, type 1 diabetes, heart disease, and osteoporosis","volume":"79","author":"Holick","year":"2004","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_8","first-page":"888","article-title":"Extrarenal expression of 25-hydroxyvitamin d(3)-1 alpha-hydroxylase","volume":"86","author":"Zehnder","year":"2001","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1689S","DOI":"10.1093\/ajcn\/80.6.1689S","article-title":"Overview of general physiologic features and functions of vitamin D","volume":"80","author":"DeLuca","year":"2004","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_10","unstructured":"Marcus, R., Feldman, D., and Kelsey, J. (2001). Chapter 9\u2014Vitamin D: Biology, Action, and Clinical Implications. Osteoporosis, Academic Press. [2nd ed.]."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1210\/er.2008-0004","article-title":"Vitamin D and human health: Lessons from vitamin D receptor null mice","volume":"29","author":"Bouillon","year":"2008","journal-title":"Endocr. Rev."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"S73","DOI":"10.1111\/j.1753-4887.2008.00105.x","article-title":"Evolution of our understanding of vitamin D","volume":"66","author":"DeLuca","year":"2008","journal-title":"Nutr. Rev."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1006\/frne.1999.0189","article-title":"Rapid, nongenomic steroid actions: A new age?","volume":"21","author":"Schmidt","year":"2000","journal-title":"Front. Neuroendocrinol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"2799","DOI":"10.1021\/bi00790a023","article-title":"Isolation and identification of 1,25-dihydroxycholecalciferol. A metabolite of vitamin D active in intestine","volume":"10","author":"DeLuca","year":"1971","journal-title":"Biochemistry"},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Hii, C.S., and Ferrante, A. (2016). The Non-Genomic Actions of Vitamin D. Nutrients, 8.","DOI":"10.3390\/nu8030135"},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Donati, S., Palmini, G., Romagnoli, C., Aurilia, C., Miglietta, F., Falsetti, I., Marini, F., Zonefrati, R., Galli, G., and Marcucci, G. (2021). In Vitro Non-Genomic Effects of Calcifediol on Human Preosteoblastic Cells. Nutrients, 13.","DOI":"10.3390\/nu13124227"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1210\/endo-30-3-437","article-title":"Correlations between the chemical structure and the pharmacological actions of the steroids","volume":"30","author":"Selye","year":"1942","journal-title":"Endocrinology"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1172\/JCI104906","article-title":"Retardation of Sodium Exchange in Dog Erythrocytes by Physiological Concentrations of Aldosterone, In Vitro","volume":"43","author":"Spach","year":"1964","journal-title":"J. Clin. Investig."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.jsbmb.2009.11.011","article-title":"25-Hydroxyvitamin D(3) is an agonistic vitamin D receptor ligand","volume":"118","author":"Lou","year":"2010","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1515\/JPEM.2000.13.7.853","article-title":"Nongenomic Actions of Steroids-From the Laboratory to Clinical Implications","volume":"13","author":"Gerdes","year":"2000","journal-title":"J. Pediat. Endocrinol. Metab."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1476","DOI":"10.1210\/endo-115-4-1476","article-title":"Calcium transport in perfused duodena from normal chicks: Enhancement within fourteen minutes of exposure to 1,25-dihydroxyvitamin D3","volume":"115","author":"Nemere","year":"1984","journal-title":"Endocrinology"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"3215","DOI":"10.1093\/jn\/134.12.3215","article-title":"Rapid, Membrane-Initiated Actions of 1,25 Dihydroxyvitamin D: What Are They and What Do They Mean?","volume":"134","author":"Fleet","year":"2004","journal-title":"J. Nutr."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.jsbmb.2014.11.002","article-title":"Membrane-mediated actions of 1,25-dihydroxy vitamin D3: A review of the roles of phospholipase A2 activating protein and Ca (2+)\/calmodulin-dependent protein kinase II","volume":"147","author":"Doroudi","year":"2015","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"29643","DOI":"10.1074\/jbc.M204561200","article-title":"Role of MAP kinases in the 1,25-dihydroxyvitamin D3-induced transactivation of the rat cytochrome P450C24 (CYP24) promoter. Specific functions for ERK1\/ERK2 and ERK5","volume":"277","author":"Dwivedi","year":"2002","journal-title":"J. Biol. Chem."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1042\/BJ20041947","article-title":"Molecular action of 1,25-dihydroxyvitamin D3 and phorbol ester on the activation of the rat cytochrome P450C24 (CYP24) promoter: Role of MAP kinase activities and identification of an important transcription factor binding site","volume":"389","author":"Nutchey","year":"2005","journal-title":"Biochem. J."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1016\/j.cellsig.2009.11.009","article-title":"A role for the phosphatidylinositol 3-kinase--protein kinase C zeta-Sp1 pathway in the 1,25-dihydroxyvitamin D3 induction of the 25-hydroxyvitamin D3 24-hydroxylase gene in human kidney cells","volume":"22","author":"Dwivedi","year":"2010","journal-title":"Cell. Signal."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"5542","DOI":"10.1210\/en.2006-0946","article-title":"Vitamin D Receptor: New Assignments for an Already Busy Receptor","volume":"147","author":"Norman","year":"2006","journal-title":"Endocrinology"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1006\/bbrc.1994.1714","article-title":"Nonnuclear effects of the steroid hormone 1 alpha,25(OH)2-vitamin D3: Analogs are able to functionally differentiate between nuclear and membrane receptors","volume":"201","author":"Dormanen","year":"1994","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"296","DOI":"10.3389\/fphys.2016.00296","article-title":"Disruption of Vitamin D and Calcium Signaling in Keratinocytes Predisposes to Skin Cancer","volume":"7","author":"Bikle","year":"2016","journal-title":"Front. Physiol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.jsbmb.2016.11.020","article-title":"The role of vitamin D and VDR in carcinogenesis: Through epidemiology and basic sciences","volume":"167","author":"Morcillo","year":"2017","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/bs.vh.2015.10.006","article-title":"Hedgehog and Vitamin D Signaling Pathways in Development and Disease","volume":"100","author":"Hadden","year":"2016","journal-title":"Vitam. Horm."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1698","DOI":"10.1210\/me.2014-1043","article-title":"The Vitamin D Receptor Is Required for Activation of cWnt and Hedgehog Signaling in Keratinocytes","volume":"28","author":"Lisse","year":"2014","journal-title":"Mol. Endocrinol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"2289","DOI":"10.1038\/jid.2011.196","article-title":"Overexpression of hedgehog signaling is associated with epidermal tumor formation in vitamin D receptor-null mice","volume":"131","author":"Teichert","year":"2011","journal-title":"J. Investig. Dermatol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1002\/jcp.22227","article-title":"Disruption of the hedgehog signaling pathway contributes to the hair follicle cycling deficiency in Vdr knockout mice","volume":"225","author":"Teichert","year":"2010","journal-title":"J. Cell. Physiol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"104748","DOI":"10.1016\/j.tiv.2019.104748","article-title":"In vitro studies revealed a downregulation of Wnt\/\u03b2-catenin cascade by active vitamin D and TX 527 analog in a Kaposi\u2019s sarcoma cellular model","volume":"63","author":"Tapia","year":"2020","journal-title":"Toxicol. In Vitr."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"5986","DOI":"10.1158\/0008-5472.CAN-18-3927","article-title":"Vitamin D\u2013VDR Signaling Inhibits Wnt\/\u03b2-Catenin\u2013Mediated Melanoma Progression and Promotes Antitumor Immunity","volume":"79","author":"Muralidhar","year":"2019","journal-title":"Cancer Res."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1038\/s41374-018-0126-4","article-title":"Vitamin D protects human melanocytes against oxidative damage by activation of Wnt\/\u03b2-catenin signaling","volume":"98","author":"Tang","year":"2018","journal-title":"Lab. Investig."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"60","DOI":"10.3389\/fphys.2014.00060","article-title":"Interaction of vitamin D with membrane-based signaling pathways","volume":"5","author":"Larriba","year":"2014","journal-title":"Front. Physiol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"8587","DOI":"10.18632\/aging.102349","article-title":"A molecular sub-cluster of colon cancer cells with low VDR expression is sensitive to chemotherapy, BRAF inhibitors and PI3K-mTOR inhibitors treatment","volume":"11","author":"Wang","year":"2019","journal-title":"Aging"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1210\/en.2015-1685","article-title":"Evidence for Vitamin D Receptor Expression and Direct Effects of 1\u03b1,25(OH)2D3 in Human Skeletal Muscle Precursor Cells","volume":"157","author":"Olsson","year":"2016","journal-title":"Endocrinology"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1038\/nrg758","article-title":"Getting under the skin of epidermal morphogenesis","volume":"3","author":"Fuchs","year":"2002","journal-title":"Nat. Rev. Genet."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"2253","DOI":"10.1210\/endo-127-5-2253","article-title":"Nongenomic Activation of the Calcium Message System by Vitamin D Metabolites in Osteoblast-like Cells","volume":"127","author":"Civitelli","year":"1990","journal-title":"Endocrinology"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/0303-7207(91)90036-R","article-title":"Evidence on the participation of the 3\u2032,5\u2032-cyclic AMP pathway in the non-genomic action of 1,25-dihydroxy-vitamin D3 in cardiac muscle","volume":"82","author":"Selles","year":"1991","journal-title":"Mol. Cell. Endocrinol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1002\/jcb.240560411","article-title":"Binding characteristics of a membrane receptor that recognizes 1 alpha,25-dihydroxyvitamin D3 and its epimer, 1 beta,25-dihydroxyvitamin D3","volume":"56","author":"Baran","year":"1994","journal-title":"J. Cell. Biochem."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1002\/jcb.10716","article-title":"Membrane actions of vitamin D metabolites 1alpha,25(OH)2D3 and 24R,25(OH)2D3 are retained in growth plate cartilage cells from vitamin D receptor knockout mice","volume":"90","author":"Boyan","year":"2003","journal-title":"J. Cell. Biochem."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1210\/mend.14.9.0523","article-title":"Intracellular vitamin D binding proteins: Novel facilitators of vitamin D-directed transactivation","volume":"14","author":"Wu","year":"2000","journal-title":"Mol. Endocrinol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"504","DOI":"10.14573\/altex.1803161","article-title":"Reevaluating the role of megalin in renal vitamin D homeostasis using a human cell-derived microphysiological system","volume":"35","author":"Chapron","year":"2018","journal-title":"ALTEX"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"13895","DOI":"10.1073\/pnas.241516998","article-title":"Cubilin dysfunction causes abnormal metabolism of the steroid hormone 25(OH) vitamin D (3)","volume":"98","author":"Nykjaer","year":"2001","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1111\/exd.14147","article-title":"Vitamin D receptor(s): In the nucleus but also at membranes?","volume":"29","author":"Zmijewski","year":"2020","journal-title":"Exp. Dermatol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"23750","DOI":"10.1016\/S0021-9258(17)31579-X","article-title":"Identification of a specific binding protein for 1 alpha,25-dihydroxyvitamin D3 in basal-lateral membranes of chick intestinal epithelium and relationship to transcaltachia","volume":"269","author":"Nemere","year":"1994","journal-title":"J. Biol. Chem."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"7392","DOI":"10.1073\/pnas.0402207101","article-title":"Ribozyme knockdown functionally links a 1,25(OH)2D3 membrane binding protein (1,25D3-MARRS) and phosphate uptake in intestinal cells","volume":"101","author":"Nemere","year":"2004","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.jsbmb.2004.03.031","article-title":"Identification and characterization of 1,25D3-membrane-associated rapid response, steroid (1,25D3-MARRS) binding protein","volume":"89\u201390","author":"Nemere","year":"2004","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.pharmthera.2017.07.011","article-title":"Multifunctional molecule ERp57: From cancer to neurodegenerative diseases","volume":"181","author":"Hettinghouse","year":"2018","journal-title":"Pharmacol. Ther."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"112110","DOI":"10.1016\/j.biopha.2021.112110","article-title":"PDIA3: Structure, functions and its potential role in viral infections","volume":"143","author":"Mahmood","year":"2021","journal-title":"Biomed. Pharmacother."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.steroids.2013.10.019","article-title":"New insights on membrane mediated effects of 1\u03b1,25-dihydroxy vitamin D3 signaling in the musculoskeletal system","volume":"81","author":"Doroudi","year":"2014","journal-title":"Steroids"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.jsbmb.2012.03.001","article-title":"Phospholipase A2 activating protein is required for 1\u03b1,25-dihydroxyvitamin D3 dependent rapid activation of protein kinase C via Pdia3","volume":"132","author":"Doroudi","year":"2012","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1210\/me.2011-1161","article-title":"The role of the vitamin D receptor and ERp57 in photoprotection by 1\u03b1,25-dihydroxyvitamin D3","volume":"26","author":"Sequeira","year":"2012","journal-title":"Mol. Endocrinol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1615\/CritRevEukarGeneExpr.v17.i1.30","article-title":"Membrane receptors for vitamin D metabolites","volume":"17","author":"Khanal","year":"2007","journal-title":"Crit. Rev. Eukaryot. Gene Expr."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.jsbmb.2015.09.019","article-title":"Vitamin D-induced ectodomain shedding of TNF receptor 1 as a nongenomic action: D3 vs D2 derivatives","volume":"155","author":"Yang","year":"2016","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.jsbmb.2015.04.002","article-title":"A review of 1\u03b1,25(OH)2D3 dependent Pdia3 receptor complex components in Wnt5a non-canonical pathway signaling","volume":"152","author":"Doroudi","year":"2015","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.jsbmb.2010.05.004","article-title":"Disruption of Pdia3 gene results in bone abnormality and affects 1alpha,25-dihydroxy-vitamin D3-induced rapid activation of PKC","volume":"121","author":"Wang","year":"2010","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1038\/ni1288","article-title":"Impaired assembly of the major histocompatibility complex class I peptide-loading complex in mice deficient in the oxidoreductase ERp57","volume":"7","author":"Garbi","year":"2006","journal-title":"Nat. Immunol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"31859","DOI":"10.1074\/jbc.M110.116954","article-title":"Intestinal cell calcium uptake and the targeted knockout of the 1,25D3-MARRS (membrane-associated, rapid response steroid-binding) receptor\/PDIA3\/Erp57","volume":"285","author":"Nemere","year":"2010","journal-title":"J. Biol. Chem."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1210\/me.2012-1277","article-title":"Chaperone properties of pdia3 participate in rapid membrane actions of 1\u03b1,25-dihydroxyvitamin d3","volume":"27","author":"Chen","year":"2013","journal-title":"Mol. Endocrinol."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"37957","DOI":"10.1038\/srep37957","article-title":"Analysis of the interaction of calcitriol with the disulfide isomerase ERp57","volume":"6","author":"Gaucci","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1016\/j.steroids.2012.02.020","article-title":"Non-genomic effects of vitamin D in human spermatozoa","volume":"77","author":"Dissing","year":"2012","journal-title":"Steroids"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1093\/humrep\/der059","article-title":"Vitamin D Is Positively Associated with Sperm Motility and Increases Intracellular Calcium in Human Spermatozoa","volume":"26","author":"Bjerrum","year":"2011","journal-title":"Hum. Reprod."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.chembiol.2016.12.017","article-title":"Vitamin D Metabolite, 25-Hydroxyvitamin D, Regulates Lipid Metabolism by Inducing Degradation of SREBP\/SCAP","volume":"24","author":"Asano","year":"2017","journal-title":"Cell Chem. Biol."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1038\/nrm1009","article-title":"Nongenomic actions of steroid hormones","volume":"4","author":"Wehling","year":"2003","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1006\/bbrc.1997.7501","article-title":"Stimulation of Ca2+ release-activated Ca2+ channels as a potential mechanism involved in non-genomic 1,25(OH)2-vitamin D3-induced Ca2+ entry in skeletal muscle cells","volume":"239","author":"Vazquez","year":"1997","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1016\/j.beem.2011.05.010","article-title":"Vitamin D receptor (VDR)-mediated actions of 1\u03b1,25(OH)\u2082vitamin D\u2083: Genomic and non-genomic mechanisms","volume":"25","author":"Haussler","year":"2011","journal-title":"Best Pract. Res. Clin. Endocrinol. 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