{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T01:09:28Z","timestamp":1792112968825,"version":"4.4.0"},"reference-count":34,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2022,3,20]],"date-time":"2022-03-20T00:00:00Z","timestamp":1647734400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Foundation for Excellence in Mental Health Care (FEMHC)","award":["NA"],"award-info":[{"award-number":["NA"]}]},{"name":"Wells Fargo\/Gratis Foundation and the Nutrition and Mental Health Research Fund","award":["NA"],"award-info":[{"award-number":["NA"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>The association of household food insecurity with symptoms of attention deficit hyperactivity disorder (ADHD) and emotional dysregulation in children was examined in this study. We utilized baseline data from 134 children aged 6\u201312 years who were enrolled in a clinical trial investigating multinutrient supplementation as a treatment for ADHD and emotional dysregulation. Household food security status was assessed using the 18-item US Household Food Security Survey Module. The symptoms of ADHD and emotional dysregulation disorders (oppositional defiant disorder (ODD) and disruptive mood dysregulation disorder (DMDD)) were assessed using the Child and Adolescent Symptom Inventory-5 and other comorbid emotional dysregulation symptoms were assessed using the Strengths and Difficulties Questionnaire (SDQ). Multiple linear regression determined associations between household food security status and symptoms of ADHD, ODD and DMDD, emotional symptoms and conduct problems. Household food insecurity was associated with more severe emotional symptoms (\u03b2 = 2.30; 95% CI = 0.87\u20133.73; p = 0.002), conduct problems (\u03b2 = 1.15; 95% CI = 0.01\u20132.30; p = 0.049) and total difficulties scores (\u03b2 = 4.59; 95% CI = 1.82\u20137.37; p = 0.001) after adjusting for covariates (child\u2019s sex, parent marital status, household income, parental anxiety and other parental psychopathology). In unadjusted analyses, household food insecurity was also associated with increased ODD (\u03b2 = 0.58; 95% CI = 0.21\u20130.95; p = 0.003) and DMDD symptoms (\u03b2 = 0.69; 95% CI = 0.20\u20131.19; p = 0.006), but these associations attenuated to non-significance after adjusting for all covariates. Household food insecurity was associated with more severe emotional dysregulation symptoms. Discussing and addressing food insecurity may be appropriate initial steps for youths with ADHD and emotional dysregulation.<\/jats:p>","DOI":"10.3390\/nu14061306","type":"journal-article","created":{"date-parts":[[2022,3,20]],"date-time":"2022-03-20T21:34:27Z","timestamp":1647812067000},"page":"1306","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Household Food Insecurity Is Associated with Symptoms of Emotional Dysregulation in Children with Attention Deficit Hyperactivity Disorder: The MADDY Study"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0501-9088","authenticated-orcid":false,"given":"Irene E.","family":"Hatsu","sequence":"first","affiliation":[{"name":"Department of Human Sciences, The Ohio State University, Columbus, OH 43210, USA"},{"name":"OSU Extension, The Ohio State University, Columbus, OH 43210, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leanna","family":"Eiterman","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery, The Ohio State University, Columbus, OH 43210, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madeline","family":"Stern","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery, The Ohio State University, Columbus, OH 43210, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5941-533X","authenticated-orcid":false,"given":"Stacy","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Population, Family and Reproductive Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3947-5540","authenticated-orcid":false,"given":"Jeanette M.","family":"Johnstone","sequence":"additional","affiliation":[{"name":"Department of Child & Adolescent Psychiatry, Oregon Health & Science University, Portland, OR 97239, USA"},{"name":"Helfgott Research Institute, National University of Natural Medicine, Portland, OR 97201, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brenda M. Y.","family":"Leung","sequence":"additional","affiliation":[{"name":"Faculty of Health Sciences, University of Lethbridge, Lethbridge, AB T1K 3M4, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priya","family":"Srikanth","sequence":"additional","affiliation":[{"name":"School of Public Health, Oregon Health & Science University\u2014Portland State University, Portland, OR 97239, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Robinette","sequence":"additional","affiliation":[{"name":"Department of Human Sciences, The Ohio State University, Columbus, OH 43210, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriella","family":"Tost","sequence":"additional","affiliation":[{"name":"Department of Child & Adolescent Psychiatry, Oregon Health & Science University, Portland, OR 97239, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4018-5535","authenticated-orcid":false,"given":"James B.","family":"Odei","sequence":"additional","affiliation":[{"name":"Division of Biostatistics, College of Public Health, The Ohio State University, Columbus, OH 43210, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara L.","family":"Gracious","sequence":"additional","affiliation":[{"name":"Orange Park Medical Center, Orange Park, FL 32073, USA"},{"name":"Department of Psychiatry & Behavioral Health, The Ohio State University, Columbus, OH 43210, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. Eugene","family":"Arnold","sequence":"additional","affiliation":[{"name":"Department of Psychiatry & Behavioral Health, The Ohio State University, Columbus, OH 43210, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,3,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1016\/j.jaac.2016.07.774","article-title":"Functional Adult Outcomes 16 Years after Childhood Diagnosis of Attention-Deficit\/Hyperactivity Disorder: MTA Results","volume":"55","author":"Hechtman","year":"2016","journal-title":"J. Am. Acad. Child Adolesc. Psychiatry"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/S2215-0366(17)30167-0","article-title":"ADHD in children and young people: Prevalence, care pathways, and service provision","volume":"5","author":"Sayal","year":"2018","journal-title":"Lancet Psychiatry"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1111\/1469-7610.00742","article-title":"The comorbidity of ADHD in the general population of Swedish school-age children","volume":"42","author":"Gillberg","year":"2001","journal-title":"J. Child Psychol. Psychiatry Allied Discip."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1111\/jcpp.12899","article-title":"Practitioner Review: Emotional dysregulation in attention-deficit\/hyperactivity disorder\u2013implications for clinical recognition and intervention","volume":"60","author":"Faraone","year":"2019","journal-title":"J. Child Psychol. Psychiatry"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1007\/s00787-015-0738-9","article-title":"Comorbidity and correlates of disruptive mood dysregulation disorder in 6\u20138-year-old children with ADHD","volume":"25","author":"Mulraney","year":"2016","journal-title":"Eur. Child Adolesc. Psychiatry"},{"key":"ref_6","first-page":"291","article-title":"Attention deficit hyperactivity disorder (ADHD)","volume":"9","year":"2011","journal-title":"J. Pediatr. Neurol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1126\/science.160.3825.265","article-title":"Orthomolecular psychiatry. Varying the concentrations of substances normally present in the human body may control mental disease","volume":"160","author":"Pauling","year":"1968","journal-title":"Science"},{"key":"ref_8","first-page":"127","article-title":"The influence of components of diet on the symptoms of ADHD in children","volume":"63","author":"Konikowska","year":"2012","journal-title":"Rocz. Pa\u0144stw. Zak\u0142. Hig."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/j.psychres.2019.05.043","article-title":"Focus on Disruptive Mood Dysregulation Disorder: A review of the literature","volume":"279","author":"Bruno","year":"2019","journal-title":"Psychiatry Res."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1177\/1087054710365990","article-title":"ADHD is associated with a \u201cWestern\u201d dietary pattern in adolescents","volume":"15","author":"Howard","year":"2011","journal-title":"J. Atten. Disord."},{"key":"ref_11","first-page":"6","article-title":"Micronutrient deficiencies in ADHD: A global research consensus","volume":"32","author":"Greenblatt","year":"2017","journal-title":"J. Orthomol. Med."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.jaac.2011.10.015","article-title":"Meta-analysis of attention-deficit\/hyperactivity disorder or attention-deficit\/hyperactivity disorder symptoms, restriction diet, and synthetic food color additives","volume":"51","author":"Nigg","year":"2012","journal-title":"J. Am. Acad. Child Adolesc. Psychiatry"},{"key":"ref_13","unstructured":"Kaplan, B.J., and Rucklidge, J.J. (2021). The Better Brain: Overcome Antiety, Combact Depression, and Reduce ADHD, and Stress with Nutrition, Houghton Mifflin Harcourt."},{"key":"ref_14","unstructured":"Hamilton, W.L., Cook, J.T., Thompson, W.W., and Buron, L.F. (1997). Household Food Security in the United States in 1995: Summary Report of the Food Security Measurement Project, Abt Associates."},{"key":"ref_15","unstructured":"Coleman-Jensen, A., Rabbitt, M.P., Gregory, C.A., and Singh, A. (2020). Household Food Security in the United States in 2019, ERR-270."},{"key":"ref_16","unstructured":"Tarasuk, V., and Mitchell, A. (2020). Household Food Insecurity in Canada, 2017\u20132018, Research to Identify Policy Options to Reduce Food Insecurity Food Insecurity and Policy Research (PROOF)."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1830","DOI":"10.1377\/hlthaff.2015.0645","article-title":"Food insecurity and health outcomes","volume":"34","author":"Gundersen","year":"2015","journal-title":"Health Aff."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1097\/DBP.0000000000000383","article-title":"Association of Food Insecurity with Children\u2019s Behavioral, Emotional, and Academic Outcomes: A Systematic Review","volume":"38","author":"Shankar","year":"2017","journal-title":"J. Dev. Behav. Pediatr."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Lu, S., Perez, L., Leslein, A., and Hatsu, I. (2019). The Relationship between Food Insecurity and Symptoms of Attention-Deficit Hyperactivity Disorder in Children: A Summary of the Literature. Nutrients, 11.","DOI":"10.3390\/nu11030659"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"100478","DOI":"10.1016\/j.conctc.2019.100478","article-title":"Rationale and design of an international randomized placebo-controlled trial of a 36-ingredient micronutrient supplement for children with ADHD and irritable mood: The Micronutrients for ADHD in Youth (MADDY) Study","volume":"16","author":"Johnstone","year":"2019","journal-title":"Contemp. Clin. Trials Commun."},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Johnstone, J.M., Hatsu, I., Tost, G., Srikanth, P., Eiterman, L.P., Bruton, A.M., and Arnold, L.E. (2021). Micronutrients for Attention-Deficit\/Hyperactivity Disorder in Youths: A Placebo-Controlled Randomized Clinical Trial. J. Am. Acad. Child Adolesc. Psychiatry.","DOI":"10.1016\/j.jaac.2021.07.005"},{"key":"ref_22","unstructured":"Gadow, K., and Sprafkin, J. (2013). Child & Adolescent Symptom Inventory-5 Manual, Checkmate Plus."},{"key":"ref_23","unstructured":"Bickel, G., Cristofer, P., William, H., and John, C. (2000). Guide to Measuring Household Food Security."},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Coleman-Jensen, A., Gregory, C., and Singh, A. (2014). Household food security in the United States in 2013, ERR-173.","DOI":"10.2139\/ssrn.2504067"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1097\/01.chi.0000159157.57075.c8","article-title":"The Strengths and Difficulties Questionnaire: U.S. normative data and psychometric properties","volume":"44","author":"Bourdon","year":"2005","journal-title":"J. Am. Acad. Child Adolesc. Psychiatry"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1111\/j.1469-7610.1997.tb01545.x","article-title":"The Strengths and Difficulties Questionnaire: A research note","volume":"38","author":"Goodman","year":"1997","journal-title":"J. Child Psychol. Psychiatry Allied Discip."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1991","DOI":"10.1016\/j.jand.2017.09.027","article-title":"Position of the Academy of Nutrition and Dietetics: Food insecurity in the United States","volume":"117","author":"Holben","year":"2017","journal-title":"J. Acad. Nutr. Diet."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1080\/07315724.2015.1080527","article-title":"Mitigation of Inflammation-Induced Mood Dysregulation by Long-Chain Omega-3 Fatty Acids","volume":"34","author":"McNamara","year":"2015","journal-title":"J. Am. Coll. Nutr."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1037\/0033-2909.133.5.747","article-title":"Vitamins, minerals, and mood","volume":"133","author":"Kaplan","year":"2007","journal-title":"Psychol. Bull."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.ypmed.2016.08.012","article-title":"The role of food insecurity in developmental psychopathology","volume":"92","author":"Althoff","year":"2016","journal-title":"Prev. Med."},{"key":"ref_31","first-page":"9","article-title":"Food Insecurity and the Behavioral and Intellectual Development of Children: A Review of the Evidence","volume":"3","year":"2012","journal-title":"J. Appl. Res. Child."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"2943","DOI":"10.1017\/S1368980014001414","article-title":"Food security status among grade 5 students in Nova Scotia, Canada and its association with health outcomes","volume":"18","author":"Kirk","year":"2015","journal-title":"Public Health Nutr."},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Melchior, M., Chastang, J.-F., Falissard, B., Gal\u00e9ra, C., Tremblay, R.E., C\u00f4t\u00e9, S.M., and Boivin, M. (2012). Food insecurity and children\u2019s mental health: A prospective birth cohort study. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0052615"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1542\/peds.2012-2390","article-title":"Racial and ethnic disparities in ADHD diagnosis from kindergarten to eighth grade","volume":"132","author":"Morgan","year":"2013","journal-title":"Pediatrics"}],"container-title":["Nutrients"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6643\/14\/6\/1306\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T22:39:52Z","timestamp":1760135992000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6643\/14\/6\/1306"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3,20]]},"references-count":34,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2022,3]]}},"alternative-id":["nu14061306"],"URL":"https:\/\/doi.org\/10.3390\/nu14061306","relation":{},"ISSN":["2072-6643"],"issn-type":[{"value":"2072-6643","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,3,20]]}}}