{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T22:55:26Z","timestamp":1771455326215,"version":"3.50.1"},"reference-count":60,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2022,3,21]],"date-time":"2022-03-21T00:00:00Z","timestamp":1647820800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Abbott (Spain)","award":["NA"],"award-info":[{"award-number":["NA"]}]},{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["MR\/P021220\/1"],"award-info":[{"award-number":["MR\/P021220\/1"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["MR\/T026014\/1"],"award-info":[{"award-number":["MR\/T026014\/1"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"name":"MRC\u2010Versus Arthritis Centre for Musculoskeletal Ageing Research awarded to the Universities of Nottingham and Birmingham","award":["NA"],"award-info":[{"award-number":["NA"]}]},{"DOI":"10.13039\/501100020624","name":"NIHR Nottingham Biomedical Research Centre","doi-asserted-by":"publisher","award":["NA"],"award-info":[{"award-number":["NA"]}],"id":[{"id":"10.13039\/501100020624","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Therapeutic interventions aimed at enhancing blood flow may combat the postprandial vascular and metabolic dysfunction that manifests with chronological ageing. We compared the effects of acute curcumin (1000 mg) coupled with an oral nutritional supplement (ONS, 7.5 g protein, 24 g carbohydrate and 6 g fat) versus a placebo and ONS (control) on cerebral and leg macrovascular blood flow, leg muscle microvascular blood flow, brachial artery endothelial function, and leg insulin and glucose responses in healthy older adults (n = 12, 50% male, 73 \u00b1 1 year). Curcumin enhanced m. tibialis anterior microvascular blood volume (MBV) at 180 and 240 min following the ONS (baseline: 1.0 vs. 180 min: 1.08 \u00b1 0.02, p = 0.01 vs. 240 min: 1.08 \u00b1 0.03, p = 0.01), and MBV was significantly higher compared with the control at both time points (p &lt; 0.05). MBV increased from baseline in the m. vastus lateralis at 240 min after the ONS in both groups (p &lt; 0.05), and there were no significant differences between groups. Following the ONS, leg blood flow and leg vascular conductance increased, and leg vascular resistance decreased similarly in both conditions (p &lt; 0.05). Brachial artery flow-mediated dilation and middle cerebral artery blood flow were unchanged in both conditions (p &gt; 0.05). Similarly, the curcumin and control groups demonstrated comparable increases in glucose uptake and insulin in response to the ONS. Thus, acute curcumin supplementation enhanced ONS-induced increases in m. tibialis anterior MBV without potentiating m. vastus lateralis MBV, muscle glucose uptake, or systemic endothelial or macrovascular function in healthy older adults.<\/jats:p>","DOI":"10.3390\/nu14061313","type":"journal-article","created":{"date-parts":[[2022,3,21]],"date-time":"2022-03-21T21:48:42Z","timestamp":1647899322000},"page":"1313","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Curcumin Enhances Fed-State Muscle Microvascular Perfusion but Not Leg Glucose Uptake in Older Adults"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2281-6479","authenticated-orcid":false,"given":"Colleen S.","family":"Deane","sequence":"first","affiliation":[{"name":"Department of Sport and Health Sciences, College of Life and Environmental Sciences, University of Exeter, Exeter EX1 2LU, UK"},{"name":"Living Systems Institute, University of Exeter, Stocker Road, Exeter EX4 4QD, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ushnah S. U.","family":"Din","sequence":"additional","affiliation":[{"name":"MRC-Versus Arthritis Centre for Musculoskeletal Ageing Research and National Institute for Health Research Nottingham Biomedical Research Centre, School of Medicine, University of Nottingham, Derby DE22 3DT, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tanvir S.","family":"Sian","sequence":"additional","affiliation":[{"name":"MRC-Versus Arthritis Centre for Musculoskeletal Ageing Research and National Institute for Health Research Nottingham Biomedical Research Centre, School of Medicine, University of Nottingham, Derby DE22 3DT, UK"},{"name":"Department of Surgery and Anaesthetics, Royal Derby Hospital, Derby DE22 3NE, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8971-6635","authenticated-orcid":false,"given":"Ken","family":"Smith","sequence":"additional","affiliation":[{"name":"MRC-Versus Arthritis Centre for Musculoskeletal Ageing Research and National Institute for Health Research Nottingham Biomedical Research Centre, School of Medicine, University of Nottingham, Derby DE22 3DT, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amanda","family":"Gates","sequence":"additional","affiliation":[{"name":"MRC-Versus Arthritis Centre for Musculoskeletal Ageing Research and National Institute for Health Research Nottingham Biomedical Research Centre, School of Medicine, University of Nottingham, Derby DE22 3DT, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5195-2181","authenticated-orcid":false,"given":"Jonathan N.","family":"Lund","sequence":"additional","affiliation":[{"name":"MRC-Versus Arthritis Centre for Musculoskeletal Ageing Research and National Institute for Health Research Nottingham Biomedical Research Centre, School of Medicine, University of Nottingham, Derby DE22 3DT, UK"},{"name":"Department of Surgery and Anaesthetics, Royal Derby Hospital, Derby DE22 3NE, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John P.","family":"Williams","sequence":"additional","affiliation":[{"name":"MRC-Versus Arthritis Centre for Musculoskeletal Ageing Research and National Institute for Health Research Nottingham Biomedical Research Centre, School of Medicine, University of Nottingham, Derby DE22 3DT, UK"},{"name":"Department of Surgery and Anaesthetics, Royal Derby Hospital, Derby DE22 3NE, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2127-3190","authenticated-orcid":false,"given":"Ricardo","family":"Rueda","sequence":"additional","affiliation":[{"name":"Research and Development, Abbott Nutrition, 18004 Granada, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5491-7266","authenticated-orcid":false,"given":"Suzette L.","family":"Pereira","sequence":"additional","affiliation":[{"name":"Research and Development, Abbott Nutrition, Columbus, OH 43219, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7286-046X","authenticated-orcid":false,"given":"Philip J.","family":"Atherton","sequence":"additional","affiliation":[{"name":"MRC-Versus Arthritis Centre for Musculoskeletal Ageing Research and National Institute for Health Research Nottingham Biomedical Research Centre, School of Medicine, University of Nottingham, Derby DE22 3DT, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bethan E.","family":"Phillips","sequence":"additional","affiliation":[{"name":"MRC-Versus Arthritis Centre for Musculoskeletal Ageing Research and National Institute for Health Research Nottingham Biomedical Research Centre, School of Medicine, University of Nottingham, Derby DE22 3DT, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,3,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2078","DOI":"10.1161\/CIRCULATIONAHA.109.873232","article-title":"The polypill in the prevention of cardiovascular diseases: Key concepts, current status, challenges, and future directions","volume":"122","author":"Lonn","year":"2010","journal-title":"Circulation"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1161\/CIR.0b013e3182285a81","article-title":"Value of primordial and primary prevention for cardiovascular disease: A policy statement from the American Heart Association","volume":"124","author":"Weintraub","year":"2011","journal-title":"Circulation"},{"key":"ref_3","first-page":"e38","article-title":"Heart Disease and Stroke Statistics-2016 Update: A Report From the American Heart 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