{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T18:47:01Z","timestamp":1787510821788,"version":"build-2736575974"},"reference-count":150,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2022,3,22]],"date-time":"2022-03-22T00:00:00Z","timestamp":1647907200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>BACKGROUND: Non-alcoholic fatty liver disease (NAFLD) is a prevalent metabolic disorder. Defects in function\/expression of genes\/proteins are critical in initiation\/progression of NAFLD. Natural products may modulate these genes\/proteins. Curcumin improves steatosis, inflammation, and fibrosis progression. Here, bioinformatic tools, gene\u2013drug and gene-disease databases were utilized to explore targets, interactions, and pathways through which curcumin could impact NAFLD. METHODS: Significant curcumin\u2013protein interaction was identified (high-confidence:0.7) in the STITCH database. Identified proteins were investigated to determine association with NAFLD. gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) were analyzed for significantly involved targets (p &lt; 0.01). Specificity of obtained targets with NAFLD was estimated and investigated in Tissue\/Cells\u2013gene associations (PanglaoDB Augmented 2021, Mouse Gene Atlas) and Disease\u2013gene association-based EnrichR algorithms (Jensen DISEASES, DisGeNET). RESULTS: Two collections were constructed: 227 protein\u2013curcumin interactions and 95 NAFLD-associated genes. By Venn diagram, 14 significant targets were identified, and their biological pathways evaluated. Based on gene ontology, most targets involved stress and lipid metabolism. KEGG revealed chemical carcinogenesis, the AGE-RAGE signaling pathway in diabetic complications and NAFLD as the most common significant pathways. Specificity to diseases database (EnrichR algorithm) revealed specificity for steatosis\/steatohepatitis. CONCLUSION: Curcumin may improve, or inhibit, progression of NAFLD through activation\/inhibition of NAFLD-related genes.<\/jats:p>","DOI":"10.3390\/nu14071331","type":"journal-article","created":{"date-parts":[[2022,3,22]],"date-time":"2022-03-22T23:30:23Z","timestamp":1647991823000},"page":"1331","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Investigation of the Effect of Curcumin on Protein Targets in NAFLD Using Bioinformatic Analysis"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1864-4766","authenticated-orcid":false,"given":"Ali","family":"Mahmoudi","sequence":"first","affiliation":[{"name":"Department of Medical Biotechnology and Nanotechnology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad 9177899191, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5762-3917","authenticated-orcid":false,"given":"Alexandra E.","family":"Butler","sequence":"additional","affiliation":[{"name":"Research Department, Royal College of Surgeons in Ireland Bahrain, Adliya 15503, Bahrain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammed","family":"Majeed","sequence":"additional","affiliation":[{"name":"Sabinsa Corporation, East Windsor, NJ 08520, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6690-6874","authenticated-orcid":false,"given":"Maciej","family":"Banach","sequence":"additional","affiliation":[{"name":"Nephrology and Hypertension, Department of Preventive Cardiology and Lipidology, Medical University of Lodz, 93-338 Lodz, Poland"},{"name":"Cardiovascular Research Centre, University of Zielona Gora, 65-417 Zielona Gora, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8656-1444","authenticated-orcid":false,"given":"Amirhossein","family":"Sahebkar","sequence":"additional","affiliation":[{"name":"Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad 9177899191, Iran"},{"name":"Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad 9177899191, Iran"},{"name":"Department of Biotechnology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad 9177899191, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,3,22]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"206","DOI":"10.5009\/gnl20127","article-title":"Recent Epidemiology of Nonalcoholic Fatty Liver Disease","volume":"15","author":"Murag","year":"2021","journal-title":"Gut Liver"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.cld.2017.08.007","article-title":"Pathophysiology of Nonalcoholic Fatty Liver Disease\/Nonalcoholic Steatohepatitis","volume":"22","author":"Manne","year":"2018","journal-title":"Clin. Liver Dis."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1016\/j.dsx.2019.03.009","article-title":"Prevalence of non-alcoholic fatty liver disease in patients with diabetes mellitus, hyperlipidemia, obesity and polycystic ovary syndrome: A cross-sectional study in north of Iran","volume":"13","author":"Joukar","year":"2019","journal-title":"Diabetes Metab. Syndr. Clin. Res. Rev."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1691","DOI":"10.1136\/gutjnl-2020-320622","article-title":"NAFLD and increased risk of cardiovascular disease: Clinical associations, pathophysiological mechanisms and pharmacological implications","volume":"69","author":"Targher","year":"2020","journal-title":"Gut"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1002\/hep.28431","article-title":"Global epidemiology of nonalcoholic fatty liver disease-Meta-analytic assessment of prevalence, incidence, and outcomes","volume":"64","author":"Younossi","year":"2016","journal-title":"Hepatology"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1002\/ncp.10449","article-title":"Evolution of NAFLD and Its Management","volume":"35","author":"Mundi","year":"2020","journal-title":"Nutr. Clin. Pract."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"461","DOI":"10.3350\/cmh.2020.0136","article-title":"Precision medicine in nonalcoholic fatty liver disease: New therapeutic insights from genetics and systems biology","volume":"26","author":"Sookoian","year":"2020","journal-title":"Clin. Mol. Hepatol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1038\/s41575-019-0169-z","article-title":"NAFLD in children: New genes, new diagnostic modalities and new drugs","volume":"16","author":"Nobili","year":"2019","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Chen, Q., Wang, T., Li, J., Wang, S., Qiu, F., Yu, H., Zhang, Y., and Wang, T. (2017). Effects of Natural Products on Fructose-Induced Nonalcoholic Fatty Liver Disease (NAFLD). Nutrients, 9.","DOI":"10.3390\/nu9020096"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1007\/s12072-019-10001-4","article-title":"New drugs for NAFLD: Lessons from basic models to the clinic","volume":"14","author":"Reimer","year":"2020","journal-title":"Hepatol. Int."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"8116","DOI":"10.2174\/0929867327666201111145212","article-title":"Anti-tumor Effects of Curcuminoids in Glioblastoma Multiforme: An Updated Literature Review","volume":"28","author":"Afshari","year":"2021","journal-title":"Curr. Med. Chem."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Gorabi, A.M., Kiaie, N., Hajighasemi, S., Jamialahmadi, T., Majeed, M., and Sahebkar, A. (2019). The Effect of Curcumin on the Differentiation of Mesenchymal Stem Cells into Mesodermal Lineage. Molecules, 24.","DOI":"10.3390\/molecules24224029"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"104765","DOI":"10.1016\/j.phrs.2020.104765","article-title":"Curcumin: A phytochemical modulator of estrogens and androgens in tumors of the reproductive system","volume":"156","author":"Mohajeri","year":"2020","journal-title":"Pharmacol. Res."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1016\/j.tifs.2020.03.026","article-title":"The potential role of plant-derived natural products in improving arterial stiffness: A review of dietary intervention studies","volume":"99","author":"Alidadi","year":"2020","journal-title":"Trends Food Sci. Technol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"5728","DOI":"10.1002\/jcp.27442","article-title":"Curcumin as an anti-inflammatory agent: Implications to radiotherapy and chemotherapy","volume":"234","author":"Farhood","year":"2019","journal-title":"J. Cell. Physiol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.phrs.2017.02.008","article-title":"Effects of curcumin on HDL functionality","volume":"119","author":"Ganjali","year":"2017","journal-title":"Pharmacol. Res."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"12537","DOI":"10.1002\/jcp.28122","article-title":"Mechanisms of apoptosis modulation by curcumin: Implications for cancer therapy","volume":"234","author":"Mortezaee","year":"2019","journal-title":"J. Cell. Physiol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1055\/s-0034-1389986","article-title":"Short-term Curcuminoid Supplementation for Chronic Pulmonary Complications due to Sulfur Mustard Intoxication: Positive Results of a Randomized Double-blind Placebo-controlled Trial","volume":"65","author":"Panahi","year":"2014","journal-title":"Drug Res."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.phrs.2018.09.012","article-title":"Therapeutic potential of curcumin in diabetic complications","volume":"136","author":"Parsamanesh","year":"2018","journal-title":"Pharmacol. Res."},{"key":"ref_20","first-page":"1192","article-title":"Analgesic Efficacy and Safety of Curcuminoids in Clinical Practice: A Systematic Review and Meta-Analysis of Randomized Controlled Trials","volume":"17","author":"Sahebkar","year":"2016","journal-title":"Pain Med."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"5643","DOI":"10.1002\/jcp.27404","article-title":"Curcumin: A naturally occurring autophagy modulator","volume":"234","author":"Shakeri","year":"2019","journal-title":"J. Cell. Physiol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"6768","DOI":"10.1002\/ptr.7264","article-title":"Current clinical developments in curcumin-based therapeutics for cancer and chronic diseases","volume":"35","author":"Kumar","year":"2021","journal-title":"Phytotherapy Res."},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Amato, A., Caldara, G.-F., Nuzzo, D., Baldassano, S., Picone, P., Rizzo, M., Mul\u00e8, F., and Di Carlo, M. (2017). NAFLD and Atherosclerosis Are Prevented by a Natural Dietary Supplement Containing Curcumin, Silymarin, Guggul, Chlorogenic Acid and Inulin in Mice Fed a High-Fat Diet. Nutrients, 9.","DOI":"10.3390\/nu9050492"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1007\/s00394-019-01916-7","article-title":"Effects of phytosomal curcumin on anthropometric parameters, insulin resistance, cortisolemia and non-alcoholic fatty liver disease indices: A double-blind, placebo-controlled clinical trial","volume":"59","author":"Cicero","year":"2020","journal-title":"Eur. J. Nutr."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"102447","DOI":"10.1016\/j.ctim.2020.102447","article-title":"A pilot study of the effect of curcumin on epigenetic changes and DNA damage among patients with non-alcoholic fatty liver disease: A randomized, double-blind, placebo-controlled, clinical trial","volume":"51","author":"Hariri","year":"2020","journal-title":"Complement. Ther. Med."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"102283","DOI":"10.1016\/j.ctim.2019.102283","article-title":"The effects of curcumin supplementation on liver function, metabolic profile and body composition in patients with non-alcoholic fatty liver disease: A systematic review and meta-analysis of randomized controlled trials","volume":"48","author":"Jalali","year":"2020","journal-title":"Complement. Ther. Med."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1016\/j.jhep.2004.08.010","article-title":"Curcumin inhibits NF-\u03baB activation and reduces the severity of experimental steatohepatitis in mice","volume":"41","author":"Leclercq","year":"2004","journal-title":"J. Hepatol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1540","DOI":"10.1002\/ptr.5659","article-title":"Treatment of Non-alcoholic Fatty Liver Disease with Curcumin: A Randomized Placebo-controlled Trial","volume":"30","author":"Rahmani","year":"2016","journal-title":"Phytother. Res."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"102322","DOI":"10.1016\/j.ctim.2020.102322","article-title":"Effects of curcuminoids on inflammatory status in patients with non-alcoholic fatty liver disease: A randomized controlled trial","volume":"49","author":"Keshvari","year":"2020","journal-title":"Complement. Ther. Med."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1038\/labinvest.2009.112","article-title":"Curcumin limits the fibrogenic evolution of experimental steatohepatitis","volume":"90","author":"Vizzutti","year":"2010","journal-title":"Lab. Investig."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.phrs.2017.12.020","article-title":"Medicinal plants and bioactive natural compounds in the treatment of non-alcoholic fatty liver disease: A clinical review","volume":"130","author":"Bagherniya","year":"2018","journal-title":"Pharmacol. Res."},{"key":"ref_32","first-page":"268925","article-title":"Systems Biology: The Next Frontier for Bioinformatics","volume":"2010","author":"McConville","year":"2010","journal-title":"Adv. Bioinform."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"D552","DOI":"10.1093\/nar\/gkp937","article-title":"STITCH 2: An interaction network database for small molecules and proteins","volume":"38","author":"Kuhn","year":"2010","journal-title":"Nucleic Acids Res."},{"key":"ref_34","first-page":"D845","article-title":"The DisGeNET knowledge platform for disease genomics: 2019 update","volume":"48","author":"Ronzano","year":"2020","journal-title":"Nucleic Acids Res."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.ymeth.2014.11.020","article-title":"DISEASES: Text mining and data integration of disease\u2013gene associations","volume":"74","author":"Tsafou","year":"2015","journal-title":"Methods"},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"The Gene Ontology Consortium (2015). gene ontology Consortium: Going forward. Nucleic Acids Res., 43, D1049\u2013D1056.","DOI":"10.1093\/nar\/gku1179"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1093\/nar\/28.1.27","article-title":"KEGG: Kyoto Encyclopedia of Genes and Genomes","volume":"28","author":"Kanehisa","year":"2000","journal-title":"Nucleic Acids Res."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"2498","DOI":"10.1101\/gr.1239303","article-title":"Cytoscape: A software environment for integrated models of Biomolecular Interaction Networks","volume":"13","author":"Shannon","year":"2003","journal-title":"Genome Res."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"W90","DOI":"10.1093\/nar\/gkw377","article-title":"Enrichr: A comprehensive gene set enrichment analysis web server 2016 update","volume":"44","author":"Kuleshov","year":"2016","journal-title":"Nucleic Acids Res."},{"key":"ref_40","first-page":"baz046","article-title":"PanglaoDB: A web server for exploration of mouse and human single-cell RNA sequencing data","volume":"2019","author":"Gan","year":"2019","journal-title":"Database"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1007\/s00335-015-9589-4","article-title":"Mouse Genome Informatics (MGI): Reflecting on 25 years","volume":"26","author":"Eppig","year":"2015","journal-title":"Mamm. Genome"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"S47","DOI":"10.1016\/j.jhep.2014.12.012","article-title":"NAFLD: A multisystem disease","volume":"62","author":"Byrne","year":"2015","journal-title":"J. Hepatol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1111\/liv.13031","article-title":"The story of HCC in NAFLD: From epidemiology, across pathogenesis, to prevention and treatment","volume":"36","author":"Margini","year":"2016","journal-title":"Liver Int. J."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"e13789","DOI":"10.14814\/phy2.13789","article-title":"Curcumin supplementation mitigates NASH development and progression in female Wistar rats","volume":"6","author":"Cunningham","year":"2018","journal-title":"Physiol. Rep."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"4146","DOI":"10.3748\/wjg.v23.i23.4146","article-title":"Antioxidant dietary approach in treatment of fatty liver: New insights and updates","volume":"23","author":"Ferramosca","year":"2017","journal-title":"World J. Gastroenterol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"108938","DOI":"10.1016\/j.biopha.2019.108938","article-title":"Therapeutic effects of curcumin and ursodexycholic acid on non-alcoholic fatty liver disease","volume":"115","author":"Gheibi","year":"2019","journal-title":"Biomed. Pharmacother."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.biochi.2016.12.019","article-title":"The role and regulation of the peroxisome proliferator activated receptor alpha in human liver","volume":"136","author":"Kersten","year":"2017","journal-title":"Biochimie"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"F122","DOI":"10.1152\/ajprenal.00352.2017","article-title":"PPAR\u03b1 agonist fenofibrate enhances fatty acid \u03b2-oxidation and attenuates polycystic kidney and liver disease in mice","volume":"314","author":"Lakhia","year":"2018","journal-title":"Am. J. Physiol. Physiol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1254\/jphs.13149FP","article-title":"Fibrates Reduce Triacylglycerol Content by Upregulating Adipose Triglyceride Lipase in the Liver of Rats","volume":"123","author":"Karahashi","year":"2013","journal-title":"J. Pharmacol. Sci."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1186\/1476-511X-11-120","article-title":"Dietary Fructus Schisandrae extracts and fenofibrate regulate the serum\/hepatic lipid-profile in normal and hypercholesterolemic mice, with attention to hepatotoxicity","volume":"11","author":"Pan","year":"2012","journal-title":"Lipids Health Dis."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1254\/jphs.13087FP","article-title":"A Novel Mouse Model of Combined Hyperlipidemia Associated with Steatosis and Liver Injury by a Single-Dose Intragastric Administration of Schisandrin B\/Cholesterol\/Bile Salts Mixture","volume":"123","author":"Pan","year":"2013","journal-title":"J. Pharmacol. Sci."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"211","DOI":"10.2147\/IJGM.S17376","article-title":"The effects of diet-induced obesity on hepatocyte insulin signaling pathways and induction of non-alcoholic liver damage","volume":"4","author":"Naderali","year":"2011","journal-title":"Int. J. Gen. Med."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1111\/j.1440-1681.2007.04547.x","article-title":"Effects of Fenofibrate and Xuezhikang on Highfat Diet-induced Nonalcoholic Fatty Liver Disease","volume":"34","author":"Hong","year":"2007","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1016\/j.jhep.2005.10.033","article-title":"Early diet-induced non-alcoholic steatohepatitis in APOE2 knock-in mice and its prevention by fibrates","volume":"44","author":"Wouters","year":"2006","journal-title":"J. Hepatol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1111\/liv.13634","article-title":"Dual PPAR\u03b1\/\u03b3 agonist saroglitazar improves liver histopathology and biochemistry in experimental NASH models","volume":"38","author":"Jain","year":"2018","journal-title":"Liver Int."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.biopha.2016.11.114","article-title":"Potential involvement of PPAR \u03b1 activation in diminishing the hepatoprotective effect of fenofibrate in NAFLD: Accuracy of non- invasive panel in determining the stage of liver fibrosis in rats","volume":"85","author":"Hamed","year":"2017","journal-title":"Biomed. Pharmacother."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1111\/j.1440-1746.2006.04819.x","article-title":"PPAR agonists treatment is effective in a nonalcoholic fatty liver disease animal model by modulating fatty-acid metabolic enzymes","volume":"23","author":"Seo","year":"2006","journal-title":"J. Gastroenterol. Hepatol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"101600","DOI":"10.1016\/j.redox.2020.101600","article-title":"Curcumin blunts epithelial-mesenchymal transition of hepatocytes to alleviate hepatic fibrosis through regulating oxidative stress and autophagy","volume":"36","author":"Kong","year":"2020","journal-title":"Redox Biol."},{"key":"ref_59","first-page":"277","article-title":"Diet polyphenol curcumin stimulates hepatic Fgf21 production and restores its sensitivity in high fat diet fed male mice","volume":"158","author":"Zeng","year":"2017","journal-title":"Endocrinology"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.cotox.2018.12.005","article-title":"Is Nrf2-ARE a potential target in NAFLD mitigation?","volume":"13","author":"Li","year":"2019","journal-title":"Curr. Opin. Toxicol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/j.freeradbiomed.2009.11.007","article-title":"Loss of Nrf2 markedly exacerbates nonalcoholic steatohepatitis","volume":"48","author":"Chowdhry","year":"2010","journal-title":"Free Radic. Biol. Med."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.freeradbiomed.2015.12.014","article-title":"Hepatocyte-specific Keap1 deletion reduces liver steatosis but not inflammation during non-alcoholic steatohepatitis development","volume":"91","author":"Ramadori","year":"2016","journal-title":"Free Radic. Biol. Med."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1093\/toxsci\/kfu184","article-title":"Activation of the Nrf2-ARE pathway in hepatocytes protects against steatosis in nutritionally induced non-alcoholic steatohepatitis in mice","volume":"142","author":"Lee","year":"2014","journal-title":"Toxicol. Sci."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"1949","DOI":"10.1080\/15548627.2020.1712108","article-title":"SQSTM1\/p62 activates NFE2L2\/NRF2 via ULK1-mediated autophagic KEAP1 degradation and protects mouse liver from lipotoxicity","volume":"16","author":"Lee","year":"2020","journal-title":"Autophagy"},{"key":"ref_65","first-page":"116","article-title":"Curcumin Activates the Nrf2 Pathway and Induces Cellular Protection Against Oxidative Injury","volume":"20","author":"Ashrafizadeh","year":"2020","journal-title":"Curr. Mol. Med."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.biopha.2018.05.135","article-title":"Curcumin regulates endogenous and exogenous metabolism via Nrf2-FXR-LXR pathway in NAFLD mice","volume":"105","author":"Yan","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"ref_67","doi-asserted-by":"crossref","unstructured":"Peng, X., Dai, C., Liu, Q., Li, J., and Qiu, J. (2018). Curcumin Attenuates on Carbon Tetrachloride-Induced Acute Liver Injury in Mice via Modulation of the Nrf2\/HO-1 and TGF-\u03b21\/Smad3 Pathway. Molecules, 23.","DOI":"10.3390\/molecules23010215"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.biopha.2017.08.037","article-title":"Nrf2 activation is required for curcumin to induce lipocyte phenotype in hepatic stellate cells","volume":"95","author":"Lu","year":"2017","journal-title":"Biomed. Pharmacother."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1002\/iub.597","article-title":"Association of nonalcoholic fatty liver disease with a single nucleotide polymorphism on the gene encoding leptin receptor","volume":"64","author":"Swellam","year":"2012","journal-title":"IUBMB Life"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"3095","DOI":"10.11569\/wcjd.v20.i32.3095","article-title":"Impaired activation of phosphatidylinositol 3-kinase by leptin in NAFLD: A novel mechanism of hepatic leptin resistance","volume":"20","author":"Xu","year":"2012","journal-title":"World Chin. J. Dig."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"1703","DOI":"10.5754\/hge11005","article-title":"Impaired Activation of Phosphatidylinositol 3-Kinase by Leptin is a Novel Mechanism of Hepatic Leptin Resistance in NAFLD","volume":"58","author":"Xu","year":"2011","journal-title":"Hepatogastroenterology"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"3011","DOI":"10.1210\/en.2008-1601","article-title":"Curcumin Eliminates Leptin\u2019s Effects on Hepatic Stellate Cell Activation via Interrupting Leptin Signaling","volume":"150","author":"Tang","year":"2009","journal-title":"Endocrinology"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1097\/TA.0b013e3182826eba","article-title":"Localized leptin release may be an important mechanism of curcumin action after acute ischemic injuries","volume":"74","author":"Deng","year":"2013","journal-title":"J. Trauma Acute Care Surg."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1186\/1475-2867-14-66","article-title":"Curcumin inhibits leptin gene expression and secretion in breast cancer cells by estrogen receptors","volume":"14","author":"Akbarzadeh","year":"2014","journal-title":"Cancer Cell Int."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"1753","DOI":"10.3109\/21691401.2015.1101000","article-title":"The anticancer effects of biodegradable nanomagnetic dual natural components on the leptin gene expression in lung cancer","volume":"44","author":"Askari","year":"2016","journal-title":"Artif. Cells Nanomed. Biotechnol."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1159\/000516892","article-title":"Curcumin Affects Leptin-Induced Expression of Methionine Adenosyltransferase 2A in Hepatic Stellate Cells by Inhibition of JNK Signaling","volume":"106","author":"Lu","year":"2021","journal-title":"Pharmacology"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1111\/bjh.16853","article-title":"Low-density lipoprotein receptor (LDLR) is an independent adverse prognostic factor in acute myeloid leukaemia","volume":"192","author":"Floeth","year":"2021","journal-title":"Br. J. Haematol."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"8250","DOI":"10.1038\/s41598-021-87761-3","article-title":"Extra virgin olive oil improved body weight and insulin sensitivity in high fat diet-induced obese LDLr\u2212\/\u2212.Leiden mice without attenuation of steatohepatitis","volume":"11","author":"Sierra","year":"2021","journal-title":"Sci. Rep."},{"key":"ref_79","doi-asserted-by":"crossref","unstructured":"Schoemaker, M.H., Kleemann, R., Morrison, M.C., Verheij, J., Salic, K., Van Tol, E.A.F., Kooistra, T., and Wielinga, P.Y. (2017). A casein hydrolysate based formulation attenuates obesity and associated non-alcoholic fatty liver disease and atherosclerosis in LDLr-\/-.Leiden mice. PLoS ONE, 12.","DOI":"10.1371\/journal.pone.0180648"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.freeradbiomed.2016.03.032","article-title":"A Western diet induced NAFLD in LDLR\u2212\/\u2212 mice is associated with reduced hepatic glutathione synthesis","volume":"96","author":"Li","year":"2016","journal-title":"Free Radic. Biol. Med."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/j.gastrohep.2020.09.014","article-title":"Silencing HIF-1\u03b1 aggravates non-alcoholic fatty liver disease in vitro through inhibiting PPAR-\u03b1\/ANGPTL4 singling pathway","volume":"44","author":"He","year":"2020","journal-title":"Gastroenterol. Hepatol."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"2133","DOI":"10.1002\/mnfr.201400366","article-title":"Curcumin enhances cell-surface LDLR level and promotes LDL uptake through downregulation of PCSK9 gene expression in HepG2 cells","volume":"58","author":"Tai","year":"2014","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_83","first-page":"572","article-title":"Effect of curcumin on the expression of low density lipoprotein receptor in HepG2 cell line","volume":"42","author":"Dou","year":"2007","journal-title":"Chin. Pharm. J."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1111\/1750-3841.13647","article-title":"Curcumin Protects Against Intestinal Origin Endotoxemia in Rat Liver Cirrhosis by Targeting PCSK9","volume":"82","author":"Cai","year":"2017","journal-title":"J. Food Sci."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"126719","DOI":"10.1016\/j.bmcl.2019.126719","article-title":"Design, synthesis, and enzymatic characterization of quinazoline-based CYP1A2 inhibitors","volume":"30","author":"Corral","year":"2020","journal-title":"Bioorganic Med. Chem. Lett."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"1567","DOI":"10.1111\/jphp.12646","article-title":"Diet-induced non-alcoholic fatty liver disease affects expression of major cytochrome P450 genes in a mouse model","volume":"68","author":"Chiba","year":"2016","journal-title":"J. Pharm. Pharmacol."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.cbi.2015.06.022","article-title":"Effect of tetrahydrocurcumin on the profiles of drug-metabolizing enzymes induced by a high fat and high fructose diet in mice","volume":"239","author":"Jearapong","year":"2015","journal-title":"Chem.-Biol. Interact."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"2087","DOI":"10.1124\/dmd.109.027466","article-title":"Hepatic Cytochrome P450 Enzyme Alterations in Humans with Progressive Stages of Nonalcoholic Fatty Liver Disease","volume":"37","author":"Fisher","year":"2009","journal-title":"Drug Metab. Dispos."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1345\/aph.1M533","article-title":"Plant Polyphenol Curcumin Significantly Affects CYPIA2 and CYP2A6 Activity in Healthy, Male Chinese Volunteers","volume":"44","author":"Chen","year":"2010","journal-title":"Ann. Pharmacother."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"104959","DOI":"10.1016\/j.pestbp.2021.104959","article-title":"The ameliorative effect of curcumin on hepatic CYP1A1 and CYP1A2 genes dysregulation and hepatorenal damage induced by fenitrothion oral intoxication in male rats","volume":"179","author":"Moustafa","year":"2021","journal-title":"Pestic. Biochem. Physiol."},{"key":"ref_91","first-page":"339","article-title":"Suppression of hepatocyte CYP1A2 expression by Kupffer cells via AhR pathway: The central role of proinflammatory cytokines","volume":"18","author":"Wu","year":"2006","journal-title":"Int. J. Mol. Med."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.tox.2007.03.007","article-title":"Inhibition of human recombinant cytochrome P450s by curcumin and curcumin decomposition products","volume":"235","author":"Appiahopong","year":"2007","journal-title":"Toxicology"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1016\/j.atherosclerosis.2011.05.014","article-title":"Liver transcriptional profile of atherosclerosis-related genes in human nonalcoholic fatty liver disease","volume":"218","author":"Sookoian","year":"2011","journal-title":"Atherosclerosis"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"151626","DOI":"10.1016\/j.aanat.2020.151626","article-title":"Can Dasatinib Ameliorate the Hepatic changes, Induced by Long Term Western Diet, in Mice?","volume":"234","author":"Elsayed","year":"2021","journal-title":"Ann. Anat. Anat. Anz."},{"key":"ref_95","first-page":"E3","article-title":"Fatty liver creates a pro-metastatic microenvironment for hepatocellular carcinoma through activation of hepatic stellate cells","volume":"136","author":"Mikuriya","year":"2014","journal-title":"Int. J. Cancer"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/j.cyto.2006.02.006","article-title":"Increased production of IL-1\u03b1 and TNF-\u03b1 in lipopolysaccharide-stimulated blood from obese patients with non-alcoholic fatty liver disease","volume":"33","author":"Poniachik","year":"2006","journal-title":"Cytokine"},{"key":"ref_97","first-page":"413","article-title":"Curcumin, a compound with anti-inflammatory and anti-oxidant properties, down-regulates chemokine expression in bone marrow stromal cells","volume":"25","author":"Xu","year":"1997","journal-title":"Exp. Hematol."},{"key":"ref_98","first-page":"49","article-title":"Curcumin inhibits IL1\u03b1 and TNF\u03b1 induction of AP-1 and NF-kB DNA-binding activity in bone marrow stromal cells","volume":"11","author":"Xu","year":"1997","journal-title":"Hematopathol. Mol. Hematol."},{"key":"ref_99","doi-asserted-by":"crossref","unstructured":"Michaud, V., Tran, M., Pronovost, B., Bouchard, P., Bilodeau, S., Alain, K., Vadnais, B., Franco, M., B\u00e9langer, F., and Turgeon, J. (2019). Impact of GSTA1 Polymorphisms on Busulfan Oral Clearance in Adult Patients Undergoing Hematopoietic Stem Cell Transplantation. Pharmaceutics, 11.","DOI":"10.3390\/pharmaceutics11090440"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.toxlet.2013.04.019","article-title":"Interactive effects of smoking and glutathione S-transferase polymorphisms on the development of non-alcoholic fatty liver disease","volume":"220","author":"Oniki","year":"2013","journal-title":"Toxicol. Lett."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.jff.2017.04.039","article-title":"Antioxidant and anti-inflammatory effects of Chinese propolis during palmitic acid-induced lipotoxicity in cultured hepatocytes","volume":"34","author":"Jin","year":"2017","journal-title":"J. Funct. Foods"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"87","DOI":"10.2131\/jts.45.87","article-title":"Taurine attenuates hepatic steatosis in a genetic model of fatty liver disease","volume":"45","author":"Miyata","year":"2020","journal-title":"J. Toxicol. Sci."},{"key":"ref_103","doi-asserted-by":"crossref","unstructured":"Miyata, M., Matsushita, K., Shindo, R., Shimokawa, Y., Sugiura, Y., and Yamashita, M. (2020). Selenoneine Ameliorates Hepatocellular Injury and Hepatic Steatosis in a Mouse Model of NAFLD. Nutrients, 12.","DOI":"10.3390\/nu12061898"},{"key":"ref_104","doi-asserted-by":"crossref","unstructured":"Robin, S.K.D., Ansari, M., and Uppugunduri, C.R.S. (2020). Spectrophotometric Screening for Potential Inhibitors of Cytosolic Glutathione S-Transferases. J. Vis. Exp., e61347.","DOI":"10.3791\/61347-v"},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1002\/ptr.3297","article-title":"Role of alpha class glutathione transferases (GSTs) in chemoprevention: GSTA1 and A4 overexpressing human leukemia (HL60) cells resist sulforaphane and curcumin induced toxicity","volume":"25","author":"Sharma","year":"2011","journal-title":"Phytother. Res."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1080\/01635581.2012.700994","article-title":"The Influence of Curcumin, Quercetin, and Eicosapentaenoic Acid on the Expression of Phase II Detoxification Enzymes in the Intestinal Cell Lines HT-29, Caco-2, HuTu 80, and LT97","volume":"64","author":"Odenthal","year":"2012","journal-title":"Nutr. Cancer"},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"3038","DOI":"10.4238\/2011.December.6.4","article-title":"Genetic polymorphism of the glutathione-S-transferase P1 gene (GSTP1) and susceptibility to prostate cancer in the Kashmiri population","volume":"10","author":"Qadri","year":"2011","journal-title":"Genet. Mol. Res."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1111\/j.1478-3231.2008.01794.x","article-title":"Association between combinations of glutathione-S-transferaseM1, T1 and P1 genotypes and non-alcoholic fatty liver disease","volume":"29","author":"Hori","year":"2009","journal-title":"Liver Int."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.jnutbio.2009.11.009","article-title":"Integrated hepatic transcriptome and proteome analysis of mice with high-fat diet-induced nonalcoholic fatty liver disease","volume":"22","author":"Kirpich","year":"2011","journal-title":"J. Nutr. Biochem."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"455","DOI":"10.3103\/S0095452717060111","article-title":"Variation in particular biochemical indicators, cytokine and adipokine profiles of the blood, and the structural and functional parameters of the liver in patients with nonalcoholic fatty liver disease and different genotypes by the polymorphic locus A313G of the GSTP1 gene","volume":"51","author":"Prysyazhnyuk","year":"2017","journal-title":"Cytol. Genet."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1089\/dna.2011.1343","article-title":"Association of Genetic Polymorphisms of Glutathione-S-Transferase Genes (GSTT1, GSTM1, and GSTP1) and Susceptibility to Nonalcoholic Fatty Liver Disease in Zahedan, Southeast Iran","volume":"31","author":"Hashemi","year":"2012","journal-title":"DNA Cell Biol."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.toxlet.2007.03.011","article-title":"Curcumin activates human glutathione S-transferase P1 expression through antioxidant response element","volume":"170","author":"Nishinaka","year":"2007","journal-title":"Toxicol. Lett."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1016\/S0006-2952(03)00501-X","article-title":"Induction of apoptosis by curcumin: Mediation by glutathione S-transferase P1-1 inhibition","volume":"66","author":"Duvoix","year":"2003","journal-title":"Biochem. Pharmacol."},{"key":"ref_114","first-page":"2478","article-title":"Relationship of GSTP1 lower expression and multidrug resistance reversing of curcumin on human colon carcinoma cells","volume":"95","author":"Li","year":"2015","journal-title":"Zhonghua Yi Xue Za Zhi"},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1002\/sctm.19-0372","article-title":"GARP is a key molecule for mesenchymal stromal cell responses to TGF-\u03b2 and fundamental to control mitochondrial ROS levels","volume":"9","author":"Cara","year":"2020","journal-title":"STEM CELLS Transl. Med."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1002\/hep4.1789","article-title":"Distinct Hepatic Gene-Expression Patterns of NAFLD in Patients with Obesity","volume":"6","author":"Subudhi","year":"2021","journal-title":"Hepatol. Commun."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"118619","DOI":"10.1016\/j.lfs.2020.118619","article-title":"Significance of MR\/OPN\/HMGB1 axis in NAFLD-associated hepatic fibrogenesis","volume":"264","author":"Tang","year":"2021","journal-title":"Life Sci."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"3011","DOI":"10.1167\/iovs.16-20633","article-title":"Transforming Growth Factor ?1\u2013Induced NADPH Oxidase-4 Expression and Fibrotic Response in Conjunctival Fibroblasts","volume":"58","author":"Brown","year":"2017","journal-title":"Investig. Opthalmol. Vis. Sci."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1159\/000369714","article-title":"Curcumin Treatment Suppresses CCR7 Expression and the Differentiation and Migration of Human Circulating Fibrocytes","volume":"35","author":"Fu","year":"2015","journal-title":"Cell. Physiol. Biochem."},{"key":"ref_120","first-page":"689","article-title":"Inhibitory effects of curcumin on inflammatory cytokines in rats with paraquat poisoning","volume":"33","author":"Li","year":"2015","journal-title":"Chin. J. Ind. Hyg. Occup. Dis."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1038\/326403a0","article-title":"Compartmentalization of a haematopoietic growth factor (GM-CSF) by glycosaminoglycans in the bone marrow microenvironment","volume":"326","author":"Gordon","year":"1987","journal-title":"Nature"},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"100062","DOI":"10.1016\/j.jhepr.2019.11.006","article-title":"Liver fibrosis and CD206+ macrophage accumulation are suppressed by anti-GM-CSF therapy","volume":"2","author":"Lai","year":"2020","journal-title":"JHEP Rep."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"6615881","DOI":"10.1155\/2021\/6615881","article-title":"A Combination of Geniposide and Chlorogenic Acid Combination Ameliorates Nonalcoholic Steatohepatitis in Mice by Inhibiting Kupffer Cell Activation","volume":"2021","author":"Xin","year":"2021","journal-title":"BioMed Res. Int."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1089\/met.2020.0116","article-title":"A High-Fat Diet Induces Lower Systemic Inflammation than a High-Carbohydrate Diet in Mice","volume":"19","author":"Antunes","year":"2021","journal-title":"Metab. Syndr. Relat. Disord."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"132","DOI":"10.3389\/fphys.2018.00132","article-title":"Key Inflammatory Processes in Human NASH Are Reflected in Ldlr\u2212\/\u2212.Leiden Mice: A Translational Gene Profiling Study","volume":"9","author":"Morrison","year":"2018","journal-title":"Front. Physiol."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1016\/S0006-2952(97)00220-7","article-title":"Curcumin inhibition of Dermatophagoides farinea-induced interleukin-5 (IL-5) and granulocyte macrophage-colony stimulating factor (GM-CSF) production by lymphocytes from bronchial asthmatics","volume":"54","author":"Kobayashi","year":"1997","journal-title":"Biochem. Pharmacol."},{"key":"ref_127","first-page":"6411","article-title":"Enhanced Systemic Bioavailability of Curcumin Through Transmucosal Administration of a Novel Microgranular Formulation","volume":"35","author":"Latimer","year":"2015","journal-title":"Anticancer Res."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1042\/bj3320281","article-title":"The extended protein kinase C superfamily","volume":"332","author":"Mellor","year":"1998","journal-title":"Biochem. J."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1016\/j.cmet.2012.03.005","article-title":"Diacylglycerol Activation of Protein Kinase C\u03b5 and Hepatic Insulin Resistance","volume":"15","author":"Jornayvaz","year":"2012","journal-title":"Cell Metab."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"1997","DOI":"10.1016\/j.celrep.2017.05.035","article-title":"Hepatic Diacylglycerol-Associated Protein Kinase C\u03b5 Translocation Links Hepatic Steatosis to Hepatic Insulin Resistance in Humans","volume":"19","author":"Gilijamse","year":"2017","journal-title":"Cell Rep."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1002\/hep.26672","article-title":"Nonalcoholic fatty liver disease, hepatic insulin resistance, and type 2 Diabetes","volume":"59","author":"Birkenfeld","year":"2013","journal-title":"Hepatology"},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"6327","DOI":"10.1021\/acs.biochem.6b00932","article-title":"Curcumin Inhibits Protein Kinase C\u03b1 Activity by Binding to Its C1 Domain","volume":"55","author":"Pany","year":"2016","journal-title":"Biochemistry"},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1194\/jlr.M067397","article-title":"Curcumin inhibits lipolysis via suppression of ER stress in adipose tissue and prevents hepatic insulin resistance","volume":"57","author":"Wang","year":"2016","journal-title":"J. Lipid Res."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"402","DOI":"10.3109\/03602530903491741","article-title":"ABCC2\/Abcc2: A multispecific transporter with dominant excretory functions","volume":"42","author":"Jemnitz","year":"2010","journal-title":"Drug Metab. Rev."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1016\/j.jnutbio.2008.07.005","article-title":"Polymorphisms of MRP2 (ABCC2) are associated with susceptibility to nonalcoholic fatty liver disease","volume":"20","author":"Sookoian","year":"2009","journal-title":"J. Nutr. Biochem."},{"key":"ref_136","first-page":"5337","article-title":"Curcumin resistance induced by hypoxia in HepG2 cells is mediated by multidrug-resistance-associated proteins","volume":"32","author":"Sakulterdkiat","year":"2012","journal-title":"Anticancer Res."},{"key":"ref_137","first-page":"6869","article-title":"The modulation study of multiple drug resistance in bladder cancer by curcumin and resveratrol","volume":"18","author":"Cho","year":"2019","journal-title":"Oncol. Lett."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1002\/kjm2.12306","article-title":"Decreased drug resistance of bladder cancer using phytochemicals treatment","volume":"37","author":"Cho","year":"2021","journal-title":"Kaohsiung J. Med Sci."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"113905","DOI":"10.1016\/j.bcp.2020.113905","article-title":"Modulation of aryl hydrocarbon receptor (AHR) and the NAD+-consuming enzyme CD38: Searches of therapeutic options for nonalcoholic fatty liver disease (NAFLD)","volume":"175","author":"Bock","year":"2020","journal-title":"Biochem. Pharmacol."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"114220","DOI":"10.1016\/j.bcp.2020.114220","article-title":"Aryl hydrocarbon receptor (AHR)-mediated inflammation and resolution: Non-genomic and genomic signaling","volume":"182","author":"Bock","year":"2020","journal-title":"Biochem. Pharmacol."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"2518","DOI":"10.1111\/j.1349-7006.2008.00984.x","article-title":"Curcumin attenuates cytochrome P450 induction in response to 2,3,7,8-tetrachlorodibenzo-p-dioxin by ROS-dependently degrading AhR and ARNT","volume":"99","author":"Choi","year":"2008","journal-title":"Cancer Sci."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.abb.2007.08.007","article-title":"Curcumin suppresses the transformation of an aryl hydrocarbon receptor through its phosphorylation","volume":"466","author":"Nishiumi","year":"2007","journal-title":"Arch. Biochem. Biophys."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"BSR20170869","DOI":"10.1042\/BSR20170869","article-title":"PKC\u03b4 silencing alleviates saturated fatty acid induced ER stress by enhancing SERCA activity","volume":"37","author":"Lai","year":"2017","journal-title":"Biosci. Rep."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"69","DOI":"10.3233\/CBM-190169","article-title":"Identification of genes in hepatocellular carcinoma induced by non-alcoholic fatty liver disease","volume":"29","author":"Cai","year":"2020","journal-title":"Cancer Biomarkers"},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"19320","DOI":"10.1073\/pnas.1012044107","article-title":"Sarco(endo)plasmic reticulum Ca 2+ -ATPase 2b is a major regulator of endoplasmic reticulum stress and glucose homeostasis in obesity","volume":"107","author":"Park","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"2616","DOI":"10.1007\/s00125-009-1543-0","article-title":"Diverse roles for protein kinase C \u03b4 and protein kinase C \u03b5 in the generation of high-fat-diet-induced glucose intolerance in mice: Regulation of lipogenesis by protein kinase C \u03b4","volume":"52","author":"Frangioudakis","year":"2009","journal-title":"Diabetologia"},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"2504","DOI":"10.1172\/JCI46045","article-title":"PKC\u03b4 regulates hepatic insulin sensitivity and hepatosteatosis in mice and humans","volume":"121","author":"Bezy","year":"2011","journal-title":"J. Clin. Investig."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1016\/j.bbrc.2006.01.065","article-title":"Role of protein kinase C \u03b4 in curcumin-induced antioxidant response element-mediated gene expression in human monocytes","volume":"341","author":"Rushworth","year":"2006","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"1214","DOI":"10.1002\/jcb.21348","article-title":"Delayed activation of PKC\u03b4 and NF\u03baB and higher radioprotection in splenic lymphocytes by copper (II)\u2013Curcumin (1:1) complex as compared to curcumin","volume":"102","author":"Kunwar","year":"2007","journal-title":"J. Cell. Biochem."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1002\/jcp.21206","article-title":"Heme oxygenase-1 mediates the anti-inflammatory effect of Curcumin within LPS-stimulated human monocytes","volume":"215","author":"Hsu","year":"2008","journal-title":"J. Cell. Physiol."}],"container-title":["Nutrients"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6643\/14\/7\/1331\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T22:41:12Z","timestamp":1760136072000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6643\/14\/7\/1331"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3,22]]},"references-count":150,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2022,4]]}},"alternative-id":["nu14071331"],"URL":"https:\/\/doi.org\/10.3390\/nu14071331","relation":{},"ISSN":["2072-6643"],"issn-type":[{"value":"2072-6643","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,3,22]]}}}