{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T22:24:01Z","timestamp":1790029441743,"version":"4.0.1"},"reference-count":62,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2022,3,25]],"date-time":"2022-03-25T00:00:00Z","timestamp":1648166400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100009376","name":"Harokopio University","doi-asserted-by":"publisher","award":["-"],"award-info":[{"award-number":["-"]}],"id":[{"id":"10.13039\/501100009376","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010353","name":"Hellenic Atherosclerosis Society","doi-asserted-by":"publisher","award":["-"],"award-info":[{"award-number":["-"]}],"id":[{"id":"10.13039\/501100010353","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Evidence from research studies reports that wine consumption is associated with lower cardiovascular disease risk, partly through the amelioration of oxidative stress. The aim of the present study was to examine the effect of regular light to moderate wine consumption from coronary heart disease (CHD) patients compared to the effect induced by alcohol intake without the presence of wine microconstituents, on oxidation-induced macromolecular damage as well as on endogenous antioxidant enzyme activity. A randomized, single-blind, controlled, three-arm parallel intervention was carried out, in which 64 CHD patients were allocated to three intervention groups. Group A consumed no alcohol, and Group B (wine) and Group C (ethanol) consumed 27 g of alcohol\/day for 8 weeks. Blood and urine samples were collected at baseline and at 4 and 8 weeks. Urine oxidized guanine species levels, protein carbonyls, thiobarbituric acid substances (TBARS) levels, as well as superoxide dismutase (SOD) and glutathione peroxidase (GPx) activities, were measured. Oxidized guanine species and protein carbonyl levels were significantly increased in the ethanol group during the intervention and were significantly decreased in the wine group. These results support the idea that wine\u2019s bioactive compounds may exert antioxidant actions that counteract the macromolecular oxidative damage induced by alcohol in CHD patients.<\/jats:p>","DOI":"10.3390\/nu14071377","type":"journal-article","created":{"date-parts":[[2022,3,27]],"date-time":"2022-03-27T21:29:36Z","timestamp":1648416576000},"page":"1377","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Effect of Moderate Wine Consumption on Oxidative Stress Markers in Coronary Heart Disease Patients"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4364-9489","authenticated-orcid":false,"given":"Maria","family":"Choleva","sequence":"first","affiliation":[{"name":"Department of Nutrition and Dietetics, Harokopio University, 70 Eleftheriou Venizelou Avenue Kallithea, 17671 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chrysa","family":"Argyrou","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Dietetics, Harokopio University, 70 Eleftheriou Venizelou Avenue Kallithea, 17671 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Detopoulou","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Dietetics, Harokopio University, 70 Eleftheriou Venizelou Avenue Kallithea, 17671 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria-Eleni","family":"Donta","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Dietetics, Harokopio University, 70 Eleftheriou Venizelou Avenue Kallithea, 17671 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anastasia","family":"Gerogianni","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Dietetics, Harokopio University, 70 Eleftheriou Venizelou Avenue Kallithea, 17671 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evanggelia","family":"Moustou","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Dietetics, Harokopio University, 70 Eleftheriou Venizelou Avenue Kallithea, 17671 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Androniki","family":"Papaemmanouil","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Dietetics, Harokopio University, 70 Eleftheriou Venizelou Avenue Kallithea, 17671 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Skitsa","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Dietetics, Harokopio University, 70 Eleftheriou Venizelou Avenue Kallithea, 17671 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Genovefa","family":"Kolovou","sequence":"additional","affiliation":[{"name":"Cardiology Department, Onassis Cardiac Surgery Center, 17674 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petros","family":"Kalogeropoulos","sequence":"additional","affiliation":[{"name":"Department of Cardiology, General Ongology Hospital, 14564 Kifisia, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Fragopoulou","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Dietetics, Harokopio University, 70 Eleftheriou Venizelou Avenue Kallithea, 17671 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,3,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1161\/CIR.0000000000000510","article-title":"Dietary Fats and Cardiovascular Disease: A Presidential Advisory from the American Heart Association","volume":"136","author":"Sacks","year":"2017","journal-title":"Circulation"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1097\/00075197-200503000-00004","article-title":"Phospholipid Mediators in the Vessel Wall: Involvement in Atherosclerosis","volume":"8","author":"Ninio","year":"2005","journal-title":"Curr. Opin. Clin. Nutr. Metab. Care"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1002\/ejlt.200300845","article-title":"Platelet Activating Factor\u2013A Molecular Link between Atherosclerosis Theories","volume":"105","author":"Demopoulos","year":"2003","journal-title":"Eur. J. Lipid Sci. Technol."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Senoner, T., and Dichtl, W. (2019). Oxidative Stress in Cardiovascular Diseases: Still a Therapeutic Target?. Nutrients, 11.","DOI":"10.3390\/nu11092090"},{"key":"ref_5","first-page":"1017","article-title":"Factors Associated with Cardiac Mortality in Developed Countries with Particular Reference to the Consumption of Wine","volume":"1","author":"Cochrane","year":"1979","journal-title":"Lancet"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.1016\/0140-6736(92)91277-F","article-title":"Wine, Alcohol, Platelets, and the French Paradox for Coronary Heart Disease","volume":"339","author":"Renaud","year":"1992","journal-title":"Lancet"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/j.atherosclerosis.2009.06.031","article-title":"Wine and Oxidative Stress: Up-to-Date Evidence of the Effects of Moderate Wine Consumption on Oxidative Damage in Humans","volume":"208","author":"Covas","year":"2010","journal-title":"Atherosclerosis"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1007\/s10654-011-9631-0","article-title":"Wine, Beer or Spirit Drinking in Relation to Fatal and Non-Fatal Cardiovascular Events: A Meta-Analysis","volume":"26","author":"Costanzo","year":"2011","journal-title":"Eur. J. Epidemiol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.pcad.2018.02.001","article-title":"Alcohol and CV Health: Jekyll and Hyde J-Curves","volume":"61","author":"DiNicolantonio","year":"2018","journal-title":"Prog. Cardiovasc. Dis."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1016\/j.jacc.2010.01.006","article-title":"Alcohol Consumption and Mortality in Patients with Cardiovascular Disease: A Meta-Analysis","volume":"55","author":"Costanzo","year":"2010","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1651","DOI":"10.1016\/j.amjcard.2010.01.339","article-title":"Comparison of Outcomes Among Moderate Alcohol Drinkers Before Acute Myocardial Infarction to Effect of Continued Versus Discontinuing Alcohol Intake After the Infarct","volume":"105","author":"Carter","year":"2010","journal-title":"Am. J. Cardiol."},{"key":"ref_12","first-page":"131","article-title":"Lipid Minor Constituents in Wines. A Biochemical Approach in the French Paradox","volume":"1","author":"Fragopoulou","year":"2009","journal-title":"Int. J. Wine Res."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.1021\/jf990554p","article-title":"Separation of Biologically Active Lipids from Red Wine","volume":"48","author":"Fragopoulou","year":"2000","journal-title":"J. Agric. Food Chem."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"5186","DOI":"10.1021\/jf0106392","article-title":"Biological Activity of Total Lipids from Red and White Wine\/Must","volume":"49","author":"Fragopoulou","year":"2001","journal-title":"J. Agric. Food Chem."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"2684","DOI":"10.1021\/jf011288u","article-title":"Biologically Active Lipids with Antiatherogenic Properties from White Wine and Must","volume":"50","author":"Fragopoulou","year":"2002","journal-title":"J. Agric. Food Chem."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/S1388-1981(03)00066-0","article-title":"Structure Elucidation of Phenolic Compounds from Red\/White Wine with Antiatherogenic Properties","volume":"1632","author":"Fragopoulou","year":"2003","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.foodchem.2014.05.085","article-title":"Effect of Robola and Cabernet Sauvignon Extracts on Platelet Activating Factor Enzymes Activity on U937 Cells","volume":"165","author":"Xanthopoulou","year":"2014","journal-title":"Food Chem"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1016\/j.foodchem.2009.10.058","article-title":"Antioxidant and Anti-Inflammatory Activity of Red and White Wine Extracts","volume":"120","author":"Xanthopoulou","year":"2010","journal-title":"Food Chem."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.foodchem.2014.12.092","article-title":"In Vitro Assessment of Antioxidant Activity of Tyrosol, Resveratrol and Their Acetylated Derivatives","volume":"177","author":"Vlachogianni","year":"2015","journal-title":"Food Chem."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.prostaglandins.2015.09.001","article-title":"Platelet Activating Factor (PAF) Biosynthesis Is Inhibited by Phenolic Compounds in U-937 Cells under Inflammatory Conditions","volume":"121","author":"Vlachogianni","year":"2015","journal-title":"Prostaglandins Other Lipid Mediat."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.metabol.2018.01.024","article-title":"Wine and Its Metabolic Effects. A Comprehensive Review of Clinical Trials","volume":"83","author":"Fragopoulou","year":"2018","journal-title":"Metabolism."},{"key":"ref_22","first-page":"217","article-title":"Postprandial Effects of Wine Consumption on Lipids and Oxidative Stress Biomarkers","volume":"29","author":"Covas","year":"2003","journal-title":"Drugs Exp. Clin. Res."},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Micallef, M., Lexis, L., and Lewandowski, P. (2007). Red Wine Consumption Increases Antioxidant Status and Decreases Oxidative Stress in the Circulation of Both Young and Old Humans. Nutr. J., 6.","DOI":"10.1186\/1475-2891-6-27"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"203","DOI":"10.33549\/physiolres.930936","article-title":"Effect of White Wine Consumption on Oxidative Stress Markers and Homocysteine Levels","volume":"56","author":"Rajdl","year":"2007","journal-title":"Physiol. Res."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1093\/alcalc\/ags086","article-title":"Effect of Red Wine Consumption on Biomarkers of Oxidative Stress","volume":"48","author":"Schrieks","year":"2013","journal-title":"Alcohol Alcohol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.numecd.2009.07.006","article-title":"Moderate Consumption of Red Wine, but Not Gin, Decreases Erythrocyte Superoxide Dismutase Activity: A Randomised Cross-over Trial","volume":"21","author":"Estruch","year":"2011","journal-title":"Nutr. Metab. Cardiovasc. Dis. NMCD"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1079\/BJN20041311","article-title":"The Influence of Moderate Red Wine Consumption on Antioxidant Status and Indices of Oxidative Stress Associated with CHD in Healthy Volunteers","volume":"93","author":"Tsang","year":"2005","journal-title":"Br. J. Nutr."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.ijcard.2004.10.013","article-title":"Red Wine Reduces Oxidative Stress in Patients with Acute Coronary Syndrome","volume":"104","author":"Guarda","year":"2005","journal-title":"Int. J. Cardiol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1111\/j.1464-5491.2006.01886.x","article-title":"Effect of Moderate Red Wine Intake on Cardiac Prognosis after Recent Acute Myocardial Infarction of Subjects with Type 2 Diabetes Mellitus","volume":"23","author":"Marfella","year":"2006","journal-title":"Diabet. Med. J. Br. Diabet. Assoc."},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Fragopoulou, E., Argyrou, C., Detopoulou, M., Tsitsou, S., Seremeti, S., Yannakoulia, M., Antonopoulou, S., Kolovou, G., and Kalogeropoulos, P. (2021). The Effect of Moderate Wine Consumption on Cytokine Secretion by Peripheral Blood Mononuclear Cells: A Randomized Clinical Study in Coronary Heart Disease Patients. Cytokine, 146.","DOI":"10.1016\/j.cyto.2021.155629"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1016\/j.numecd.2010.10.015","article-title":"Development, Repeatability and Validity Regarding Energy and Macronutrient Intake of a Semi-Quantitative Food Frequency Questionnaire: Methodological Considerations","volume":"22","author":"Bountziouka","year":"2012","journal-title":"Nutr. Metab. Cardiovasc. Dis."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.ypmed.2006.12.009","article-title":"Adherence to the Mediterranean Food Pattern Predicts the Prevalence of Hypertension, Hypercholesterolemia, Diabetes and Obesity, among Healthy Adults; the Accuracy of the MedDietScore","volume":"44","author":"Panagiotakos","year":"2007","journal-title":"Prev. Med."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"e47","DOI":"10.1016\/j.scispo.2016.01.007","article-title":"Development, Reliability and Validity of a Physical Activity Questionnaire for Estimating Energy Expenditure in Greek Adults","volume":"31","author":"Kavouras","year":"2016","journal-title":"Sci. Sport."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","article-title":"A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding","volume":"72","author":"Bradford","year":"1976","journal-title":"Anal. Biochem."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/0891-5849(95)02043-8","article-title":"Improved Analysis of Malondialdehyde in Human Body Fluids","volume":"20","author":"Jentzsch","year":"1996","journal-title":"Free Radic. Biol. Med."},{"key":"ref_36","first-page":"7.3.1","article-title":"Analysis of Superoxide Dismutase Activity","volume":"1","author":"McCord","year":"1999","journal-title":"Curr. Protoc. Toxicol."},{"key":"ref_37","first-page":"158","article-title":"Studies on the Quantitative and Qualitative Characterization of Erythrocyte Glutathione Peroxidase","volume":"70","author":"Paglia","year":"1967","journal-title":"J. Lab. Clin. Med."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1056\/NEJMsr1203730","article-title":"The Prevention and Treatment of Missing Data in Clinical Trials","volume":"367","author":"Little","year":"2012","journal-title":"N. Engl. J. Med."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1055\/s-0039-3402675","article-title":"Evaluating the Role of Oxidative Stress in Acute Ischemic Stroke","volume":"11","author":"Menon","year":"2020","journal-title":"J. Neurosci. Rural Pract."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"284","DOI":"10.2478\/jomb-2018-0041","article-title":"Superoxide Dismutase Isoenzymes Gene Expression in Peripheral Blood Mononuclear Cells in Patients with Coronary Artery Disease","volume":"38","author":"Munjas","year":"2019","journal-title":"J. Med. Biochem."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1089\/ars.2019.7955","article-title":"Lipid Peroxidation in Atherosclerotic Cardiovascular Diseases","volume":"34","author":"Gianazza","year":"2021","journal-title":"Antioxid. Redox Signal."},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Lubrano, V. (2015). Enzymatic Antioxidant System in Vascular Inflammation and Coronary Artery Disease. World J. Exp. Med., 5.","DOI":"10.5493\/wjem.v5.i4.218"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"621","DOI":"10.7150\/ijms.4768","article-title":"Correlations between Oxidative DNA Damage, Oxidative Stress and Coenzyme Q10 in Patients with Coronary Artery Disease","volume":"9","author":"Kaya","year":"2012","journal-title":"Int. J. Med. Sci."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"1822","DOI":"10.1021\/bi201912c","article-title":"DNA Damage Products (5\u2019R)- and (5\u2019S)-8,5\u2019-Cyclo-2\u2019-Deoxyadenosines as Potential Biomarkers in Human Urine for Atherosclerosis","volume":"51","author":"Jaruga","year":"2012","journal-title":"Biochemistry"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1097\/MCA.0b013e328344b615","article-title":"Association of Serum 8-Hydroxy-2\u2019-Deoxyguanosine Levels with the Presence and Severity of Coronary Artery Disease","volume":"22","author":"Xiang","year":"2011","journal-title":"Coron. Artery Dis."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1080\/10715762.2017.1379602","article-title":"Oxidative Status and Reduced Glutathione Levels in Premature Coronary Artery Disease and Coronary Artery Disease","volume":"51","author":"Musthafa","year":"2017","journal-title":"Free Radic. Res."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"723","DOI":"10.2337\/dc14-1556","article-title":"The Effect of Alcohol Consumption on Insulin Sensitivity and Glycemic Status: A Systematic Review and Meta-Analysis of Intervention Studies","volume":"38","author":"Schrieks","year":"2015","journal-title":"Diabetes Care"},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Kroese, L.J., and Scheffer, P.G. (2014). 8-Hydroxy-2\u2032-Deoxyguanosine and Cardiovascular Disease: A Systematic Review. Curr. Atheroscler. Rep., 16.","DOI":"10.1007\/s11883-014-0452-y"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/j.mrfmmm.2005.03.031","article-title":"Moderate Acute Intake of De-Alcoholized Red Wine, but Not Alcohol, Is Protective against Radiation-Induced DNA Damage Ex Vivo\u2014Results of a Comparative in Vivo Intervention Study in Younger Men","volume":"591","author":"Greenrod","year":"2005","journal-title":"Mutat. Res."},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Gryszczy\u0144ska, B., Formanowicz, D., Budzy\u0144, M., Wanic-Kossowska, M., Pawliczak, E., Formanowicz, P., Majewski, W., Strzy\u017cewski, K.W., Kasprzak, M.P., and Iskra, M. (2017). Advanced Oxidation Protein Products and Carbonylated Proteins as Biomarkers of Oxidative Stress in Selected Atherosclerosis-Mediated Diseases. BioMed Res. Int., 2017.","DOI":"10.1155\/2017\/4975264"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.biochi.2021.12.002","article-title":"Oxidative Distress in Aging and Age-Related Diseases: Spatiotemporal Dysregulation of Protein Oxidation and Degradation","volume":"195","author":"Zavadskiy","year":"2021","journal-title":"Biochimie"},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Carracedo, J., Ram\u00edrez-Carracedo, R., Mart\u00ednez de Toda, I., Vida, C., Alique, M., De la Fuente, M., and Ram\u00edrez-Chamond, R. (2018). Protein Carbamylation: A Marker Reflecting Increased Age-Related Cell Oxidation. Int. J. Mol. Sci., 19.","DOI":"10.3390\/ijms19051495"},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"Martin-Ventura, J., Rodrigues-Diez, R., Martinez-Lopez, D., Salaices, M., Blanco-Colio, L., and Briones, A. (2017). Oxidative Stress in Human Atherothrombosis: Sources, Markers and Therapeutic Targets. Int. J. Mol. Sci., 18.","DOI":"10.3390\/ijms18112315"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1002\/clc.20724","article-title":"Comparison of Effects of Simvastatin Versus Atorvastatin on Oxidative Stress in Patients with Coronary Heart Disease","volume":"33","author":"Li","year":"2010","journal-title":"Clin. Cardiol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.clinbiochem.2006.09.007","article-title":"Correlation of Oxidative Stress Parameters and Inflammatory Markers in Coronary Artery Disease Patients","volume":"40","author":"Memon","year":"2007","journal-title":"Clin. Biochem."},{"key":"ref_56","first-page":"5886","article-title":"Effect of Dan Hong Injection on PON1, SOD Activity and MDA Levels in Elderly Patients with Coronary Heart Disease","volume":"7","author":"Su","year":"2014","journal-title":"Int. J. Clin. Exp. Med."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1038\/hr.2015.156","article-title":"Biomarkers of Lipid Peroxidation Related to Hypertension in Aging","volume":"39","author":"Yavuzer","year":"2016","journal-title":"Hypertens. Res. Off. J. Jpn. Soc. Hypertens."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1517\/14728220903099668","article-title":"Correlation of Antioxidants with Lipid Peroxidation and Lipid Profile in Patients Suffering from Coronary Artery Disease","volume":"13","author":"Gupta","year":"2009","journal-title":"Expert Opin. Ther. Targets"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/0009-8981(95)06192-4","article-title":"Investigation of Erythrocyte Membrane Lipid Peroxidation and Antioxidant Defense Systems of Patients with Coronary Artery Disease (CAD) Documented by Angiography","volume":"244","author":"Vural","year":"1996","journal-title":"Clin. Chim. Acta Int. J. Clin. Chem."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"2264","DOI":"10.1161\/01.CIR.101.19.2264","article-title":"Vascular Extracellular Superoxide Dismutase Activity in Patients with Coronary Artery Disease: Relation to Endothelium-Dependent Vasodilation","volume":"101","author":"Landmesser","year":"2000","journal-title":"Circulation"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1002\/clc.4960150307","article-title":"Relationship between the Extent of Coronary Artery Disease and Indicators of Free Radical Activity","volume":"15","author":"Bridges","year":"1992","journal-title":"Clin. Cardiol."},{"key":"ref_62","doi-asserted-by":"crossref","unstructured":"Cheng, Y.-C., Sheen, J.-M., Hu, W.L., and Hung, Y.-C. (2017). Polyphenols and Oxidative Stress in Atherosclerosis-Related Ischemic Heart Disease and Stroke. Oxid. Med. Cell. Longev., 2017.","DOI":"10.1155\/2017\/8526438"}],"container-title":["Nutrients"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6643\/14\/7\/1377\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T22:43:24Z","timestamp":1760136204000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6643\/14\/7\/1377"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3,25]]},"references-count":62,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2022,4]]}},"alternative-id":["nu14071377"],"URL":"https:\/\/doi.org\/10.3390\/nu14071377","relation":{},"ISSN":["2072-6643"],"issn-type":[{"value":"2072-6643","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,3,25]]}}}