{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T11:43:24Z","timestamp":1778327004449,"version":"3.51.4"},"reference-count":41,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2022,3,26]],"date-time":"2022-03-26T00:00:00Z","timestamp":1648252800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Chinese Oolong Tea Industry Innovation Center project","award":["J201575"],"award-info":[{"award-number":["J201575"]}]},{"name":"the Platform Construction Project of Chinese White Tea Science and Technology Correspondent, China","award":["2020L3031"],"award-info":[{"award-number":["2020L3031"]}]},{"name":"the Science and Technology Innovation Platform Project of Fujian Provincial Department of Science and Technology, China","award":["2018N2004"],"award-info":[{"award-number":["2018N2004"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Theaflavin-3,3\u2032-digallate (TF3) is a representative theaflavin of black tea and is remarkable for the anti-coronary heart disease effect. As an adaptive response to heart failure, pathological cardiac hypertrophy (PCH) has attracted great interest. In this study, the PCH cell model was established with H9c2 cells by angiotensin II, and the prevention effect and mechanisms of TF3 were investigated. The results showed that the cell size and fetal gene mRNA level were significantly reduced as pretreated with TF3 at the concentration range of 1\u201310 \u03bcM, also the balance of the redox system was recovered by TF3 at the concentration of 10 \u03bcM. The intracellular Ca2+ level decreased, Calcineurin (CaN) expression was down-regulated and the p-NFATc3 expression was up-regulated. These results indicated that TF3 could inhibit the activation of the CaN-NFAT signal pathway to prevent PCH, and TF3 may be a potentially effective natural compound for PCH and heart failure.<\/jats:p>","DOI":"10.3390\/nu14071391","type":"journal-article","created":{"date-parts":[[2022,3,27]],"date-time":"2022-03-27T21:29:36Z","timestamp":1648416576000},"page":"1391","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["The Prevention Role of Theaflavin-3,3\u2032-digallate in Angiotensin II Induced Pathological Cardiac Hypertrophy via CaN-NFAT Signal Pathway"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0820-9437","authenticated-orcid":false,"given":"Hui","family":"Zhou","sequence":"first","affiliation":[{"name":"Department of Tea Science, Zhejiang University, Hangzhou 310058, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chen","family":"Xia","sequence":"additional","affiliation":[{"name":"Department of Tea Science, Zhejiang University, Hangzhou 310058, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yaqing","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Tea Science, Zhejiang University, Hangzhou 310058, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hasitha Kalhari","family":"Warusawitharana","sequence":"additional","affiliation":[{"name":"Department of Tea Science, Zhejiang University, Hangzhou 310058, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaohui","family":"Liu","sequence":"additional","affiliation":[{"name":"College of Tea Science, Yunnan Agricultural University, Kunming 650201, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Youying","family":"Tu","sequence":"additional","affiliation":[{"name":"Department of Tea Science, Zhejiang University, Hangzhou 310058, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,3,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"6699054","DOI":"10.1155\/2021\/6699054","article-title":"Alleviation of inflammation and oxidative stress in pressure overload-induced cardiac remodeling and heart failure via IL-6\/STAT3 inhibition by raloxifene","volume":"2021","author":"Huo","year":"2021","journal-title":"Oxid. 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