{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T18:57:43Z","timestamp":1785351463017,"version":"3.55.0"},"reference-count":54,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2022,3,30]],"date-time":"2022-03-30T00:00:00Z","timestamp":1648598400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Shandong Medical and Health Science and Technology Development Project","award":["2019WS436"],"award-info":[{"award-number":["2019WS436"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Background: To study the relationship between serum vitamin A (VA) level and blood lipid profiles in children and adolescents aged 6\u201318 years, as well as the effect of VA on dyslipidemia. Methods: The project adopted a multistage stratified cluster sampling method. The Food Frequency Questionnaire (FFQ) was used to obtain dietary factors data. Blood samples of subjects were taken via venipuncture. Generalized linear models were used to explore the correlation be-tween VA and biochemical indicators, as well as stratified and inter-actions analysis to explore the influence of confounders on these relationships. Generalized linear models were constructed to explore the association between VA and blood lipids. Restricted cubic splines were used to characterize dose\u2013response associations between serum VA and dyslipidemia based on logistic regression. Results: Serum VA was positively correlated with TC, TG and HDL-C (p &lt; 0.05), but these associations were influenced by age (p &lt; 0.05). The adjusted odds ratio (OR) values of VA for hypercho lesterolemia, hypertriglyceridemia, mixed hyperlipidemia and low high-density lipoprotein cholesterolemia were 3.283, 3.239, 5.219 and 0.346, respectively (p &lt; 0.01). Meanwhile, significant age interactions affected the relationship between VA and TC, as well as TG and LDL-C (p &lt; 0.01). Conclusion: Serum VA was positively correlated with blood lipids, but these associations were influenced by age. VA was a risk factor for dyslipidemias, such as hypercholesterolemia, hypertriglyceridemia and mixed hyperlipidemia, but was a protective factor for low high-density lipoprotein cholesterolemia.<\/jats:p>","DOI":"10.3390\/nu14071444","type":"journal-article","created":{"date-parts":[[2022,3,30]],"date-time":"2022-03-30T21:28:39Z","timestamp":1648675719000},"page":"1444","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Association between Serum Vitamin A, Blood Lipid Level and Dyslipidemia among Chinese Children and Adolescents"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6631-5254","authenticated-orcid":false,"given":"Lianlong","family":"Yu","sequence":"first","affiliation":[{"name":"Shandong Center for Disease Control and Prevention, Jinan 250014, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5703-1620","authenticated-orcid":false,"given":"Yongjun","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Clinical Nutrition, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Jinan 250014, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongmei","family":"Yu","sequence":"additional","affiliation":[{"name":"National Institute for Nutrition and Health, Chinese Center for Disease Control and Prevention, Beijing 100050, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shixiu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Food Hygiene, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan 250012, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fengjia","family":"Zheng","sequence":"additional","affiliation":[{"name":"Shandong Center for Disease Control and Prevention, Jinan 250014, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ning","family":"Ding","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan 250021, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lichao","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan 250021, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8547-144X","authenticated-orcid":false,"given":"Qianrang","family":"Zhu","sequence":"additional","affiliation":[{"name":"Jiangsu Provincial Center for Disease Control and Prevention, Nanjing 210009, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenkui","family":"Sun","sequence":"additional","affiliation":[{"name":"Shandong Center for Disease Control and Prevention, Jinan 250014, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suyun","family":"Li","sequence":"additional","affiliation":[{"name":"Shandong Center for Disease Control and Prevention, Jinan 250014, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaohui","family":"Zhang","sequence":"additional","affiliation":[{"name":"Shandong Center for Disease Control and Prevention, Jinan 250014, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liangxia","family":"Chen","sequence":"additional","affiliation":[{"name":"Shandong Center for Disease Control and Prevention, Jinan 250014, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiya","family":"Liu","sequence":"additional","affiliation":[{"name":"Guizhou Center for Disease Control and Prevention, Guiyang 550001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Yang","sequence":"additional","affiliation":[{"name":"Jinan Center for Disease Control and Prevention, Jinan 250021, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7100-4872","authenticated-orcid":false,"given":"Jian","family":"Feng","sequence":"additional","affiliation":[{"name":"Department of Clinical Nutrition, Qilu Hospital of Shandong University, Jinan 250012, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,3,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/S0140-6736(95)91157-X","article-title":"Vitamin A","volume":"345","author":"Bates","year":"1995","journal-title":"Lancet"},{"key":"ref_2","unstructured":"WHO (2009). 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