{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T20:19:56Z","timestamp":1790367596983,"version":"4.1.0"},"reference-count":103,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2022,4,12]],"date-time":"2022-04-12T00:00:00Z","timestamp":1649721600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Conflicting evidence exists concerning the effects of nutrient intake in osteoarthritis (OA). A systematic literature review and meta-analysis were performed using PubMed, EMBASE, and Cochrane Library up to November 2021 to assess the effects of nutrients on pain, stiffness, function, quality of life, and inflammation markers. We obtained 52 references including 50 on knee OA. Twelve studies compared 724 curcumin patients and 714 controls. Using the standardized mean difference, improvement was significant with regard to pain and function in the curcumin group compared to placebo, but not with active treatment (i.e., nonsteroidal anti-inflammatory drugs, chondroitin, or paracetamol). Three studies assessed the effects of ginger on OA symptoms in 166 patients compared to 164 placebo controls. Pain was the only clinical parameter that significantly decreased. Vitamin D supplementation caused a significant decrease in pain and function. Omega-3 and vitamin E caused no changes in OA parameters. Herbal formulations effects were significant only for stiffness compared to placebo, but not with active treatment. A significant decrease in inflammatory markers was found, especially with ginger. Thus, curcumin and ginger supplementation can have a favorable impact on knee OA symptoms. Other studies are needed to better assess the effects of omega-3 and vitamin D.<\/jats:p>","DOI":"10.3390\/nu14081607","type":"journal-article","created":{"date-parts":[[2022,4,12]],"date-time":"2022-04-12T22:48:45Z","timestamp":1649803725000},"page":"1607","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":62,"title":["A Meta-Analysis of the Impact of Nutritional Supplementation on Osteoarthritis Symptoms"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2017-3227","authenticated-orcid":false,"given":"Sylvain","family":"Mathieu","sequence":"first","affiliation":[{"name":"Service de Rhumatologie, Centre Hospitalier Universitaire Gabriel Montpied, F-63000 Clermont-Ferrand, France"},{"name":"Neuro-Dol, Inserm, CHU Clermont-Ferrand, Universit\u00e9 Clermont Auvergne, F-63000 Clermont-Ferrand, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9349-0720","authenticated-orcid":false,"given":"Martin","family":"Soubrier","sequence":"additional","affiliation":[{"name":"Service de Rhumatologie, Centre Hospitalier Universitaire Gabriel Montpied, F-63000 Clermont-Ferrand, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2296-0323","authenticated-orcid":false,"given":"Cedric","family":"Peirs","sequence":"additional","affiliation":[{"name":"Neuro-Dol, Inserm, CHU Clermont-Ferrand, Universit\u00e9 Clermont Auvergne, F-63000 Clermont-Ferrand, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9836-0255","authenticated-orcid":false,"given":"Laurent-Emmanuel","family":"Monfoulet","sequence":"additional","affiliation":[{"name":"CRNH Auvergne, Unit\u00e9 de Nutrition Humaine, INRAE, Universit\u00e9 Clermont Auvergne, F-63000 Clermont-Ferrand, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3999-1599","authenticated-orcid":false,"given":"Yves","family":"Boirie","sequence":"additional","affiliation":[{"name":"CRNH Auvergne, Unit\u00e9 de Nutrition Humaine, INRAE, Universit\u00e9 Clermont Auvergne, F-63000 Clermont-Ferrand, France"},{"name":"Service de Nutrition Clinique, CHU Gabriel Montpied, F-63000 Clermont-Ferrand, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Tournadre","sequence":"additional","affiliation":[{"name":"Service de Rhumatologie, Centre Hospitalier Universitaire Gabriel Montpied, F-63000 Clermont-Ferrand, France"},{"name":"CRNH Auvergne, Unit\u00e9 de Nutrition Humaine, INRAE, Universit\u00e9 Clermont Auvergne, F-63000 Clermont-Ferrand, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,4,12]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"105203","DOI":"10.1016\/j.jbspin.2021.105203","article-title":"Osteoarthritis and gut microbiome","volume":"88","author":"Binvignat","year":"2021","journal-title":"Jt. 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