{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T04:03:19Z","timestamp":1790395399314,"version":"4.1.0"},"reference-count":107,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2022,4,15]],"date-time":"2022-04-15T00:00:00Z","timestamp":1649980800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Polycystic ovary syndrome (PCOS) is one of the most common endocrine reproductive disorders in women. Vitamin D deficiency is also quite common in this condition. The degree of vitamin D deficiency correlates with the severity of PCOS. Both male and female vitamin D levels play a role in fertility and affect the outcomes of in vitro fertilization (IVF). Moreover, fertility and IVF indicators are improved by vitamin D not only in healthy women but in those diagnosed with PCOS. Both vitamin D deficiency and PCOS increase pregnancy-related complications. Vitamin D supplementation and optimal vitamin D levels decrease both maternal and fetal risk for complications and adverse events. Furthermore, vitamin D supplementation may ameliorate or even prevent pregnancy-related reversible bone loss in mothers. This review emphasizes the roles of vitamin D deficiency and vitamin D supplementation and their correlation with PCOS regarding reproductive health.<\/jats:p>","DOI":"10.3390\/nu14081649","type":"journal-article","created":{"date-parts":[[2022,4,19]],"date-time":"2022-04-19T01:03:01Z","timestamp":1650330181000},"page":"1649","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":73,"title":["Effects of Vitamin D on Fertility, Pregnancy and Polycystic Ovary Syndrome\u2014A Review"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7109-6906","authenticated-orcid":false,"given":"Szabolcs","family":"V\u00e1rb\u00edr\u00f3","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Semmelweis University, \u00dcll\u0151i Street 78\/a, 1082 Budapest, Hungary"},{"name":"Workgroup of Research Management, Doctoral School, Semmelweis University, \u00dcll\u0151i Street 22, 1085 Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Istv\u00e1n","family":"Tak\u00e1cs","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Oncology, Semmelweis University, S\u00e1ndor Kor\u00e1nyi Street 2\/a, 1098 Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L\u00e1szl\u00f3","family":"T\u0171\u0171","sequence":"additional","affiliation":[{"name":"EndoCare Institute, Endocrinology Center, Bokor Street 17-21, 1037 Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katalin","family":"Nas","sequence":"additional","affiliation":[{"name":"EndoCare Institute, Endocrinology Center, Bokor Street 17-21, 1037 Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9170-4331","authenticated-orcid":false,"given":"R\u00e9ka Eszter","family":"Sziva","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Semmelweis University, \u00dcll\u0151i Street 78\/a, 1082 Budapest, Hungary"},{"name":"Workgroup of Research Management, Doctoral School, Semmelweis University, \u00dcll\u0151i Street 22, 1085 Budapest, Hungary"},{"name":"Department of Physiology, Semmelweis University, T\u0171zolt\u00f3 Street 37-47, 1094 Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judit R\u00e9ka","family":"Hetth\u00e9ssy","sequence":"additional","affiliation":[{"name":"Workgroup of Research Management, Doctoral School, Semmelweis University, \u00dcll\u0151i Street 22, 1085 Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2832-0626","authenticated-orcid":false,"given":"Marianna","family":"T\u00f6r\u00f6k","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Semmelweis University, \u00dcll\u0151i Street 78\/a, 1082 Budapest, Hungary"},{"name":"Workgroup of Research Management, Doctoral School, Semmelweis University, \u00dcll\u0151i Street 22, 1085 Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,4,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1111\/j.1365-2265.2012.04434.x","article-title":"Vitamin D in the aetiology and management of polycystic ovary syndrome","volume":"77","author":"Thomson","year":"2012","journal-title":"Clin. 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