{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T03:00:32Z","timestamp":1760151632630,"version":"build-2065373602"},"reference-count":41,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2022,4,15]],"date-time":"2022-04-15T00:00:00Z","timestamp":1649980800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>The intent of this study was an evaluation of our effort to reduce the incidence of hypercalcemia in critically ill vitamin D-deficient patients with multiple traumatic injuries given cholecalciferol. Vitamin D deficiency was defined as a serum 25-hydroxy vitamin D concentration (25-OH vit D) of &lt;20 ng\/mL. Adult patients (&gt;17 years of age) were given 10,000 IU of cholecalciferol daily with an intended target 25-OH vit D of &gt;19.9 ng\/mL. These patients were compared to a historical control group that underwent therapy with a higher target of &gt;29.9 ng\/mL. Patients received cholecalciferol via the feeding tube along with enteral nutrition (EN) until the target 25-OH vit D was achieved, EN discontinued, the nutrition support service signed off the patient, or the patient was discharged from the TICU. Patients were included if two consecutive weekly 25-OH vit D were measured. One hundred and three critically ill trauma patients were retrospectively studied. Fifty were given cholecalciferol therapy with the new lower target 25-OH vit D, and 53 were from a historical cohort aiming for the higher target. Hypercalcemia (serum ionized calcium concentration &gt; 1.32 mmol\/L) was reduced from 40% (21 out of 53 patients) to 4% (2 out of 50 patients; p &lt; 0.001). None of the hypercalcemic patients were symptomatic. Readjustment of target 25-OH vit D concentration resulted in a ten-fold decrease in the rate of hypercalcemia and improved the safety of cholecalciferol therapy for critically ill patients with traumatic injuries.<\/jats:p>","DOI":"10.3390\/nu14081650","type":"journal-article","created":{"date-parts":[[2022,4,19]],"date-time":"2022-04-19T01:03:01Z","timestamp":1650330181000},"page":"1650","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Reduction in Hypercalcemia Following Readjustment of Target Serum 25-Hydroxy Vitamin D Concentration during Cholecalciferol Therapy in Vitamin D-Deficient Critically Ill Patients"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2086-6317","authenticated-orcid":false,"given":"Roland N.","family":"Dickerson","sequence":"first","affiliation":[{"name":"Department of Clinical Pharmacy and Translational Science, University of Tennessee College of Pharmacy, Memphis, TN 38163, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen C.","family":"Turner","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Mobile Infirmary, Mobile, AL 36607, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Whitney L.","family":"Holmes","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Regional One Health, Memphis, TN 38103, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edward T.","family":"Van Matre","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy and Translational Science, University of Tennessee College of Pharmacy, Memphis, TN 38163, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0428-519X","authenticated-orcid":false,"given":"Joseph M.","family":"Swanson","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy and Translational Science, University of Tennessee College of Pharmacy, Memphis, TN 38163, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saskya","family":"Byerly","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of Tennessee Health Science Center, Memphis, TN 38163, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dina M.","family":"Filiberto","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of Tennessee Health Science Center, Memphis, TN 38163, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter E.","family":"Fischer","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of Tennessee Health Science Center, Memphis, TN 38163, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,4,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"R47","DOI":"10.1186\/cc13790","article-title":"Vitamin D status and its association with season, hospital and sepsis mortality in critical illness","volume":"18","author":"Amrein","year":"2014","journal-title":"Crit. 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