{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T00:00:23Z","timestamp":1788912023316,"version":"build-2803163510"},"reference-count":37,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2022,4,20]],"date-time":"2022-04-20T00:00:00Z","timestamp":1650412800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["42077398"],"award-info":[{"award-number":["42077398"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Program for Huazhong University of Science and Technology (HUST) Academic Frontier Youth Team","award":["2018QYTD12"],"award-info":[{"award-number":["2018QYTD12"]}]},{"name":"the National Institutes of Health","award":["R01ES029082"],"award-info":[{"award-number":["R01ES029082"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Serum selenium (Se) has been reported to be associated with serum 25-hydroxyvitamin D [25(OH)D], but epidemiological findings are limited in pregnant women. We aimed to assess the associations between maternal urinary Se concentrations and cord serum 25(OH)D levels. We measured urinary concentrations of Se in the first, second, and third trimesters and cord serum 25(OH)D of 1695 mother-infant pairs from a prospective cohort study in Wuhan, China. The results showed that each doubling of urinary Se concentrations in the first, second, third trimester, and whole pregnancy (average SG-adjusted concentrations across three trimesters) were associated with 8.76% (95% confidence interval (CI): 4.30%, 13.41%), 15.44% (95% CI: 9.18%, 22.06%), 11.84% (95% CI: 6.09%, 17.89%), and 21.14% (95% CI: 8.69%, 35.02%) increases in 25(OH)D levels. Newborns whose mothers with low (&lt;10 \u03bcg\/L) or medium (10.92\u201314.34 \u03bcg\/L) tertiles of urinary Se concentrations in whole pregnancy were more likely to be vitamin D deficient (&lt;20 ng\/mL) compared with those with the highest tertile (&gt;14.34 \u03bcg\/L). Our study provides evidence that maternal Se levels were positively associated with cord serum vitamin D status.<\/jats:p>","DOI":"10.3390\/nu14091715","type":"journal-article","created":{"date-parts":[[2022,4,21]],"date-time":"2022-04-21T03:46:11Z","timestamp":1650512771000},"page":"1715","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Associations between Maternal Selenium Status and Cord Serum Vitamin D Levels: A Birth Cohort Study in Wuhan, China"],"prefix":"10.3390","volume":"14","author":[{"given":"Huiqing","family":"Gang","sequence":"first","affiliation":[{"name":"Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, and State Key Laboratory of Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongling","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Health and Nursing, Wuchang University of Technology, Wuhan 430000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tongzhang","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Brown University, Providence, RI 02912, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Xia","sequence":"additional","affiliation":[{"name":"Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, and State Key Laboratory of Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shunqing","family":"Xu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, and State Key Laboratory of Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanyuan","family":"Li","sequence":"additional","affiliation":[{"name":"Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, and State Key Laboratory of Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,4,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/S0140-6736(00)02490-9","article-title":"The importance of selenium to human health","volume":"356","author":"Rayman","year":"2000","journal-title":"Lancet"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1152\/physrev.00039.2013","article-title":"Selenoproteins: Molecular pathways and physiological roles","volume":"94","author":"Labunskyy","year":"2014","journal-title":"Physiol. Rev."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1182\/blood.V73.1.318.318","article-title":"Antihuman plasma glutathione peroxidase antibodies: Immunologic investigations to determine plasma glutathione peroxidase protein and selenium content in plasma","volume":"73","author":"Avissar","year":"1989","journal-title":"Blood"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.1016\/S0140-6736(11)61452-9","article-title":"Selenium and human health","volume":"379","author":"Rayman","year":"2012","journal-title":"Lancet"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"2209","DOI":"10.3390\/nu7042209","article-title":"Biomarkers of selenium status","volume":"7","author":"Combs","year":"2015","journal-title":"Nutrients"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1038\/s12276-020-0408-y","article-title":"The role of selenium metabolism and selenoproteins in cartilage homeostasis and arthropathies","volume":"52","author":"Kang","year":"2020","journal-title":"Exp. Mol. Med."},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Habibi, N., Grieger, J.A., and Bianco-Miotto, T. (2020). A Review of the Potential Interaction of Selenium and Iodine on Placental and Child Health. Nutrients, 12.","DOI":"10.3390\/nu12092678"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1016\/j.clnu.2018.08.032","article-title":"Feeding mitochondria: Potential role of nutritional components to improve critical illness convalescence","volume":"38","author":"Wesselink","year":"2019","journal-title":"Clin. Nutr."},{"key":"ref_9","unstructured":"Institute of Medicine (US) National Academies Press (US) (2000). Dietary Reference Intakes for Vitamin C, Vitamin E, Selenium, and Carotenoids, Institute of Medicine."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1017\/S0029665109991807","article-title":"Symposium on \u2019Geographical and geological influences on nutrition\u2019: Factors controlling the distribution of selenium in the environment and their impact on health and nutrition","volume":"69","author":"Johnson","year":"2010","journal-title":"Proc. Nutr. Soc."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1503\/cmaj.101095","article-title":"Maternal selenium status during early gestation and risk for preterm birth","volume":"183","author":"Rayman","year":"2011","journal-title":"CMAJ"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1017\/S000711451400364X","article-title":"Selenium status in U.K. pregnant women and its relationship with hypertensive conditions of pregnancy","volume":"113","author":"Rayman","year":"2015","journal-title":"Br. J. Nutr."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1097\/00001648-199607000-00008","article-title":"Use of selenium concentration in whole blood, serum, toenails, or urine as a surrogate measure of selenium intake","volume":"7","author":"Longnecker","year":"1996","journal-title":"Epidemiology"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"105218","DOI":"10.1016\/j.envint.2019.105218","article-title":"Urine selenium concentration is a useful biomarker for assessing population level selenium status","volume":"134","author":"Phiri","year":"2020","journal-title":"Environ. Int."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.jtemb.2017.08.005","article-title":"Severe selenium deficits in pregnant women irrespective of autoimmune thyroid disease in an area with marginal selenium intake","volume":"44","author":"Ambroziak","year":"2017","journal-title":"J. Trace Elem. Med. Biol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1056\/NEJMra070553","article-title":"Vitamin D deficiency","volume":"357","author":"Holick","year":"2007","journal-title":"N. Engl. J. Med."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"353","DOI":"10.4065\/81.3.353","article-title":"High prevalence of vitamin D inadequacy and implications for health","volume":"81","author":"Holick","year":"2006","journal-title":"Mayo Clin. Proc."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1508","DOI":"10.1016\/j.jaci.2016.06.065","article-title":"In utero exposure to 25-hydroxyvitamin D and risk of childhood asthma, wheeze, and respiratory tract infections: A meta-analysis of birth cohort studies","volume":"139","author":"Feng","year":"2017","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"553","DOI":"10.2337\/dc18-2176","article-title":"Maternal and Newborn Vitamin D-Binding Protein, Vitamin D Levels, Vitamin D Receptor Genotype, and Childhood Type 1 Diabetes","volume":"42","author":"Tapia","year":"2019","journal-title":"Diabetes Care"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"115","DOI":"10.2340\/00015555-0980","article-title":"Factors influencing vitamin D status","volume":"91","author":"Tsiaras","year":"2011","journal-title":"Acta Derm. Venereol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"106660","DOI":"10.1016\/j.envint.2021.106660","article-title":"Associations of urine metals and metal mixtures during pregnancy with cord serum vitamin D Levels: A prospective cohort study with repeated measurements of maternal urinary metal concentrations","volume":"155","author":"Fang","year":"2021","journal-title":"Environ. Int."},{"key":"ref_22","first-page":"1329","article-title":"Relationship between serum selenium level and bone mineral density and bone metabolism indexes in postmenopausal women","volume":"27","author":"Yixin","year":"2021","journal-title":"Chin. J. Osteoporos."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1183\/13993003.01016-2015","article-title":"The independent role of prenatal and postnatal exposure to active and passive smoking on the development of early wheeze in children","volume":"48","author":"Vardavas","year":"2016","journal-title":"Eur. Respir. J."},{"key":"ref_24","unstructured":"Weather, C. (2022, April 15). Introduction of Wuhan City. (In Chinese)."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"027006","DOI":"10.1289\/EHP2716","article-title":"Cadmium Body Burden and Gestational Diabetes Mellitus: A Prospective Study","volume":"126","author":"Liu","year":"2018","journal-title":"Environ. Health Perspect."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1911","DOI":"10.1210\/jc.2011-0385","article-title":"Evaluation, treatment, and prevention of vitamin D deficiency: An Endocrine Society clinical practice guideline","volume":"96","author":"Holick","year":"2011","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"e16","DOI":"10.1097\/EDE.0000000000000247","article-title":"Models with transformed variables: Interpretation and software","volume":"26","author":"Basagana","year":"2015","journal-title":"Epidemiology"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"4087","DOI":"10.1210\/jc.2012-1943","article-title":"Gestational exposure to urban air pollution related to a decrease in cord blood vitamin d levels","volume":"97","author":"Baiz","year":"2012","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1007\/s12011-018-1604-7","article-title":"Serum and Urinary Selenium Status in Patients with the Pre-diabetes and Diabetes in Northeast China","volume":"191","author":"Zhou","year":"2019","journal-title":"Biol. Trace Elem. Res."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12940-020-00685-9","article-title":"Prenatal metal mixtures and child blood pressure in the Rhea mother-child cohort in Greece","volume":"20","author":"Howe","year":"2021","journal-title":"Environ. Health"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1007\/s10654-016-0151-9","article-title":"Impact of prenatal exposure to cadmium on cognitive development at preschool age and the importance of selenium and iodine","volume":"31","author":"Kippler","year":"2016","journal-title":"Eur. J. Epidemiol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"027001","DOI":"10.1289\/EHP1912","article-title":"Associations between Methylated Metabolites of Arsenic and Selenium in Urine of Pregnant Bangladeshi Women and Interactions between the Main Genes Involved","volume":"126","author":"Skroder","year":"2018","journal-title":"Environ. Health Perspect."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"6578","DOI":"10.1021\/nn202452c","article-title":"Selenium nanoparticles as a carrier of 5-fluorouracil to achieve anticancer synergism","volume":"6","author":"Liu","year":"2012","journal-title":"ACS Nano"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1089\/ars.2009.2865","article-title":"Structure-function relations, physiological roles, and evolution of mammalian ER-resident selenoproteins","volume":"12","author":"Shchedrina","year":"2010","journal-title":"Antioxid. Redox Signal."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.1089\/ars.2010.3275","article-title":"Selenium in human health and disease","volume":"14","author":"Bao","year":"2011","journal-title":"Antioxid. Redox Signal."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"e1128","DOI":"10.1542\/peds.2012-1172","article-title":"Cord blood 25-hydroxyvitamin D3 and allergic disease during infancy","volume":"130","author":"Jones","year":"2012","journal-title":"Pediatrics"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"3473","DOI":"10.1007\/s00394-021-02528-w","article-title":"Associations between maternal vitamin D status during three trimesters and cord blood 25(OH)D concentrations in newborns: A prospective Shanghai birth cohort study","volume":"60","author":"Wang","year":"2021","journal-title":"Eur. J. Nutr."}],"container-title":["Nutrients"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6643\/14\/9\/1715\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T22:57:51Z","timestamp":1760137071000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6643\/14\/9\/1715"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4,20]]},"references-count":37,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2022,5]]}},"alternative-id":["nu14091715"],"URL":"https:\/\/doi.org\/10.3390\/nu14091715","relation":{},"ISSN":["2072-6643"],"issn-type":[{"value":"2072-6643","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,4,20]]}}}