{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T22:30:15Z","timestamp":1781130615493,"version":"3.54.1"},"reference-count":28,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2022,4,22]],"date-time":"2022-04-22T00:00:00Z","timestamp":1650585600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Evolva (Switzerland)","award":["2000006"],"award-info":[{"award-number":["2000006"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Resveratrol, a vasoactive phytoestrogen, has beneficial effects on cerebrovascular function. Previous research has shown that hormonal migraineurs have poorer cerebrovascular function than non-migraineur women. We aimed to investigate if resveratrol supplementation for three months could reduce the hormonal migraine burden index (HMBI: the number of days with menstrual migraine per month), reduce migraine-related disability and improve migraine-related quality of life. A randomised, double-blind, placebo-controlled, crossover, intervention trial was conducted in 62 hormonal migraineurs (mean age: 37.5 \u00b1 0.8 years). Participants consumed 75 mg of resveratrol or matching placebo capsules twice daily for three months before crossing over to the other treatment arm. Participants completed a daily diary and the Headache Impact Test-6\u2122, Migraine Disability Assessment and Migraine-Specific Quality of Life questionnaires at months 0, 3 and 6. The HMBI was the primary outcome and was calculated using data extracted from the participant\u2019s diary. No differences in the HMBI (p = 0.895), the Headache Impact Test-6\u2122, the Migraine Disability Assessment and Migraine-Specific Quality of Life were found between the resveratrol and placebo treatments. Resveratrol supplementation for three months did not affect the HMBI, the migraine-related disability or quality of life measures in our cohort of hormonal migraineurs.<\/jats:p>","DOI":"10.3390\/nu14091763","type":"journal-article","created":{"date-parts":[[2022,4,23]],"date-time":"2022-04-23T21:39:45Z","timestamp":1650749985000},"page":"1763","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["A Randomised, Double-Blind, Placebo-Controlled Crossover Trial of Resveratrol Supplementation for Prophylaxis of Hormonal Migraine"],"prefix":"10.3390","volume":"14","author":[{"given":"Jemima S. A.","family":"Dzator","sequence":"first","affiliation":[{"name":"School of Biomedical Sciences and Pharmacy, University of Newcastle, Callaghan 2308, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6546-7742","authenticated-orcid":false,"given":"Peter R. C.","family":"Howe","sequence":"additional","affiliation":[{"name":"School of Biomedical Sciences and Pharmacy, University of Newcastle, Callaghan 2308, Australia"},{"name":"Adelaide Medical School, University of Adelaide, Adelaide 5005, Australia"},{"name":"Centre for Health Research, University of Southern Queensland, Raceview 4305, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirsten G.","family":"Coupland","sequence":"additional","affiliation":[{"name":"School of Biomedical Sciences and Pharmacy, University of Newcastle, Callaghan 2308, Australia"},{"name":"Hunter Medical Research Institute, New Lambton Heights 2305, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel H. X.","family":"Wong","sequence":"additional","affiliation":[{"name":"School of Biomedical Sciences and Pharmacy, University of Newcastle, Callaghan 2308, Australia"},{"name":"Centre for Health Research, University of Southern Queensland, Raceview 4305, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,4,22]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1129-2377-14-1","article-title":"Migraine: The seventh disabler","volume":"14","author":"Steiner","year":"2013","journal-title":"J. Headache Pain"},{"key":"ref_2","unstructured":"World Health Organization (2022, January 14). 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