{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T07:50:43Z","timestamp":1793260243116,"version":"4.5.0"},"reference-count":240,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2022,5,6]],"date-time":"2022-05-06T00:00:00Z","timestamp":1651795200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>The ketogenic diet (KD) is a high-fat, low-carbohydrate and adequate-protein diet that has gained popularity in recent years in the context of neurological diseases (NDs). The complexity of the pathogenesis of these diseases means that effective forms of treatment are still lacking. Conventional therapy is often associated with increasing tolerance and\/or drug resistance. Consequently, more effective therapeutic strategies are being sought to increase the effectiveness of available forms of therapy and improve the quality of life of patients. For the moment, it seems that KD can provide therapeutic benefits in patients with neurological problems by effectively controlling the balance between pro- and antioxidant processes and pro-excitatory and inhibitory neurotransmitters, and modulating inflammation or changing the composition of the gut microbiome. In this review we evaluated the potential therapeutic efficacy of KD in epilepsy, depression, migraine, Alzheimer\u2019s disease and Parkinson\u2019s disease. In our opinion, KD should be considered as an adjuvant therapeutic option for some neurological diseases.<\/jats:p>","DOI":"10.3390\/nu14091952","type":"journal-article","created":{"date-parts":[[2022,5,8]],"date-time":"2022-05-08T21:31:20Z","timestamp":1652045480000},"page":"1952","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":114,"title":["The Therapeutic Role of Ketogenic Diet in Neurological Disorders"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-5060-534X","authenticated-orcid":false,"given":"Diana","family":"Pietrzak","sequence":"first","affiliation":[{"name":"Chair and Department of Toxicology, Faculty of Pharmacy, Medical University of Lublin, Jaczewskiego 8b Street, 20-090 Lublin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamila","family":"Kasperek","sequence":"additional","affiliation":[{"name":"Chair and Department of Toxicology, Faculty of Pharmacy, Medical University of Lublin, Jaczewskiego 8b Street, 20-090 Lublin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pawe\u0142","family":"R\u0119kawek","sequence":"additional","affiliation":[{"name":"Chair and Department of Toxicology, Faculty of Pharmacy, Medical University of Lublin, Jaczewskiego 8b Street, 20-090 Lublin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1829-6981","authenticated-orcid":false,"given":"Iwona","family":"Pi\u0105tkowska-Chmiel","sequence":"additional","affiliation":[{"name":"Chair and Department of Toxicology, Faculty of Pharmacy, Medical University of Lublin, Jaczewskiego 8b Street, 20-090 Lublin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,5,6]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1186\/s42494-021-00053-1","article-title":"Recent aspects of ketogenic diet in neurological disorders","volume":"3","author":"Kwon","year":"2021","journal-title":"Acta Epileptol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"ENEURO.0303-20.2020","DOI":"10.1523\/ENEURO.0303-20.2020","article-title":"Glucose-Sparing Action of Ketones Boosts Functions Exclusive to Glucose in the Brain","volume":"7","author":"Zilberter","year":"2020","journal-title":"Eneuro"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"426","DOI":"10.21692\/haps.2019.002","article-title":"The Effects of Ketogenic Diets on Psychiatric Disorders Involving Mitochondrial Dysfunction: A Literature Review of the Influence of Dieting on Autism, Depression, Anxiety, and Schizophrenia","volume":"23","author":"Niepoetter","year":"2019","journal-title":"HAPS Educ."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"211","DOI":"10.9740\/mhc.2021.05.211","article-title":"The use of the ketogenic diet in the treatment of psychiatric disorders","volume":"11","author":"Tillery","year":"2021","journal-title":"Mental Health Clin."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1002\/(SICI)1520-7560(199911\/12)15:6<412::AID-DMRR72>3.0.CO;2-8","article-title":"Ketone bodies: A review of physiology, pathophysiology and application of monitoring to diabetes","volume":"15","author":"Laffel","year":"1999","journal-title":"Diabetes Metab. 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