{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T12:03:43Z","timestamp":1781697823306,"version":"3.54.5"},"reference-count":34,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2022,5,7]],"date-time":"2022-05-07T00:00:00Z","timestamp":1651881600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003712","name":"Main Research Program","doi-asserted-by":"publisher","award":["E0210602-02"],"award-info":[{"award-number":["E0210602-02"]}],"id":[{"id":"10.13039\/501100003712","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Diet-induced obesity is one of the major causes of the development of metabolic disorders such as insulin resistance and nonalcoholic fatty liver disease (NAFLD). Recently, specific probiotic strains have been found to improve the symptoms of NAFLD. We examined the effects of Bifidobacterium animalis ssp. lactis MG741 (MG741) on NAFLD and weight gain, using a mouse model of high-fat-diet (HFD)-induced obesity. HFD-fed mice were supplemented daily with MG741. After 12 weeks, MG741-administered mice exhibited reduced fat deposition, and serum metabolic alterations, including fasting hyperinsulinemia, were modulated. In addition, MG741 regulated Acetyl-CoA carboxylase (ACC), fatty acid synthase (FAS), sterol regulatory element-binding protein 1 (SREBP-1), and carbohydrate-responsive element-binding protein (ChREBP) expression and lipid accumulation in the liver, thereby reducing the hepatic steatosis score. To determine whether the effects of MG741 were related to improvements in gut health, MG741 improved the HFD-induced deterioration in gut permeability by reducing toxic substances and inflammatory cytokine expression, and upregulating tight junctions. These results collectively demonstrate that the oral administration of MG741 could prevent NAFLD and obesity, thereby improving metabolic health.<\/jats:p>","DOI":"10.3390\/nu14091965","type":"journal-article","created":{"date-parts":[[2022,5,8]],"date-time":"2022-05-08T21:31:20Z","timestamp":1652045480000},"page":"1965","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":42,"title":["Bifidobacterium animalis ssp. lactis MG741 Reduces Body Weight and Ameliorates Nonalcoholic Fatty Liver Disease via Improving the Gut Permeability and Amelioration of Inflammatory Cytokines"],"prefix":"10.3390","volume":"14","author":[{"given":"Moon Ho","family":"Do","sequence":"first","affiliation":[{"name":"Research Division of Food Functionality, Korea Food Research Institute, Wanju 55365, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mi-Jin","family":"Oh","sequence":"additional","affiliation":[{"name":"Research Division of Food Functionality, Korea Food Research Institute, Wanju 55365, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hye-Bin","family":"Lee","sequence":"additional","affiliation":[{"name":"Research Division of Food Functionality, Korea Food Research Institute, Wanju 55365, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6466-8550","authenticated-orcid":false,"given":"Chang-Ho","family":"Kang","sequence":"additional","affiliation":[{"name":"Central Research Institute, MEDIOGEN Co., Ltd., Jecheon 27159, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guijae","family":"Yoo","sequence":"additional","affiliation":[{"name":"Research Division of Food Functionality, Korea Food Research Institute, Wanju 55365, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9966-9059","authenticated-orcid":false,"given":"Ho-Young","family":"Park","sequence":"additional","affiliation":[{"name":"Research Division of Food Functionality, Korea Food Research Institute, Wanju 55365, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,5,7]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"9665","DOI":"10.1021\/acs.jafc.7b03782","article-title":"Orally administered Baker\u2019s Yeast \u03b2-glucan promotes glucose and lipid homeostasis in the livers of obesity and diabetes model mice","volume":"65","author":"Cao","year":"2017","journal-title":"J. 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