{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T19:03:26Z","timestamp":1785265406966,"version":"3.55.0"},"reference-count":207,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2022,5,10]],"date-time":"2022-05-10T00:00:00Z","timestamp":1652140800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Several studies have demonstrated a strong relation between periodontal diseases and chronic kidney disease (CKD). The main mechanisms at the base of this link are malnutrition, vitamin dysregulation, especially of B-group vitamins and of C and D vitamins, oxidative stress, metabolic acidosis and low-grade inflammation. In particular, in hemodialysis (HD) adult patients, an impairment of nutritional status has been observed, induced not only by the HD procedures themselves, but also due to numerous CKD-related comorbidities. The alteration of nutritional assessment induces systemic manifestations that have repercussions on oral health, like oral microbiota dysbiosis, slow healing of wounds related to hypovitaminosis C, and an alteration of the supporting bone structures of the oral cavity related to metabolic acidosis and vitamin D deficiency. Low-grade inflammation has been observed to characterize periodontal diseases locally and, in a systemic manner, CKD contributes to the amplification of the pathological process, bidirectionally. Therefore, CKD and oral disease patients should be managed by a multidisciplinary professional team that can evaluate the possible co-presence of these two pathological conditions, that negatively influence each other, and set up therapeutic strategies to treat them. Once these patients have been identified, they should be included in a follow-up program, characterized by periodic checks in order to manage these pathological conditions.<\/jats:p>","DOI":"10.3390\/nu14102002","type":"journal-article","created":{"date-parts":[[2022,5,10]],"date-time":"2022-05-10T21:52:11Z","timestamp":1652219531000},"page":"2002","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["The Impact of Chronic Kidney Disease on Nutritional Status and Its Possible Relation with Oral Diseases"],"prefix":"10.3390","volume":"14","author":[{"given":"Micaela","family":"Costacurta","sequence":"first","affiliation":[{"name":"Pediatric Dentistry, Department of Surgical Sciences, University of Rome Tor Vergata, 00133 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele","family":"Basilicata","sequence":"additional","affiliation":[{"name":"UOSD Special Care Dentistry, Department of Experimental Medicine and Surgery, University of Rome Tor Vergata, 00100 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5854-2086","authenticated-orcid":false,"given":"Giulia","family":"Marrone","sequence":"additional","affiliation":[{"name":"UOC of Internal Medicine-Center of Hypertension and Nephrology Unit, Department of Systems Medicine, University of Rome Tor Vergata, 00133 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8118-1330","authenticated-orcid":false,"given":"Manuela","family":"Di Lauro","sequence":"additional","affiliation":[{"name":"UOC of Internal Medicine-Center of Hypertension and Nephrology Unit, Department of Systems Medicine, University of Rome Tor Vergata, 00133 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincenzo","family":"Campolattano","sequence":"additional","affiliation":[{"name":"UOSD Special Care Dentistry, Department of Systems Medicine, University of Rome Tor Vergata, 00100 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrizio","family":"Bollero","sequence":"additional","affiliation":[{"name":"UOSD Special Care Dentistry, Department of Systems Medicine, University of Rome Tor Vergata, 00100 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raffaella","family":"Docimo","sequence":"additional","affiliation":[{"name":"Pediatric Dentistry, Department of Surgical Sciences, University of Rome Tor Vergata, 00133 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7671-0015","authenticated-orcid":false,"given":"Nicola","family":"Di Daniele","sequence":"additional","affiliation":[{"name":"UOC of Internal Medicine-Center of Hypertension and Nephrology Unit, Department of Systems Medicine, University of Rome Tor Vergata, 00133 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1310-3730","authenticated-orcid":false,"given":"Annalisa","family":"Noce","sequence":"additional","affiliation":[{"name":"UOC of Internal Medicine-Center of Hypertension and Nephrology Unit, Department of Systems Medicine, University of Rome Tor Vergata, 00133 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,5,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"S162","DOI":"10.1111\/jcpe.12946","article-title":"Periodontitis: Consensus report of workgroup 2 of the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions","volume":"45","author":"Papapanou","year":"2018","journal-title":"J. Clin. Periodontol."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Kitamura, M., Mochizuki, Y., Miyata, Y., Obata, Y., Mitsunari, K., Matsuo, T., Ohba, K., Mukae, H., Yoshimura, A., and Nishino, T. (2019). Pathological Characteristics of Periodontal Disease in Patients with Chronic Kidney Disease and Kidney Transplantation. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20143413"},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Serni, L., Caroti, L., Barbato, L., Nieri, M., Serni, S., Cirami, C.L., and Cairo, F. (2021). Association between chronic kidney disease and periodontitis. A systematic review and metanalysis. Oral Dis.","DOI":"10.1111\/odi.14062"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1002\/JPER.19-0679","article-title":"Tooth loss and risk of end-stage renal disease: A nationwide cohort study","volume":"92","author":"Han","year":"2021","journal-title":"J. Periodontol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1111\/odi.12486","article-title":"Early tooth loss in end-stage renal disease patients on haemodialysis","volume":"22","author":"Limeres","year":"2016","journal-title":"Oral Dis."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1002\/cre2.50","article-title":"Periodontitis and health-related quality of life in hemodialysis patients","volume":"3","author":"Iwasaki","year":"2017","journal-title":"Clin. Exp. Dent. Res."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1902\/jop.2009.080226","article-title":"A prediction model for chronic kidney disease includes periodontal disease","volume":"80","author":"Fisher","year":"2009","journal-title":"J. Periodontol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1111\/jcpe.12067","article-title":"Periodontitis and chronic kidney disease: A systematic review of the association of diseases and the effect of periodontal treatment on estimated glomerular filtration rate","volume":"40","author":"Chambrone","year":"2013","journal-title":"J. Clin. Periodontol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1177\/0022034511402209","article-title":"Disparities in periodontitis prevalence among chronic kidney disease patients","volume":"90","author":"Ioannidou","year":"2011","journal-title":"J. Dent. Res."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1111\/j.1752-7325.2012.00350.x","article-title":"Periodontitis associated with chronic kidney disease among Mexican Americans","volume":"73","author":"Ioannidou","year":"2013","journal-title":"J. Public Health Dent."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1053\/j.ajkd.2011.08.027","article-title":"Periodontal disease and decreased kidney function in Japanese elderly","volume":"59","author":"Iwasaki","year":"2012","journal-title":"Am. J. Kidney Dis."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Huang, S.T., Yu, T.M., Ke, T.Y., Wu, M.J., Chuang, Y.W., Li, C.Y., Chiu, C.W., Lin, C.L., Liang, W.M., and Chou, T.C. (2018). Intensive Periodontal Treatment Reduces Risks of Hospitalization for Cardiovascular Disease and All-Cause Mortality in the Hemodialysis Population. J. Clin. Med., 7.","DOI":"10.3390\/jcm7100344"},{"key":"ref_13","first-page":"e169","article-title":"Association among oral health parameters, periodontitis, and its treatment and mortality in patients undergoing hemodialysis","volume":"85","author":"Braosi","year":"2014","journal-title":"J. Periodontol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1053\/j.ajkd.2010.09.016","article-title":"Relationship between periodontal disease and mortality in patients treated with maintenance hemodialysis","volume":"57","author":"Chen","year":"2011","journal-title":"Am. J. Kidney Dis."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"21872","DOI":"10.1038\/s41598-020-78724-1","article-title":"Poor oral hygiene and dental caries predict high mortality rate in hemodialysis: A 3-year cohort study","volume":"10","author":"Mizutani","year":"2020","journal-title":"Sci. Rep."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Ricardo, A.C., Athavale, A., Chen, J., Hampole, H., Garside, D., Marucha, P., and Lash, J.P. (2015). Periodontal disease, chronic kidney disease and mortality: Results from the third National Health and Nutrition Examination Survey. BMC Nephrol., 16.","DOI":"10.1186\/s12882-015-0101-x"},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Noce, A., Marrone, G., Wilson Jones, G., Di Lauro, M., Pietroboni Zaitseva, A., Ramadori, L., Celotto, R., Mitterhofer, A.P., and Di Daniele, N. (2021). Nutritional Approaches for the Management of Metabolic Acidosis in Chronic Kidney Disease. Nutrients, 13.","DOI":"10.3390\/nu13082534"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"20","DOI":"10.5935\/01012800.20130004","article-title":"Serum levels of vitamin D and chronic periodontitis in patients with chronic kidney disease","volume":"35","author":"Andrade","year":"2013","journal-title":"Braz. J. Nephrol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"e011836","DOI":"10.1136\/bmjopen-2016-011836","article-title":"Association of dental and periodontal disease with chronic kidney disease in patients of a single, tertiary care centre in Thailand","volume":"6","author":"Ausavarungnirun","year":"2016","journal-title":"BMJ Open"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/sdi.12030","article-title":"Is vitamin C intake too low in dialysis patients?","volume":"26","author":"Raimann","year":"2013","journal-title":"Semin. Dial."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1111\/sdi.12099","article-title":"Water-soluble vitamins in people with low glomerular filtration rate or on dialysis: A review","volume":"26","author":"Clase","year":"2013","journal-title":"Semin. Dial."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"16026","DOI":"10.1038\/cddiscovery.2016.26","article-title":"Is low-protein diet a possible risk factor of malnutrition in chronic kidney disease patients?","volume":"2","author":"Noce","year":"2016","journal-title":"Cell Death Discov."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1007\/s00592-019-01413-7","article-title":"Hemodialysis biomarkers: Total advanced glycation end products (AGEs) against oxidized human serum albumin (HSAox)","volume":"56","author":"Noce","year":"2019","journal-title":"Acta Diabetol."},{"key":"ref_24","unstructured":"Benjamin, O., and Lappin, S.L. (2022). End-Stage Renal Disease, StatPearls Publishing."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1080\/08860220802669891","article-title":"Malnutrition in the elderly patient on dialysis","volume":"31","author":"Lacquaniti","year":"2009","journal-title":"Ren. Fail."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1046\/j.1523-1755.1998.00812.x","article-title":"Factors predicting malnutrition in hemodialysis patients: A cross-sectional study","volume":"53","author":"Qureshi","year":"1998","journal-title":"Kidney Int."},{"key":"ref_27","first-page":"206","article-title":"Nutrition in dialysis patients","volume":"99","author":"Sharma","year":"2001","journal-title":"J. Indian Med. Assoc."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1093\/ndt\/15.7.953","article-title":"Are there two types of malnutrition in chronic renal failure? Evidence for relationships between malnutrition, inflammation and atherosclerosis (MIA syndrome)","volume":"15","author":"Stenvinkel","year":"2000","journal-title":"Nephrol. Dial. Transplant."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1053\/j.jrn.2005.01.004","article-title":"Variables associated with reduced dietary intake in hemodialysis patients","volume":"15","author":"Bossola","year":"2005","journal-title":"J. Ren. Nutr."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1007\/s40620-014-0067-y","article-title":"Effects of Italian Mediterranean organic diet vs. low-protein diet in nephropathic patients according to MTHFR genotypes","volume":"27","author":"Noce","year":"2014","journal-title":"J. Nephrol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1002\/jcsm.12421","article-title":"Kidney cachexia or protein-energy wasting in chronic kidney disease: Facts and numbers","volume":"10","author":"Koppe","year":"2019","journal-title":"J. Cachexia Sarcopenia Muscle"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1038\/sj.ki.5002585","article-title":"A proposed nomenclature and diagnostic criteria for protein-energy wasting in acute and chronic kidney disease","volume":"73","author":"Fouque","year":"2008","journal-title":"Kidney Int."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1038\/ki.2013.147","article-title":"Prevention and treatment of protein energy wasting in chronic kidney disease patients: A consensus statement by the International Society of Renal Nutrition and Metabolism","volume":"84","author":"Ikizler","year":"2013","journal-title":"Kidney Int."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"2453","DOI":"10.1681\/ASN.V7112453","article-title":"Middle-sized molecule fractions isolated from uremic ultrafiltrate and normal urine inhibit ingestive behavior in the rat","volume":"7","author":"Anderstam","year":"1996","journal-title":"J. Am. Soc. Nephrol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"2161","DOI":"10.1681\/ASN.2006111207","article-title":"Growth hormone treatment during hemodialysis in a randomized trial improves nutrition, quality of life, and cardiovascular risk","volume":"18","author":"Lange","year":"2007","journal-title":"J. Am. Soc. Nephrol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1111\/sdi.12020","article-title":"Can treating persistent inflammation limit protein energy wasting?","volume":"26","author":"Stenvinkel","year":"2013","journal-title":"Semin. Dial."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1053\/ajkd.2002.30543","article-title":"Nutritional status in the HEMO Study cohort at baseline","volume":"39","author":"Rocco","year":"2002","journal-title":"Am. J. Kidney Dis."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"2127","DOI":"10.1172\/JCI117208","article-title":"Metabolic acidosis stimulates muscle protein degradation by activating the adenosine triphosphate-dependent pathway involving ubiquitin and proteasomes","volume":"93","author":"Mitch","year":"1994","journal-title":"J. Clin. Investig."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1447","DOI":"10.1172\/JCI118566","article-title":"The acidosis of chronic renal failure activates muscle proteolysis in rats by augmenting transcription of genes encoding proteins of the ATP-dependent ubiquitin-proteasome pathway","volume":"97","author":"Bailey","year":"1996","journal-title":"J. Clin. Investig."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1159\/000014479","article-title":"Inflammatory and atherosclerotic interactions in the depleted uremic patient","volume":"19","author":"Stenvinkel","year":"2001","journal-title":"Blood Purif."},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Piccoli, G.B., Moio, M.R., Fois, A., Sofronie, A., Gendrot, L., Cabiddu, G., D\u2019Alessandro, C., and Cupisti, A. (2017). The Diet and Haemodialysis Dyad: Three Eras, Four Open Questions and Four Paradoxes. A Narrative Review, Towards a Personalized, Patient-Centered Approach. Nutrients, 9.","DOI":"10.3390\/nu9040372"},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Maraj, M., Kusnierz-Cabala, B., Dumnicka, P., Gala-Bladzinska, A., Gawlik, K., Pawlica-Gosiewska, D., Zabek-Adamska, A., Mazur-Laskowska, M., Ceranowicz, P., and Kuzniewski, M. (2018). Malnutrition, Inflammation, Atherosclerosis Syndrome (MIA) and Diet Recommendations among End-Stage Renal Disease Patients Treated with Maintenance Hemodialysis. Nutrients, 10.","DOI":"10.3390\/nu10010069"},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Noce, A., Romani, A., and Bernini, R. (2021). Dietary Intake and Chronic Disease Prevention. Nutrients, 13.","DOI":"10.3390\/nu13041358"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1053\/j.ajkd.2015.08.028","article-title":"Metabolic Acidosis of CKD: An Update","volume":"67","author":"Kraut","year":"2016","journal-title":"Am. J. Kidney Dis."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1111\/j.0894-0959.2004.17606.x","article-title":"Metabolic acidosis and malnutrition-inflammation complex syndrome in chronic renal failure","volume":"17","author":"Mehrotra","year":"2004","journal-title":"Semin. Dial."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1053\/j.jrn.2010.09.001","article-title":"Dietary intake in hemodialysis patients does not reflect a heart healthy diet","volume":"21","author":"Khoueiry","year":"2011","journal-title":"J. Ren. Nutr."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"827652","DOI":"10.1155\/2009\/827652","article-title":"Brown tumour in a patient with secondary hyperparathyroidism resistant to medical therapy: Case report on successful treatment after subtotal parathyroidectomy","volume":"2009","author":"Condo","year":"2009","journal-title":"Int. J. Endocrinol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"269","DOI":"10.18632\/aging.100740","article-title":"Coronary artery calcifications predict long term cardiovascular events in non diabetic Caucasian hemodialysis patients","volume":"7","author":"Noce","year":"2015","journal-title":"Aging"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1681\/ASN.2009080829","article-title":"Ultrastructural analysis of vascular calcifications in uremia","volume":"21","author":"Schlieper","year":"2010","journal-title":"J. Am. Soc. Nephrol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1161\/01.RES.0000141775.67189.98","article-title":"Pathophysiology of vascular calcification in chronic kidney disease","volume":"95","author":"Moe","year":"2004","journal-title":"Circ. Res."},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"Choi, S.R., Lee, Y.K., Cho, A.J., Park, H.C., Han, C.H., Choi, M.J., Koo, J.R., Yoon, J.W., and Noh, J.W. (2019). Malnutrition, inflammation, progression of vascular calcification and survival: Inter-relationships in hemodialysis patients. PLoS ONE, 14.","DOI":"10.1371\/journal.pone.0216415"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1097\/MNH.0b013e32830d5bfa","article-title":"Hypercatabolism in dialysis patients","volume":"17","author":"Raj","year":"2008","journal-title":"Curr. Opin. Nephrol. Hypertens."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1038\/ki.1994.339","article-title":"Amino acid and albumin losses during hemodialysis","volume":"46","author":"Ikizler","year":"1994","journal-title":"Kidney Int."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.semnephrol.2005.09.006","article-title":"Amino Acid and protein kinetics in renal failure: An integrated approach","volume":"26","author":"Raj","year":"2006","journal-title":"Semin. Nephrol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"1633","DOI":"10.1039\/C5MB00058K","article-title":"Biocompatibility assessment of haemodialysis membrane materials by proteomic investigations","volume":"11","author":"Pieroni","year":"2015","journal-title":"Mol. Biosyst."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"S274","DOI":"10.1681\/ASN.2006080926","article-title":"Inflammatory syndrome in patients on hemodialysis","volume":"17","author":"Jofre","year":"2006","journal-title":"J. Am. Soc. Nephrol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1046\/j.1365-2362.2002.01063.x","article-title":"Soluble leptin receptors and serum leptin in end-stage renal disease: Relationship with inflammation and body composition","volume":"32","author":"Nordfors","year":"2002","journal-title":"Eur. J. Clin. Investig."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1111\/sdi.12348","article-title":"Dietary restrictions in dialysis patients: Is there anything left to eat?","volume":"28","author":"Tortorici","year":"2015","journal-title":"Semin. Dial."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1177\/095148480101400102","article-title":"Cost analysis of dialysis modalities in Italy","volume":"14","author":"Tediosi","year":"2001","journal-title":"Health Serv. Manag. Res."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1053\/j.ajkd.2020.05.006","article-title":"KDOQI Nutrition in CKD Guideline Work Group. KDOQI clinical practice guideline for nutrition in CKD: 2020 update","volume":"76","author":"Ikizler","year":"2020","journal-title":"Am. J. Kidney Dis."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1053\/j.jrn.2020.05.008","article-title":"Dietary Potassium Intake and Mortality in a Prospective Hemodialysis Cohort","volume":"31","author":"Narasaki","year":"2021","journal-title":"J. Ren. Nutr."},{"key":"ref_62","doi-asserted-by":"crossref","unstructured":"Cupisti, A., Kovesdy, C.P., D\u2019Alessandro, C., and Kalantar-Zadeh, K. (2018). Dietary Approach to Recurrent or Chronic Hyperkalaemia in Patients with Decreased Kidney Function. Nutrients, 10.","DOI":"10.3390\/nu10030261"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1007\/s40620-014-0142-4","article-title":"Phosphate balance in ESRD: Diet, dialysis and binders against the low evident masked pool","volume":"28","author":"Galassi","year":"2015","journal-title":"J. Nephrol."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1038\/sj.ki.5002412","article-title":"The fallacy of the calcium-phosphorus product","volume":"72","year":"2007","journal-title":"Kidney Int."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1007\/s11255-005-0083-x","article-title":"K\/DOQI guideline requirements for calcium, phosphate, calcium phosphate product, and parathyroid hormone control in dialysis patients: Can we achieve them?","volume":"38","author":"Wei","year":"2006","journal-title":"Int. Urol. Nephrol."},{"key":"ref_66","first-page":"1785","article-title":"New Developments in CKD-MBD. Why is phosphate overload harmful?","volume":"24","author":"Kuroo","year":"2014","journal-title":"Clin. Calcium"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1007\/s10741-017-9615-6","article-title":"Phosphate imbalance in patients with heart failure","volume":"22","author":"Christopoulou","year":"2017","journal-title":"Heart Fail. Rev."},{"key":"ref_68","doi-asserted-by":"crossref","unstructured":"D\u2019Alessandro, C., Piccoli, G.B., and Cupisti, A. (2015). The \u201cphosphorus pyramid\u201d: A visual tool for dietary phosphate management in dialysis and CKD patients. BMC Nephrol., 16.","DOI":"10.1186\/1471-2369-16-9"},{"key":"ref_69","first-page":"89","article-title":"Organic and inorganic dietary phosphorus and its management in chronic kidney disease","volume":"4","author":"Noori","year":"2010","journal-title":"Iran. J. Kidney Dis."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/S1051-2276(01)38751-4","article-title":"Demineralization of a wide variety of foods for the renal patient","volume":"11","author":"Jones","year":"2001","journal-title":"J. Ren. Nutr."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"e37","DOI":"10.1053\/j.jrn.2018.02.001","article-title":"The Importance of Sodium Restrictions in Chronic Kidney Disease","volume":"28","author":"Cobb","year":"2018","journal-title":"J. Ren. Nutr."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1093\/ajh\/hpt294","article-title":"Sodium intake and renal outcomes: A systematic review","volume":"27","author":"Smyth","year":"2014","journal-title":"Am. J. Hypertens."},{"key":"ref_73","doi-asserted-by":"crossref","unstructured":"Borrelli, S., Provenzano, M., Gagliardi, I., Michael, A., Liberti, M.E., De Nicola, L., Conte, G., Garofalo, C., and Andreucci, M. (2020). Sodium Intake and Chronic Kidney Disease. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21134744"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"427","DOI":"10.5301\/ijao.5000329","article-title":"Coping with fluid restriction and the quality of life in hemodialysis patients with very low or no daily urine output","volume":"37","author":"Silva","year":"2014","journal-title":"Int. J. Artif. Organs"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1038\/ki.2013.23","article-title":"The medicinal use of water in renal disease","volume":"84","author":"Wang","year":"2013","journal-title":"Kidney Int."},{"key":"ref_76","doi-asserted-by":"crossref","unstructured":"National Kidney Foundation (2015). KDOQI Clinical Practice Guideline for Hemodialysis Adequacy: 2015 update. Am. J. Kidney Dis., 66, 884\u2013930.","DOI":"10.1053\/j.ajkd.2015.07.015"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1172\/JCI0216494","article-title":"Malnutrition: A frequent misdiagnosis for hemodialysis patients","volume":"110","author":"Mitch","year":"2002","journal-title":"J. Clin. Investig."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"47","DOI":"10.3109\/08860220903391234","article-title":"Food intake and nutritional status in stable hemodialysis patients","volume":"32","author":"Cupisti","year":"2010","journal-title":"Ren. Fail."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"S39","DOI":"10.1093\/sleep\/15.suppl_6.S39","article-title":"Sleep apnea syndrome in the elderly","volume":"15","author":"Fleury","year":"1992","journal-title":"Sleep"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1053\/jren.2002.29598","article-title":"Food intake characteristics of hemodialysis patients as obtained by food frequency questionnaire","volume":"12","author":"Kopple","year":"2002","journal-title":"J. Ren. Nutr."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"1697","DOI":"10.1001\/jama.1972.03200130029006","article-title":"Ascorbic acid depletion during hemodialysis","volume":"220","author":"Sullivan","year":"1972","journal-title":"JAMA"},{"key":"ref_82","first-page":"471","article-title":"Effect of chronic renal failure on intestinal transport of biotin in the rat","volume":"120","author":"Said","year":"1992","journal-title":"J. Lab. Clin. Med."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"210","DOI":"10.3181\/00379727-196-43181","article-title":"Vitamin D absorption, plasma concentration and urinary excretion of 25-hydroxyvitamin D in nephrotic syndrome","volume":"196","author":"Khamiseh","year":"1991","journal-title":"Proc. Soc. Exp. Biol. Med."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"16","DOI":"10.3945\/an.113.005157","article-title":"Vitamin C","volume":"5","author":"Lykkesfeldt","year":"2014","journal-title":"Adv. Nutr."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1111\/odi.12446","article-title":"Vitamin C: The known and the unknown and Goldilocks","volume":"22","author":"Padayatty","year":"2016","journal-title":"Oral Dis."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"212","DOI":"10.2174\/2213337207999200726231300","article-title":"Ascorbic Acid-mediated Reactions in Organic Synthesis","volume":"7","author":"Das","year":"2020","journal-title":"Curr. Organocatal."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1016\/S0001-7310(06)73466-4","article-title":"Vitamin C","volume":"97","author":"Valdes","year":"2006","journal-title":"Actas Dermo-Sifiliogr\u00e1ficas"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1159\/000455372","article-title":"Chapter 6: Vitamins and Oral Health","volume":"28","author":"Gossweiler","year":"2020","journal-title":"Monogr. Oral Sci."},{"key":"ref_89","doi-asserted-by":"crossref","unstructured":"Kazmierczak-Baranska, J., Boguszewska, K., Adamus-Grabicka, A., and Karwowski, B.T. (2020). Two Faces of Vitamin C-Antioxidative and Pro-Oxidative Agent. Nutrients, 12.","DOI":"10.3390\/nu12051501"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"S6","DOI":"10.12968\/bjcn.2013.18.Sup12.S6","article-title":"Vitamin C: A wound healing perspective","volume":"18","author":"Moores","year":"2013","journal-title":"Br. J. Community Nurs."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1096\/fj.02-1167fje","article-title":"Impaired adrenal catecholamine system function in mice with deficiency of the ascorbic acid transporter (SVCT2)","volume":"17","author":"Bornstein","year":"2003","journal-title":"FASEB J."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1186\/s13054-015-1131-2","article-title":"Ascorbate-dependent vasopressor synthesis: A rationale for vitamin C administration in severe sepsis and septic shock?","volume":"19","author":"Carr","year":"2015","journal-title":"Crit. Care"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.3945\/ajcn.111.027995","article-title":"Effects of vitamin C supplementation on blood pressure: A meta-analysis of randomized controlled trials","volume":"95","author":"Juraschek","year":"2012","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1126\/science.179.4074.702","article-title":"Cholesterol: Vitamin C controls its transformation to bile acids","volume":"179","author":"Ginter","year":"1973","journal-title":"Science"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1007\/s00709-013-0560-5","article-title":"The role of ascorbate in protein folding","volume":"251","author":"Szarka","year":"2014","journal-title":"Protoplasma"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1007\/s10695-019-00727-1","article-title":"Vitamin C inhibits lipid deposition through GSK-3beta\/mTOR signaling in the liver of zebrafish","volume":"46","author":"Liu","year":"2020","journal-title":"Fish Physiol. Biochem."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1111\/j.1749-6632.1980.tb21325.x","article-title":"Interaction of vitamin C and iron","volume":"355","author":"Lynch","year":"1980","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref_98","first-page":"163","article-title":"The celluar interaction of ascorbic acid with histamine, cyclic nucleotides and prostaglandins in the immediate hypersensitivity reaction","volume":"50","author":"Sharma","year":"1980","journal-title":"Int. J. Vitam. Nutr. Res."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"3940","DOI":"10.1021\/jf104575w","article-title":"Antioxidant action of glutathione and the ascorbic acid\/glutathione pair in a model white wine","volume":"59","author":"Sonni","year":"2011","journal-title":"J. Agric. Food Chem."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1542\/peds.83.1.53","article-title":"Neonatal hyperparathyroidism: The natural course in the absence of surgical intervention","volume":"83","author":"Harris","year":"1989","journal-title":"Pediatrics"},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1053\/j.jrn.2016.03.003","article-title":"Gingival Bleeding and Bloody Dialysate: A Case Report of Scurvy in a Child With End-Stage Renal Disease Receiving Peritoneal Dialysis","volume":"26","author":"Kittisakmontri","year":"2016","journal-title":"J. Ren. Nutr."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1111\/j.1440-1797.2012.01595.x","article-title":"Association between vitamin C deficiency and dialysis modalities","volume":"17","author":"Zhang","year":"2012","journal-title":"Nephrology"},{"key":"ref_103","doi-asserted-by":"crossref","unstructured":"Chaghouri, P., Maalouf, N., Peters, S.L., Nowak, P.J., Peczek, K., Zasowska-Nowak, A., and Nowicki, M. (2021). Two Faces of Vitamin C in Hemodialysis Patients: Relation to Oxidative Stress and Inflammation. Nutrients, 13.","DOI":"10.3390\/nu13030791"},{"key":"ref_104","doi-asserted-by":"crossref","unstructured":"Zhang, K., Liu, L., Cheng, X., Dong, J., Geng, Q., and Zuo, L. (2011). Low levels of vitamin C in dialysis patients is associated with decreased prealbumin and increased C-reactive protein. BMC Nephrol., 12.","DOI":"10.1186\/1471-2369-12-18"},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"1384","DOI":"10.18632\/aging.100988","article-title":"FOXM1 regulates proliferation, senescence and oxidative stress in keratinocytes and cancer cells","volume":"8","author":"Smirnov","year":"2016","journal-title":"Aging"},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"3081856","DOI":"10.1155\/2017\/3081856","article-title":"Oxidative Stress in Hemodialysis Patients: A Review of the Literature","volume":"2017","author":"Liakopoulos","year":"2017","journal-title":"Oxid. Med. Cell Longev."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.ab.2017.07.009","article-title":"Mitochondrial membrane potential","volume":"552","author":"Zorova","year":"2018","journal-title":"Anal. Biochem."},{"key":"ref_108","doi-asserted-by":"crossref","unstructured":"Granata, S., Zaza, G., Simone, S., Villani, G., Latorre, D., Pontrelli, P., Carella, M., Schena, F.P., Grandaliano, G., and Pertosa, G. (2009). Mitochondrial dysregulation and oxidative stress in patients with chronic kidney disease. BMC Genom., 10.","DOI":"10.1186\/1471-2164-10-388"},{"key":"ref_109","first-page":"435","article-title":"Open comparison study of oxidative stress markers between patients with chronic renal failure in conservative therapy and patients in haemodialysis","volume":"161","author":"Coaccioli","year":"2010","journal-title":"Clin. Ter."},{"key":"ref_110","first-page":"39","article-title":"Acute effects of hemodialysis on oxidative stress parameters in chronic uremic patients: Comparison of two dialysis membranes","volume":"3","author":"Varan","year":"2010","journal-title":"Int. J. Nephrol. Renov. Dis."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1038\/ki.1985.199","article-title":"Plasma levels of granulocyte elastase during hemodialysis: Effects of different dialyzer membranes","volume":"28","author":"Horl","year":"1985","journal-title":"Kidney Int."},{"key":"ref_112","doi-asserted-by":"crossref","unstructured":"Lee, J.H., Shin, M.S., Kim, E.J., Ahn, Y.B., and Kim, H.D. (2017). The association of dietary vitamin C intake with periodontitis among Korean adults: Results from KNHANES. PLoS ONE, 12.","DOI":"10.1371\/journal.pone.0177074"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1111\/j.1600-051X.2004.00643.x","article-title":"Serum vitamin C-periodontal relationship in community-dwelling elderly Japanese","volume":"32","author":"Amarasena","year":"2005","journal-title":"J. Clin. Periodontol."},{"key":"ref_114","doi-asserted-by":"crossref","unstructured":"Pullar, J.M., Carr, A.C., and Vissers, M.C.M. (2017). The Roles of Vitamin C in Skin Health. Nutrients, 9.","DOI":"10.3390\/nu9080866"},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.ejim.2010.10.006","article-title":"Scurvy: Past, present and future","volume":"22","author":"Magiorkinis","year":"2011","journal-title":"Eur. J. Intern. Med."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1007\/s12291-013-0375-3","article-title":"Vitamin C in disease prevention and cure: An overview","volume":"28","author":"Chambial","year":"2013","journal-title":"Indian J. Clin. Biochem."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1159\/000090495","article-title":"Immune-enhancing role of vitamin C and zinc and effect on clinical conditions","volume":"50","author":"Wintergerst","year":"2006","journal-title":"Ann. Nutr. Metab."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1111\/j.1600-051X.2012.01927.x","article-title":"Vitamin C in plasma and leucocytes in relation to periodontitis","volume":"39","author":"Kuzmanova","year":"2012","journal-title":"J. Clin. Periodontol."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1079\/PNS19460041","article-title":"The effect of vitamin C on the healing of wounds","volume":"4","author":"Bourne","year":"1946","journal-title":"Proc. Nutr. Soc."},{"key":"ref_120","first-page":"e13158","article-title":"Scurvy, Starvation, and Flea Infestation\u2014A Case Report From 21st Century Europe","volume":"13","author":"Esteves","year":"2021","journal-title":"Cureus"},{"key":"ref_121","doi-asserted-by":"crossref","unstructured":"Basilicata, M., Di Lauro, M., Campolattano, V., Marrone, G., Celotto, R., Mitterhofer, A.P., Bollero, P., Di Daniele, N., and Noce, A. (2022). Natural Bioactive Compounds in the Management of Oral Diseases in Nephropathic Patients. Int. J. Environ. Res. Public Health, 19.","DOI":"10.3390\/ijerph19031665"},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1111\/j.1600-0757.2006.00178.x","article-title":"The role of reactive oxygen and antioxidant species in periodontal tissue destruction","volume":"43","author":"Chapple","year":"2007","journal-title":"Periodontology 2000"},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1007\/s13238-013-3030-0","article-title":"Vitamin C induces periodontal ligament progenitor cell differentiation via activation of ERK pathway mediated by PELP1","volume":"4","author":"Yan","year":"2013","journal-title":"Protein Cell"},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1038\/sj.bdj.4812613","article-title":"Grapefruit consumption improves vitamin C status in periodontitis patients","volume":"199","author":"Staudte","year":"2005","journal-title":"Br. Dent. J."},{"key":"ref_125","first-page":"25","article-title":"High fruit consumption and the periodontal status of farm workers","volume":"14","author":"Blignaut","year":"1992","journal-title":"Clin. Prev. Dent."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"2978741","DOI":"10.1155\/2016\/2978741","article-title":"Evaluation of the Anti-Inflammatory Effect of Locally Delivered Vitamin C in the Treatment of Persistent Gingival Inflammation: Clinical and Histopathological Study","volume":"2016","author":"Yussif","year":"2016","journal-title":"J. Nutr. Metab."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"256","DOI":"10.4103\/jioh.jioh_158_18","article-title":"Vitamin C supplementation as an adjunct to nonsurgical therapy in the treatment of chronic periodontitis: A clinical and biochemical study","volume":"10","author":"Raghavendra","year":"2018","journal-title":"J. Int. Oral Health"},{"key":"ref_128","first-page":"302","article-title":"The effect of nutrition on periodontal disease: A systematic review","volume":"42","author":"Kulkarni","year":"2014","journal-title":"J. Calif. Dent. Assoc."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"3228","DOI":"10.3390\/molecules15053228","article-title":"Vitamin B12: Unique metalorganic compounds and the most complex vitamins","volume":"15","author":"Randaccio","year":"2010","journal-title":"Molecules"},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1146\/annurev.nu.12.070192.001431","article-title":"Hyperhomocyst(e)inemia as a risk factor for occlusive vascular disease","volume":"12","author":"Kang","year":"1992","journal-title":"Annu. Rev. Nutr."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"3116","DOI":"10.1001\/jama.287.23.3116","article-title":"Vitamins for chronic disease prevention in adults: Scientific review","volume":"287","author":"Fairfield","year":"2002","journal-title":"JAMA"},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"3127","DOI":"10.1001\/jama.287.23.3127","article-title":"Vitamins for chronic disease prevention in adults: Clinical applications","volume":"287","author":"Fletcher","year":"2002","journal-title":"JAMA"},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1093\/ndt\/gfw090","article-title":"Association of serum vitamin B12 and folate with mortality in incident hemodialysis patients","volume":"32","author":"Soohoo","year":"2017","journal-title":"Nephrol. Dial. Transplant."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"303","DOI":"10.18203\/2349-3933.ijam20200085","article-title":"Study of vitamin B12 deficiency in chronic kidney disease","volume":"7","author":"Dandge","year":"2020","journal-title":"Int. J. Adv. Med."},{"key":"ref_135","first-page":"e901308","article-title":"Gut Microbioma Population: An Indicator Really Sensible to Any Change in Age, Diet, Metabolic Syndrome, and Life-Style","volume":"2014","author":"Noce","year":"2014","journal-title":"Mediat. Inflamm."},{"key":"ref_136","doi-asserted-by":"crossref","unstructured":"Noce, A., Marrone, G., Di Daniele, F., Ottaviani, E., Wilson Jones, G., Bernini, R., Romani, A., and Rovella, V. (2019). Impact of Gut Microbiota Composition on Onset and Progression of Chronic Non-Communicable Diseases. Nutrients, 11.","DOI":"10.3390\/nu11051073"},{"key":"ref_137","doi-asserted-by":"crossref","unstructured":"Al Mutairi, F. (2020). Hyperhomocysteinemia: Clinical Insights. J. Cent. Nerv. Syst. Dis., 12.","DOI":"10.1177\/1179573520962230"},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1007\/s10157-014-0961-6","article-title":"Influence of dialysis techniques and alternate vitamin supplementation on homocysteine levels in patients with known MTHFR genotypes","volume":"19","author":"Dessi","year":"2015","journal-title":"Clin. Exp. Nephrol."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1007\/s40620-014-0126-4","article-title":"Homocysteine, cysteine, folate and vitamin B(1)(2) status in type 2 diabetic patients with chronic kidney disease","volume":"28","author":"Pastore","year":"2015","journal-title":"J. Nephrol."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1373\/clinchem.2005.056119","article-title":"Effects of folic acid before and after vitamin B12 on plasma homocysteine concentrations in hemodialysis patients with known MTHFR genotypes","volume":"52","author":"Pastore","year":"2006","journal-title":"Clin. Chem."},{"key":"ref_141","doi-asserted-by":"crossref","unstructured":"Capelli, I., Cianciolo, G., Gasperoni, L., Zappulo, F., Tondolo, F., Cappuccilli, M., and La Manna, G. (2019). Folic Acid and Vitamin B12 Administration in CKD. Why Not?. Nutrients, 11.","DOI":"10.3390\/nu11020383"},{"key":"ref_142","first-page":"1425","article-title":"Update on vitamin B12 deficiency","volume":"83","author":"Langan","year":"2011","journal-title":"Am. Fam. Physician"},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1902\/jop.1976.47.11.667","article-title":"The effect of folic acid on gingival health","volume":"47","author":"Vogel","year":"1976","journal-title":"J. Periodontol."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"283","DOI":"10.2147\/CCIDE.S288137","article-title":"Dietary Factors Affecting the Prevalence and Impact of Periodontal Disease","volume":"13","author":"Santonocito","year":"2021","journal-title":"Clin. Cosmet. Investig. Dent."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1111\/jcpe.13276","article-title":"The effect of the systemic folic acid intake as an adjunct to scaling and root planing on clinical parameters and homocysteine and C-reactive protein levels in gingival crevicular fluid of periodontitis patients: A randomized placebo-controlled clinical trial","volume":"47","author":"Keceli","year":"2020","journal-title":"J. Clin. Periodontol."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1111\/j.1601-0825.2009.01619.x","article-title":"Relationship between folic acid intake and gingival health in non-smoking adults in Japan","volume":"16","author":"Esaki","year":"2010","journal-title":"Oral Dis."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1111\/j.1532-5415.2006.01020.x","article-title":"The association between serum folate levels and periodontal disease in older adults: Data from the National Health and Nutrition Examination Survey 2001\/02","volume":"55","author":"Yu","year":"2007","journal-title":"J. Am. Geriatr. Soc."},{"key":"ref_148","unstructured":"(2022, April 05). LARN, Livelli di Assunzione di Riferimento di Nutrienti ed Energia per la Popolazione Italiana. Available online: https:\/\/sinu.it\/2019\/07\/09\/vitamine-fabbisogno-medio-ar\/."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1111\/jcpe.12483","article-title":"Serum vitamin B12 is inversely associated with periodontal progression and risk of tooth loss: A prospective cohort study","volume":"43","author":"Zong","year":"2016","journal-title":"J. Clin. Periodontol."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1177\/0022034511407771","article-title":"The impact of vitamin D status on periodontal surgery outcomes","volume":"90","author":"Bashutski","year":"2011","journal-title":"J. Dent. Res."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1902\/jop.2005.76.7.1084","article-title":"Effects of vitamin-B complex supplementation on periodontal wound healing","volume":"76","author":"Neiva","year":"2005","journal-title":"J. Periodontol."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1590\/S0100-879X2006000900012","article-title":"Efficacy and safety of combined piroxicam, dexamethasone, orphenadrine, and cyanocobalamin treatment in mandibular molar surgery","volume":"39","author":"Barroso","year":"2006","journal-title":"Braz. J. Med. Biol. Res."},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1186\/1476-511X-13-54","article-title":"Plasma and erythrocyte membrane phospholipids and fatty acids in Italian general population and hemodialysis patients","volume":"13","author":"Dessi","year":"2014","journal-title":"Lipids Health Dis."},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"1635","DOI":"10.1902\/jop.2010.090628","article-title":"Adjunctive treatment of chronic periodontitis with daily dietary supplementation with omega-3 Fatty acids and low-dose aspirin","volume":"81","author":"Aboelsaad","year":"2010","journal-title":"J. Periodontol."},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1111\/j.1600-0765.2010.01336.x","article-title":"The efficacy of host response modulation therapy (omega-3 plus low-dose aspirin) as an adjunctive treatment of chronic periodontitis (clinical and biochemical study)","volume":"46","author":"Elkhouli","year":"2011","journal-title":"J. Periodontal Res."},{"key":"ref_156","doi-asserted-by":"crossref","unstructured":"Rizzo, G., Lagana, A.S., Rapisarda, A.M., La Ferrera, G.M., Buscema, M., Rossetti, P., Nigro, A., Muscia, V., Valenti, G., and Sapia, F. (2016). Vitamin B12 among Vegetarians: Status, Assessment and Supplementation. Nutrients, 8.","DOI":"10.3390\/nu8120767"},{"key":"ref_157","doi-asserted-by":"crossref","unstructured":"Marrone, G., Guerriero, C., Palazzetti, D., Lido, P., Marolla, A., Di Daniele, F., and Noce, A. (2021). Vegan Diet Health Benefits in Metabolic Syndrome. Nutrients, 13.","DOI":"10.3390\/nu13030817"},{"key":"ref_158","doi-asserted-by":"crossref","unstructured":"Varela-Lopez, A., Navarro-Hortal, M.D., Giampieri, F., Bullon, P., Battino, M., and Quiles, J.L. (2018). Nutraceuticals in Periodontal Health: A Systematic Review on the Role of Vitamins in Periodontal Health Maintenance. Molecules, 23.","DOI":"10.3390\/molecules23051226"},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1056\/NEJMra070553","article-title":"Vitamin D deficiency","volume":"357","author":"Holick","year":"2007","journal-title":"N. Engl. J. Med."},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1046\/j.1523-1755.1999.0550031019.x","article-title":"Serum levels of 1,25-dihydroxyvitamin D, 24,25-dihydroxyvitamin D, and 25-hydroxyvitamin D in nondialyzed patients with chronic renal failure","volume":"55","author":"Ishimura","year":"1999","journal-title":"Kidney Int."},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.jfda.2015.11.003","article-title":"Dietary antioxidants and their indispensable role in periodontal health","volume":"24","author":"Kaur","year":"2016","journal-title":"J. Food Drug Anal."},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1159\/000455379","article-title":"Chapter 12: Nutrient Deficiencies and Oral Health","volume":"28","author":"Rahman","year":"2020","journal-title":"Monogr. Oral Sci."},{"key":"ref_163","doi-asserted-by":"crossref","unstructured":"Martinon, P., Fraticelli, L., Giboreau, A., Dussart, C., Bourgeois, D., and Carrouel, F. (2021). Nutrition as a Key Modifiable Factor for Periodontitis and Main Chronic Diseases. J. Clin. Med., 10.","DOI":"10.3390\/jcm10020197"},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"S39","DOI":"10.1111\/jcpe.12685","article-title":"Interaction of lifestyle, behaviour or systemic diseases with dental caries and periodontal diseases: Consensus report of group 2 of the joint EFP\/ORCA workshop on the boundaries between caries and periodontal diseases","volume":"44","author":"Chapple","year":"2017","journal-title":"J. Clin. Periodontol."},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"209","DOI":"10.14238\/pi28.9-10.1988.209-13","article-title":"Hypovolemic shock complicating nephrotic syndrome in a child","volume":"28","author":"Kosnadi","year":"1988","journal-title":"Paediatr. Indones."},{"key":"ref_166","first-page":"103","article-title":"Association of Vitamin D With Periodontal Disease: A Narrative Review","volume":"18","author":"Dragonas","year":"2020","journal-title":"Oral Health Prev. Dent."},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1111\/jre.12531","article-title":"Vitamin D levels and risk for periodontal disease: A systematic review","volume":"53","author":"Pinto","year":"2018","journal-title":"J. Periodontal Res."},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1111\/jre.12560","article-title":"Serum vitamin D levels and chronic periodontitis in adult, Caucasian population-a systematic review","volume":"53","author":"Peric","year":"2018","journal-title":"J. Periodontal Res."},{"key":"ref_169","doi-asserted-by":"crossref","unstructured":"Machado, V., Lobo, S., Proenca, L., Mendes, J.J., and Botelho, J. (2020). Vitamin D and Periodontitis: A Systematic Review and Meta-Analysis. Nutrients, 12.","DOI":"10.3390\/nu12082177"},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1042\/bj2560159","article-title":"Effect of serum proteins on haem uptake and metabolism in primary cultures of liver cells","volume":"256","author":"Sinclair","year":"1988","journal-title":"Biochem. J."},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1111\/jre.12746","article-title":"Association of vitamin D in patients with periodontitis: A cross-sectional study","volume":"55","author":"Isola","year":"2020","journal-title":"J. Periodontal Res."},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1093\/ajcn\/80.1.108","article-title":"Association between serum concentrations of 25-hydroxyvitamin D3 and periodontal disease in the US population","volume":"80","author":"Dietrich","year":"2004","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1053\/j.jrn.2016.07.003","article-title":"The Association of Vitamin D With Estimated Glomerular Filtration Rate and Albuminuria: 5th Korean National Health and Nutritional Examination Survey 2011-2012","volume":"26","author":"Park","year":"2016","journal-title":"J. Ren. Nutr."},{"key":"ref_174","doi-asserted-by":"crossref","unstructured":"Satirapoj, B., Limwannata, P., Chaiprasert, A., Supasyndh, O., and Choovichian, P. (2013). Vitamin D insufficiency and deficiency with stages of chronic kidney disease in an Asian population. BMC Nephrol., 14.","DOI":"10.1186\/1471-2369-14-206"},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1038\/sj.ki.5002002","article-title":"25-Hydroxyvitamin D, insulin resistance, and kidney function in the Third National Health and Nutrition Examination Survey","volume":"71","author":"Chonchol","year":"2007","journal-title":"Kidney Int."},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1038\/ki.1989.64","article-title":"Metabolic clearance rate and production rate of calcitriol in uremia","volume":"35","author":"Dusso","year":"1989","journal-title":"Kidney Int."},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1258\/000456306775141713","article-title":"Vitamins: Their Role in the Human Body by GFM Ball","volume":"43","author":"Stewart","year":"2006","journal-title":"Ann. Clin. Biochem."},{"key":"ref_178","doi-asserted-by":"crossref","unstructured":"Botelho, J., Machado, V., Proenca, L., Delgado, A.S., and Mendes, J.J. (2020). Vitamin D Deficiency and Oral Health: A Comprehensive Review. Nutrients, 12.","DOI":"10.3390\/nu12051471"},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1002\/JPER.19-0510","article-title":"Calcitriol decreases live Porphyromonas gingivalis internalized into epithelial cells and monocytes by promoting autophagy","volume":"91","author":"Hu","year":"2020","journal-title":"J. Periodontol."},{"key":"ref_180","doi-asserted-by":"crossref","unstructured":"Li, H., Li, W., and Wang, Q. (2019). 1,25-dihydroxyvitamin D3 suppresses lipopolysaccharide-induced interleukin-6 production through aryl hydrocarbon receptor\/nuclear factor-kappaB signaling in oral epithelial cells. BMC Oral Health, 19.","DOI":"10.1186\/s12903-019-0935-x"},{"key":"ref_181","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1111\/jre.12823","article-title":"Mechanisms involved in regulation of periodontal ligament cell production of pro-inflammatory cytokines: Implications in periodontitis","volume":"56","author":"Nilsson","year":"2021","journal-title":"J. Periodontal Res."},{"key":"ref_182","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1007\/s00795-007-0381-8","article-title":"Role of beta-defensins in oral epithelial health and disease","volume":"40","author":"Abiko","year":"2007","journal-title":"Med. Mol. Morphol."},{"key":"ref_183","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1111\/nep.13225","article-title":"Periodontal and chronic kidney disease association: A systematic review and meta-analysis","volume":"24","author":"Kapellas","year":"2019","journal-title":"Nephrology"},{"key":"ref_184","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1677\/jme.0.0250141","article-title":"1alpha-Hydroxylase and the action of vitamin D","volume":"25","author":"Hewison","year":"2000","journal-title":"J. Mol. Endocrinol."},{"key":"ref_185","doi-asserted-by":"crossref","unstructured":"Costantini, E., Sinjari, B., Piscopo, F., Porreca, A., Reale, M., Caputi, S., and Murmura, G. (2020). Evaluation of Salivary Cytokines and Vitamin D Levels in Periodontopathic Patients. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21082669"},{"key":"ref_186","doi-asserted-by":"crossref","first-page":"104827","DOI":"10.1016\/j.archoralbio.2020.104827","article-title":"Serum vitamin D concentration is associated with antimicrobial peptide level in periodontal diseases","volume":"117","author":"Bayirli","year":"2020","journal-title":"Arch. Oral Biol."},{"key":"ref_187","doi-asserted-by":"crossref","first-page":"7315797","DOI":"10.1155\/2018\/7315797","article-title":"Vitamin D Deficiency as It Relates to Oral Immunity and Chronic Periodontitis","volume":"2018","author":"Khammissa","year":"2018","journal-title":"Int. J. Dent."},{"key":"ref_188","doi-asserted-by":"crossref","first-page":"100105","DOI":"10.1016\/j.jnim.2019.100105","article-title":"Micronutrients and bioactive compounds in oral inflammatory diseases","volume":"18","author":"Kaur","year":"2019","journal-title":"J. Nutr. Intermed. Metab."},{"key":"ref_189","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1111\/odi.13097","article-title":"The influence of vitamin D supplementation on local and systemic inflammatory markers in periodontitis patients: A pilot study","volume":"25","author":"Meghil","year":"2019","journal-title":"Oral Dis."},{"key":"ref_190","doi-asserted-by":"crossref","unstructured":"Cagetti, M.G., Wolf, T.G., Tennert, C., Camoni, N., Lingstrom, P., and Campus, G. (2020). The Role of Vitamins in Oral Health. A Systematic Review and Meta-Analysis. Int. J. Environ. Res. Public Health, 17.","DOI":"10.3390\/ijerph17030938"},{"key":"ref_191","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1111\/jre.12719","article-title":"Effect of short-term vitamin D supplementation after nonsurgical periodontal treatment: A randomized, double-masked, placebo-controlled clinical trial","volume":"55","author":"Gao","year":"2020","journal-title":"J. Periodontal Res."},{"key":"ref_192","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1681\/ASN.2017040422","article-title":"Metabolic Acidosis and Subclinical Metabolic Acidosis in CKD","volume":"29","author":"Raphael","year":"2018","journal-title":"J. Am. Soc. Nephrol."},{"key":"ref_193","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1172\/JCI100045","article-title":"The Excretion of Ammonia and Titratable Acid in Nephritis","volume":"2","author":"Linder","year":"1926","journal-title":"J. Clin. Investig."},{"key":"ref_194","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1172\/JCI112924","article-title":"Mechanisms for defects in muscle protein metabolism in rats with chronic uremia. Influence of metabolic acidosis","volume":"79","author":"May","year":"1987","journal-title":"J. Clin. Investig."},{"key":"ref_195","doi-asserted-by":"crossref","first-page":"1608","DOI":"10.1172\/JCI105467","article-title":"The effects of chronic acid loads in normal man: Further evidence for the participation of bone mineral in the defense against chronic metabolic acidosis","volume":"45","author":"Lemann","year":"1966","journal-title":"J. Clin. Investig."},{"key":"ref_196","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1111\/nep.12315","article-title":"Prevalence of and risk factors for reduced serum bicarbonate in chronic kidney disease","volume":"19","author":"Raphael","year":"2014","journal-title":"Nephrology"},{"key":"ref_197","first-page":"40","article-title":"The role of metabolic acidosis in the pathogenesis of renal osteodystrophy","volume":"2","author":"Kraut","year":"1995","journal-title":"Adv. Chronic Kidney Dis."},{"key":"ref_198","doi-asserted-by":"crossref","first-page":"F442","DOI":"10.1152\/ajprenal.1992.262.3.F442","article-title":"Acidosis inhibits osteoblastic and stimulates osteoclastic activity in vitro","volume":"262","author":"Krieger","year":"1992","journal-title":"Am. J. Physiol. Ren. Physiol."},{"key":"ref_199","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1097\/00005792-196509000-00002","article-title":"The composition of human bone in uremia. Observations on the reservoir functions of bone and demonstration of a labile fraction of bone carbonate","volume":"44","author":"Pellegrino","year":"1965","journal-title":"Medicine"},{"key":"ref_200","doi-asserted-by":"crossref","unstructured":"Cecoro, G., Annunziata, M., Iuorio, M.T., Nastri, L., and Guida, L. (2020). Periodontitis, Low-Grade Inflammation and Systemic Health: A Scoping Review. Medicina, 56.","DOI":"10.3390\/medicina56060272"},{"key":"ref_201","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1007\/s12282-020-01137-5","article-title":"Awake breast cancer surgery: Strategy in the beginning of COVID-19 emergency","volume":"28","author":"Vanni","year":"2021","journal-title":"Breast Cancer"},{"key":"ref_202","doi-asserted-by":"crossref","unstructured":"Ebert, T., Pawelzik, S.C., Witasp, A., Arefin, S., Hobson, S., Kublickiene, K., Shiels, P.G., Back, M., and Stenvinkel, P. (2020). Inflammation and Premature Ageing in Chronic Kidney Disease. Toxins, 12.","DOI":"10.3390\/toxins12040227"},{"key":"ref_203","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1007\/s00125-011-2342-y","article-title":"Periodontitis and diabetes: A two-way relationship","volume":"55","author":"Preshaw","year":"2012","journal-title":"Diabetologia"},{"key":"ref_204","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.jebdp.2016.11.002","article-title":"Low-grade Systemic Inflammation May Increase the Risk of Periodontitis","volume":"16","author":"Josey","year":"2016","journal-title":"J. Evid. Based Dent. Pract."},{"key":"ref_205","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1007\/s11892-013-0367-y","article-title":"Diabetes mellitus and periodontal diseases","volume":"13","author":"Sima","year":"2013","journal-title":"Curr. Diabetes Rep."},{"key":"ref_206","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1111\/jcpe.12473","article-title":"Longitudinal effects of systemic inflammation markers on periodontitis","volume":"42","author":"Pink","year":"2015","journal-title":"J. Clin. Periodontol."},{"key":"ref_207","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1080\/1040841X.2020.1724872","article-title":"Exploring the putative interactions between chronic kidney disease and chronic periodontitis","volume":"46","author":"Hickey","year":"2020","journal-title":"Crit. Rev. Microbiol."}],"container-title":["Nutrients"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6643\/14\/10\/2002\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T23:08:46Z","timestamp":1760137726000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6643\/14\/10\/2002"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5,10]]},"references-count":207,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2022,5]]}},"alternative-id":["nu14102002"],"URL":"https:\/\/doi.org\/10.3390\/nu14102002","relation":{},"ISSN":["2072-6643"],"issn-type":[{"value":"2072-6643","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,5,10]]}}}