{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T14:56:04Z","timestamp":1789829764717,"version":"4.0.1"},"reference-count":63,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2022,5,12]],"date-time":"2022-05-12T00:00:00Z","timestamp":1652313600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Age-related macular degeneration (AMD) is a serious degenerative disease affecting the eyes, and is the main cause of severe vision loss among people &gt;55 years of age in developed countries. Its onset and progression have been associated with several genetic and lifestyle factors, with diet appearing to play a pivotal role in the latter. In particular, dietary eating patterns rich in plant foods have been shown to lower the risk of developing the disease, and to decrease the odds of progressing to more advanced stages in individuals already burdened with early AMD. We systematically reviewed the literature to analyse the relationship between the adherence to a Mediterranean diet, a mainly plant-based dietary pattern, and the onset\/progression of AMD. Eight human observational studies were analysed. Despite some differences, they consistently indicate that higher adherence to a Mediterranean eating pattern lowers the odds of developing AMD and decreases the risk of progression to more advanced stages of the disease, establishing the way for preventative measures emphasizing dietary patterns rich in plant-foods.<\/jats:p>","DOI":"10.3390\/nu14102028","type":"journal-article","created":{"date-parts":[[2022,5,12]],"date-time":"2022-05-12T21:46:53Z","timestamp":1652392013000},"page":"2028","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Adherence to the Mediterranean-Style Eating Pattern and Macular Degeneration: A Systematic Review of Observational Studies"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4365-1191","authenticated-orcid":false,"given":"Annalisa","family":"Gastaldello","sequence":"first","affiliation":[{"name":"Research Group on Foods, Nutritional Biochemistry and Health, Universidad Europea del Atl\u00e1ntico, Isabel Torres 21, 39011 Santander, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8151-9132","authenticated-orcid":false,"given":"Francesca","family":"Giampieri","sequence":"additional","affiliation":[{"name":"Research Group on Foods, Nutritional Biochemistry and Health, Universidad Europea del Atl\u00e1ntico, Isabel Torres 21, 39011 Santander, Spain"},{"name":"Department of Biochemistry, Faculty of Sciences, King Abdulaziz University, Jeddah 80200, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9048-9086","authenticated-orcid":false,"given":"Jos\u00e9 L.","family":"Quiles","sequence":"additional","affiliation":[{"name":"Research Group on Foods, Nutritional Biochemistry and Health, Universidad Europea del Atl\u00e1ntico, Isabel Torres 21, 39011 Santander, Spain"},{"name":"Department of Physiology, Institute of Nutrition and Food Technology \u201cJos\u00e9 Mataix\u201d, Biomedical Research Centre, University of Granada, 18100 Granada, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6225-8379","authenticated-orcid":false,"given":"Mar\u00eda D.","family":"Navarro-Hortal","sequence":"additional","affiliation":[{"name":"Department of Physiology, Institute of Nutrition and Food Technology \u201cJos\u00e9 Mataix\u201d, Biomedical Research Centre, University of Granada, 18100 Granada, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5777-6967","authenticated-orcid":false,"given":"Silvia","family":"Aparicio","sequence":"additional","affiliation":[{"name":"Research Group on Foods, Nutritional Biochemistry and Health, Universidad Europea del Atl\u00e1ntico, Isabel Torres 21, 39011 Santander, Spain"},{"name":"Faculdade de Ci\u00eancias Sociais e Humanas, Universidade Internacional do Cuanza Bairro Kaluanda, Cuito EN 250, Bi\u00e9, Angola"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7549-3733","authenticated-orcid":false,"given":"Eduardo","family":"Garc\u00eda Villena","sequence":"additional","affiliation":[{"name":"Research Group on Foods, Nutritional Biochemistry and Health, Universidad Europea del Atl\u00e1ntico, Isabel Torres 21, 39011 Santander, Spain"},{"name":"Department de Salud, Universidad Internacional Iberoamericana Campeche, Campeche 24560, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kilian","family":"Tutusaus Pifarre","sequence":"additional","affiliation":[{"name":"Research Group on Foods, Nutritional Biochemistry and Health, Universidad Europea del Atl\u00e1ntico, Isabel Torres 21, 39011 Santander, Spain"},{"name":"Department de Salud, Universidad Internacional Iberoamericana Campeche, Campeche 24560, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5583-7735","authenticated-orcid":false,"given":"Rachele","family":"De Giuseppe","sequence":"additional","affiliation":[{"name":"Laboratory of Dietetics and Clinical Nutrition, Department of Public Health, Experimental and Forensic Medicine, University of Pavia, 27100 Pavia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3930-5285","authenticated-orcid":false,"given":"Giuseppe","family":"Grosso","sequence":"additional","affiliation":[{"name":"Department of Biomedical and Biotechnological Sciences, University of Catania, 95124 Catania, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8781-3535","authenticated-orcid":false,"given":"Danila","family":"Cianciosi","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Polytechnic University of Marche, 60131 Ancona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamara Y.","family":"Forbes-Hern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Department of Physiology, Institute of Nutrition and Food Technology \u201cJos\u00e9 Mataix\u201d, Biomedical Research Centre, University of Granada, 18100 Granada, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seyed M.","family":"Nabavi","sequence":"additional","affiliation":[{"name":"Applied Biotechnology Research Center, Baqiyatallah University of Medical Sciences, Tehran 1435916471, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7250-1782","authenticated-orcid":false,"given":"Maurizio","family":"Battino","sequence":"additional","affiliation":[{"name":"Research Group on Foods, Nutritional Biochemistry and Health, Universidad Europea del Atl\u00e1ntico, Isabel Torres 21, 39011 Santander, Spain"},{"name":"Department of Clinical Sciences, Polytechnic University of Marche, 60131 Ancona, Italy"},{"name":"International Joint Research Laboratory of Intelligent Agriculture and Agri-Products Processing, Jiangsu University, Zhenjiang 212013, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,5,12]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1016\/j.mam.2012.03.006","article-title":"How does the macula protect itself from oxidative stress?","volume":"33","author":"Handa","year":"2012","journal-title":"Mol. 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