{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T22:33:48Z","timestamp":1782513228796,"version":"3.54.5"},"reference-count":168,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2022,5,12]],"date-time":"2022-05-12T00:00:00Z","timestamp":1652313600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Fondation Jerome Lejeune","award":["2017a-1634"],"award-info":[{"award-number":["2017a-1634"]}]},{"name":"Fondation Jerome Lejeune","award":["ANR-18-CE16-0020 DYRKDOWN"],"award-info":[{"award-number":["ANR-18-CE16-0020 DYRKDOWN"]}]},{"name":"French state funds through the \u201cAgence Nationale de la Recherche\u201d program","award":["2017a-1634"],"award-info":[{"award-number":["2017a-1634"]}]},{"name":"French state funds through the \u201cAgence Nationale de la Recherche\u201d program","award":["ANR-18-CE16-0020 DYRKDOWN"],"award-info":[{"award-number":["ANR-18-CE16-0020 DYRKDOWN"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Plant-derived polyphenols flavonoids are increasingly being recognized for their medicinal potential. These bioactive compounds derived from plants are gaining more interest in ameliorating adverse health risks because of their low toxicity and few side effects. Among them, therapeutic approaches demonstrated the efficacy of catechins, a major group of flavonoids, in reverting several aspects of Down syndrome, the most common genomic disorder that causes intellectual disability. Down syndrome is characterized by increased incidence of developing Alzheimer\u2019s disease, obesity, and subsequent metabolic disorders. In this focused review, we examine the main effects of catechins on comorbidities linked with Down syndrome. We also provide evidence of catechin effects on DYRK1A, a dosage-sensitive gene encoding a protein kinase involved in brain defects and metabolic disease associated with Down syndrome.<\/jats:p>","DOI":"10.3390\/nu14102039","type":"journal-article","created":{"date-parts":[[2022,5,12]],"date-time":"2022-05-12T21:46:53Z","timestamp":1652392013000},"page":"2039","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Catechins as a Potential Dietary Supplementation in Prevention of Comorbidities Linked with Down Syndrome"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2874-2060","authenticated-orcid":false,"given":"Christophe","family":"Noll","sequence":"first","affiliation":[{"name":"Division of Endocrinology, Department of Medicine, Centre de Recherche du CHUS, Universit\u00e9 de Sherbrooke, Sherbrooke, QC J1K 2R1, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janany","family":"Kandiah","sequence":"additional","affiliation":[{"name":"Unit\u00e9 de Biologie Fonctionnelle et Adaptative, UMR 8251 CNRS, Universit\u00e9 Paris Cit\u00e9, F-75013 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8973-0477","authenticated-orcid":false,"given":"Gautier","family":"Moroy","sequence":"additional","affiliation":[{"name":"Unit\u00e9 de Biologie Fonctionnelle et Adaptative, INSERM CNRS, Universit\u00e9 Paris Cit\u00e9, F-75013 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3188-2264","authenticated-orcid":false,"given":"Yuchen","family":"Gu","sequence":"additional","affiliation":[{"name":"Unit\u00e9 de Biologie Fonctionnelle et Adaptative, UMR 8251 CNRS, Universit\u00e9 Paris Cit\u00e9, F-75013 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1767-0572","authenticated-orcid":false,"given":"Julien","family":"Dairou","sequence":"additional","affiliation":[{"name":"Laboratoire de Chimie et Biochimie Pharmacologiques et Toxicologiques, UMR 8601 CNRS, Universit\u00e9 Paris Cit\u00e9, F-75006 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalie","family":"Janel","sequence":"additional","affiliation":[{"name":"Unit\u00e9 de Biologie Fonctionnelle et Adaptative, UMR 8251 CNRS, Universit\u00e9 Paris Cit\u00e9, F-75013 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,5,12]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1093\/ajcn\/79.5.727","article-title":"Polyphenols: Food sources and bioavailability","volume":"79","author":"Manach","year":"2004","journal-title":"Am. 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