{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T00:19:46Z","timestamp":1760228386062,"version":"build-2065373602"},"reference-count":72,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2022,5,13]],"date-time":"2022-05-13T00:00:00Z","timestamp":1652400000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Semmelweis Science and Innovation Fund","award":["STIA-OTKA-2021"],"award-info":[{"award-number":["STIA-OTKA-2021"]}]},{"name":"Hungarian Hypertension Society","award":["STIA-OTKA-2021"],"award-info":[{"award-number":["STIA-OTKA-2021"]}]},{"name":"Dean of the Medical Faculty, Semmelweis University","award":["STIA-OTKA-2021"],"award-info":[{"award-number":["STIA-OTKA-2021"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>The aim of our study was to identify whether vitamin-D deficiency (VDD) can alter the geometry of the coronary-resistance-artery system. Male Wistar rats were divided into vitamin-D-deficient (VD\u2212, n = 10) and vitamin-D-supplemented (VD+, n = 8) groups. After eight weeks, branches and segments of the left-anterior-descending-coronary-artery (LAD) network were analyzed by a video-microscopy technique. Segments were divided into 50 \u03bcm-long cylindrical ring units. VDD did not increase the number of morphological abnormalities. The number of segments did not differ between the groups (VD\u2212: 210 and VD+: 224; pooled data of 8 networks). A larger lumen area of branches was found in VD+ group, while 1\u20134-order branches were lengthier in the VD\u2212 group. VD\u2212 rats had less rich coronary-resistance-artery networks in terms of 50 \u00b5m-long units. (VD\u2212: 6365 vs. VD+: 6602; pooled data of 8 networks). VD+ animals were richer in the 100\u2013350 \u00b5m outer diameter range, and VD\u2212 animals were richer in the 400\u2013550 \u00b5m-diameter units. In VD\u2212 rats, 150\u2013200 and 300 \u00b5m units were almost missing at higher flow distances from the orifice. Serum vitamin-D alterations caused by dietary changes can affect the geometry of the coronary-artery network, which may contribute to vitamin-D-dependent changes in cardiovascular mortality.<\/jats:p>","DOI":"10.3390\/nu14102041","type":"journal-article","created":{"date-parts":[[2022,5,13]],"date-time":"2022-05-13T08:37:02Z","timestamp":1652431022000},"page":"2041","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Vitamin-D Deficiency and Supplementation Altered the Network of the Coronary Arteries in a Rodent Model\u2014In Situ Video Microscopic Technique"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7871-544X","authenticated-orcid":false,"given":"Hicham","family":"Dalloul","sequence":"first","affiliation":[{"name":"K\u00e1roly R\u00e1cz Doctoral School of Clinical Medicine, Semmelweis University, \u00dcll\u0151i Street 26, H-1085 Budapest, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tobias","family":"Hainzl","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Semmelweis University, \u00dcll\u0151i Street 78\/a, H-1082 Budapest, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Monori-Kiss","sequence":"additional","affiliation":[{"name":"Department of Translational Medicine, Faculty of Medicine, Semmelweis University,\u00dcll\u0151i Street 78\/a, H-1082 Budapest, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leila","family":"Hadjadj","sequence":"additional","affiliation":[{"name":"Department of Translational Medicine, Faculty of Medicine, Semmelweis University,\u00dcll\u0151i Street 78\/a, H-1082 Budapest, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gy\u00f6rgy L.","family":"N\u00e1dasy","sequence":"additional","affiliation":[{"name":"Department of Physiology, Faculty of Medicine, Semmelweis University, T\u0171zolt\u00f3 Street 37-47, H-1094 Budapest, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2832-0626","authenticated-orcid":false,"given":"Marianna","family":"T\u00f6r\u00f6k","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Semmelweis University, \u00dcll\u0151i Street 78\/a, H-1082 Budapest, Hungary"},{"name":"Workgroup for Science Management, Doctoral School, Semmelweis University, \u00dcll\u0151i Street 22, H-1085 Budapest, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7109-6906","authenticated-orcid":false,"given":"Szabolcs","family":"V\u00e1rb\u00edr\u00f3","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Semmelweis University, \u00dcll\u0151i Street 78\/a, H-1082 Budapest, Hungary"},{"name":"Workgroup for Science Management, Doctoral School, Semmelweis University, \u00dcll\u0151i Street 22, H-1085 Budapest, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,5,13]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/S0021-9258(18)85783-0","article-title":"Studies on experimental rickets: XXI. 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