{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T17:18:31Z","timestamp":1791047911435,"version":"4.1.0"},"reference-count":25,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2022,5,16]],"date-time":"2022-05-16T00:00:00Z","timestamp":1652659200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>The present research purposed to examine the gastro-protective effect of Glycine max (L.) Merr. fermented using Lactobacillus delbrueckii ssp. delbrueckii Rosell-187 (Gastro-AD\u00ae) on ethanol\/HCl-induced gastric damage, specifically on gastric acid secretion. After oral supplementation of Gastro-AD\u00ae to Sprague\u2013Dawley (SD) rats with ethanol\/HCl-induced gastric damage, we determined that Gastro-AD\u00ae attenuated the gastric mucosal lesion, hemorrhage and gastric acid secretion induced by ethanol\/HCl. In addition, we observed that the Gastro-AD\u00ae treatment increased the serum prostaglandin E2 level and decreased the levels of gastric acid secretion-related receptors in both gastric tissues and primary gastric parietal cells. Furthermore, it decreased the levels of inflammatory factors, including serum histamine and expression of p-I\u03baB, p-p65, iNOS and COX-2 and the activity of apoptotic signaling pathways, including those involving p-JNK, Bcl2\/Bax, Fas, FADD, caspase-8 and caspase-3, in the stomach of the ethanol\/HCl-treated rats. Thus, we suggest that Gastro-AD\u00ae supplementation may reduce ethanol\/HCl-induced gastric acid secretion and prevent gastric injury.<\/jats:p>","DOI":"10.3390\/nu14102079","type":"journal-article","created":{"date-parts":[[2022,5,16]],"date-time":"2022-05-16T21:36:06Z","timestamp":1652736966000},"page":"2079","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Gastro-Protective Effect of Fermented Soybean (Glycine max (L.) Merr.) in a Rat Model of Ethanol\/HCl-Induced Gastric Injury"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8820-4395","authenticated-orcid":false,"given":"Minhee","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Medical Nutrition, Kyung Hee University, Yongin 17104, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9619-5081","authenticated-orcid":false,"given":"Dakyung","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Medical Nutrition, Kyung Hee University, Yongin 17104, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyunji","family":"Kim","sequence":"additional","affiliation":[{"name":"Cosmax NBT, Inc., Seongnam-si 13486, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sukyung","family":"Jo","sequence":"additional","affiliation":[{"name":"Bision Corporation, Seoul 05854, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8338-2571","authenticated-orcid":false,"given":"Ok-Kyung","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Food and Nutrition and Human Ecology Research Institute, Chonnam National University, Gwangju 61186, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeongmin","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Medical Nutrition, Kyung Hee University, Yongin 17104, Korea"},{"name":"Research Institute of Clinical Nutrition, Kyung Hee University, Seoul 02447, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,5,16]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1136\/bmj.323.7319.980","article-title":"ABC of the upper gastrointestinal tract: Pathophysiology of duodenal and gastric ulcer and gastric cancer","volume":"323","author":"Calam","year":"2001","journal-title":"BMJ"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1016\/S1052-5157(18)30044-8","article-title":"Gastritis","volume":"11","author":"Glickman","year":"2001","journal-title":"Gastrointest. 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