{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T23:04:16Z","timestamp":1788217456064,"version":"build-2803163510"},"reference-count":41,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2022,5,18]],"date-time":"2022-05-18T00:00:00Z","timestamp":1652832000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Scharper S.p.A."}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>We aimed to evaluate if dietary supplementation with a nutraceutical compound (Eufortyn\u00ae Colesterolo Plus) containing standardized bergamot polyphenolic fraction phytosome (Vazguard\u00ae), artichoke extract (Pycrinil\u00ae), artichoke dry extract. (Cynara scolymus L.), Q10 phytosome(Ubiqosome\u00ae) and zinc, could positively affect serum lipids concentration, systemic inflammation and indexes of non-alcoholic fatty liver disease (NAFLD) in 60 healthy subjects with polygenic hypercholesterolemia. Participants were adhering to a low-fat, low-sodium Mediterranean diet for a month before being randomly allocated to 8-week treatment with 1 pill each day of either Eufortyn\u00ae Colesterolo Plus or placebo. Dietary supplementation with Eufortyn\u00ae Colesterolo Plus was associated with significant improvement in total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), non-high-density lipoprotein cholesterol (non-HDL-C), high-sensitivity C-reactive protein (hs-CRP) and endothelial reactivity (ER) in comparison with baseline, and with significant reductions in waist circumference, TC, LDL-C, LDL-C\/HDL-C, lipid accumulation product and fatty liver index compared to placebo. The study shows that dietary supplementation with standardized bergamot polyphenolic fraction phytosome, artichoke extracts, Q10 phytosome and zinc safely exerts significant improvements in serum lipids, systemic inflammation, indexes of NAFLD and endothelial reactivity in healthy subjects with moderate hypercholesterolemia.<\/jats:p>","DOI":"10.3390\/nu14102099","type":"journal-article","created":{"date-parts":[[2022,5,18]],"date-time":"2022-05-18T23:14:26Z","timestamp":1652915666000},"page":"2099","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Effect of Dietary Supplementation with Eufortyn\u00ae Colesterolo Plus on Serum Lipids, Endothelial Reactivity, Indexes of Non-Alcoholic Fatty Liver Disease and Systemic Inflammation in Healthy Subjects with Polygenic Hypercholesterolemia: The ANEMONE Study"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7853-0042","authenticated-orcid":false,"given":"Federica","family":"Fogacci","sequence":"first","affiliation":[{"name":"Hypertension and Cardiovascular Risk Research Center, Medical and Surgical Sciences Department, Sant\u2019Orsola-Malpighi University Hospital, 40138 Bologna, Italy"},{"name":"IRCCS Policlinico S. Orsola\u2014Malpighi di Bologna, 40138 Bologna, Italy"},{"name":"Italian Nutraceutical Society (SINut), 40138 Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabetta","family":"Rizzoli","sequence":"additional","affiliation":[{"name":"Hypertension and Cardiovascular Risk Research Center, Medical and Surgical Sciences Department, Sant\u2019Orsola-Malpighi University Hospital, 40138 Bologna, Italy"},{"name":"IRCCS Policlinico S. Orsola\u2014Malpighi di Bologna, 40138 Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"Giovannini","sequence":"additional","affiliation":[{"name":"Hypertension and Cardiovascular Risk Research Center, Medical and Surgical Sciences Department, Sant\u2019Orsola-Malpighi University Hospital, 40138 Bologna, Italy"},{"name":"IRCCS Policlinico S. Orsola\u2014Malpighi di Bologna, 40138 Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marilisa","family":"Bove","sequence":"additional","affiliation":[{"name":"Hypertension and Cardiovascular Risk Research Center, Medical and Surgical Sciences Department, Sant\u2019Orsola-Malpighi University Hospital, 40138 Bologna, Italy"},{"name":"IRCCS Policlinico S. Orsola\u2014Malpighi di Bologna, 40138 Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6631-4342","authenticated-orcid":false,"given":"Sergio","family":"D\u2019Addato","sequence":"additional","affiliation":[{"name":"Hypertension and Cardiovascular Risk Research Center, Medical and Surgical Sciences Department, Sant\u2019Orsola-Malpighi University Hospital, 40138 Bologna, Italy"},{"name":"IRCCS Policlinico S. Orsola\u2014Malpighi di Bologna, 40138 Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8039-8781","authenticated-orcid":false,"given":"Claudio","family":"Borghi","sequence":"additional","affiliation":[{"name":"Hypertension and Cardiovascular Risk Research Center, Medical and Surgical Sciences Department, Sant\u2019Orsola-Malpighi University Hospital, 40138 Bologna, Italy"},{"name":"IRCCS Policlinico S. Orsola\u2014Malpighi di Bologna, 40138 Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4367-3884","authenticated-orcid":false,"given":"Arrigo F. G.","family":"Cicero","sequence":"additional","affiliation":[{"name":"Hypertension and Cardiovascular Risk Research Center, Medical and Surgical Sciences Department, Sant\u2019Orsola-Malpighi University Hospital, 40138 Bologna, Italy"},{"name":"IRCCS Policlinico S. Orsola\u2014Malpighi di Bologna, 40138 Bologna, Italy"},{"name":"Italian Nutraceutical Society (SINut), 40138 Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,5,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1007\/s11883-013-0324-x","article-title":"Polyphenols, inflammation, and cardiovascular disease","volume":"15","author":"Tangney","year":"2013","journal-title":"Curr. Atheroscler. Rep."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Di Lorenzo, C., Colombo, F., Biella, S., Stockley, C., and Restani, P. (2021). Polyphenols and human health: The role of bioavailability. 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