{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T19:34:10Z","timestamp":1782416050992,"version":"3.54.5"},"reference-count":50,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2022,5,23]],"date-time":"2022-05-23T00:00:00Z","timestamp":1653264000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Swiss National Science Foundation","award":["PP00P3_150531"],"award-info":[{"award-number":["PP00P3_150531"]}]},{"name":"Swiss National Science Foundation","award":["PP00P3_176972"],"award-info":[{"award-number":["PP00P3_176972"]}]},{"name":"Swiss National Science Foundation","award":["1410.000.058"],"award-info":[{"award-number":["1410.000.058"]}]},{"name":"Swiss National Science Foundation","award":["1410.000.044"],"award-info":[{"award-number":["1410.000.044"]}]},{"name":"Research Council of the Kantonsspital Aarau","award":["PP00P3_150531"],"award-info":[{"award-number":["PP00P3_150531"]}]},{"name":"Research Council of the Kantonsspital Aarau","award":["PP00P3_176972"],"award-info":[{"award-number":["PP00P3_176972"]}]},{"name":"Research Council of the Kantonsspital Aarau","award":["1410.000.058"],"award-info":[{"award-number":["1410.000.058"]}]},{"name":"Research Council of the Kantonsspital Aarau","award":["1410.000.044"],"award-info":[{"award-number":["1410.000.044"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Background: Cancer-related malnutrition is a prevalent condition associated with a loss of muscle mass and impaired functional status, leading to immunodeficiency, impaired quality of life and adverse clinical outcomes. Handgrip strength (HGS) is a practical measure to assess muscle strength in individual patients during clinical practice. However, HGS reference values refer to populations of healthy people, and population-specific values, such as those in the population of cancer patients, still need to be defined. Methods: Within a secondary analysis of a previous randomized controlled nutritional trial focusing on hospitalized cancer patients at risk for malnutrition, we investigated sex-specific HGS values stratified by age and tumor entity. Additionally, we examined the association between HGS and 180-day all-cause mortality. Results: We included data from 628 cancer patients, which were collected from eight hospitals in Switzerland. Depending on the age of patients, HGS varied among female patients from 7 kg to 26 kg and among male patients from 20.5 kg to 44 kg. An incremental decrease in handgrip strength by 10 kg resulted in a 50% increase in 180-day all-cause mortality (odds ratio 1.52 (95%CI 1.19 to 1.94), p = 0.001). Conclusion: Our data provide evidence of the prognostic implications of HGS measurement in cancer patients and validate the prognostic value of handgrip strength in regard to long-term mortality. In addition, our results provide expected HGS values in the population of hospitalized malnourished cancer patients, which may allow better interpretation of values in individual patients.<\/jats:p>","DOI":"10.3390\/nu14102173","type":"journal-article","created":{"date-parts":[[2022,5,24]],"date-time":"2022-05-24T03:16:55Z","timestamp":1653362215000},"page":"2173","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Handgrip Strength Values Depend on Tumor Entity and Predict 180-Day Mortality in Malnourished Cancer Patients"],"prefix":"10.3390","volume":"14","author":[{"given":"Pascal","family":"Tribolet","sequence":"first","affiliation":[{"name":"Department of Health Professions, Bern University of Applied Sciences, 3008 Bern, Switzerland"},{"name":"Department of Nutritional Sciences and Research Platform Active Ageing, University of Vienna, 1090 Vienna, Austria"},{"name":"Division of General Internal and Emergency Medicine, Medical University Department, Kantonsspital Aarau, 5001 Aarau, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4015-295X","authenticated-orcid":false,"given":"Nina","family":"Kaegi-Braun","sequence":"additional","affiliation":[{"name":"Division of General Internal and Emergency Medicine, Medical University Department, Kantonsspital Aarau, 5001 Aarau, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carla","family":"Gressies","sequence":"additional","affiliation":[{"name":"Division of General Internal and Emergency Medicine, Medical University Department, Kantonsspital Aarau, 5001 Aarau, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annic","family":"Baumgartner","sequence":"additional","affiliation":[{"name":"Division of General Internal and Emergency Medicine, Medical University Department, Kantonsspital Aarau, 5001 Aarau, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1683-7265","authenticated-orcid":false,"given":"Karl-Heinz","family":"Wagner","sequence":"additional","affiliation":[{"name":"Department of Nutritional Sciences and Research Platform Active Ageing, University of Vienna, 1090 Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeno","family":"Stanga","sequence":"additional","affiliation":[{"name":"Division of Diabetes, Endocrinology, Nutritional Medicine and Metabolism, Inselspital, Bern University Hospital, University of Bern, 4001 Bern, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6400-4949","authenticated-orcid":false,"given":"Philipp","family":"Schuetz","sequence":"additional","affiliation":[{"name":"Division of General Internal and Emergency Medicine, Medical University Department, Kantonsspital Aarau, 5001 Aarau, Switzerland"},{"name":"Medical Faculty, University of Basel, 4056 Basel, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,5,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1927","DOI":"10.1016\/S0140-6736(21)01451-3","article-title":"Management of disease-related malnutrition for patients being treated in hospital","volume":"398","author":"Schuetz","year":"2021","journal-title":"Lancet"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1017\/S002966511500419X","article-title":"Cancer-associated malnutrition, cachexia and sarcopenia: The skeleton in the hospital closet 40 years later","volume":"75","author":"Ryan","year":"2016","journal-title":"Proc. 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